Amastin surface glycoprotein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0F7_LEIDO

TriTrypDb:

LdCL_270010300 , LDHU3_27.0710

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X0F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0F7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	39	43	PF00082	0.528
DEG_Nend_UBRbox_3	1	3	PF02207	0.588
DEG_SCF_FBW7_2	26	32	PF00400	0.365
DOC_CKS1_1	26	31	PF01111	0.361
DOC_MAPK_MEF2A_6	142	149	PF00069	0.480
DOC_PP4_FxxP_1	31	34	PF00568	0.356
DOC_USP7_MATH_1	73	77	PF00917	0.322
DOC_USP7_MATH_1	90	94	PF00917	0.312
DOC_WW_Pin1_4	171	176	PF00397	0.309
DOC_WW_Pin1_4	25	30	PF00397	0.357
DOC_WW_Pin1_4	47	52	PF00397	0.397
LIG_APCC_ABBA_1	204	209	PF00400	0.464
LIG_APCC_ABBA_1	27	32	PF00400	0.398
LIG_BRCT_BRCA1_1	49	53	PF00533	0.374
LIG_deltaCOP1_diTrp_1	181	188	PF00928	0.312
LIG_FHA_1	118	124	PF00498	0.402
LIG_FHA_1	14	20	PF00498	0.246
LIG_FHA_1	157	163	PF00498	0.351
LIG_FHA_1	172	178	PF00498	0.348
LIG_FHA_1	38	44	PF00498	0.287
LIG_FHA_1	50	56	PF00498	0.300
LIG_FHA_1	7	13	PF00498	0.496
LIG_LIR_Apic_2	28	34	PF02991	0.430
LIG_LIR_Gen_1	131	141	PF02991	0.404
LIG_LIR_Gen_1	98	109	PF02991	0.307
LIG_LIR_Nem_3	131	136	PF02991	0.404
LIG_LIR_Nem_3	63	68	PF02991	0.416
LIG_LIR_Nem_3	98	104	PF02991	0.297
LIG_Pex14_1	182	186	PF04695	0.261
LIG_Pex14_1	81	85	PF04695	0.322
LIG_Pex14_2	133	137	PF04695	0.305
LIG_Pex14_2	27	31	PF04695	0.301
LIG_SH2_CRK	186	190	PF00017	0.204
LIG_SH2_SRC	167	170	PF00017	0.304
LIG_SH2_STAT5	100	103	PF00017	0.279
LIG_SH2_STAT5	148	151	PF00017	0.293
LIG_SH2_STAT5	167	170	PF00017	0.304
LIG_SH2_STAT5	4	7	PF00017	0.574
LIG_SH3_3	138	144	PF00018	0.514
LIG_SH3_3	23	29	PF00018	0.387
LIG_SH3_3	45	51	PF00018	0.315
LIG_SH3_3	66	72	PF00018	0.328
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.287
LIG_SUMO_SIM_par_1	202	209	PF11976	0.372
LIG_TYR_ITIM	184	189	PF00017	0.195
MOD_CDK_SPxxK_3	171	178	PF00069	0.252
MOD_CK1_1	202	208	PF00069	0.291
MOD_CK1_1	47	53	PF00069	0.453
MOD_CK1_1	76	82	PF00069	0.331
MOD_CMANNOS	182	185	PF00535	0.472
MOD_GlcNHglycan	137	140	PF01048	0.403
MOD_GlcNHglycan	69	72	PF01048	0.575
MOD_GlcNHglycan	87	90	PF01048	0.541
MOD_GSK3_1	156	163	PF00069	0.324
MOD_GSK3_1	191	198	PF00069	0.307
MOD_GSK3_1	2	9	PF00069	0.657
MOD_GSK3_1	33	40	PF00069	0.328
MOD_GSK3_1	54	61	PF00069	0.334
MOD_GSK3_1	81	88	PF00069	0.363
MOD_N-GLC_1	44	49	PF02516	0.566
MOD_N-GLC_1	90	95	PF02516	0.521
MOD_NEK2_1	128	133	PF00069	0.325
MOD_NEK2_1	13	18	PF00069	0.351
MOD_NEK2_1	135	140	PF00069	0.326
MOD_NEK2_1	191	196	PF00069	0.402
MOD_NEK2_1	199	204	PF00069	0.403
MOD_NEK2_1	44	49	PF00069	0.400
MOD_NEK2_1	67	72	PF00069	0.347
MOD_OFUCOSY	3	10	PF10250	0.328
MOD_PIKK_1	176	182	PF00454	0.321
MOD_Plk_1	44	50	PF00069	0.413
MOD_Plk_1	90	96	PF00069	0.296
MOD_Plk_2-3	58	64	PF00069	0.323
MOD_Plk_4	128	134	PF00069	0.392
MOD_Plk_4	195	201	PF00069	0.327
MOD_Plk_4	202	208	PF00069	0.342
MOD_Plk_4	76	82	PF00069	0.358
MOD_ProDKin_1	171	177	PF00069	0.309
MOD_ProDKin_1	25	31	PF00069	0.357
MOD_ProDKin_1	47	53	PF00069	0.393
TRG_DiLeu_BaEn_1	63	68	PF01217	0.277
TRG_ENDOCYTIC_2	148	151	PF00928	0.293
TRG_ENDOCYTIC_2	186	189	PF00928	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T4	Leptomonas seymouri	52%	100%
A0A1X0NW81	Trypanosomatidae	35%	100%
A4HFI0	Leishmania braziliensis	67%	100%
C9ZWE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	93%
E9AD31	Leishmania major	94%	100%
E9AHC4	Leishmania infantum	100%	100%
E9AYV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%