Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X0F9_LEIDO

TriTrypDb:

LdCL_270010200 , LDHU3_27.0700

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.716
CLV_C14_Caspase3-7	499	503	PF00656	0.785
CLV_NRD_NRD_1	113	115	PF00675	0.614
CLV_NRD_NRD_1	157	159	PF00675	0.524
CLV_NRD_NRD_1	166	168	PF00675	0.580
CLV_NRD_NRD_1	204	206	PF00675	0.721
CLV_NRD_NRD_1	309	311	PF00675	0.740
CLV_NRD_NRD_1	333	335	PF00675	0.559
CLV_NRD_NRD_1	364	366	PF00675	0.703
CLV_NRD_NRD_1	39	41	PF00675	0.622
CLV_NRD_NRD_1	541	543	PF00675	0.608
CLV_NRD_NRD_1	558	560	PF00675	0.644
CLV_NRD_NRD_1	584	586	PF00675	0.613
CLV_PCSK_FUR_1	331	335	PF00082	0.549
CLV_PCSK_KEX2_1	113	115	PF00082	0.614
CLV_PCSK_KEX2_1	157	159	PF00082	0.507
CLV_PCSK_KEX2_1	166	168	PF00082	0.590
CLV_PCSK_KEX2_1	204	206	PF00082	0.721
CLV_PCSK_KEX2_1	309	311	PF00082	0.740
CLV_PCSK_KEX2_1	333	335	PF00082	0.559
CLV_PCSK_KEX2_1	364	366	PF00082	0.703
CLV_PCSK_KEX2_1	541	543	PF00082	0.608
CLV_PCSK_KEX2_1	558	560	PF00082	0.644
CLV_PCSK_KEX2_1	584	586	PF00082	0.615
CLV_PCSK_KEX2_1	77	79	PF00082	0.379
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.379
CLV_PCSK_PC7_1	73	79	PF00082	0.355
CLV_PCSK_SKI1_1	149	153	PF00082	0.511
CLV_PCSK_SKI1_1	184	188	PF00082	0.682
CLV_PCSK_SKI1_1	424	428	PF00082	0.716
CLV_PCSK_SKI1_1	548	552	PF00082	0.603
CLV_PCSK_SKI1_1	569	573	PF00082	0.619
CLV_PCSK_SKI1_1	579	583	PF00082	0.600
CLV_PCSK_SKI1_1	82	86	PF00082	0.497
CLV_Separin_Metazoa	70	74	PF03568	0.586
DEG_APCC_DBOX_1	148	156	PF00400	0.513
DEG_Nend_UBRbox_3	1	3	PF02207	0.727
DEG_SCF_FBW7_1	457	463	PF00400	0.739
DEG_SPOP_SBC_1	249	253	PF00917	0.724
DEG_SPOP_SBC_1	526	530	PF00917	0.648
DOC_CKS1_1	457	462	PF01111	0.730
DOC_MAPK_FxFP_2	572	575	PF00069	0.604
DOC_PP4_FxxP_1	374	377	PF00568	0.553
DOC_PP4_FxxP_1	572	575	PF00568	0.604
DOC_USP7_MATH_1	224	228	PF00917	0.730
DOC_USP7_MATH_1	240	244	PF00917	0.614
DOC_USP7_MATH_1	250	254	PF00917	0.679
DOC_USP7_MATH_1	270	274	PF00917	0.382
DOC_USP7_MATH_1	375	379	PF00917	0.720
DOC_USP7_MATH_1	387	391	PF00917	0.701
DOC_USP7_MATH_1	410	414	PF00917	0.685
DOC_USP7_MATH_1	418	422	PF00917	0.675
DOC_USP7_MATH_1	526	530	PF00917	0.789
DOC_USP7_UBL2_3	350	354	PF12436	0.708
DOC_WW_Pin1_4	140	145	PF00397	0.520
DOC_WW_Pin1_4	173	178	PF00397	0.677
DOC_WW_Pin1_4	211	216	PF00397	0.714
DOC_WW_Pin1_4	281	286	PF00397	0.694
DOC_WW_Pin1_4	359	364	PF00397	0.831
DOC_WW_Pin1_4	381	386	PF00397	0.668
DOC_WW_Pin1_4	39	44	PF00397	0.572
DOC_WW_Pin1_4	424	429	PF00397	0.723
DOC_WW_Pin1_4	456	461	PF00397	0.731
DOC_WW_Pin1_4	463	468	PF00397	0.721
DOC_WW_Pin1_4	505	510	PF00397	0.808
