RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0I2_LEIDO

TriTrypDb:

LdBPK_270550.1 , LdCL_270012000 , LDHU3_27.0900

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.479
CLV_NRD_NRD_1	160	162	PF00675	0.713
CLV_NRD_NRD_1	368	370	PF00675	0.702
CLV_NRD_NRD_1	385	387	PF00675	0.702
CLV_NRD_NRD_1	421	423	PF00675	0.762
CLV_PCSK_KEX2_1	160	162	PF00082	0.713
CLV_PCSK_KEX2_1	310	312	PF00082	0.440
CLV_PCSK_KEX2_1	368	370	PF00082	0.644
CLV_PCSK_KEX2_1	373	375	PF00082	0.712
CLV_PCSK_KEX2_1	385	387	PF00082	0.706
CLV_PCSK_KEX2_1	420	422	PF00082	0.760
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.464
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.690
CLV_PCSK_PC7_1	306	312	PF00082	0.472
CLV_PCSK_PC7_1	369	375	PF00082	0.633
CLV_PCSK_SKI1_1	17	21	PF00082	0.714
CLV_PCSK_SKI1_1	201	205	PF00082	0.507
CLV_PCSK_SKI1_1	310	314	PF00082	0.450
DEG_Nend_UBRbox_3	1	3	PF02207	0.839
DEG_SCF_FBW7_1	105	112	PF00400	0.631
DEG_SCF_FBW7_1	140	146	PF00400	0.816
DEG_SCF_FBW7_1	25	31	PF00400	0.712
DOC_CKS1_1	106	111	PF01111	0.623
DOC_CKS1_1	140	145	PF01111	0.714
DOC_CKS1_1	25	30	PF01111	0.720
DOC_CYCLIN_RxL_1	306	315	PF00134	0.459
DOC_MAPK_gen_1	204	212	PF00069	0.489
DOC_MAPK_gen_1	347	355	PF00069	0.499
DOC_PP1_RVXF_1	206	213	PF00149	0.484
DOC_PP1_RVXF_1	308	315	PF00149	0.450
DOC_PP2B_LxvP_1	337	340	PF13499	0.607
DOC_PP4_FxxP_1	192	195	PF00568	0.538
DOC_PP4_FxxP_1	44	47	PF00568	0.720
DOC_USP7_MATH_1	109	113	PF00917	0.826
DOC_USP7_MATH_1	118	122	PF00917	0.668
DOC_USP7_MATH_1	147	151	PF00917	0.742
DOC_USP7_MATH_1	156	160	PF00917	0.620
DOC_USP7_MATH_1	279	283	PF00917	0.483
DOC_USP7_MATH_1	349	353	PF00917	0.499
DOC_USP7_MATH_1	362	366	PF00917	0.631
DOC_USP7_MATH_1	394	398	PF00917	0.781
DOC_WW_Pin1_4	101	106	PF00397	0.685
DOC_WW_Pin1_4	133	138	PF00397	0.689
DOC_WW_Pin1_4	139	144	PF00397	0.711
DOC_WW_Pin1_4	24	29	PF00397	0.788
DOC_WW_Pin1_4	37	42	PF00397	0.612
DOC_WW_Pin1_4	48	53	PF00397	0.732
DOC_WW_Pin1_4	87	92	PF00397	0.678
LIG_14-3-3_CanoR_1	17	25	PF00244	0.711
LIG_14-3-3_CanoR_1	374	381	PF00244	0.721
LIG_14-3-3_CanoR_1	390	399	PF00244	0.731
LIG_Clathr_ClatBox_1	84	88	PF01394	0.794
LIG_EVH1_2	441	445	PF00568	0.729
LIG_FHA_1	189	195	PF00498	0.594
LIG_FHA_1	37	43	PF00498	0.776
LIG_FHA_2	263	269	PF00498	0.463
LIG_FHA_2	322	328	PF00498	0.478
LIG_FHA_2	427	433	PF00498	0.748
LIG_FHA_2	81	87	PF00498	0.702
LIG_GSK3_LRP6_1	37	42	PF00069	0.737
LIG_IBAR_NPY_1	125	127	PF08397	0.684
LIG_LIR_Apic_2	104	109	PF02991	0.697
LIG_LIR_Apic_2	189	195	PF02991	0.570
LIG_LIR_Apic_2	62	67	PF02991	0.688
LIG_LIR_Gen_1	333	342	PF02991	0.605
LIG_LIR_Nem_3	333	337	PF02991	0.598
LIG_SH2_CRK	106	110	PF00017	0.812
LIG_SH2_CRK	72	76	PF00017	0.695
LIG_SH2_PTP2	334	337	PF00017	0.594
LIG_SH2_SRC	430	433	PF00017	0.739
LIG_SH2_STAP1	127	131	PF00017	0.698
LIG_SH2_STAP1	430	434	PF00017	0.819
LIG_SH2_STAT3	32	35	PF00017	0.717
LIG_SH2_STAT3	440	443	PF00017	0.729
LIG_SH2_STAT3	8	11	PF00017	0.747
LIG_SH2_STAT5	127	130	PF00017	0.759
LIG_SH2_STAT5	209	212	PF00017	0.416
LIG_SH2_STAT5	292	295	PF00017	0.441
LIG_SH2_STAT5	334	337	PF00017	0.594
LIG_SH3_3	137	143	PF00018	0.626
LIG_SH3_3	214	220	PF00018	0.566
LIG_SH3_3	35	41	PF00018	0.699
LIG_SH3_3	432	438	PF00018	0.704
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.472
LIG_SUMO_SIM_par_1	83	90	PF11976	0.691
