Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X0H3_LEIDO

TriTrypDb:

LdCL_270011100 , LDHU3_27.0800

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X0H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.698
CLV_NRD_NRD_1	230	232	PF00675	0.413
CLV_NRD_NRD_1	271	273	PF00675	0.633
CLV_NRD_NRD_1	91	93	PF00675	0.412
CLV_PCSK_KEX2_1	230	232	PF00082	0.413
CLV_PCSK_KEX2_1	271	273	PF00082	0.659
CLV_PCSK_KEX2_1	91	93	PF00082	0.417
CLV_PCSK_SKI1_1	235	239	PF00082	0.395
CLV_PCSK_SKI1_1	251	255	PF00082	0.424
CLV_PCSK_SKI1_1	413	417	PF00082	0.344
CLV_PCSK_SKI1_1	418	422	PF00082	0.294
CLV_PCSK_SKI1_1	91	95	PF00082	0.418
DEG_SPOP_SBC_1	125	129	PF00917	0.731
DEG_SPOP_SBC_1	185	189	PF00917	0.627
DOC_MAPK_gen_1	230	238	PF00069	0.605
DOC_MAPK_MEF2A_6	251	259	PF00069	0.356
DOC_MAPK_MEF2A_6	367	375	PF00069	0.490
DOC_MAPK_MEF2A_6	418	426	PF00069	0.567
DOC_PP1_RVXF_1	233	239	PF00149	0.592
DOC_PP1_RVXF_1	89	96	PF00149	0.658
DOC_SPAK_OSR1_1	272	276	PF12202	0.325
DOC_USP7_MATH_1	154	158	PF00917	0.767
DOC_USP7_MATH_1	160	164	PF00917	0.795
DOC_USP7_MATH_1	181	185	PF00917	0.703
DOC_USP7_MATH_1	28	32	PF00917	0.577
DOC_USP7_MATH_1	38	42	PF00917	0.490
DOC_USP7_MATH_1	463	467	PF00917	0.492
DOC_USP7_UBL2_3	311	315	PF12436	0.760
DOC_WW_Pin1_4	126	131	PF00397	0.758
DOC_WW_Pin1_4	14	19	PF00397	0.567
DOC_WW_Pin1_4	177	182	PF00397	0.755
DOC_WW_Pin1_4	186	191	PF00397	0.721
DOC_WW_Pin1_4	303	308	PF00397	0.689
DOC_WW_Pin1_4	392	397	PF00397	0.665
LIG_14-3-3_CanoR_1	113	123	PF00244	0.749
LIG_14-3-3_CanoR_1	126	130	PF00244	0.736
LIG_14-3-3_CanoR_1	327	332	PF00244	0.684
LIG_BRCT_BRCA1_1	139	143	PF00533	0.629
LIG_BRCT_BRCA1_1	474	478	PF00533	0.429
LIG_CaM_IQ_9	84	100	PF13499	0.696
LIG_Clathr_ClatBox_1	297	301	PF01394	0.537
LIG_Dynein_DLC8_1	111	117	PF01221	0.722
LIG_EH1_1	291	299	PF00400	0.645
LIG_EH1_1	319	327	PF00400	0.716
LIG_eIF4E_1	292	298	PF01652	0.549
LIG_eIF4E_1	372	378	PF01652	0.490
LIG_EVH1_2	19	23	PF00568	0.459
LIG_FHA_1	115	121	PF00498	0.704
LIG_FHA_1	126	132	PF00498	0.623
LIG_FHA_1	164	170	PF00498	0.785
LIG_FHA_1	252	258	PF00498	0.390
LIG_FHA_1	304	310	PF00498	0.762
LIG_FHA_1	328	334	PF00498	0.643
LIG_FHA_1	342	348	PF00498	0.505
LIG_FHA_1	419	425	PF00498	0.375
LIG_FHA_1	53	59	PF00498	0.356
LIG_FHA_2	442	448	PF00498	0.425
LIG_GBD_Chelix_1	218	226	PF00786	0.455
LIG_IRF3_LxIS_1	322	329	PF10401	0.713
LIG_LIR_Gen_1	21	30	PF02991	0.427
LIG_LIR_Gen_1	252	261	PF02991	0.427
LIG_LIR_Gen_1	291	300	PF02991	0.620
LIG_LIR_Gen_1	344	354	PF02991	0.358
LIG_LIR_Gen_1	421	429	PF02991	0.426
