Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0E2_LEIDO

TriTrypDb:

LdBPK_270330.1 , LdCL_270008100 , LDHU3_27.0400

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0E2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.612
CLV_NRD_NRD_1	232	234	PF00675	0.502
CLV_NRD_NRD_1	344	346	PF00675	0.471
CLV_NRD_NRD_1	365	367	PF00675	0.475
CLV_NRD_NRD_1	375	377	PF00675	0.329
CLV_NRD_NRD_1	413	415	PF00675	0.660
CLV_NRD_NRD_1	464	466	PF00675	0.669
CLV_NRD_NRD_1	468	470	PF00675	0.631
CLV_NRD_NRD_1	475	477	PF00675	0.540
CLV_NRD_NRD_1	486	488	PF00675	0.500
CLV_PCSK_FUR_1	462	466	PF00082	0.676
CLV_PCSK_KEX2_1	2	4	PF00082	0.612
CLV_PCSK_KEX2_1	232	234	PF00082	0.502
CLV_PCSK_KEX2_1	343	345	PF00082	0.473
CLV_PCSK_KEX2_1	365	367	PF00082	0.478
CLV_PCSK_KEX2_1	375	377	PF00082	0.331
CLV_PCSK_KEX2_1	413	415	PF00082	0.660
CLV_PCSK_KEX2_1	464	466	PF00082	0.667
CLV_PCSK_KEX2_1	468	470	PF00082	0.628
CLV_PCSK_KEX2_1	475	477	PF00082	0.535
CLV_PCSK_KEX2_1	485	487	PF00082	0.488
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.488
CLV_PCSK_PC7_1	340	346	PF00082	0.409
CLV_PCSK_PC7_1	464	470	PF00082	0.615
CLV_PCSK_SKI1_1	344	348	PF00082	0.397
CLV_PCSK_SKI1_1	375	379	PF00082	0.417
CLV_PCSK_SKI1_1	469	473	PF00082	0.700
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DEG_SPOP_SBC_1	125	129	PF00917	0.465
DOC_CKS1_1	261	266	PF01111	0.638
DOC_CYCLIN_RxL_1	340	351	PF00134	0.471
DOC_CYCLIN_RxL_1	372	382	PF00134	0.496
DOC_MAPK_gen_1	340	350	PF00069	0.457
DOC_MAPK_gen_1	365	373	PF00069	0.523
DOC_MAPK_gen_1	462	472	PF00069	0.687
DOC_MAPK_gen_1	81	90	PF00069	0.492
DOC_MAPK_MEF2A_6	343	350	PF00069	0.460
DOC_MAPK_NFAT4_5	343	351	PF00069	0.497
DOC_MAPK_RevD_3	217	233	PF00069	0.489
DOC_PP2B_LxvP_1	252	255	PF13499	0.625
DOC_PP4_FxxP_1	441	444	PF00568	0.528
DOC_PP4_FxxP_1	97	100	PF00568	0.511
DOC_USP7_MATH_1	10	14	PF00917	0.662
DOC_USP7_MATH_1	125	129	PF00917	0.473
DOC_USP7_MATH_1	158	162	PF00917	0.518
DOC_USP7_MATH_1	186	190	PF00917	0.586
DOC_USP7_MATH_1	28	32	PF00917	0.501
DOC_USP7_MATH_1	43	47	PF00917	0.339
DOC_USP7_MATH_1	79	83	PF00917	0.575
DOC_USP7_UBL2_3	479	483	PF12436	0.482
DOC_WW_Pin1_4	260	265	PF00397	0.644
DOC_WW_Pin1_4	385	390	PF00397	0.550
DOC_WW_Pin1_4	448	453	PF00397	0.615
DOC_WW_Pin1_4	98	103	PF00397	0.553
LIG_14-3-3_CanoR_1	115	121	PF00244	0.587
LIG_14-3-3_CanoR_1	166	170	PF00244	0.503
LIG_14-3-3_CanoR_1	195	202	PF00244	0.669
LIG_14-3-3_CanoR_1	303	312	PF00244	0.533
LIG_14-3-3_CanoR_1	343	349	PF00244	0.458
LIG_14-3-3_CanoR_1	403	407	PF00244	0.571
LIG_14-3-3_CanoR_1	91	97	PF00244	0.454
LIG_Actin_WH2_2	150	168	PF00022	0.483
