Ring finger domain/Zinc finger, C3HC4 type (RING finger)/PHD-finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zinc finger, C3HC4 type (RING finger)/PHD-finger containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0G9_LEIDO

TriTrypDb:

LdCL_270010600 , LDHU3_27.0740

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0G9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.484
CLV_NRD_NRD_1	160	162	PF00675	0.406
CLV_NRD_NRD_1	186	188	PF00675	0.353
CLV_NRD_NRD_1	232	234	PF00675	0.582
CLV_NRD_NRD_1	303	305	PF00675	0.735
CLV_NRD_NRD_1	424	426	PF00675	0.568
CLV_NRD_NRD_1	453	455	PF00675	0.454
CLV_NRD_NRD_1	461	463	PF00675	0.389
CLV_NRD_NRD_1	475	477	PF00675	0.419
CLV_NRD_NRD_1	515	517	PF00675	0.616
CLV_PCSK_FUR_1	473	477	PF00082	0.418
CLV_PCSK_FUR_1	513	517	PF00082	0.447
CLV_PCSK_KEX2_1	112	114	PF00082	0.516
CLV_PCSK_KEX2_1	160	162	PF00082	0.406
CLV_PCSK_KEX2_1	231	233	PF00082	0.600
CLV_PCSK_KEX2_1	303	305	PF00082	0.755
CLV_PCSK_KEX2_1	426	428	PF00082	0.556
CLV_PCSK_KEX2_1	453	455	PF00082	0.454
CLV_PCSK_KEX2_1	473	475	PF00082	0.483
CLV_PCSK_KEX2_1	513	515	PF00082	0.449
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.577
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.556
CLV_PCSK_SKI1_1	154	158	PF00082	0.361
CLV_PCSK_SKI1_1	177	181	PF00082	0.408
CLV_PCSK_SKI1_1	232	236	PF00082	0.595
DEG_ODPH_VHL_1	370	383	PF01847	0.528
DEG_SCF_FBW7_1	335	342	PF00400	0.584
DEG_SCF_FBW7_1	351	357	PF00400	0.541
DEG_SPOP_SBC_1	10	14	PF00917	0.559
DEG_SPOP_SBC_1	275	279	PF00917	0.577
DEG_SPOP_SBC_1	339	343	PF00917	0.628
DOC_CKS1_1	219	224	PF01111	0.668
DOC_CKS1_1	336	341	PF01111	0.639
DOC_CKS1_1	351	356	PF01111	0.568
DOC_PP1_RVXF_1	175	182	PF00149	0.408
DOC_PP1_RVXF_1	324	330	PF00149	0.642
DOC_PP4_FxxP_1	329	332	PF00568	0.734
DOC_PP4_FxxP_1	369	372	PF00568	0.496
DOC_PP4_FxxP_1	447	450	PF00568	0.498
DOC_USP7_MATH_1	10	14	PF00917	0.622
DOC_USP7_MATH_1	275	279	PF00917	0.613
DOC_USP7_MATH_1	309	313	PF00917	0.585
DOC_USP7_MATH_1	414	418	PF00917	0.509
DOC_USP7_MATH_1	428	432	PF00917	0.472
DOC_USP7_UBL2_3	504	508	PF12436	0.405
DOC_USP7_UBL2_3	76	80	PF12436	0.282
DOC_WW_Pin1_4	2	7	PF00397	0.656
DOC_WW_Pin1_4	210	215	PF00397	0.602
DOC_WW_Pin1_4	218	223	PF00397	0.602
DOC_WW_Pin1_4	238	243	PF00397	0.665
DOC_WW_Pin1_4	28	33	PF00397	0.595
DOC_WW_Pin1_4	335	340	PF00397	0.631
DOC_WW_Pin1_4	350	355	PF00397	0.788
LIG_14-3-3_CanoR_1	177	182	PF00244	0.401
LIG_14-3-3_CanoR_1	19	28	PF00244	0.600
LIG_14-3-3_CanoR_1	231	240	PF00244	0.585
LIG_14-3-3_CanoR_1	249	253	PF00244	0.623
LIG_14-3-3_CanoR_1	273	280	PF00244	0.575
LIG_14-3-3_CanoR_1	303	313	PF00244	0.601
LIG_14-3-3_CanoR_1	427	433	PF00244	0.501
LIG_14-3-3_CanoR_1	62	70	PF00244	0.305
LIG_14-3-3_CanoR_1	94	99	PF00244	0.364
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_EH1_1	374	382	PF00400	0.436
LIG_FHA_1	164	170	PF00498	0.468
LIG_FHA_1	239	245	PF00498	0.595
LIG_FHA_1	275	281	PF00498	0.604
LIG_LIR_Apic_2	328	332	PF02991	0.760
LIG_LIR_Apic_2	366	372	PF02991	0.494
LIG_LIR_Apic_2	417	421	PF02991	0.437
LIG_LIR_Apic_2	444	450	PF02991	0.495
LIG_LIR_Gen_1	39	50	PF02991	0.445
LIG_LIR_Nem_3	364	370	PF02991	0.523
LIG_LIR_Nem_3	39	45	PF02991	0.476
LIG_LIR_Nem_3	67	73	PF02991	0.223
LIG_Pex14_1	118	122	PF04695	0.511
LIG_RPA_C_Fungi	493	505	PF08784	0.382
LIG_SH2_GRB2like	42	45	PF00017	0.444
LIG_SH2_SRC	42	45	PF00017	0.444
LIG_SH2_SRC	477	480	PF00017	0.441
LIG_SH2_STAP1	165	169	PF00017	0.343
LIG_SH2_STAP1	96	100	PF00017	0.478
