LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X0C2_LEIDO
TriTrypDb:
LdBPK_270200.1 * , LdCL_270006900 , LDHU3_27.0250
Length:
372

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 15
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005929 cilium 4 17
GO:0016020 membrane 2 11
GO:0042995 cell projection 2 17
GO:0043226 organelle 2 17
GO:0043227 membrane-bounded organelle 3 17
GO:0110165 cellular anatomical entity 1 17
GO:0120025 plasma membrane bounded cell projection 3 17
GO:0005737 cytoplasm 2 2
GO:0005741 mitochondrial outer membrane 5 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A0A3S7X0C2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0C2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 16
GO:0043167 ion binding 2 16
GO:0043169 cation binding 3 16
GO:0046872 metal ion binding 4 16
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003729 mRNA binding 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 313 315 PF00675 0.685
CLV_NRD_NRD_1 363 365 PF00675 0.534
CLV_PCSK_FUR_1 311 315 PF00082 0.620
CLV_PCSK_KEX2_1 302 304 PF00082 0.754
CLV_PCSK_KEX2_1 311 313 PF00082 0.664
CLV_PCSK_KEX2_1 363 365 PF00082 0.514
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.775
CLV_PCSK_SKI1_1 82 86 PF00082 0.609
DEG_Nend_UBRbox_2 1 3 PF02207 0.539
DOC_MAPK_gen_1 136 144 PF00069 0.341
DOC_USP7_MATH_1 126 130 PF00917 0.320
DOC_USP7_MATH_1 153 157 PF00917 0.315
DOC_USP7_MATH_1 367 371 PF00917 0.600
DOC_WW_Pin1_4 144 149 PF00397 0.309
DOC_WW_Pin1_4 301 306 PF00397 0.617
DOC_WW_Pin1_4 317 322 PF00397 0.491
DOC_WW_Pin1_4 336 341 PF00397 0.499
LIG_14-3-3_CterR_2 368 372 PF00244 0.609
LIG_Actin_WH2_2 103 120 PF00022 0.336
LIG_Actin_WH2_2 153 170 PF00022 0.361
LIG_APCC_ABBA_1 84 89 PF00400 0.344
LIG_BRCT_BRCA1_1 102 106 PF00533 0.328
LIG_BRCT_BRCA1_1 270 274 PF00533 0.530
LIG_BRCT_BRCA1_1 90 94 PF00533 0.362
LIG_eIF4E_1 233 239 PF01652 0.456
LIG_FHA_1 167 173 PF00498 0.311
LIG_FHA_1 302 308 PF00498 0.444
LIG_FHA_2 11 17 PF00498 0.411
LIG_FHA_2 145 151 PF00498 0.318
LIG_IBAR_NPY_1 164 166 PF08397 0.294
LIG_LIR_Apic_2 293 297 PF02991 0.465
LIG_LIR_Gen_1 59 69 PF02991 0.444
LIG_LIR_Nem_3 336 341 PF02991 0.489
LIG_LIR_Nem_3 59 64 PF02991 0.443
LIG_LIR_Nem_3 66 72 PF02991 0.403
LIG_LIR_Nem_3 88 93 PF02991 0.393
LIG_MLH1_MIPbox_1 90 94 PF16413 0.440
LIG_Pex14_2 90 94 PF04695 0.348
LIG_SH2_CRK 61 65 PF00017 0.414
LIG_SH2_GRB2like 61 64 PF00017 0.480
LIG_SH2_PTP2 141 144 PF00017 0.324
LIG_SH2_STAP1 100 104 PF00017 0.346
LIG_SH2_STAP1 250 254 PF00017 0.449
LIG_SH2_STAT5 141 144 PF00017 0.324
LIG_SH2_STAT5 166 169 PF00017 0.303
LIG_SH2_STAT5 233 236 PF00017 0.406
LIG_SH2_STAT5 53 56 PF00017 0.438
LIG_SH2_STAT5 61 64 PF00017 0.432