LIG_BRCT_BRCA1_1	127	131	PF00533	0.445
LIG_BRCT_BRCA1_1	308	312	PF00533	0.494
LIG_FHA_1	202	208	PF00498	0.652
LIG_FHA_1	256	262	PF00498	0.768
LIG_FHA_1	296	302	PF00498	0.431
LIG_FHA_1	345	351	PF00498	0.531
LIG_FHA_1	395	401	PF00498	0.503
LIG_FHA_1	472	478	PF00498	0.554
LIG_FHA_1	52	58	PF00498	0.483
LIG_FHA_2	101	107	PF00498	0.648
LIG_FHA_2	195	201	PF00498	0.644
LIG_FHA_2	261	267	PF00498	0.689
LIG_FHA_2	319	325	PF00498	0.469
LIG_FHA_2	330	336	PF00498	0.593
LIG_LIR_Apic_2	439	444	PF02991	0.522
LIG_LIR_Apic_2	448	452	PF02991	0.544
LIG_LIR_Apic_2	95	100	PF02991	0.501
LIG_LIR_Gen_1	128	139	PF02991	0.482
LIG_LIR_Gen_1	390	400	PF02991	0.517
LIG_LIR_Gen_1	82	93	PF02991	0.466
LIG_LIR_Nem_3	167	172	PF02991	0.347
LIG_LIR_Nem_3	390	395	PF02991	0.441
LIG_LIR_Nem_3	82	88	PF02991	0.480
LIG_LRP6_Inhibitor_1	477	483	PF00058	0.536
LIG_MYND_1	385	389	PF01753	0.459
LIG_NBox_RRM_1	313	323	PF00076	0.465
LIG_PCNA_yPIPBox_3	214	223	PF02747	0.455
LIG_REV1ctd_RIR_1	310	319	PF16727	0.461
LIG_SH2_CRK	169	173	PF00017	0.481
LIG_SH2_SRC	333	336	PF00017	0.564
LIG_SH2_SRC	85	88	PF00017	0.362
LIG_SH2_STAP1	126	130	PF00017	0.529
LIG_SH2_STAP1	333	337	PF00017	0.538
LIG_SH2_STAP1	424	428	PF00017	0.567
LIG_SH2_STAP1	85	89	PF00017	0.353
LIG_SH2_STAT3	304	307	PF00017	0.480
LIG_SH2_STAT5	126	129	PF00017	0.453
LIG_SH2_STAT5	304	307	PF00017	0.543
LIG_SH2_STAT5	363	366	PF00017	0.525
LIG_SH2_STAT5	481	484	PF00017	0.471
LIG_SH3_3	324	330	PF00018	0.555
LIG_SH3_CIN85_PxpxPR_1	452	457	PF14604	0.701
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.436
LIG_SUMO_SIM_anti_2	370	375	PF11976	0.493
LIG_SUMO_SIM_par_1	429	434	PF11976	0.657
LIG_TRAF2_1	208	211	PF00917	0.702
LIG_TRAF2_1	332	335	PF00917	0.581
LIG_TYR_ITIM	157	162	PF00017	0.494
LIG_TYR_ITIM	83	88	PF00017	0.364
LIG_UBA3_1	419	427	PF00899	0.575
LIG_UBA3_1	89	98	PF00899	0.400
MOD_CDK_SPK_2	452	457	PF00069	0.673
MOD_CK1_1	108	114	PF00069	0.686
MOD_CK1_1	121	127	PF00069	0.448
MOD_CK1_1	190	196	PF00069	0.670
MOD_CK1_1	29	35	PF00069	0.561
MOD_CK1_1	409	415	PF00069	0.659
MOD_CK2_1	116	122	PF00069	0.511
MOD_CK2_1	178	184	PF00069	0.447
MOD_CK2_1	194	200	PF00069	0.575
MOD_CK2_1	318	324	PF00069	0.487
MOD_CK2_1	329	335	PF00069	0.598
MOD_GlcNHglycan	12	15	PF01048	0.717
MOD_GlcNHglycan	122	126	PF01048	0.481
MOD_GlcNHglycan	128	131	PF01048	0.463
MOD_GlcNHglycan	172	175	PF01048	0.441
MOD_GlcNHglycan	27	31	PF01048	0.526
MOD_GlcNHglycan	308	311	PF01048	0.487
MOD_GlcNHglycan	334	338	PF01048	0.557
MOD_GlcNHglycan	350	353	PF01048	0.412
MOD_GlcNHglycan	45	48	PF01048	0.436
MOD_GSK3_1	10	17	PF00069	0.586
MOD_GSK3_1	105	112	PF00069	0.733
