TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0D8_LEIDO

TriTrypDb:

LdBPK_270340.1 , LdCL_270008200 , LDHU3_27.0410

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X0D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.681
CLV_C14_Caspase3-7	425	429	PF00656	0.600
CLV_NRD_NRD_1	107	109	PF00675	0.682
CLV_NRD_NRD_1	127	129	PF00675	0.336
CLV_NRD_NRD_1	287	289	PF00675	0.654
CLV_NRD_NRD_1	316	318	PF00675	0.665
CLV_NRD_NRD_1	563	565	PF00675	0.516
CLV_NRD_NRD_1	717	719	PF00675	0.466
CLV_NRD_NRD_1	727	729	PF00675	0.405
CLV_PCSK_FUR_1	104	108	PF00082	0.688
CLV_PCSK_KEX2_1	106	108	PF00082	0.622
CLV_PCSK_KEX2_1	127	129	PF00082	0.355
CLV_PCSK_KEX2_1	186	188	PF00082	0.258
CLV_PCSK_KEX2_1	316	318	PF00082	0.557
CLV_PCSK_KEX2_1	562	564	PF00082	0.528
CLV_PCSK_KEX2_1	663	665	PF00082	0.630
CLV_PCSK_KEX2_1	717	719	PF00082	0.466
CLV_PCSK_KEX2_1	727	729	PF00082	0.405
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.307
CLV_PCSK_PC1ET2_1	663	665	PF00082	0.630
CLV_PCSK_PC7_1	559	565	PF00082	0.372
CLV_PCSK_SKI1_1	150	154	PF00082	0.305
CLV_PCSK_SKI1_1	164	168	PF00082	0.422
CLV_PCSK_SKI1_1	17	21	PF00082	0.784
CLV_PCSK_SKI1_1	284	288	PF00082	0.647
CLV_PCSK_SKI1_1	543	547	PF00082	0.392
CLV_PCSK_SKI1_1	550	554	PF00082	0.410
CLV_PCSK_SKI1_1	582	586	PF00082	0.555
CLV_Separin_Metazoa	556	560	PF03568	0.367
CLV_Separin_Metazoa	6	10	PF03568	0.741
DEG_APCC_DBOX_1	542	550	PF00400	0.461
DEG_MDM2_SWIB_1	637	645	PF02201	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.769
DEG_SPOP_SBC_1	99	103	PF00917	0.656
DOC_CYCLIN_RxL_1	474	484	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.462
DOC_MAPK_gen_1	475	483	PF00069	0.460
DOC_MAPK_gen_1	562	570	PF00069	0.526
DOC_MAPK_gen_1	717	725	PF00069	0.442
DOC_MAPK_MEF2A_6	475	483	PF00069	0.531
DOC_PP2B_LxvP_1	479	482	PF13499	0.474
DOC_PP2B_LxvP_1	76	79	PF13499	0.703
DOC_PP2B_PxIxI_1	697	703	PF00149	0.608
DOC_SPAK_OSR1_1	608	612	PF12202	0.524
DOC_USP7_MATH_1	111	115	PF00917	0.346
DOC_USP7_MATH_1	138	142	PF00917	0.447
DOC_USP7_MATH_1	422	426	PF00917	0.701
DOC_USP7_MATH_1	499	503	PF00917	0.608
DOC_USP7_MATH_1	597	601	PF00917	0.446
DOC_USP7_MATH_1	8	12	PF00917	0.779
DOC_USP7_MATH_1	99	103	PF00917	0.662
DOC_WW_Pin1_4	726	731	PF00397	0.442
LIG_14-3-3_CanoR_1	300	304	PF00244	0.542
LIG_14-3-3_CanoR_1	316	321	PF00244	0.641
LIG_14-3-3_CanoR_1	340	345	PF00244	0.580
LIG_14-3-3_CanoR_1	424	428	PF00244	0.723
LIG_14-3-3_CanoR_1	477	482	PF00244	0.532
LIG_14-3-3_CanoR_1	52	58	PF00244	0.711
LIG_14-3-3_CanoR_1	608	612	PF00244	0.503
LIG_14-3-3_CanoR_1	625	634	PF00244	0.377
LIG_14-3-3_CanoR_1	664	670	PF00244	0.513
LIG_14-3-3_CanoR_1	68	72	PF00244	0.441
LIG_14-3-3_CanoR_1	717	726	PF00244	0.448
LIG_Actin_WH2_2	197	212	PF00022	0.447
LIG_Actin_WH2_2	553	571	PF00022	0.548
LIG_Actin_WH2_2	638	653	PF00022	0.525
