Ribokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribokinase

Gene product:

ribokinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0F5_LEIDO

TriTrypDb:

LdBPK_270430.1 , LdCL_270009100 , LDHU3_27.0510

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1

Expansion

Sequence features

A0A3S7X0F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0F5

PDB structure(s): 6a8a_A , 6a8a_B , 6a8b_A , 6a8b_B , 6a8c_A , 6a8c_B

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006014	D-ribose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0019303	D-ribose catabolic process	6	12
GO:0019321	pentose metabolic process	4	12
GO:0019323	pentose catabolic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046365	monosaccharide catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004747	ribokinase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0019200	carbohydrate kinase activity	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.540
CLV_NRD_NRD_1	310	312	PF00675	0.363
CLV_PCSK_KEX2_1	299	301	PF00082	0.358
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.367
CLV_PCSK_SKI1_1	197	201	PF00082	0.341
CLV_PCSK_SKI1_1	266	270	PF00082	0.410
CLV_PCSK_SKI1_1	292	296	PF00082	0.421
CLV_Separin_Metazoa	135	139	PF03568	0.570
DOC_CYCLIN_RxL_1	289	296	PF00134	0.587
DOC_MAPK_DCC_7	197	205	PF00069	0.567
DOC_MAPK_MEF2A_6	197	205	PF00069	0.567
DOC_PP2B_PxIxI_1	15	21	PF00149	0.492
DOC_USP7_MATH_1	201	205	PF00917	0.564
DOC_USP7_MATH_1	319	323	PF00917	0.697
DOC_USP7_MATH_1	70	74	PF00917	0.543
DOC_WW_Pin1_4	130	135	PF00397	0.595
LIG_14-3-3_CanoR_1	100	110	PF00244	0.608
LIG_14-3-3_CanoR_1	176	182	PF00244	0.527
LIG_14-3-3_CanoR_1	5	14	PF00244	0.547
LIG_AP_GAE_1	225	231	PF02883	0.475
LIG_BRCT_BRCA1_1	43	47	PF00533	0.518
LIG_BRCT_BRCA1_2	43	49	PF00533	0.527
LIG_eIF4E_1	14	20	PF01652	0.416
LIG_FHA_1	131	137	PF00498	0.569
LIG_FHA_2	163	169	PF00498	0.516
LIG_FHA_2	220	226	PF00498	0.535
LIG_FHA_2	75	81	PF00498	0.618
LIG_HP1_1	201	205	PF01393	0.606
LIG_LIR_Apic_2	317	321	PF02991	0.586
LIG_LIR_Gen_1	141	152	PF02991	0.527
LIG_LIR_Gen_1	225	234	PF02991	0.565
LIG_LIR_LC3C_4	17	21	PF02991	0.616
LIG_LIR_Nem_3	141	147	PF02991	0.516
LIG_LIR_Nem_3	225	231	PF02991	0.628
LIG_LIR_Nem_3	23	28	PF02991	0.522
LIG_PCNA_yPIPBox_3	232	243	PF02747	0.556
LIG_Pex14_2	47	51	PF04695	0.516
LIG_SH2_PTP2	202	205	PF00017	0.558
LIG_SH2_SRC	31	34	PF00017	0.555
LIG_SH2_STAP1	144	148	PF00017	0.570
LIG_SH2_STAT5	154	157	PF00017	0.614
LIG_SH2_STAT5	179	182	PF00017	0.544
LIG_SH2_STAT5	202	205	PF00017	0.545
LIG_SH2_STAT5	28	31	PF00017	0.534
LIG_SH2_STAT5	286	289	PF00017	0.608
LIG_SH2_STAT5	84	87	PF00017	0.532
LIG_SH3_3	120	126	PF00018	0.516
LIG_SH3_3	195	201	PF00018	0.567
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.543
LIG_SUMO_SIM_par_1	109	115	PF11976	0.570
LIG_SUMO_SIM_par_1	17	23	PF11976	0.537
LIG_TYR_ITIM	200	205	PF00017	0.558
MOD_CK1_1	226	232	PF00069	0.554
MOD_CK2_1	115	121	PF00069	0.550
MOD_CK2_1	166	172	PF00069	0.627
MOD_CK2_1	219	225	PF00069	0.531
MOD_GlcNHglycan	183	186	PF01048	0.332
MOD_GlcNHglycan	225	228	PF01048	0.315
MOD_GSK3_1	126	133	PF00069	0.518
MOD_GSK3_1	162	169	PF00069	0.570
MOD_GSK3_1	177	184	PF00069	0.424
MOD_GSK3_1	219	226	PF00069	0.580
MOD_GSK3_1	307	314	PF00069	0.556
MOD_GSK3_1	70	77	PF00069	0.583
MOD_GSK3_1	98	105	PF00069	0.618
MOD_N-GLC_1	126	131	PF02516	0.316
MOD_N-GLC_2	302	304	PF02516	0.327
MOD_NEK2_1	112	117	PF00069	0.478
MOD_NEK2_1	280	285	PF00069	0.532
MOD_NEK2_1	98	103	PF00069	0.564
MOD_NEK2_2	177	182	PF00069	0.516
MOD_NEK2_2	201	206	PF00069	0.576
MOD_PIKK_1	311	317	PF00454	0.516
MOD_PKA_1	311	317	PF00069	0.527
MOD_Plk_1	211	217	PF00069	0.544
MOD_Plk_4	177	183	PF00069	0.538