LIG_TRAF2_1	429	432	PF00917	0.826
LIG_TRAF2_2	52	57	PF00917	0.731
LIG_TRFH_1	192	196	PF08558	0.522
MOD_CDC14_SPxK_1	90	93	PF00782	0.782
MOD_CDK_SPxK_1	87	93	PF00069	0.781
MOD_CK1_1	132	138	PF00069	0.691
MOD_CK1_1	141	147	PF00069	0.712
MOD_CK1_1	237	243	PF00069	0.818
MOD_CK1_1	24	30	PF00069	0.502
MOD_CK1_1	246	252	PF00069	0.511
MOD_CK1_1	377	383	PF00069	0.746
MOD_CK1_1	4	10	PF00069	0.819
MOD_CK1_1	62	68	PF00069	0.711
MOD_CK2_1	262	268	PF00069	0.475
MOD_CK2_1	279	285	PF00069	0.477
MOD_CK2_1	321	327	PF00069	0.476
MOD_CK2_1	426	432	PF00069	0.828
MOD_CK2_1	441	447	PF00069	0.559
MOD_CK2_1	80	86	PF00069	0.708
MOD_Cter_Amidation	366	369	PF01082	0.688
MOD_GlcNHglycan	119	123	PF01048	0.781
MOD_GlcNHglycan	131	134	PF01048	0.602
MOD_GlcNHglycan	149	152	PF01048	0.721
MOD_GlcNHglycan	153	157	PF01048	0.695
MOD_GlcNHglycan	164	167	PF01048	0.570
MOD_GlcNHglycan	242	245	PF01048	0.658
MOD_GlcNHglycan	364	367	PF01048	0.758
MOD_GlcNHglycan	381	384	PF01048	0.731
MOD_GlcNHglycan	392	395	PF01048	0.497
MOD_GlcNHglycan	396	399	PF01048	0.580
MOD_GlcNHglycan	406	409	PF01048	0.742
MOD_GlcNHglycan	431	435	PF01048	0.705
MOD_GlcNHglycan	48	51	PF01048	0.627
MOD_GlcNHglycan	59	62	PF01048	0.563
MOD_GSK3_1	105	112	PF00069	0.625
MOD_GSK3_1	125	132	PF00069	0.765
MOD_GSK3_1	139	146	PF00069	0.644
MOD_GSK3_1	147	154	PF00069	0.801
MOD_GSK3_1	17	24	PF00069	0.599
MOD_GSK3_1	233	240	PF00069	0.811
MOD_GSK3_1	243	250	PF00069	0.511
MOD_GSK3_1	279	286	PF00069	0.480
MOD_GSK3_1	3	10	PF00069	0.716
MOD_GSK3_1	300	307	PF00069	0.475
MOD_GSK3_1	390	397	PF00069	0.741
MOD_GSK3_1	400	407	PF00069	0.830
MOD_GSK3_1	426	433	PF00069	0.813
MOD_GSK3_1	95	102	PF00069	0.675
MOD_N-GLC_1	232	237	PF02516	0.822
MOD_N-GLC_1	4	9	PF02516	0.810
MOD_NEK2_1	1	6	PF00069	0.830
MOD_NEK2_1	129	134	PF00069	0.694
MOD_NEK2_1	152	157	PF00069	0.651
MOD_NEK2_1	162	167	PF00069	0.683
MOD_NEK2_1	188	193	PF00069	0.678
MOD_NEK2_1	262	267	PF00069	0.501
MOD_NEK2_1	304	309	PF00069	0.473
MOD_NEK2_1	402	407	PF00069	0.756
MOD_NEK2_1	59	64	PF00069	0.821
MOD_PIKK_1	30	36	PF00454	0.720
MOD_PIKK_1	400	406	PF00454	0.759
MOD_PIKK_1	7	13	PF00454	0.705
MOD_PKA_2	349	355	PF00069	0.493
MOD_PKB_1	15	23	PF00069	0.713
MOD_Plk_1	188	194	PF00069	0.601
MOD_Plk_1	247	253	PF00069	0.626
MOD_Plk_1	300	306	PF00069	0.472
MOD_Plk_1	377	383	PF00069	0.746
MOD_Plk_1	4	10	PF00069	0.812
MOD_Plk_4	300	306	PF00069	0.472
MOD_Plk_4	349	355	PF00069	0.493
MOD_Plk_4	59	65	PF00069	0.737
MOD_ProDKin_1	101	107	PF00069	0.687
MOD_ProDKin_1	133	139	PF00069	0.692
MOD_ProDKin_1	143	149	PF00069	0.717
MOD_ProDKin_1	24	30	PF00069	0.788
MOD_ProDKin_1	37	43	PF00069	0.615
MOD_ProDKin_1	48	54	PF00069	0.733
MOD_ProDKin_1	87	93	PF00069	0.679
MOD_SUMO_rev_2	351	360	PF00179	0.520
TRG_DiLeu_BaEn_1	268	273	PF01217	0.448
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.615
TRG_ENDOCYTIC_2	209	212	PF00928	0.416
TRG_ENDOCYTIC_2	334	337	PF00928	0.594
TRG_ER_diArg_1	14	17	PF00400	0.724
TRG_ER_diArg_1	160	162	PF00400	0.710
TRG_ER_diArg_1	206	209	PF00400	0.481
TRG_ER_diArg_1	420	422	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L6	Leptomonas seymouri	57%	100%
A4HFJ4	Leishmania braziliensis	72%	100%
E9AD47	Leishmania major	92%	100%
E9AHE1	Leishmania infantum	99%	100%
E9AYX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%