LIG_APCC_ABBA_1	146	151	PF00400	0.432
LIG_BRCT_BRCA1_1	361	365	PF00533	0.695
LIG_BRCT_BRCA1_1	69	73	PF00533	0.634
LIG_Clathr_ClatBox_1	247	251	PF01394	0.621
LIG_CtBP_PxDLS_1	554	558	PF00389	0.501
LIG_CtBP_PxDLS_1	730	734	PF00389	0.569
LIG_EH1_1	363	371	PF00400	0.543
LIG_FHA_1	365	371	PF00498	0.657
LIG_FHA_1	449	455	PF00498	0.668
LIG_FHA_1	469	475	PF00498	0.536
LIG_FHA_1	482	488	PF00498	0.407
LIG_FHA_1	647	653	PF00498	0.406
LIG_FHA_1	671	677	PF00498	0.472
LIG_FHA_1	707	713	PF00498	0.497
LIG_FHA_1	719	725	PF00498	0.414
LIG_FHA_1	89	95	PF00498	0.754
LIG_FHA_2	195	201	PF00498	0.426
LIG_FHA_2	237	243	PF00498	0.515
LIG_FHA_2	256	262	PF00498	0.587
LIG_LIR_Gen_1	151	160	PF02991	0.331
LIG_LIR_Gen_1	319	326	PF02991	0.679
LIG_LIR_Gen_1	586	597	PF02991	0.431
LIG_LIR_Gen_1	630	637	PF02991	0.386
LIG_LIR_Gen_1	685	694	PF02991	0.553
LIG_LIR_Gen_1	70	81	PF02991	0.622
LIG_LIR_Nem_3	151	156	PF02991	0.317
LIG_LIR_Nem_3	161	166	PF02991	0.324
LIG_LIR_Nem_3	319	323	PF02991	0.638
LIG_LIR_Nem_3	586	592	PF02991	0.460
LIG_LIR_Nem_3	630	636	PF02991	0.434
LIG_LIR_Nem_3	685	691	PF02991	0.553
LIG_LIR_Nem_3	70	76	PF02991	0.629
LIG_PDZ_Class_2	731	736	PF00595	0.611
LIG_Pex14_2	149	153	PF04695	0.455
LIG_Pex14_2	156	160	PF04695	0.355
LIG_Pex14_2	507	511	PF04695	0.484
LIG_Pex14_2	585	589	PF04695	0.528
LIG_Pex14_2	633	637	PF04695	0.507
LIG_SH2_CRK	163	167	PF00017	0.378
LIG_SH2_CRK	688	692	PF00017	0.548
LIG_SH2_NCK_1	320	324	PF00017	0.734
LIG_SH2_PTP2	690	693	PF00017	0.549
LIG_SH2_SRC	192	195	PF00017	0.441
LIG_SH2_STAP1	174	178	PF00017	0.335
LIG_SH2_STAP1	361	365	PF00017	0.686
LIG_SH2_STAT5	133	136	PF00017	0.305
LIG_SH2_STAT5	192	195	PF00017	0.417
LIG_SH2_STAT5	632	635	PF00017	0.463
LIG_SH2_STAT5	688	691	PF00017	0.521
LIG_SH3_2	4	9	PF14604	0.660
LIG_SH3_3	1	7	PF00018	0.732
LIG_SH3_3	450	456	PF00018	0.577
LIG_SH3_3	54	60	PF00018	0.711
LIG_SUMO_SIM_par_1	246	251	PF11976	0.579
LIG_SUMO_SIM_par_1	698	703	PF11976	0.576
LIG_TRAF2_1	226	229	PF00917	0.482
LIG_TRAF2_1	729	732	PF00917	0.526
LIG_TRFH_1	45	49	PF08558	0.728
LIG_UBA3_1	206	210	PF00899	0.447
LIG_UBA3_1	247	255	PF00899	0.595
LIG_WRC_WIRS_1	153	158	PF05994	0.422
LIG_WW_3	6	10	PF00397	0.741
MOD_CK1_1	246	252	PF00069	0.476
MOD_CK1_1	277	283	PF00069	0.629
MOD_CK1_1	36	42	PF00069	0.663
MOD_CK1_1	412	418	PF00069	0.796
MOD_CK1_1	490	496	PF00069	0.529
MOD_CK1_1	571	577	PF00069	0.557
MOD_CK1_1	628	634	PF00069	0.501
MOD_CK1_1	692	698	PF00069	0.497
MOD_CK2_1	194	200	PF00069	0.461
MOD_CK2_1	236	242	PF00069	0.470
MOD_CK2_1	255	261	PF00069	0.582
MOD_CK2_1	611	617	PF00069	0.570
MOD_CK2_1	700	706	PF00069	0.575
MOD_CK2_1	726	732	PF00069	0.519
MOD_GlcNHglycan	17	20	PF01048	0.636
MOD_GlcNHglycan	224	227	PF01048	0.480
MOD_GlcNHglycan	275	279	PF01048	0.567
MOD_GlcNHglycan	35	38	PF01048	0.661
