Ribokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribokinase

Gene product:

ribokinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0F5_LEIDO

TriTrypDb:

LdBPK_270430.1 , LdCL_270009100 , LDHU3_27.0510

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	11
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7X0F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0F5

PDB structure(s): 6a8a_A , 6a8a_B , 6a8b_A , 6a8b_B , 6a8c_A , 6a8c_B

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006014	D-ribose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0019303	D-ribose catabolic process	6	12
GO:0019321	pentose metabolic process	4	12
GO:0019323	pentose catabolic process	5	12
GO:0044238	primary metabolic process	2	12

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004747	ribokinase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.540
CLV_NRD_NRD_1	310	312	PF00675	0.363
CLV_PCSK_KEX2_1	299	301	PF00082	0.358
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.367
CLV_PCSK_SKI1_1	197	201	PF00082	0.341
CLV_PCSK_SKI1_1	266	270	PF00082	0.410
CLV_PCSK_SKI1_1	292	296	PF00082	0.421
CLV_Separin_Metazoa	135	139	PF03568	0.570
DOC_CYCLIN_RxL_1	289	296	PF00134	0.587
DOC_MAPK_DCC_7	197	205	PF00069	0.567

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0H2WZY4	Staphylococcus aureus (strain COL)	32%	100%
A0A0N0P5S6	Leptomonas seymouri	79%	100%
A0A0S4JY74	Bodo saltans	57%	99%
A0A1X0P4P4	Trypanosomatidae	65%	98%
A0A3R7NMP1	Trypanosoma rangeli	67%	100%
A0A422P4V2	Trypanosoma rangeli	28%	96%
A1A6H3	Arabidopsis thaliana	28%	87%
A1AFX4	Escherichia coli O1:K1 / APEC	24%	69%
A1AV12	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	25%	67%
A2WXV8	Oryza sativa subsp. indica	27%	100%

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