Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 60, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0H0_LEIDO

TriTrypDb:

LdBPK_270490.1 , LdCL_270009700 , LDHU3_27.0590

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.602
CLV_C14_Caspase3-7	355	359	PF00656	0.724
CLV_C14_Caspase3-7	40	44	PF00656	0.402
CLV_NRD_NRD_1	130	132	PF00675	0.595
CLV_NRD_NRD_1	172	174	PF00675	0.553
CLV_NRD_NRD_1	196	198	PF00675	0.652
CLV_NRD_NRD_1	273	275	PF00675	0.493
CLV_NRD_NRD_1	487	489	PF00675	0.665
CLV_NRD_NRD_1	568	570	PF00675	0.643
CLV_PCSK_FUR_1	271	275	PF00082	0.540
CLV_PCSK_KEX2_1	130	132	PF00082	0.647
CLV_PCSK_KEX2_1	172	174	PF00082	0.553
CLV_PCSK_KEX2_1	196	198	PF00082	0.652
CLV_PCSK_KEX2_1	273	275	PF00082	0.522
CLV_PCSK_KEX2_1	487	489	PF00082	0.688
CLV_PCSK_KEX2_1	568	570	PF00082	0.629
CLV_PCSK_SKI1_1	104	108	PF00082	0.503
CLV_PCSK_SKI1_1	120	124	PF00082	0.539
CLV_PCSK_SKI1_1	470	474	PF00082	0.647
CLV_Separin_Metazoa	536	540	PF03568	0.738
DOC_CKS1_1	401	406	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.598
DOC_MAPK_gen_1	101	109	PF00069	0.284
DOC_MAPK_gen_1	22	30	PF00069	0.505
DOC_MAPK_gen_1	539	549	PF00069	0.774
DOC_MAPK_gen_1	568	574	PF00069	0.609
DOC_MAPK_gen_1	87	94	PF00069	0.489
DOC_MAPK_MEF2A_6	22	30	PF00069	0.511
DOC_MAPK_MEF2A_6	87	94	PF00069	0.552
DOC_PP2B_LxvP_1	108	111	PF13499	0.529
DOC_PP2B_LxvP_1	112	115	PF13499	0.531
DOC_PP2B_LxvP_1	136	139	PF13499	0.595
DOC_PP2B_LxvP_1	443	446	PF13499	0.613
DOC_PP2B_LxvP_1	54	57	PF13499	0.533
DOC_PP4_FxxP_1	401	404	PF00568	0.541
DOC_PP4_FxxP_1	476	479	PF00568	0.553
DOC_USP7_MATH_1	365	369	PF00917	0.741
DOC_USP7_MATH_1	417	421	PF00917	0.562
DOC_USP7_MATH_1	472	476	PF00917	0.545
DOC_USP7_MATH_1	586	590	PF00917	0.635
DOC_WW_Pin1_4	154	159	PF00397	0.596
DOC_WW_Pin1_4	213	218	PF00397	0.698
DOC_WW_Pin1_4	373	378	PF00397	0.774
DOC_WW_Pin1_4	400	405	PF00397	0.560
DOC_WW_Pin1_4	44	49	PF00397	0.608
DOC_WW_Pin1_4	540	545	PF00397	0.657
DOC_WW_Pin1_4	552	557	PF00397	0.482
LIG_14-3-3_CanoR_1	22	27	PF00244	0.531
LIG_14-3-3_CanoR_1	242	250	PF00244	0.373
LIG_14-3-3_CanoR_1	297	301	PF00244	0.571
LIG_14-3-3_CanoR_1	470	479	PF00244	0.631
LIG_14-3-3_CanoR_1	89	95	PF00244	0.601
LIG_AP2alpha_1	63	67	PF02296	0.629
LIG_AP2alpha_2	300	302	PF02296	0.609
LIG_BRCT_BRCA1_1	454	458	PF00533	0.580
LIG_FHA_1	13	19	PF00498	0.517
LIG_FHA_1	151	157	PF00498	0.527
LIG_FHA_1	23	29	PF00498	0.473
LIG_FHA_1	242	248	PF00498	0.523
LIG_FHA_1	267	273	PF00498	0.571
LIG_FHA_1	322	328	PF00498	0.566
LIG_FHA_1	438	444	PF00498	0.576