LIG_14-3-3_CanoR_1	166	171	PF00244	0.687
LIG_14-3-3_CanoR_1	172	177	PF00244	0.606
LIG_14-3-3_CanoR_1	239	245	PF00244	0.767
LIG_14-3-3_CanoR_1	333	342	PF00244	0.683
LIG_14-3-3_CanoR_1	584	591	PF00244	0.597
LIG_14-3-3_CanoR_1	78	85	PF00244	0.358
LIG_APCC_ABBA_1	100	105	PF00400	0.489
LIG_FHA_1	173	179	PF00498	0.663
LIG_FHA_1	181	187	PF00498	0.597
LIG_FHA_1	409	415	PF00498	0.683
LIG_FHA_1	457	463	PF00498	0.752
LIG_FHA_1	464	470	PF00498	0.696
LIG_FHA_1	476	482	PF00498	0.615
LIG_FHA_1	5	11	PF00498	0.621
LIG_FHA_2	25	31	PF00498	0.589
LIG_LIR_Apic_2	372	377	PF02991	0.557
LIG_LIR_Apic_2	570	575	PF02991	0.607
LIG_LYPXL_yS_3	260	263	PF13949	0.626
LIG_MYND_3	535	539	PF01753	0.731
LIG_PCNA_yPIPBox_3	541	551	PF02747	0.580
LIG_RPA_C_Fungi	537	549	PF08784	0.611
LIG_SH2_NCK_1	431	435	PF00017	0.731
LIG_SH2_PTP2	68	71	PF00017	0.480
LIG_SH2_SRC	68	71	PF00017	0.580
LIG_SH2_STAP1	298	302	PF00017	0.618
LIG_SH2_STAT5	103	106	PF00017	0.469
LIG_SH2_STAT5	225	228	PF00017	0.690
LIG_SH2_STAT5	58	61	PF00017	0.457
LIG_SH2_STAT5	68	71	PF00017	0.497
LIG_SH3_1	197	203	PF00018	0.666
LIG_SH3_1	40	46	PF00018	0.607
LIG_SH3_2	200	205	PF14604	0.668
LIG_SH3_3	183	189	PF00018	0.667
LIG_SH3_3	197	203	PF00018	0.618
LIG_SH3_3	360	366	PF00018	0.781
LIG_SH3_3	40	46	PF00018	0.607
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.503
LIG_SUMO_SIM_par_1	18	23	PF11976	0.470
LIG_TRAF2_1	131	134	PF00917	0.609
LIG_TRAF2_1	245	248	PF00917	0.676
LIG_TRAF2_1	315	318	PF00917	0.656
LIG_TRFH_1	185	189	PF08558	0.642
LIG_UBA3_1	84	90	PF00899	0.592
MOD_CDC14_SPxK_1	470	473	PF00782	0.713
MOD_CDK_SPK_2	359	364	PF00069	0.700
MOD_CDK_SPK_2	456	461	PF00069	0.705
MOD_CDK_SPxK_1	173	179	PF00069	0.681
MOD_CDK_SPxK_1	359	365	PF00069	0.832
MOD_CDK_SPxK_1	424	430	PF00069	0.740
MOD_CDK_SPxK_1	467	473	PF00069	0.718
MOD_CDK_SPxxK_3	42	49	PF00069	0.530
MOD_CDK_SPxxK_3	505	512	PF00069	0.723
MOD_CK1_1	214	220	PF00069	0.676
MOD_CK1_1	243	249	PF00069	0.729
MOD_CK1_1	251	257	PF00069	0.607
MOD_CK1_1	36	42	PF00069	0.547
MOD_CK1_1	4	10	PF00069	0.453
MOD_CK1_1	463	469	PF00069	0.707
MOD_CK1_1	476	482	PF00069	0.733
MOD_CK1_1	514	520	PF00069	0.710
MOD_CK2_1	128	134	PF00069	0.522
MOD_CK2_1	187	193	PF00069	0.779
MOD_CK2_1	24	30	PF00069	0.594
MOD_CK2_1	270	276	PF00069	0.705
MOD_CK2_1	480	486	PF00069	0.804
MOD_GlcNHglycan	130	133	PF01048	0.616
MOD_GlcNHglycan	189	192	PF01048	0.717
MOD_GlcNHglycan	222	225	PF01048	0.723
MOD_GlcNHglycan	254	257	PF01048	0.778
MOD_GlcNHglycan	272	275	PF01048	0.408
MOD_GlcNHglycan	35	38	PF01048	0.716
MOD_GlcNHglycan	414	417	PF01048	0.670