MOD_GlcNHglycan	411	414	PF01048	0.704
MOD_GlcNHglycan	574	577	PF01048	0.550
MOD_GlcNHglycan	665	668	PF01048	0.571
MOD_GlcNHglycan	701	705	PF01048	0.547
MOD_GSK3_1	209	216	PF00069	0.356
MOD_GSK3_1	477	484	PF00069	0.531
MOD_GSK3_1	568	575	PF00069	0.566
MOD_GSK3_1	607	614	PF00069	0.539
MOD_GSK3_1	628	635	PF00069	0.501
MOD_GSK3_1	63	70	PF00069	0.650
MOD_GSK3_1	702	709	PF00069	0.565
MOD_GSK3_1	84	91	PF00069	0.717
MOD_N-GLC_1	213	218	PF02516	0.447
MOD_NEK2_1	209	214	PF00069	0.422
MOD_NEK2_1	339	344	PF00069	0.755
MOD_NEK2_1	468	473	PF00069	0.555
MOD_NEK2_1	487	492	PF00069	0.276
MOD_NEK2_1	529	534	PF00069	0.552
MOD_NEK2_1	568	573	PF00069	0.553
MOD_NEK2_1	607	612	PF00069	0.548
MOD_NEK2_1	719	724	PF00069	0.479
MOD_NEK2_2	632	637	PF00069	0.519
MOD_PIKK_1	192	198	PF00454	0.411
MOD_PIKK_1	291	297	PF00454	0.616
MOD_PIKK_1	403	409	PF00454	0.738
MOD_PIKK_1	511	517	PF00454	0.551
MOD_PIKK_1	63	69	PF00454	0.746
MOD_PIKK_1	692	698	PF00454	0.409
MOD_PKA_1	316	322	PF00069	0.668
MOD_PKA_1	385	391	PF00069	0.669
MOD_PKA_1	663	669	PF00069	0.530
MOD_PKA_2	299	305	PF00069	0.544
MOD_PKA_2	316	322	PF00069	0.619
MOD_PKA_2	339	345	PF00069	0.664
MOD_PKA_2	423	429	PF00069	0.726
MOD_PKA_2	568	574	PF00069	0.510
MOD_PKA_2	607	613	PF00069	0.457
MOD_PKA_2	663	669	PF00069	0.530
MOD_PKA_2	67	73	PF00069	0.655
MOD_PKA_2	719	725	PF00069	0.479
MOD_PKA_2	8	14	PF00069	0.802
MOD_Plk_1	213	219	PF00069	0.422
MOD_Plk_1	499	505	PF00069	0.623
MOD_Plk_1	597	603	PF00069	0.447
MOD_Plk_1	628	634	PF00069	0.502
MOD_Plk_2-3	194	200	PF00069	0.480
MOD_Plk_4	152	158	PF00069	0.410
MOD_Plk_4	165	171	PF00069	0.208
MOD_Plk_4	243	249	PF00069	0.542
MOD_Plk_4	487	493	PF00069	0.483
MOD_Plk_4	628	634	PF00069	0.491
MOD_Plk_4	686	692	PF00069	0.536
MOD_Plk_4	719	725	PF00069	0.474
MOD_ProDKin_1	726	732	PF00069	0.452
MOD_SUMO_rev_2	161	166	PF00179	0.480
TRG_DiLeu_BaEn_2	462	468	PF01217	0.588
TRG_DiLeu_BaEn_2	628	634	PF01217	0.553
TRG_ENDOCYTIC_2	163	166	PF00928	0.322
TRG_ENDOCYTIC_2	320	323	PF00928	0.684
TRG_ENDOCYTIC_2	688	691	PF00928	0.550
TRG_ER_diArg_1	104	107	PF00400	0.688
TRG_ER_diArg_1	126	128	PF00400	0.355
TRG_ER_diArg_1	26	29	PF00400	0.594
TRG_ER_diArg_1	315	317	PF00400	0.671
TRG_ER_diArg_1	562	564	PF00400	0.530
TRG_ER_diArg_1	612	615	PF00400	0.587
TRG_ER_diArg_1	716	718	PF00400	0.476
TRG_ER_diArg_1	726	728	PF00400	0.480
TRG_NES_CRM1_1	180	194	PF08389	0.456
TRG_NES_CRM1_1	640	654	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY0	Leptomonas seymouri	54%	97%
A0A1X0ND09	Trypanosomatidae	33%	100%
A0A422NTD8	Trypanosoma rangeli	33%	98%
A4HFF1	Leishmania braziliensis	78%	99%
A4I2M0	Leishmania infantum	99%	100%
D0A5N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9AD10	Leishmania major	95%	100%
E9AYT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DP68	Trypanosoma cruzi	32%	98%