LIG_FHA_1	549	555	PF00498	0.736
LIG_FHA_1	69	75	PF00498	0.555
LIG_FHA_2	326	332	PF00498	0.483
LIG_LIR_Apic_2	398	404	PF02991	0.556
LIG_LIR_Apic_2	473	479	PF02991	0.493
LIG_LIR_Gen_1	305	314	PF02991	0.417
LIG_LIR_Nem_3	163	169	PF02991	0.522
LIG_LIR_Nem_3	305	310	PF02991	0.397
LIG_LIR_Nem_3	400	405	PF02991	0.534
LIG_PDZ_Class_1	594	599	PF00595	0.649
LIG_Pex14_2	63	67	PF04695	0.629
LIG_SH2_CRK	307	311	PF00017	0.441
LIG_SH2_CRK	402	406	PF00017	0.501
LIG_SH2_CRK	466	470	PF00017	0.541
LIG_SH2_NCK_1	307	311	PF00017	0.336
LIG_SH2_SRC	261	264	PF00017	0.563
LIG_SH2_SRC	279	282	PF00017	0.576
LIG_SH2_SRC	311	314	PF00017	0.548
LIG_SH2_STAP1	190	194	PF00017	0.658
LIG_SH2_STAP1	279	283	PF00017	0.555
LIG_SH2_STAP1	307	311	PF00017	0.432
LIG_SH2_STAP1	49	53	PF00017	0.551
LIG_SH2_STAP1	68	72	PF00017	0.574
LIG_SH2_STAT3	180	183	PF00017	0.616
LIG_SH2_STAT5	180	183	PF00017	0.582
LIG_SH2_STAT5	311	314	PF00017	0.466
LIG_SH2_STAT5	329	332	PF00017	0.374
LIG_SH2_STAT5	335	338	PF00017	0.468
LIG_SH2_STAT5	402	405	PF00017	0.467
LIG_SH2_STAT5	68	71	PF00017	0.534
LIG_SH3_2	263	268	PF14604	0.570
LIG_SH3_3	257	263	PF00018	0.466
LIG_SH3_3	307	313	PF00018	0.549
LIG_SH3_3	436	442	PF00018	0.580
LIG_SH3_3	443	449	PF00018	0.606
LIG_SH3_3	80	86	PF00018	0.623
LIG_SUMO_SIM_par_1	25	31	PF11976	0.457
LIG_SUMO_SIM_par_1	348	353	PF11976	0.511
LIG_SUMO_SIM_par_1	409	415	PF11976	0.557
LIG_TRAF2_1	122	125	PF00917	0.464
LIG_TRAF2_1	313	316	PF00917	0.642
LIG_TYR_ITSM	398	405	PF00017	0.524
MOD_CDC14_SPxK_1	376	379	PF00782	0.747
MOD_CDK_SPxK_1	373	379	PF00069	0.777
MOD_CDK_SPxK_1	400	406	PF00069	0.566
MOD_CDK_SPxK_1	540	546	PF00069	0.626
MOD_CK1_1	208	214	PF00069	0.759
MOD_CK1_1	216	222	PF00069	0.692
MOD_CK1_1	340	346	PF00069	0.483
MOD_CK1_1	37	43	PF00069	0.669
MOD_CK1_1	412	418	PF00069	0.495
MOD_CK1_1	522	528	PF00069	0.762
MOD_CK1_1	552	558	PF00069	0.622
MOD_CK1_1	589	595	PF00069	0.628
MOD_CK2_1	148	154	PF00069	0.567
MOD_CK2_1	325	331	PF00069	0.490
MOD_Cter_Amidation	194	197	PF01082	0.739
MOD_GlcNHglycan	104	107	PF01048	0.504
MOD_GlcNHglycan	150	153	PF01048	0.520
MOD_GlcNHglycan	190	193	PF01048	0.764
MOD_GlcNHglycan	206	210	PF01048	0.522
MOD_GlcNHglycan	342	345	PF01048	0.450
MOD_GlcNHglycan	367	370	PF01048	0.669
MOD_GlcNHglycan	39	42	PF01048	0.641
MOD_GlcNHglycan	450	453	PF01048	0.560
MOD_GlcNHglycan	494	497	PF01048	0.729
MOD_GlcNHglycan	521	524	PF01048	0.764
MOD_GlcNHglycan	590	594	PF01048	0.773
MOD_GlcNHglycan	596	599	PF01048	0.776
MOD_GSK3_1	150	157	PF00069	0.509
