Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0E6_LEIDO

TriTrypDb:

LdBPK_270450.1 , LdCL_270009300 , LDHU3_27.0530

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.497
CLV_C14_Caspase3-7	449	453	PF00656	0.473
CLV_C14_Caspase3-7	526	530	PF00656	0.477
CLV_NRD_NRD_1	141	143	PF00675	0.438
CLV_NRD_NRD_1	169	171	PF00675	0.579
CLV_NRD_NRD_1	324	326	PF00675	0.564
CLV_NRD_NRD_1	549	551	PF00675	0.515
CLV_PCSK_KEX2_1	128	130	PF00082	0.541
CLV_PCSK_KEX2_1	141	143	PF00082	0.392
CLV_PCSK_KEX2_1	171	173	PF00082	0.584
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.530
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.635
CLV_PCSK_SKI1_1	142	146	PF00082	0.389
CLV_PCSK_SKI1_1	253	257	PF00082	0.545
CLV_PCSK_SKI1_1	38	42	PF00082	0.419
CLV_PCSK_SKI1_1	399	403	PF00082	0.535
CLV_PCSK_SKI1_1	445	449	PF00082	0.573
CLV_PCSK_SKI1_1	49	53	PF00082	0.522
CLV_PCSK_SKI1_1	538	542	PF00082	0.444
CLV_PCSK_SKI1_1	78	82	PF00082	0.398
DEG_APCC_DBOX_1	312	320	PF00400	0.390
DOC_CKS1_1	379	384	PF01111	0.361
DOC_CYCLIN_RxL_1	107	120	PF00134	0.411
DOC_CYCLIN_RxL_1	249	257	PF00134	0.488
DOC_MAPK_gen_1	128	135	PF00069	0.386
DOC_MAPK_gen_1	33	43	PF00069	0.450
DOC_MAPK_MEF2A_6	313	320	PF00069	0.395
DOC_PP1_RVXF_1	76	83	PF00149	0.420
DOC_PP1_SILK_1	137	142	PF00149	0.374
DOC_PP2B_LxvP_1	12	15	PF13499	0.414
DOC_PP4_FxxP_1	3	6	PF00568	0.452
DOC_PP4_FxxP_1	379	382	PF00568	0.329
DOC_USP7_MATH_1	101	105	PF00917	0.480
DOC_USP7_MATH_1	192	196	PF00917	0.538
DOC_USP7_MATH_1	238	242	PF00917	0.565
DOC_USP7_MATH_1	293	297	PF00917	0.485
DOC_USP7_MATH_1	343	347	PF00917	0.518
DOC_USP7_MATH_1	478	482	PF00917	0.555
DOC_USP7_UBL2_3	538	542	PF12436	0.398
DOC_WW_Pin1_4	1	6	PF00397	0.579
DOC_WW_Pin1_4	217	222	PF00397	0.552
DOC_WW_Pin1_4	232	237	PF00397	0.651
DOC_WW_Pin1_4	318	323	PF00397	0.344
DOC_WW_Pin1_4	364	369	PF00397	0.574
DOC_WW_Pin1_4	378	383	PF00397	0.387
DOC_WW_Pin1_4	508	513	PF00397	0.424
LIG_14-3-3_CanoR_1	399	408	PF00244	0.510
LIG_14-3-3_CanoR_1	502	512	PF00244	0.454
LIG_Actin_WH2_2	287	305	PF00022	0.518
LIG_APCC_ABBA_1	41	46	PF00400	0.404
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	320	324	PF00533	0.370
LIG_BRCT_BRCA1_1	425	429	PF00533	0.527
LIG_BRCT_BRCA1_2	320	326	PF00533	0.374
LIG_Clathr_ClatBox_1	185	189	PF01394	0.550
LIG_CtBP_PxDLS_1	15	19	PF00389	0.460
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.346
LIG_EH_1	414	418	PF12763	0.375
LIG_EH1_1	206	214	PF00400	0.500
LIG_FHA_1	217	223	PF00498	0.447
LIG_FHA_1	379	385	PF00498	0.533
LIG_FHA_1	400	406	PF00498	0.383
LIG_FHA_2	153	159	PF00498	0.540
LIG_FHA_2	206	212	PF00498	0.427
LIG_FHA_2	392	398	PF00498	0.501
LIG_FHA_2	512	518	PF00498	0.326
LIG_LIR_Apic_2	2	6	PF02991	0.457
LIG_LIR_Gen_1	264	272	PF02991	0.447
LIG_LIR_Gen_1	473	478	PF02991	0.502
LIG_LIR_Nem_3	264	268	PF02991	0.515
LIG_LIR_Nem_3	321	327	PF02991	0.380
LIG_LIR_Nem_3	411	417	PF02991	0.477
LIG_LIR_Nem_3	473	477	PF02991	0.557
LIG_MYND_1	11	15	PF01753	0.473
LIG_MYND_1	147	151	PF01753	0.530
LIG_NBox_RRM_1	500	510	PF00076	0.417
LIG_NRBOX	224	230	PF00104	0.518
LIG_NRBOX	315	321	PF00104	0.433
LIG_SH2_CRK	265	269	PF00017	0.533
LIG_SH2_SRC	93	96	PF00017	0.401
LIG_SH2_STAP1	533	537	PF00017	0.425