MOD_Plk_4	201	207	PF00069	0.517
MOD_Plk_4	211	217	PF00069	0.525
MOD_Plk_4	280	286	PF00069	0.574
MOD_Plk_4	70	76	PF00069	0.529
MOD_ProDKin_1	130	136	PF00069	0.595
TRG_ENDOCYTIC_2	144	147	PF00928	0.527
TRG_ENDOCYTIC_2	179	182	PF00928	0.544
TRG_ENDOCYTIC_2	202	205	PF00928	0.568
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2WZY4	Staphylococcus aureus (strain COL)	32%	100%
A0A0N0P5S6	Leptomonas seymouri	79%	100%
A0A0S4JY74	Bodo saltans	57%	99%
A0A1X0P4P4	Trypanosomatidae	65%	98%
A0A3R7NMP1	Trypanosoma rangeli	67%	100%
A0A422P4V2	Trypanosoma rangeli	28%	96%
A1A6H3	Arabidopsis thaliana	28%	87%
A1AFX4	Escherichia coli O1:K1 / APEC	24%	69%
A1AV12	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	25%	67%
A2WXV8	Oryza sativa subsp. indica	27%	100%
A3D837	Shewanella baltica (strain OS155 / ATCC BAA-1091)	22%	69%
A3MZC0	Actinobacillus pleuropneumoniae serotype 5b (strain L20)	23%	69%
A4HFG6	Leishmania braziliensis	90%	100%
A4HI44	Leishmania braziliensis	27%	100%
A4I2M8	Leishmania infantum	100%	100%
A4WEI4	Enterobacter sp. (strain 638)	24%	69%
A5UCC3	Haemophilus influenzae (strain PittEE)	23%	69%
A5UEH8	Haemophilus influenzae (strain PittGG)	23%	69%
A5W9W6	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	25%	70%
A6Q4Z6	Nitratiruptor sp. (strain SB155-2)	25%	71%
A6WJS7	Shewanella baltica (strain OS185)	22%	69%
A7HUC7	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	25%	67%
A7MP93	Cronobacter sakazakii (strain ATCC BAA-894)	24%	69%
A7ZE26	Campylobacter concisus (strain 13826)	25%	70%
A7ZRT3	Escherichia coli O139:H28 (strain E24377A / ETEC)	24%	69%
A8A4K6	Escherichia coli O9:H4 (strain HS)	24%	69%
A8FZZ3	Shewanella sediminis (strain HAW-EB3)	22%	69%
A9N5X8	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	23%	69%
B1IRR4	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	24%	69%
B1LF43	Escherichia coli (strain SMS-3-5 / SECEC)	24%	69%
B1XG57	Escherichia coli (strain K12 / DH10B)	24%	69%
B2U1F7	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	24%	69%
B3E5M9	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	26%	67%
B4EW46	Proteus mirabilis (strain HI4320)	25%	69%
B4T670	Salmonella newport (strain SL254)	23%	69%
B4TI51	Salmonella heidelberg (strain SL476)	23%	69%
B4TVT4	Salmonella schwarzengrund (strain CVM19633)	23%	69%
B5BG11	Salmonella paratyphi A (strain AKU_12601)	23%	69%
B5EEZ1	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	26%	68%
B5F696	Salmonella agona (strain SL483)	23%	69%
B5FHT5	Salmonella dublin (strain CT_02021853)	24%	69%
B5QZ36	Salmonella enteritidis PT4 (strain P125109)	23%	69%
B5REF8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	23%	69%
B5YR91	Escherichia coli O157:H7 (strain EC4115 / EHEC)	24%	69%
B6I423	Escherichia coli (strain SE11)	24%	69%
B7LGY7	Escherichia coli (strain 55989 / EAEC)	24%	69%
B7LQC9	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	24%	69%
B7LZK1	Escherichia coli O8 (strain IAI1)	24%	69%
B7MAC8	Escherichia coli O45:K1 (strain S88 / ExPEC)	24%	69%
B7N0K1	Escherichia coli O81 (strain ED1a)	24%	69%
B7ND40	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	24%	69%
B7NJR5	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	24%	69%
B7UIW0	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	24%	69%
B8CVJ1	Shewanella piezotolerans (strain WP3 / JCM 13877)	22%	69%
C0PYX3	Salmonella paratyphi C (strain RKS4594)	23%	69%
C4ZQW9	Escherichia coli (strain K12 / MC4100 / BW2952)	24%	69%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
D0A5P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	99%
E9AD19	Leishmania major	96%	100%
E9AYU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O05074	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	69%
