Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein-like protein (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X0C7_LEIDO

TriTrypDb:

LdBPK_270240.1 , LdCL_270007300

Length:

1616

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X0C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.454
CLV_NRD_NRD_1	1531	1533	PF00675	0.400
CLV_NRD_NRD_1	1553	1555	PF00675	0.372
CLV_NRD_NRD_1	1559	1561	PF00675	0.373
CLV_PCSK_KEX2_1	15	17	PF00082	0.454
CLV_PCSK_KEX2_1	1531	1533	PF00082	0.400
CLV_PCSK_KEX2_1	1553	1555	PF00082	0.376
CLV_PCSK_KEX2_1	1557	1559	PF00082	0.369
CLV_PCSK_KEX2_1	1570	1572	PF00082	0.325
CLV_PCSK_PC1ET2_1	1553	1555	PF00082	0.376
CLV_PCSK_PC1ET2_1	1557	1559	PF00082	0.369
CLV_PCSK_PC1ET2_1	1570	1572	PF00082	0.300
CLV_PCSK_PC7_1	1554	1560	PF00082	0.384
DOC_MAPK_gen_1	1553	1563	PF00069	0.577
DOC_MAPK_gen_1	1591	1601	PF00069	0.483
DOC_MAPK_MEF2A_6	1591	1599	PF00069	0.491
DOC_PP1_RVXF_1	1557	1564	PF00149	0.521
DOC_USP7_MATH_1	1534	1538	PF00917	0.561
DOC_USP7_MATH_1	1587	1591	PF00917	0.596
DOC_USP7_MATH_1	36	40	PF00917	0.780
DOC_USP7_UBL2_3	1553	1557	PF12436	0.578
LIG_14-3-3_CanoR_1	1558	1564	PF00244	0.545
LIG_14-3-3_CanoR_1	1573	1582	PF00244	0.631
LIG_14-3-3_CanoR_1	7	13	PF00244	0.672
LIG_FHA_1	3	9	PF00498	0.656
LIG_FHA_2	1584	1590	PF00498	0.615
LIG_FHA_2	7	13	PF00498	0.655
LIG_Pex14_2	1563	1567	PF04695	0.610
LIG_Pex14_2	1600	1604	PF04695	0.351
LIG_SH2_GRB2like	4	7	PF00017	0.657
LIG_SH2_STAP1	4	8	PF00017	0.656
LIG_SH2_STAT5	4	7	PF00017	0.657
LIG_SH3_3	1558	1564	PF00018	0.524
LIG_SH3_3	1576	1582	PF00018	0.594
LIG_TRAF2_1	1537	1540	PF00917	0.523
MOD_CK2_1	1521	1527	PF00069	0.624
MOD_CK2_1	1533	1539	PF00069	0.618
MOD_CK2_1	1583	1589	PF00069	0.706
MOD_Cter_Amidation	1551	1554	PF01082	0.297
MOD_Cter_Amidation	1555	1558	PF01082	0.292
MOD_GlcNHglycan	1516	1519	PF01048	0.519
MOD_GlcNHglycan	1539	1544	PF01048	0.344
MOD_GlcNHglycan	1575	1578	PF01048	0.452
MOD_GlcNHglycan	38	41	PF01048	0.508
MOD_GSK3_1	1514	1521	PF00069	0.536
MOD_GSK3_1	1534	1541	PF00069	0.573
MOD_GSK3_1	1583	1590	PF00069	0.754
MOD_GSK3_1	2	9	PF00069	0.656
MOD_N-GLC_1	21	26	PF02516	0.439
MOD_N-GLC_1	28	33	PF02516	0.525
MOD_PIKK_1	30	36	PF00454	0.731
MOD_PKA_1	1559	1565	PF00069	0.610
MOD_PKA_2	1559	1565	PF00069	0.610
MOD_PKA_2	1572	1578	PF00069	0.557
MOD_PKA_2	2	8	PF00069	0.656
MOD_PKB_1	1571	1579	PF00069	0.639
MOD_Plk_1	28	34	PF00069	0.726
MOD_SUMO_rev_2	1589	1596	PF00179	0.600
TRG_ER_diArg_1	1558	1560	PF00400	0.517
TRG_NLS_MonoCore_2	1556	1561	PF00514	0.513
TRG_NLS_MonoExtC_3	1552	1557	PF00514	0.579
TRG_NLS_MonoExtN_4	1553	1558	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AKC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AYS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%