Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0I5_LEIDO

TriTrypDb:

LdBPK_270681.1 , LdCL_270013400 , LDHU3_27.1080

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.544
CLV_C14_Caspase3-7	50	54	PF00656	0.564
CLV_NRD_NRD_1	174	176	PF00675	0.688
CLV_NRD_NRD_1	19	21	PF00675	0.633
CLV_NRD_NRD_1	296	298	PF00675	0.574
CLV_NRD_NRD_1	312	314	PF00675	0.648
CLV_NRD_NRD_1	394	396	PF00675	0.488
CLV_NRD_NRD_1	397	399	PF00675	0.492
CLV_NRD_NRD_1	463	465	PF00675	0.653
CLV_PCSK_FUR_1	395	399	PF00082	0.561
CLV_PCSK_KEX2_1	122	124	PF00082	0.658
CLV_PCSK_KEX2_1	160	162	PF00082	0.582
CLV_PCSK_KEX2_1	174	176	PF00082	0.591
CLV_PCSK_KEX2_1	19	21	PF00082	0.633
CLV_PCSK_KEX2_1	298	300	PF00082	0.563
CLV_PCSK_KEX2_1	311	313	PF00082	0.493
CLV_PCSK_KEX2_1	396	398	PF00082	0.550
CLV_PCSK_KEX2_1	462	464	PF00082	0.588
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.658
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.759
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.575
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.585
CLV_PCSK_SKI1_1	122	126	PF00082	0.558
CLV_PCSK_SKI1_1	157	161	PF00082	0.601
CLV_PCSK_SKI1_1	397	401	PF00082	0.555
CLV_PCSK_SKI1_1	439	443	PF00082	0.462
DEG_SPOP_SBC_1	374	378	PF00917	0.508
DOC_CKS1_1	56	61	PF01111	0.585
DOC_MAPK_gen_1	216	224	PF00069	0.680
DOC_MAPK_gen_1	323	330	PF00069	0.546
DOC_PP2B_LxvP_1	110	113	PF13499	0.669
DOC_PP2B_LxvP_1	205	208	PF13499	0.634
DOC_PP4_FxxP_1	326	329	PF00568	0.566
DOC_SPAK_OSR1_1	325	329	PF12202	0.491
DOC_USP7_MATH_1	114	118	PF00917	0.703
DOC_USP7_MATH_1	233	237	PF00917	0.645
DOC_USP7_MATH_1	259	263	PF00917	0.662
DOC_USP7_MATH_1	364	368	PF00917	0.657
DOC_USP7_MATH_1	65	69	PF00917	0.488
DOC_WW_Pin1_4	126	131	PF00397	0.645
DOC_WW_Pin1_4	169	174	PF00397	0.680
DOC_WW_Pin1_4	229	234	PF00397	0.701
DOC_WW_Pin1_4	331	336	PF00397	0.561
DOC_WW_Pin1_4	55	60	PF00397	0.576
LIG_14-3-3_CanoR_1	115	119	PF00244	0.626
LIG_14-3-3_CanoR_1	189	193	PF00244	0.661
LIG_14-3-3_CanoR_1	199	207	PF00244	0.581
LIG_14-3-3_CanoR_1	271	280	PF00244	0.716
LIG_14-3-3_CanoR_1	445	453	PF00244	0.475
LIG_14-3-3_CanoR_1	78	82	PF00244	0.654
LIG_APCC_ABBA_1	300	305	PF00400	0.602
LIG_APCC_ABBA_1	327	332	PF00400	0.502
LIG_BRCT_BRCA1_1	127	131	PF00533	0.525
LIG_EVH1_1	110	114	PF00568	0.649
LIG_FHA_1	105	111	PF00498	0.659
LIG_FHA_1	304	310	PF00498	0.611
LIG_FHA_1	376	382	PF00498	0.525
LIG_FHA_1	398	404	PF00498	0.565
LIG_FHA_1	430	436	PF00498	0.562
LIG_FHA_1	438	444	PF00498	0.503
LIG_LIR_Apic_2	204	209	PF02991	0.758
LIG_LIR_Apic_2	324	329	PF02991	0.572
LIG_LIR_Gen_1	45	56	PF02991	0.636
LIG_LIR_Nem_3	262	266	PF02991	0.557
LIG_LIR_Nem_3	45	51	PF02991	0.651
LIG_Pex14_2	213	217	PF04695	0.663
LIG_Pex14_2	326	330	PF04695	0.629
LIG_Pex14_2	343	347	PF04695	0.338
LIG_SH2_CRK	266	270	PF00017	0.625
LIG_SH2_GRB2like	346	349	PF00017	0.524
LIG_SH2_SRC	206	209	PF00017	0.632
LIG_SH2_STAP1	387	391	PF00017	0.467
LIG_SH2_STAT5	206	209	PF00017	0.632
LIG_SH2_STAT5	266	269	PF00017	0.626
LIG_SH2_STAT5	303	306	PF00017	0.621
LIG_SH2_STAT5	346	349	PF00017	0.437
LIG_SH2_STAT5	385	388	PF00017	0.497
LIG_SH2_STAT5	57	60	PF00017	0.661
LIG_SH3_1	206	212	PF00018	0.632
LIG_SH3_2	170	175	PF14604	0.579
LIG_SH3_3	108	114	PF00018	0.590
LIG_SH3_3	167	173	PF00018	0.586