O27587	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O29891	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O60116	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O82616	Arabidopsis thaliana	26%	100%
O93919	Schizophyllum commune	25%	96%
P0A9J6	Escherichia coli (strain K12)	37%	100%
P0A9J7	Escherichia coli O157:H7	37%	100%
P22824	Vibrio alginolyticus	27%	100%
P25332	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
P30235	Escherichia coli (strain K12)	21%	100%
P32143	Escherichia coli (strain K12)	30%	100%
P33020	Escherichia coli (strain K12)	26%	91%
P36945	Bacillus subtilis (strain 168)	33%	100%
P37829	Solanum tuberosum	29%	100%
P44330	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P44331	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P45416	Dickeya dadantii (strain 3937)	22%	100%
P50053	Homo sapiens	24%	100%
P57168	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	22%	100%
P76658	Escherichia coli (strain K12)	24%	69%
P77493	Escherichia coli (strain K12)	25%	100%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	97%
P97328	Mus musculus	22%	100%
Q02974	Rattus norvegicus	22%	100%
Q07Y78	Shewanella frigidimarina (strain NCIMB 400)	23%	69%
Q0JGZ6	Oryza sativa subsp. japonica	27%	100%
Q0T0L1	Shigella flexneri serotype 5b (strain 8401)	24%	69%
Q0TD55	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	24%	69%
Q1R6S9	Escherichia coli (strain UTI89 / UPEC)	24%	69%
Q30T22	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	24%	69%
Q31IC2	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	24%	69%
Q31WY3	Shigella boydii serotype 4 (strain Sb227)	24%	69%
Q32BR2	Shigella dysenteriae serotype 1 (strain Sd197)	24%	69%
Q3YXJ0	Shigella sonnei (strain Ss046)	24%	69%
Q42896	Solanum lycopersicum	29%	100%
Q48P39	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	24%	69%
Q4QKN8	Haemophilus influenzae (strain 86-028NP)	23%	69%
Q4ZZ15	Pseudomonas syringae pv. syringae (strain B728a)	25%	69%
Q53W83	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	28%	100%
Q54UQ4	Dictyostelium discoideum	32%	100%
Q57JQ9	Salmonella choleraesuis (strain SC-B67)	23%	69%
Q5JDG9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	100%
Q5PC86	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	23%	69%
Q5RD71	Pongo abelii	23%	100%
Q6XZ78	Zea mays	27%	98%
Q6XZ79	Zea mays	27%	100%
Q74BF6	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	26%	67%
Q7AAQ7	Escherichia coli O157:H7	24%	69%
Q7CPR9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	69%
Q7N0C3	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	24%	69%
Q7UBI8	Shigella flexneri	24%	69%
Q7VFZ3	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	25%	68%
Q7VQQ6	Blochmannia floridanus	22%	69%
Q7XJ81	Solanum habrochaites	29%	100%
Q87VF4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	24%	69%
Q88D93	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	25%	70%
Q8EAZ2	Shewanella oneidensis (strain MR-1)	22%	69%
Q8FDH5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	69%
Q8GLU7	Actinobacillus pleuropneumoniae	23%	69%
Q8R1Q9	Mus musculus	42%	100%
Q8XEW9	Salmonella typhi	23%	69%
Q8ZKR2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
Q9CF42	Lactococcus lactis subsp. lactis (strain IL1403)	31%	100%
Q9H477	Homo sapiens	42%	100%
Q9K6K1	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	35%	100%
Q9LNE3	Arabidopsis thaliana	29%	100%
Q9LNE4	Arabidopsis thaliana	29%	95%
Q9LZG0	Arabidopsis thaliana	25%	95%
Q9M1B9	Arabidopsis thaliana	28%	100%
Q9SF85	Arabidopsis thaliana	26%	96%
Q9SID0	Arabidopsis thaliana	30%	100%
V5B941	Trypanosoma cruzi	23%	95%
V5BXE5	Trypanosoma cruzi	67%	100%