Heat shock protein DNAJ, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein DNAJ, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0F2_LEIDO

TriTrypDb:

LdBPK_270420.1 , LdCL_270009000 , LDHU3_27.0500

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X0F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0F2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.744
CLV_C14_Caspase3-7	361	365	PF00656	0.618
CLV_NRD_NRD_1	105	107	PF00675	0.493
CLV_NRD_NRD_1	145	147	PF00675	0.496
CLV_NRD_NRD_1	165	167	PF00675	0.540
CLV_NRD_NRD_1	233	235	PF00675	0.299
CLV_NRD_NRD_1	373	375	PF00675	0.491
CLV_PCSK_FUR_1	230	234	PF00082	0.398
CLV_PCSK_FUR_1	366	370	PF00082	0.546
CLV_PCSK_KEX2_1	105	107	PF00082	0.528
CLV_PCSK_KEX2_1	145	147	PF00082	0.475
CLV_PCSK_KEX2_1	165	167	PF00082	0.532
CLV_PCSK_KEX2_1	232	234	PF00082	0.301
CLV_PCSK_KEX2_1	368	370	PF00082	0.511
CLV_PCSK_KEX2_1	373	375	PF00082	0.492
CLV_PCSK_KEX2_1	90	92	PF00082	0.353
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.325
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.539
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.353
CLV_PCSK_PC7_1	369	375	PF00082	0.487
CLV_PCSK_SKI1_1	105	109	PF00082	0.530
CLV_PCSK_SKI1_1	198	202	PF00082	0.287
CLV_PCSK_SKI1_1	291	295	PF00082	0.401
CLV_PCSK_SKI1_1	336	340	PF00082	0.474
CLV_PCSK_SKI1_1	368	372	PF00082	0.506
DEG_APCC_DBOX_1	30	38	PF00400	0.345
DEG_SPOP_SBC_1	341	345	PF00917	0.633
DOC_CKS1_1	16	21	PF01111	0.328
DOC_CYCLIN_RxL_1	193	202	PF00134	0.505
DOC_CYCLIN_RxL_1	99	111	PF00134	0.558
DOC_MAPK_gen_1	31	39	PF00069	0.176
DOC_PP1_RVXF_1	31	37	PF00149	0.439
DOC_PP4_FxxP_1	412	415	PF00568	0.744
DOC_SPAK_OSR1_1	369	373	PF12202	0.696
DOC_USP7_MATH_1	122	126	PF00917	0.773
DOC_USP7_MATH_1	380	384	PF00917	0.680
DOC_USP7_UBL2_3	193	197	PF12436	0.497
DOC_WW_Pin1_4	15	20	PF00397	0.327
DOC_WW_Pin1_4	429	434	PF00397	0.678
DOC_WW_Pin1_4	52	57	PF00397	0.554
LIG_14-3-3_CanoR_1	131	137	PF00244	0.717
LIG_14-3-3_CanoR_1	153	161	PF00244	0.733
LIG_14-3-3_CanoR_1	336	342	PF00244	0.735
LIG_14-3-3_CanoR_1	369	373	PF00244	0.630
LIG_14-3-3_CanoR_1	374	380	PF00244	0.644
LIG_BRCT_BRCA1_1	125	129	PF00533	0.716
LIG_BRCT_BRCA1_1	156	160	PF00533	0.678
LIG_BRCT_BRCA1_1	2	6	PF00533	0.332
LIG_BRCT_BRCA1_1	263	267	PF00533	0.775
LIG_BRCT_BRCA1_1	408	412	PF00533	0.732
LIG_BRCT_BRCA1_1	50	54	PF00533	0.428
LIG_EVH1_1	15	19	PF00568	0.324
LIG_FHA_1	343	349	PF00498	0.682
LIG_FHA_1	442	448	PF00498	0.371
LIG_FHA_2	186	192	PF00498	0.560
LIG_FHA_2	359	365	PF00498	0.684
LIG_FHA_2	385	391	PF00498	0.670
LIG_LIR_Apic_2	409	415	PF02991	0.747
LIG_LIR_Gen_1	176	185	PF02991	0.503
LIG_LIR_Gen_1	21	30	PF02991	0.342
LIG_LIR_Gen_1	221	231	PF02991	0.525
LIG_LIR_Gen_1	449	458	PF02991	0.381
LIG_LIR_Nem_3	176	181	PF02991	0.486
LIG_LIR_Nem_3	21	25	PF02991	0.344
LIG_LIR_Nem_3	214	220	PF02991	0.558
LIG_LIR_Nem_3	221	227	PF02991	0.501
LIG_LIR_Nem_3	287	293	PF02991	0.589
LIG_LIR_Nem_3	300	306	PF02991	0.576
LIG_LIR_Nem_3	332	338	PF02991	0.719
LIG_LIR_Nem_3	449	455	PF02991	0.346
LIG_LIR_Nem_3	78	84	PF02991	0.544
LIG_NRBOX	446	452	PF00104	0.438
LIG_Pex14_2	143	147	PF04695	0.763
LIG_Pex14_2	290	294	PF04695	0.588
LIG_Pex14_2	335	339	PF04695	0.695
LIG_PTB_Apo_2	70	77	PF02174	0.534
LIG_SH2_CRK	196	200	PF00017	0.480
LIG_SH2_CRK	22	26	PF00017	0.345