LIG_LIR_Gen_1	466	474	PF02991	0.361
LIG_LIR_Gen_1	55	64	PF02991	0.429
LIG_LIR_Nem_3	21	26	PF02991	0.431
LIG_LIR_Nem_3	239	243	PF02991	0.678
LIG_LIR_Nem_3	252	256	PF02991	0.277
LIG_LIR_Nem_3	344	349	PF02991	0.358
LIG_LIR_Nem_3	421	426	PF02991	0.409
LIG_LIR_Nem_3	466	471	PF02991	0.382
LIG_LIR_Nem_3	55	59	PF02991	0.387
LIG_PCNA_yPIPBox_3	409	418	PF02747	0.577
LIG_PDZ_Class_2	474	479	PF00595	0.371
LIG_Pex14_2	423	427	PF04695	0.364
LIG_Pex14_2	464	468	PF04695	0.472
LIG_REV1ctd_RIR_1	141	149	PF16727	0.648
LIG_SH2_CRK	451	455	PF00017	0.349
LIG_SH2_NCK_1	138	142	PF00017	0.672
LIG_SH2_PTP2	244	247	PF00017	0.490
LIG_SH2_PTP2	368	371	PF00017	0.442
LIG_SH2_PTP2	372	375	PF00017	0.472
LIG_SH2_SRC	445	448	PF00017	0.417
LIG_SH2_STAP1	292	296	PF00017	0.649
LIG_SH2_STAT5	191	194	PF00017	0.682
LIG_SH2_STAT5	244	247	PF00017	0.438
LIG_SH2_STAT5	258	261	PF00017	0.526
LIG_SH2_STAT5	368	371	PF00017	0.412
LIG_SH2_STAT5	372	375	PF00017	0.411
LIG_SH2_STAT5	379	382	PF00017	0.372
LIG_SH2_STAT5	4	7	PF00017	0.573
LIG_SH3_3	100	106	PF00018	0.707
LIG_SH3_3	12	18	PF00018	0.563
LIG_SH3_3	128	134	PF00018	0.699
LIG_SH3_3	210	216	PF00018	0.659
LIG_SH3_3	349	355	PF00018	0.390
LIG_SH3_3	48	54	PF00018	0.377
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.783
LIG_SUMO_SIM_anti_2	55	63	PF11976	0.417
LIG_SUMO_SIM_par_1	298	303	PF11976	0.618
LIG_SUMO_SIM_par_1	306	314	PF11976	0.707
LIG_SUMO_SIM_par_1	329	335	PF11976	0.633
LIG_SUMO_SIM_par_1	55	63	PF11976	0.398
LIG_TYR_ITIM	366	371	PF00017	0.507
LIG_TYR_ITIM	377	382	PF00017	0.420
LIG_TYR_ITIM	449	454	PF00017	0.354
LIG_WRC_WIRS_1	357	362	PF05994	0.390
LIG_WRC_WIRS_1	53	58	PF05994	0.353
LIG_WRC_WIRS_1	84	89	PF05994	0.692
MOD_CDK_SPK_2	392	397	PF00069	0.634
MOD_CDK_SPxxK_3	392	399	PF00069	0.677
MOD_CK1_1	161	167	PF00069	0.771
MOD_CK1_1	175	181	PF00069	0.641
MOD_CK1_1	184	190	PF00069	0.650
MOD_CK1_1	31	37	PF00069	0.566
MOD_CK1_1	392	398	PF00069	0.663
MOD_CK1_1	49	55	PF00069	0.256
MOD_CK1_1	9	15	PF00069	0.601
MOD_CK2_1	130	136	PF00069	0.673
MOD_CK2_1	285	291	PF00069	0.402
MOD_CK2_1	31	37	PF00069	0.530
MOD_CK2_1	326	332	PF00069	0.684
MOD_CK2_1	441	447	PF00069	0.460
MOD_DYRK1A_RPxSP_1	126	130	PF00069	0.693
MOD_GlcNHglycan	106	109	PF01048	0.507
MOD_GlcNHglycan	139	142	PF01048	0.463
MOD_GlcNHglycan	160	163	PF01048	0.596
MOD_GlcNHglycan	174	177	PF01048	0.505
MOD_GlcNHglycan	183	186	PF01048	0.463
MOD_GlcNHglycan	282	285	PF01048	0.365
MOD_GlcNHglycan	362	365	PF01048	0.655
MOD_GSK3_1	121	128	PF00069	0.747
MOD_GSK3_1	14	21	PF00069	0.525
MOD_GSK3_1	154	161	PF00069	0.746