MOD_GSK3_1	121	128	PF00069	0.424
MOD_GSK3_1	186	193	PF00069	0.600
MOD_GSK3_1	26	33	PF00069	0.546
MOD_GSK3_1	295	302	PF00069	0.430
MOD_GSK3_1	329	336	PF00069	0.610
MOD_GSK3_1	344	351	PF00069	0.329
MOD_GSK3_1	379	386	PF00069	0.523
MOD_GSK3_1	402	409	PF00069	0.611
MOD_GSK3_1	448	455	PF00069	0.753
MOD_GSK3_1	471	478	PF00069	0.568
MOD_NEK2_1	165	170	PF00069	0.473
MOD_NEK2_1	178	183	PF00069	0.463
MOD_NEK2_1	234	239	PF00069	0.408
MOD_NEK2_1	26	31	PF00069	0.561
MOD_NEK2_1	348	353	PF00069	0.491
MOD_NEK2_2	394	399	PF00069	0.515
MOD_NEK2_2	64	69	PF00069	0.369
MOD_NEK2_2	79	84	PF00069	0.439
MOD_NEK2_2	92	97	PF00069	0.461
MOD_PIKK_1	303	309	PF00454	0.469
MOD_PIKK_1	406	412	PF00454	0.595
MOD_PK_1	429	435	PF00069	0.629
MOD_PKA_1	344	350	PF00069	0.400
MOD_PKA_1	464	470	PF00069	0.643
MOD_PKA_1	475	481	PF00069	0.515
MOD_PKA_2	10	16	PF00069	0.663
MOD_PKA_2	165	171	PF00069	0.537
MOD_PKA_2	194	200	PF00069	0.503
MOD_PKA_2	267	273	PF00069	0.580
MOD_PKA_2	344	350	PF00069	0.433
MOD_PKA_2	402	408	PF00069	0.589
MOD_PKA_2	464	470	PF00069	0.643
MOD_PKA_2	475	481	PF00069	0.515
MOD_PKB_1	462	470	PF00069	0.539
MOD_Plk_1	105	111	PF00069	0.736
MOD_Plk_1	121	127	PF00069	0.342
MOD_Plk_1	209	215	PF00069	0.691
MOD_Plk_1	64	70	PF00069	0.324
MOD_Plk_2-3	105	111	PF00069	0.712
MOD_Plk_2-3	329	335	PF00069	0.591
MOD_Plk_4	318	324	PF00069	0.460
MOD_ProDKin_1	260	266	PF00069	0.640
MOD_ProDKin_1	385	391	PF00069	0.542
MOD_ProDKin_1	448	454	PF00069	0.615
MOD_ProDKin_1	98	104	PF00069	0.568
MOD_SUMO_rev_2	439	448	PF00179	0.635
TRG_DiLeu_BaEn_2	271	277	PF01217	0.500
TRG_DiLeu_BaEn_2	436	442	PF01217	0.537
TRG_ENDOCYTIC_2	159	162	PF00928	0.508
TRG_ENDOCYTIC_2	169	172	PF00928	0.245
TRG_ENDOCYTIC_2	85	88	PF00928	0.362
TRG_ER_diArg_1	1	3	PF00400	0.616
TRG_ER_diArg_1	231	233	PF00400	0.452
TRG_ER_diArg_1	343	345	PF00400	0.419
TRG_ER_diArg_1	364	366	PF00400	0.442
TRG_ER_diArg_1	374	376	PF00400	0.351
TRG_ER_diArg_1	413	415	PF00400	0.660
TRG_ER_diArg_1	461	464	PF00400	0.687
TRG_ER_diArg_1	468	470	PF00400	0.624
TRG_ER_diArg_1	475	477	PF00400	0.524
TRG_NLS_Bipartite_1	468	489	PF00514	0.585
TRG_NLS_MonoCore_2	484	489	PF00514	0.490
TRG_NLS_MonoExtN_4	483	489	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S3	Leptomonas seymouri	58%	100%
A0A1X0P4N9	Trypanosomatidae	34%	100%
A0A3R7KSE1	Trypanosoma rangeli	35%	100%
A4HFF0	Leishmania braziliensis	80%	100%
A4I2L9	Leishmania infantum	99%	100%
D0A5N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD09	Leishmania major	93%	100%
E9AYT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSR3	Trypanosoma cruzi	35%	100%