LIG_SH2_STAT5	115	118	PF00017	0.564
LIG_SH2_STAT5	165	168	PF00017	0.463
LIG_SH2_STAT5	21	24	PF00017	0.511
LIG_SH2_STAT5	368	371	PF00017	0.505
LIG_SH2_STAT5	418	421	PF00017	0.539
LIG_SH2_STAT5	477	480	PF00017	0.473
LIG_SH2_STAT5	73	76	PF00017	0.288
LIG_SH2_STAT5	96	99	PF00017	0.398
LIG_SH3_3	211	217	PF00018	0.618
LIG_SH3_3	294	300	PF00018	0.749
LIG_SH3_3	329	335	PF00018	0.607
LIG_SH3_3	53	59	PF00018	0.370
LIG_TRAF2_1	363	366	PF00917	0.461
LIG_TRAF2_1	442	445	PF00917	0.478
LIG_TRFH_1	368	372	PF08558	0.499
LIG_UBA3_1	380	387	PF00899	0.434
LIG_WRC_WIRS_1	95	100	PF05994	0.370
MOD_CK1_1	2	8	PF00069	0.799
MOD_CK1_1	205	211	PF00069	0.589
MOD_CK1_1	269	275	PF00069	0.668
MOD_CK1_1	276	282	PF00069	0.581
MOD_CK1_1	305	311	PF00069	0.630
MOD_CK1_1	314	320	PF00069	0.665
MOD_CK1_1	344	350	PF00069	0.669
MOD_CK1_1	9	15	PF00069	0.678
MOD_CK2_1	292	298	PF00069	0.617
MOD_CK2_1	439	445	PF00069	0.482
MOD_CK2_1	99	105	PF00069	0.466
MOD_GlcNHglycan	101	104	PF01048	0.594
MOD_GlcNHglycan	204	207	PF01048	0.646
MOD_GlcNHglycan	24	27	PF01048	0.632
MOD_GlcNHglycan	262	265	PF01048	0.594
MOD_GlcNHglycan	307	310	PF01048	0.665
MOD_GlcNHglycan	360	363	PF01048	0.660
MOD_GlcNHglycan	421	424	PF01048	0.639
MOD_GlcNHglycan	441	444	PF01048	0.318
MOD_GSK3_1	2	9	PF00069	0.728
MOD_GSK3_1	265	272	PF00069	0.599
MOD_GSK3_1	274	281	PF00069	0.587
MOD_GSK3_1	289	296	PF00069	0.527
MOD_GSK3_1	298	305	PF00069	0.585
MOD_GSK3_1	307	314	PF00069	0.621
MOD_GSK3_1	335	342	PF00069	0.683
MOD_GSK3_1	350	357	PF00069	0.730
MOD_GSK3_1	492	499	PF00069	0.430
MOD_GSK3_1	90	97	PF00069	0.370
MOD_N-GLC_1	292	297	PF02516	0.641
MOD_N-GLC_2	44	46	PF02516	0.305
MOD_N-GLC_2	64	66	PF02516	0.305
MOD_N-GLC_2	83	85	PF02516	0.305
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	137	142	PF00069	0.533
MOD_NEK2_1	200	205	PF00069	0.697
MOD_NEK2_1	274	279	PF00069	0.604
MOD_NEK2_1	69	74	PF00069	0.339
MOD_PIKK_1	341	347	PF00454	0.608
MOD_PIKK_1	4	10	PF00454	0.570
MOD_PIKK_1	492	498	PF00454	0.408
MOD_PKA_1	232	238	PF00069	0.599
MOD_PKA_1	303	309	PF00069	0.542
MOD_PKA_2	232	238	PF00069	0.624
MOD_PKA_2	248	254	PF00069	0.666
MOD_PKA_2	289	295	PF00069	0.677
MOD_PKA_2	302	308	PF00069	0.622
MOD_PKA_2	90	96	PF00069	0.374
MOD_PKB_1	60	68	PF00069	0.305
MOD_Plk_1	118	124	PF00069	0.527
MOD_Plk_1	292	298	PF00069	0.642
MOD_Plk_1	317	323	PF00069	0.598
MOD_Plk_4	11	17	PF00069	0.511
MOD_Plk_4	118	124	PF00069	0.511
MOD_Plk_4	137	143	PF00069	0.465
MOD_ProDKin_1	2	8	PF00069	0.657
MOD_ProDKin_1	210	216	PF00069	0.595
MOD_ProDKin_1	218	224	PF00069	0.605
MOD_ProDKin_1	238	244	PF00069	0.666
MOD_ProDKin_1	28	34	PF00069	0.592
MOD_ProDKin_1	335	341	PF00069	0.634
MOD_ProDKin_1	350	356	PF00069	0.786
MOD_SUMO_for_1	403	406	PF00179	0.498
MOD_SUMO_for_1	507	510	PF00179	0.448
MOD_SUMO_rev_2	101	110	PF00179	0.483
TRG_ENDOCYTIC_2	367	370	PF00928	0.519
TRG_ENDOCYTIC_2	42	45	PF00928	0.444
TRG_ER_diArg_1	110	113	PF00400	0.481
TRG_ER_diArg_1	231	233	PF00400	0.617
TRG_ER_diArg_1	284	287	PF00400	0.563
TRG_ER_diArg_1	323	326	PF00400	0.535
TRG_ER_diArg_1	453	455	PF00400	0.459
TRG_ER_diArg_1	472	475	PF00400	0.286
TRG_ER_diArg_1	512	515	PF00400	0.435
TRG_ER_diArg_1	59	62	PF00400	0.317
TRG_NLS_MonoExtN_4	109	115	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U0	Leptomonas seymouri	54%	98%
A4HFI3	Leishmania braziliensis	71%	100%
E9AD34	Leishmania major	89%	100%
E9AHC7	Leishmania infantum	99%	100%
E9AYV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%