MOD_GSK3_1	177	184	PF00069	0.717
MOD_GSK3_1	185	192	PF00069	0.740
MOD_GSK3_1	280	287	PF00069	0.356
MOD_GSK3_1	356	363	PF00069	0.483
MOD_GSK3_1	425	432	PF00069	0.356
MOD_GSK3_1	6	13	PF00069	0.576
MOD_GSK3_1	60	67	PF00069	0.433
MOD_N-GLC_1	31	36	PF02516	0.726
MOD_N-GLC_1	38	43	PF02516	0.706
MOD_NEK2_1	114	119	PF00069	0.562
MOD_NEK2_1	137	142	PF00069	0.634
MOD_NEK2_1	285	290	PF00069	0.416
MOD_NEK2_1	326	331	PF00069	0.680
MOD_NEK2_1	341	346	PF00069	0.559
MOD_NEK2_1	356	361	PF00069	0.292
MOD_NEK2_1	425	430	PF00069	0.370
MOD_NEK2_1	464	469	PF00069	0.428
MOD_NEK2_1	59	64	PF00069	0.359
MOD_NEK2_1	6	11	PF00069	0.560
MOD_NEK2_1	94	99	PF00069	0.637
MOD_PIKK_1	112	118	PF00454	0.791
MOD_PIKK_1	230	236	PF00454	0.610
MOD_PIKK_1	472	478	PF00454	0.348
MOD_PK_1	315	321	PF00069	0.696
MOD_PKA_1	230	236	PF00069	0.647
MOD_PKA_2	112	118	PF00069	0.736
MOD_PKA_2	125	131	PF00069	0.736
MOD_PKA_2	230	236	PF00069	0.628
MOD_PKA_2	326	332	PF00069	0.684
MOD_PKA_2	6	12	PF00069	0.487
MOD_Plk_1	251	257	PF00069	0.249
MOD_Plk_1	38	44	PF00069	0.495
MOD_Plk_1	49	55	PF00069	0.396
MOD_Plk_2-3	441	447	PF00069	0.423
MOD_Plk_4	18	24	PF00069	0.554
MOD_Plk_4	285	291	PF00069	0.468
MOD_Plk_4	315	321	PF00069	0.648
MOD_Plk_4	335	341	PF00069	0.598
MOD_Plk_4	342	348	PF00069	0.501
MOD_Plk_4	39	45	PF00069	0.487
MOD_Plk_4	418	424	PF00069	0.513
MOD_Plk_4	429	435	PF00069	0.326
MOD_Plk_4	52	58	PF00069	0.278
MOD_Plk_4	60	66	PF00069	0.352
MOD_ProDKin_1	126	132	PF00069	0.748
MOD_ProDKin_1	14	20	PF00069	0.570
MOD_ProDKin_1	177	183	PF00069	0.756
MOD_ProDKin_1	186	192	PF00069	0.719
MOD_ProDKin_1	303	309	PF00069	0.692
MOD_ProDKin_1	392	398	PF00069	0.663
MOD_SUMO_for_1	310	313	PF00179	0.762
MOD_SUMO_rev_2	312	316	PF00179	0.716
TRG_DiLeu_BaEn_1	252	257	PF01217	0.359
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.438
TRG_ENDOCYTIC_2	243	246	PF00928	0.392
TRG_ENDOCYTIC_2	292	295	PF00928	0.609
TRG_ENDOCYTIC_2	368	371	PF00928	0.412
TRG_ENDOCYTIC_2	372	375	PF00928	0.385
TRG_ENDOCYTIC_2	379	382	PF00928	0.320
TRG_ENDOCYTIC_2	451	454	PF00928	0.381
TRG_ER_diArg_1	229	231	PF00400	0.614
TRG_ER_diArg_1	270	272	PF00400	0.464
TRG_ER_diArg_1	396	399	PF00400	0.719
TRG_ER_diArg_1	90	92	PF00400	0.647
TRG_NES_CRM1_1	323	335	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L9	Leptomonas seymouri	65%	100%
A4HFI8	Leishmania braziliensis	75%	100%
D0A5R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AD39	Leishmania major	94%	100%
E9AHD2	Leishmania infantum	100%	100%
E9AYW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BIJ3	Trypanosoma cruzi	34%	100%