LIG_SH3_3 204 210 PF00018 0.515
LIG_SH3_3 282 288 PF00018 0.463
LIG_SUMO_SIM_par_1 168 175 PF11976 0.318
LIG_TYR_ITIM 139 144 PF00017 0.388
LIG_WW_3 284 288 PF00397 0.667
MOD_CDK_SPK_2 301 306 PF00069 0.588
MOD_CK1_1 38 44 PF00069 0.549
MOD_CK1_1 59 65 PF00069 0.525
MOD_CK2_1 10 16 PF00069 0.565
MOD_CK2_1 126 132 PF00069 0.493
MOD_CK2_1 144 150 PF00069 0.246
MOD_CK2_1 191 197 PF00069 0.446
MOD_GlcNHglycan 18 21 PF01048 0.628
MOD_GlcNHglycan 256 259 PF01048 0.646
MOD_GlcNHglycan 266 269 PF01048 0.635
MOD_GlcNHglycan 342 345 PF01048 0.497
MOD_GlcNHglycan 35 38 PF01048 0.591
MOD_GlcNHglycan 88 93 PF01048 0.460
MOD_GSK3_1 12 19 PF00069 0.605
MOD_GSK3_1 250 257 PF00069 0.595
MOD_GSK3_1 264 271 PF00069 0.633
MOD_GSK3_1 286 293 PF00069 0.731
MOD_GSK3_1 336 343 PF00069 0.680
MOD_GSK3_1 52 59 PF00069 0.585
MOD_N-GLC_1 108 113 PF02516 0.439
MOD_N-GLC_1 120 125 PF02516 0.423
MOD_N-GLC_1 191 196 PF02516 0.406
MOD_N-GLC_1 59 64 PF02516 0.654
MOD_N-GLC_2 63 65 PF02516 0.425
MOD_NEK2_1 134 139 PF00069 0.393
MOD_NEK2_1 191 196 PF00069 0.534
MOD_NEK2_1 254 259 PF00069 0.615
MOD_NEK2_1 80 85 PF00069 0.420
MOD_PKA_2 286 292 PF00069 0.691
MOD_Plk_1 108 114 PF00069 0.437
MOD_Plk_1 172 178 PF00069 0.421
MOD_Plk_1 203 209 PF00069 0.672
MOD_Plk_1 262 268 PF00069 0.666
MOD_Plk_1 73 79 PF00069 0.494
MOD_Plk_4 172 178 PF00069 0.421
MOD_Plk_4 203 209 PF00069 0.644
MOD_ProDKin_1 144 150 PF00069 0.375
MOD_ProDKin_1 301 307 PF00069 0.790
MOD_ProDKin_1 317 323 PF00069 0.625
MOD_ProDKin_1 336 342 PF00069 0.631
MOD_SUMO_rev_2 298 304 PF00179 0.813
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.687
TRG_ENDOCYTIC_2 141 144 PF00928 0.532
TRG_ENDOCYTIC_2 61 64 PF00928 0.574
TRG_ENDOCYTIC_2 87 90 PF00928 0.534
TRG_ER_diArg_1 135 138 PF00400 0.482
TRG_ER_diArg_1 311 314 PF00400 0.669
TRG_ER_diArg_1 363 365 PF00400 0.632
TRG_ER_diArg_1 4 7 PF00400 0.593
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.637
TRG_Pf-PMV_PEXEL_1 28 33 PF00026 0.430

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T9 Leptomonas seymouri 76% 100%
A0A1X0NNG2 Trypanosomatidae 49% 100%
A0A3R7NQS8 Trypanosoma rangeli 56% 100%
A0A3S5H5P9 Leishmania donovani 22% 93%
A4H4K3 Leishmania braziliensis 21% 99%
A4HFD8 Leishmania braziliensis 85% 98%
A4HSS9 Leishmania infantum 22% 93%
A4I356 Leishmania infantum 99% 100%
C9ZKV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
C9ZTD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 94%
E9ACZ7 Leishmania major 94% 98%
E9AKR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 99%
E9AYS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QJ41 Leishmania major 22% 93%
V5DCE2 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS