Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0C3_LEIDO

TriTrypDb:

LdBPK_270080.1 , LdCL_270005700 , LDHU3_27.0100

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.631
CLV_C14_Caspase3-7	7	11	PF00656	0.461
CLV_NRD_NRD_1	111	113	PF00675	0.706
CLV_NRD_NRD_1	124	126	PF00675	0.492
CLV_NRD_NRD_1	133	135	PF00675	0.533
CLV_NRD_NRD_1	73	75	PF00675	0.603
CLV_PCSK_KEX2_1	111	113	PF00082	0.706
CLV_PCSK_KEX2_1	123	125	PF00082	0.504
CLV_PCSK_KEX2_1	133	135	PF00082	0.517
CLV_PCSK_KEX2_1	73	75	PF00082	0.603
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.691
CLV_PCSK_SKI1_1	155	159	PF00082	0.685
CLV_PCSK_SKI1_1	73	77	PF00082	0.596
DOC_PP1_RVXF_1	72	79	PF00149	0.593
DOC_USP7_MATH_1	96	100	PF00917	0.569
DOC_WW_Pin1_4	61	66	PF00397	0.573
LIG_14-3-3_CanoR_1	159	163	PF00244	0.663
LIG_14-3-3_CanoR_1	84	93	PF00244	0.627
LIG_BIR_II_1	1	5	PF00653	0.781
LIG_Clathr_ClatBox_1	28	32	PF01394	0.595
LIG_eIF4E_1	42	48	PF01652	0.598
LIG_FHA_1	57	63	PF00498	0.537
LIG_FHA_2	5	11	PF00498	0.471
LIG_IBAR_NPY_1	130	132	PF08397	0.711
LIG_LIR_Apic_2	18	23	PF02991	0.688
LIG_LIR_LC3C_4	59	63	PF02991	0.565
LIG_LIR_Nem_3	176	182	PF02991	0.658
LIG_LIR_Nem_3	41	47	PF02991	0.519
LIG_PTB_Apo_2	147	154	PF02174	0.686
LIG_SH2_CRK	20	24	PF00017	0.671
LIG_SH2_NCK_1	193	197	PF00017	0.757
LIG_SH2_STAT5	20	23	PF00017	0.677
LIG_SH2_STAT5	42	45	PF00017	0.454
LIG_SH3_3	59	65	PF00018	0.566
LIG_SUMO_SIM_anti_2	27	32	PF11976	0.600
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.561
LIG_SUMO_SIM_par_1	57	64	PF11976	0.511
MOD_CK2_1	12	18	PF00069	0.707
MOD_CK2_1	49	55	PF00069	0.593
MOD_Cter_Amidation	121	124	PF01082	0.717
MOD_GlcNHglycan	68	71	PF01048	0.444
MOD_GSK3_1	9	16	PF00069	0.713
MOD_NEK2_1	140	145	PF00069	0.627
MOD_NEK2_1	4	9	PF00069	0.492
MOD_PKA_2	158	164	PF00069	0.668
MOD_Plk_1	9	15	PF00069	0.715
MOD_Plk_4	38	44	PF00069	0.555
MOD_Plk_4	49	55	PF00069	0.465
MOD_Plk_4	56	62	PF00069	0.492
MOD_ProDKin_1	61	67	PF00069	0.578
TRG_DiLeu_BaEn_2	135	141	PF01217	0.722
TRG_ER_diArg_1	110	112	PF00400	0.708
TRG_ER_diArg_1	124	127	PF00400	0.489
TRG_ER_diArg_1	132	134	PF00400	0.560
TRG_ER_diArg_1	72	74	PF00400	0.593
TRG_ER_diArg_1	81	84	PF00400	0.401
TRG_NLS_Bipartite_1	111	127	PF00514	0.707
TRG_NLS_MonoExtC_3	122	127	PF00514	0.628
TRG_NLS_MonoExtN_4	120	127	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I2K4	Leishmania infantum	99%	100%
E9ACY5	Leishmania major	90%	100%