MOD_GSK3_1	201	208	PF00069	0.723
MOD_GSK3_1	213	220	PF00069	0.665
MOD_GSK3_1	296	303	PF00069	0.594
MOD_GSK3_1	317	324	PF00069	0.497
MOD_GSK3_1	448	455	PF00069	0.658
MOD_GSK3_1	518	525	PF00069	0.712
MOD_GSK3_1	548	555	PF00069	0.640
MOD_GSK3_1	589	596	PF00069	0.641
MOD_N-GLC_1	470	475	PF02516	0.645
MOD_N-GLC_1	586	591	PF02516	0.710
MOD_N-GLC_2	370	372	PF02516	0.721
MOD_NEK2_1	34	39	PF00069	0.636
MOD_NEK2_1	419	424	PF00069	0.651
MOD_NEK2_2	266	271	PF00069	0.577
MOD_PK_1	409	415	PF00069	0.454
MOD_PKA_1	196	202	PF00069	0.710
MOD_PKA_2	148	154	PF00069	0.567
MOD_PKA_2	195	201	PF00069	0.683
MOD_PKA_2	241	247	PF00069	0.377
MOD_PKA_2	296	302	PF00069	0.596
MOD_PKA_2	378	384	PF00069	0.771
MOD_PKA_2	518	524	PF00069	0.729
MOD_Plk_1	266	272	PF00069	0.578
MOD_Plk_1	549	555	PF00069	0.674
MOD_Plk_4	113	119	PF00069	0.587
MOD_Plk_4	176	182	PF00069	0.529
MOD_Plk_4	325	331	PF00069	0.540
MOD_Plk_4	397	403	PF00069	0.583
MOD_Plk_4	4	10	PF00069	0.512
MOD_Plk_4	419	425	PF00069	0.599
MOD_Plk_4	464	470	PF00069	0.502
MOD_Plk_4	472	478	PF00069	0.566
MOD_Plk_4	549	555	PF00069	0.634
MOD_ProDKin_1	154	160	PF00069	0.599
MOD_ProDKin_1	213	219	PF00069	0.694
MOD_ProDKin_1	373	379	PF00069	0.777
MOD_ProDKin_1	400	406	PF00069	0.570
MOD_ProDKin_1	44	50	PF00069	0.596
MOD_ProDKin_1	540	546	PF00069	0.664
MOD_ProDKin_1	552	558	PF00069	0.474
MOD_SUMO_rev_2	252	256	PF00179	0.538
MOD_SUMO_rev_2	353	361	PF00179	0.605
MOD_SUMO_rev_2	525	535	PF00179	0.783
TRG_DiLeu_BaEn_1	305	310	PF01217	0.397
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.583
TRG_DiLeu_LyEn_5	165	170	PF01217	0.614
TRG_ENDOCYTIC_2	257	260	PF00928	0.450
TRG_ENDOCYTIC_2	279	282	PF00928	0.576
TRG_ENDOCYTIC_2	307	310	PF00928	0.389
TRG_ENDOCYTIC_2	402	405	PF00928	0.500
TRG_ENDOCYTIC_2	466	469	PF00928	0.487
TRG_ER_diArg_1	129	131	PF00400	0.569
TRG_ER_diArg_1	172	174	PF00400	0.545
TRG_ER_diArg_1	21	24	PF00400	0.595
TRG_ER_diArg_1	270	273	PF00400	0.475
TRG_ER_diArg_1	382	385	PF00400	0.740
TRG_ER_diArg_1	486	488	PF00400	0.680
TRG_ER_diArg_1	491	494	PF00400	0.715
TRG_ER_diArg_1	567	569	PF00400	0.641
TRG_ER_diArg_1	86	89	PF00400	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I592	Leptomonas seymouri	54%	97%
A0A1X0P512	Trypanosomatidae	36%	100%
A0A422NTD4	Trypanosoma rangeli	37%	100%
A4HFH4	Leishmania braziliensis	74%	100%
A4I2N4	Leishmania infantum	100%	100%
D0A5Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AD25	Leishmania major	91%	100%
E9AYV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BSP9	Trypanosoma cruzi	36%	100%