LIG_SH3_3	206	212	PF00018	0.653
LIG_SH3_3	53	59	PF00018	0.577
LIG_SH3_3	96	102	PF00018	0.712
LIG_SUMO_SIM_par_1	100	109	PF11976	0.640
LIG_SUMO_SIM_par_1	220	227	PF11976	0.669
LIG_TRAF2_1	14	17	PF00917	0.629
LIG_TYR_ITSM	262	269	PF00017	0.621
LIG_WW_3	112	116	PF00397	0.601
LIG_WW_3	207	211	PF00397	0.632
MOD_CDC14_SPxK_1	172	175	PF00782	0.597
MOD_CDK_SPK_2	169	174	PF00069	0.671
MOD_CDK_SPK_2	331	336	PF00069	0.561
MOD_CDK_SPxK_1	169	175	PF00069	0.607
MOD_CK1_1	11	17	PF00069	0.637
MOD_CK1_1	129	135	PF00069	0.722
MOD_CK1_1	201	207	PF00069	0.674
MOD_CK1_1	21	27	PF00069	0.503
MOD_CK1_1	246	252	PF00069	0.566
MOD_CK1_1	437	443	PF00069	0.464
MOD_CK2_1	11	17	PF00069	0.756
MOD_CK2_1	220	226	PF00069	0.666
MOD_CK2_1	44	50	PF00069	0.580
MOD_Cter_Amidation	309	312	PF01082	0.633
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.583
MOD_GlcNHglycan	10	13	PF01048	0.596
MOD_GlcNHglycan	131	134	PF01048	0.717
MOD_GlcNHglycan	142	145	PF01048	0.559
MOD_GlcNHglycan	2	5	PF01048	0.608
MOD_GlcNHglycan	246	249	PF01048	0.729
MOD_GlcNHglycan	273	276	PF01048	0.688
MOD_GlcNHglycan	35	38	PF01048	0.553
MOD_GlcNHglycan	67	70	PF01048	0.556
MOD_GSK3_1	11	18	PF00069	0.666
MOD_GSK3_1	125	132	PF00069	0.623
MOD_GSK3_1	229	236	PF00069	0.704
MOD_GSK3_1	271	278	PF00069	0.748
MOD_GSK3_1	360	367	PF00069	0.599
MOD_GSK3_1	373	380	PF00069	0.620
MOD_GSK3_1	412	419	PF00069	0.586
MOD_N-GLC_1	229	234	PF02516	0.663
MOD_NEK2_1	188	193	PF00069	0.627
MOD_NEK2_1	330	335	PF00069	0.665
MOD_NEK2_1	434	439	PF00069	0.544
MOD_NEK2_1	8	13	PF00069	0.690
MOD_NEK2_2	261	266	PF00069	0.651
MOD_OFUCOSY	258	265	PF10250	0.617
MOD_PIKK_1	233	239	PF00454	0.684
MOD_PKA_1	312	318	PF00069	0.558
MOD_PKA_1	397	403	PF00069	0.580
MOD_PKA_2	114	120	PF00069	0.625
MOD_PKA_2	18	24	PF00069	0.625
MOD_PKA_2	188	194	PF00069	0.565
MOD_PKA_2	198	204	PF00069	0.553
MOD_PKA_2	312	318	PF00069	0.608
MOD_PKA_2	357	363	PF00069	0.558
MOD_PKA_2	397	403	PF00069	0.557
MOD_PKA_2	415	421	PF00069	0.481
MOD_PKA_2	444	450	PF00069	0.575
MOD_PKA_2	77	83	PF00069	0.588
MOD_PKB_1	395	403	PF00069	0.573
MOD_Plk_1	201	207	PF00069	0.674
MOD_Plk_1	407	413	PF00069	0.553
MOD_Plk_4	177	183	PF00069	0.531
MOD_Plk_4	201	207	PF00069	0.601
MOD_Plk_4	44	50	PF00069	0.657
MOD_ProDKin_1	126	132	PF00069	0.645
MOD_ProDKin_1	169	175	PF00069	0.675
MOD_ProDKin_1	229	235	PF00069	0.702
MOD_ProDKin_1	331	337	PF00069	0.557
MOD_ProDKin_1	55	61	PF00069	0.582
MOD_SUMO_rev_2	223	229	PF00179	0.540
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.529
TRG_ENDOCYTIC_2	266	269	PF00928	0.674
TRG_ER_diArg_1	173	175	PF00400	0.680
TRG_ER_diArg_1	296	299	PF00400	0.645
TRG_ER_diArg_1	311	313	PF00400	0.446
TRG_ER_diArg_1	395	398	PF00400	0.548
TRG_ER_diArg_1	462	464	PF00400	0.631
TRG_NLS_MonoExtC_3	296	301	PF00514	0.623
TRG_NLS_MonoExtN_4	119	126	PF00514	0.527
TRG_NLS_MonoExtN_4	295	302	PF00514	0.621
TRG_NLS_MonoExtN_4	395	400	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D2	Leptomonas seymouri	39%	83%
A4HFK5	Leishmania braziliensis	73%	100%
D0A5T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AD60	Leishmania major	93%	100%
E9AHF5	Leishmania infantum	100%	100%
E9AYY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DA38	Trypanosoma cruzi	24%	100%