MOD_GlcNHglycan	420	423	PF01048	0.672
MOD_GlcNHglycan	446	449	PF01048	0.741
MOD_GlcNHglycan	478	481	PF01048	0.706
MOD_GlcNHglycan	515	519	PF01048	0.793
MOD_GlcNHglycan	576	579	PF01048	0.594
MOD_GSK3_1	162	169	PF00069	0.556
MOD_GSK3_1	214	221	PF00069	0.646
MOD_GSK3_1	248	255	PF00069	0.704
MOD_GSK3_1	323	330	PF00069	0.685
MOD_GSK3_1	381	388	PF00069	0.684
MOD_GSK3_1	408	415	PF00069	0.732
MOD_GSK3_1	418	425	PF00069	0.651
MOD_GSK3_1	456	463	PF00069	0.720
MOD_GSK3_1	476	483	PF00069	0.504
MOD_N-GLC_1	467	472	PF02516	0.718
MOD_N-GLC_2	63	65	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	126	131	PF00069	0.511
MOD_NEK2_1	170	175	PF00069	0.508
MOD_NEK2_1	475	480	PF00069	0.716
MOD_NEK2_1	525	530	PF00069	0.645
MOD_NEK2_1	567	572	PF00069	0.624
MOD_NEK2_2	286	291	PF00069	0.630
MOD_PIKK_1	387	393	PF00454	0.781
MOD_PKA_1	166	172	PF00069	0.588
MOD_PKA_1	333	339	PF00069	0.553
MOD_PKA_1	77	83	PF00069	0.368
MOD_PKA_2	162	168	PF00069	0.558
MOD_PKA_2	171	177	PF00069	0.607
MOD_PKA_2	218	224	PF00069	0.698
MOD_PKA_2	270	276	PF00069	0.580
MOD_PKA_2	333	339	PF00069	0.684
MOD_PKA_2	429	435	PF00069	0.819
MOD_PKA_2	460	466	PF00069	0.823
MOD_PKA_2	583	589	PF00069	0.593
MOD_PKA_2	77	83	PF00069	0.368
MOD_PKB_1	331	339	PF00069	0.549
MOD_Plk_1	147	153	PF00069	0.517
MOD_Plk_1	436	442	PF00069	0.717
MOD_Plk_1	567	573	PF00069	0.621
MOD_Plk_4	297	303	PF00069	0.628
MOD_ProDKin_1	140	146	PF00069	0.512
MOD_ProDKin_1	173	179	PF00069	0.681
MOD_ProDKin_1	211	217	PF00069	0.714
MOD_ProDKin_1	281	287	PF00069	0.685
MOD_ProDKin_1	359	365	PF00069	0.832
MOD_ProDKin_1	381	387	PF00069	0.670
MOD_ProDKin_1	39	45	PF00069	0.559
MOD_ProDKin_1	424	430	PF00069	0.725
MOD_ProDKin_1	456	462	PF00069	0.731
MOD_ProDKin_1	463	469	PF00069	0.723
MOD_ProDKin_1	505	511	PF00069	0.809
MOD_SUMO_for_1	496	499	PF00179	0.574
MOD_SUMO_rev_2	347	352	PF00179	0.646
TRG_DiLeu_BaEn_2	133	139	PF01217	0.600
TRG_DiLeu_BaEn_2	140	146	PF01217	0.497
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.419
TRG_ENDOCYTIC_2	103	106	PF00928	0.469
TRG_ENDOCYTIC_2	260	263	PF00928	0.626
TRG_ENDOCYTIC_2	298	301	PF00928	0.576
TRG_ER_diArg_1	112	114	PF00400	0.599
TRG_ER_diArg_1	203	205	PF00400	0.711
TRG_ER_diArg_1	331	334	PF00400	0.543
TRG_ER_diArg_1	363	365	PF00400	0.702
TRG_ER_diArg_1	449	452	PF00400	0.724
TRG_ER_diArg_1	540	542	PF00400	0.613
TRG_ER_diArg_1	583	585	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K9	Leptomonas seymouri	50%	96%
A4HFH9	Leishmania braziliensis	68%	98%
E9AD30	Leishmania major	91%	100%
E9AHC3	Leishmania infantum	99%	100%
E9AYV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%