LIG_SH2_STAP1	93	97	PF00017	0.403
LIG_SH2_STAT3	164	167	PF00017	0.546
LIG_SH2_STAT5	435	438	PF00017	0.571
LIG_SH3_3	356	362	PF00018	0.417
LIG_SH3_3	472	478	PF00018	0.749
LIG_SUMO_SIM_par_1	10	17	PF11976	0.579
LIG_SUMO_SIM_par_1	223	230	PF11976	0.560
LIG_TRAF2_1	45	48	PF00917	0.410
LIG_WRC_WIRS_1	327	332	PF05994	0.383
MOD_CDK_SPK_2	318	323	PF00069	0.344
MOD_CDK_SPxK_1	364	370	PF00069	0.559
MOD_CDK_SPxxK_3	217	224	PF00069	0.532
MOD_CDK_SPxxK_3	318	325	PF00069	0.354
MOD_CDK_SPxxK_3	508	515	PF00069	0.424
MOD_CK1_1	241	247	PF00069	0.592
MOD_CK1_1	296	302	PF00069	0.427
MOD_CK1_1	423	429	PF00069	0.465
MOD_CK1_1	476	482	PF00069	0.666
MOD_CK1_1	511	517	PF00069	0.538
MOD_CK2_1	152	158	PF00069	0.463
MOD_CK2_1	343	349	PF00069	0.502
MOD_CK2_1	391	397	PF00069	0.489
MOD_CK2_1	42	48	PF00069	0.496
MOD_CK2_1	511	517	PF00069	0.496
MOD_Cter_Amidation	548	551	PF01082	0.453
MOD_GlcNHglycan	23	26	PF01048	0.526
MOD_GlcNHglycan	240	243	PF01048	0.607
MOD_GlcNHglycan	245	248	PF01048	0.504
MOD_GlcNHglycan	295	298	PF01048	0.571
MOD_GlcNHglycan	338	341	PF01048	0.534
MOD_GlcNHglycan	426	429	PF01048	0.517
MOD_GlcNHglycan	467	470	PF01048	0.705
MOD_GlcNHglycan	505	508	PF01048	0.477
MOD_GSK3_1	1	8	PF00069	0.569
MOD_GSK3_1	203	210	PF00069	0.467
MOD_GSK3_1	216	223	PF00069	0.478
MOD_GSK3_1	227	234	PF00069	0.489
MOD_GSK3_1	292	299	PF00069	0.575
MOD_GSK3_1	393	400	PF00069	0.320
MOD_GSK3_1	420	427	PF00069	0.397
MOD_GSK3_1	461	468	PF00069	0.636
MOD_GSK3_1	473	480	PF00069	0.550
MOD_LATS_1	67	73	PF00433	0.411
MOD_N-GLC_1	122	127	PF02516	0.477
MOD_N-GLC_2	37	39	PF02516	0.466
MOD_NEK2_1	152	157	PF00069	0.479
MOD_PIKK_1	227	233	PF00454	0.490
MOD_PIKK_1	478	484	PF00454	0.570
MOD_PIKK_1	5	11	PF00454	0.589
MOD_PKA_1	170	176	PF00069	0.575
MOD_PKA_2	32	38	PF00069	0.643
MOD_PKA_2	423	429	PF00069	0.503
MOD_PKA_2	489	495	PF00069	0.541
MOD_PKB_1	443	451	PF00069	0.485
MOD_Plk_1	122	128	PF00069	0.534
MOD_Plk_1	142	148	PF00069	0.443
MOD_Plk_2-3	391	397	PF00069	0.307
MOD_Plk_4	180	186	PF00069	0.569
MOD_Plk_4	264	270	PF00069	0.523
MOD_Plk_4	306	312	PF00069	0.332
MOD_Plk_4	370	376	PF00069	0.496
MOD_ProDKin_1	1	7	PF00069	0.571
MOD_ProDKin_1	217	223	PF00069	0.553
MOD_ProDKin_1	232	238	PF00069	0.657
MOD_ProDKin_1	318	324	PF00069	0.354
MOD_ProDKin_1	364	370	PF00069	0.572
MOD_ProDKin_1	378	384	PF00069	0.386
MOD_ProDKin_1	508	514	PF00069	0.423
MOD_SUMO_for_1	51	54	PF00179	0.447
MOD_SUMO_rev_2	195	205	PF00179	0.493
TRG_DiLeu_BaEn_1	315	320	PF01217	0.321
TRG_DiLeu_BaEn_1	442	447	PF01217	0.500
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.508
TRG_ENDOCYTIC_2	102	105	PF00928	0.466
TRG_ENDOCYTIC_2	265	268	PF00928	0.461
TRG_ENDOCYTIC_2	533	536	PF00928	0.433
TRG_ER_diArg_1	140	142	PF00400	0.434
TRG_ER_diArg_1	169	172	PF00400	0.560
TRG_NLS_MonoExtC_3	169	174	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKI5	Leptomonas seymouri	55%	99%
A0A1X0P429	Trypanosomatidae	25%	100%
A0A3R7MVK8	Trypanosoma rangeli	28%	100%
A4HFG8	Leishmania braziliensis	79%	100%
A4I2N0	Leishmania infantum	99%	100%
D0A5P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AD21	Leishmania major	92%	99%
E9AYU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DP58	Trypanosoma cruzi	27%	100%