LIG_SH2_CRK	224	228	PF00017	0.501
LIG_SH2_NCK_1	224	228	PF00017	0.525
LIG_SH2_PTP2	178	181	PF00017	0.445
LIG_SH2_PTP2	81	84	PF00017	0.577
LIG_SH2_SRC	276	279	PF00017	0.706
LIG_SH2_STAT3	236	239	PF00017	0.664
LIG_SH2_STAT5	178	181	PF00017	0.505
LIG_SH2_STAT5	22	25	PF00017	0.345
LIG_SH2_STAT5	26	29	PF00017	0.342
LIG_SH2_STAT5	35	38	PF00017	0.169
LIG_SH2_STAT5	362	365	PF00017	0.705
LIG_SH2_STAT5	81	84	PF00017	0.577
LIG_SH3_3	11	17	PF00018	0.322
LIG_SH3_3	71	77	PF00018	0.531
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.438
LIG_SUMO_SIM_par_1	443	449	PF11976	0.438
LIG_TRAF2_1	282	285	PF00917	0.626
LIG_TYR_ITIM	79	84	PF00017	0.419
LIG_WRPW_2	335	338	PF00400	0.634
MOD_CK1_1	250	256	PF00069	0.674
MOD_CK1_1	261	267	PF00069	0.513
MOD_CK1_1	340	346	PF00069	0.656
MOD_CK2_1	185	191	PF00069	0.357
MOD_CK2_1	279	285	PF00069	0.525
MOD_CK2_1	384	390	PF00069	0.646
MOD_Cter_Amidation	366	369	PF01082	0.705
MOD_GlcNHglycan	137	140	PF01048	0.675
MOD_GlcNHglycan	170	173	PF01048	0.691
MOD_GlcNHglycan	220	223	PF01048	0.430
MOD_GlcNHglycan	252	255	PF01048	0.703
MOD_GlcNHglycan	260	263	PF01048	0.576
MOD_GSK3_1	148	155	PF00069	0.668
MOD_GSK3_1	218	225	PF00069	0.391
MOD_GSK3_1	324	331	PF00069	0.727
MOD_GSK3_1	337	344	PF00069	0.486
MOD_GSK3_1	358	365	PF00069	0.652
MOD_GSK3_1	380	387	PF00069	0.649
MOD_GSK3_1	425	432	PF00069	0.626
MOD_GSK3_1	48	55	PF00069	0.425
MOD_GSK3_1	91	98	PF00069	0.434
MOD_N-GLC_1	380	385	PF02516	0.603
MOD_N-GLC_1	406	411	PF02516	0.661
MOD_NEK2_1	108	113	PF00069	0.704
MOD_NEK2_1	130	135	PF00069	0.694
MOD_NEK2_1	154	159	PF00069	0.616
MOD_NEK2_1	357	362	PF00069	0.519
MOD_NEK2_1	464	469	PF00069	0.397
MOD_NEK2_1	48	53	PF00069	0.181
MOD_NEK2_2	123	128	PF00069	0.594
MOD_PIKK_1	185	191	PF00454	0.422
MOD_PIKK_1	407	413	PF00454	0.716
MOD_PIKK_1	417	423	PF00454	0.639
MOD_PIKK_1	58	64	PF00454	0.440
MOD_PK_1	216	222	PF00069	0.492
MOD_PKA_1	368	374	PF00069	0.650
MOD_PKA_2	130	136	PF00069	0.687
MOD_PKA_2	152	158	PF00069	0.603
MOD_PKA_2	368	374	PF00069	0.535
MOD_PKA_2	95	101	PF00069	0.444
MOD_Plk_1	357	363	PF00069	0.537
MOD_Plk_1	380	386	PF00069	0.635
MOD_Plk_2-3	358	364	PF00069	0.603
MOD_Plk_4	222	228	PF00069	0.357
MOD_Plk_4	446	452	PF00069	0.357
MOD_Plk_4	464	470	PF00069	0.357
MOD_Plk_4	75	81	PF00069	0.478
MOD_ProDKin_1	15	21	PF00069	0.396
MOD_ProDKin_1	429	435	PF00069	0.594
MOD_ProDKin_1	52	58	PF00069	0.433
MOD_SUMO_rev_2	186	195	PF00179	0.357
TRG_DiLeu_BaEn_4	307	313	PF01217	0.601
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.431
TRG_ENDOCYTIC_2	178	181	PF00928	0.360
TRG_ENDOCYTIC_2	196	199	PF00928	0.326
TRG_ENDOCYTIC_2	22	25	PF00928	0.418
TRG_ENDOCYTIC_2	224	227	PF00928	0.357
TRG_ENDOCYTIC_2	278	281	PF00928	0.539
TRG_ENDOCYTIC_2	81	84	PF00928	0.463
TRG_ER_diArg_1	104	106	PF00400	0.681
TRG_ER_diArg_1	144	146	PF00400	0.659
TRG_ER_diArg_1	165	167	PF00400	0.747
TRG_ER_diArg_1	372	374	PF00400	0.619
TRG_ER_diArg_1	392	395	PF00400	0.478
TRG_NES_CRM1_1	287	300	PF08389	0.533
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD75	Leptomonas seymouri	70%	100%
A0A0S4JV26	Bodo saltans	41%	100%
A4HFG5	Leishmania braziliensis	82%	100%
A4I2M7	Leishmania infantum	100%	100%
E9AD18	Leishmania major	95%	100%
E9AYU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BN28	Trypanosoma cruzi	48%	100%