LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X0B8_LEIDO
TriTrypDb:
LdBPK_270070.1 , LdCL_270005600 , LDHU3_27.0090
Length:
313

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 0
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7X0B8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0B8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.368
CLV_C14_Caspase3-7 226 230 PF00656 0.414
CLV_C14_Caspase3-7 294 298 PF00656 0.663
CLV_NRD_NRD_1 210 212 PF00675 0.676
CLV_NRD_NRD_1 213 215 PF00675 0.682
CLV_NRD_NRD_1 244 246 PF00675 0.526
CLV_PCSK_FUR_1 211 215 PF00082 0.671
CLV_PCSK_KEX2_1 194 196 PF00082 0.723
CLV_PCSK_KEX2_1 208 210 PF00082 0.634
CLV_PCSK_KEX2_1 212 214 PF00082 0.658
CLV_PCSK_KEX2_1 244 246 PF00082 0.526
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.747
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.679
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.699
CLV_PCSK_PC7_1 209 215 PF00082 0.694
CLV_PCSK_SKI1_1 172 176 PF00082 0.620
CLV_PCSK_SKI1_1 279 283 PF00082 0.484
CLV_PCSK_SKI1_1 3 7 PF00082 0.636
CLV_PCSK_SKI1_1 300 304 PF00082 0.402
CLV_PCSK_SKI1_1 77 81 PF00082 0.549
DEG_APCC_DBOX_1 2 10 PF00400 0.480
DEG_SPOP_SBC_1 134 138 PF00917 0.397
DOC_CKS1_1 111 116 PF01111 0.376
DOC_CKS1_1 160 165 PF01111 0.407
DOC_CKS1_1 256 261 PF01111 0.405
DOC_CYCLIN_yCln2_LP_2 157 163 PF00134 0.376
DOC_CYCLIN_yCln2_LP_2 23 29 PF00134 0.340
DOC_PP1_RVXF_1 1 8 PF00149 0.461
DOC_PP2B_LxvP_1 157 160 PF13499 0.376
DOC_PP2B_LxvP_1 23 26 PF13499 0.352
DOC_USP7_MATH_1 197 201 PF00917 0.481
DOC_USP7_MATH_1 280 284 PF00917 0.688
DOC_USP7_MATH_1 79 83 PF00917 0.409
DOC_USP7_UBL2_3 208 212 PF12436 0.561
DOC_WW_Pin1_4 110 115 PF00397 0.391
DOC_WW_Pin1_4 159 164 PF00397 0.497
DOC_WW_Pin1_4 255 260 PF00397 0.314
DOC_WW_Pin1_4 281 286 PF00397 0.712
LIG_14-3-3_CanoR_1 214 220 PF00244 0.547
LIG_14-3-3_CanoR_1 244 252 PF00244 0.439
LIG_14-3-3_CanoR_1 270 276 PF00244 0.509
LIG_14-3-3_CanoR_1 279 285 PF00244 0.709
LIG_14-3-3_CanoR_1 77 85 PF00244 0.433
LIG_BIR_II_1 1 5 PF00653 0.610
LIG_BRCT_BRCA1_1 51 55 PF00533 0.249
LIG_FHA_1 123 129 PF00498 0.328
LIG_FHA_1 149 155 PF00498 0.440
LIG_FHA_1 182 188 PF00498 0.411
LIG_FHA_1 256 262 PF00498 0.386
LIG_FHA_1 57 63 PF00498 0.367
LIG_FHA_1 78 84 PF00498 0.414
LIG_FHA_2 17 23 PF00498 0.526
LIG_FHA_2 292 298 PF00498 0.782
LIG_LIR_Nem_3 264 269 PF02991 0.412
LIG_LIR_Nem_3 63 67 PF02991 0.477
LIG_NRBOX 4 10 PF00104 0.559
LIG_Pex14_1 252 256 PF04695 0.447
LIG_Pex14_2 262 266 PF04695 0.468
LIG_SH2_CRK 131 135 PF00017 0.356
LIG_SH2_CRK 257 261 PF00017 0.400
LIG_SH2_NCK_1 277 281 PF00017 0.572
LIG_SH2_NCK_1 30 34 PF00017 0.388
LIG_SH2_SRC 30 33 PF00017 0.373
LIG_SH2_STAP1 176 180 PF00017 0.363
LIG_SH2_STAP1 277 281 PF00017 0.613
LIG_SH2_STAP1 30 34 PF00017 0.388
LIG_SH2_STAT5 101 104 PF00017 0.326
LIG_SH2_STAT5 110 113 PF00017 0.400
LIG_SH2_STAT5 127 130 PF00017 0.240
LIG_SH2_STAT5 257 260 PF00017 0.375
LIG_SH2_STAT5 277 280 PF00017 0.485
LIG_SH3_2 160 165 PF14604 0.410
LIG_SH3_3 111 117 PF00018 0.379
LIG_SH3_3 157 163 PF00018 0.376
LIG_SH3_3 64 70 PF00018 0.353
LIG_SUMO_SIM_anti_2 10 15 PF11976 0.555
LIG_SUMO_SIM_anti_2 38 44 PF11976 0.372
MOD_CDK_SPK_2 281 286 PF00069 0.663
MOD_CDK_SPxK_1 110 116 PF00069 0.372
MOD_CDK_SPxK_1 159 165 PF00069 0.383
MOD_CK1_1 136 142 PF00069 0.475
MOD_CK1_1 148 154 PF00069 0.413
MOD_CK1_1 284 290 PF00069 0.731
MOD_CK1_1 75 81 PF00069 0.423
MOD_CK2_1 16 22 PF00069 0.548
MOD_CK2_1 287 293 PF00069 0.760
MOD_GlcNHglycan 131 134 PF01048 0.631
MOD_GlcNHglycan 220 223 PF01048 0.660
MOD_GlcNHglycan 245 248 PF01048 0.671
MOD_GlcNHglycan 288 292 PF01048 0.566
MOD_GlcNHglycan 303 306 PF01048 0.369
MOD_GlcNHglycan 74 77 PF01048 0.520
MOD_GSK3_1 129 136 PF00069 0.333
MOD_GSK3_1 140 147 PF00069 0.408
MOD_GSK3_1 271 278 PF00069 0.517
MOD_GSK3_1 280 287 PF00069 0.717
MOD_GSK3_1 301 308 PF00069 0.634
MOD_GSK3_1 75 82 PF00069 0.396
MOD_GSK3_1 86 93 PF00069 0.378
MOD_N-GLC_1 56 61 PF02516 0.580
MOD_NEK2_1 1 6 PF00069 0.493
MOD_NEK2_1 123 128 PF00069 0.356
MOD_NEK2_1 223 228 PF00069 0.506
MOD_NEK2_1 271 276 PF00069 0.545
MOD_NEK2_1 41 46 PF00069 0.382
MOD_NEK2_1 49 54 PF00069 0.344
MOD_NEK2_1 7 12 PF00069 0.468
MOD_NEK2_1 72 77 PF00069 0.372
MOD_NEK2_2 236 241 PF00069 0.376
MOD_NEK2_2 51 56 PF00069 0.352
MOD_PKA_2 243 249 PF00069 0.394
MOD_Plk_1 148 154 PF00069 0.400
MOD_Plk_1 35 41 PF00069 0.380
MOD_Plk_1 56 62 PF00069 0.402
MOD_Plk_1 97 103 PF00069 0.322
MOD_Plk_4 123 129 PF00069 0.410
MOD_Plk_4 261 267 PF00069 0.393
MOD_Plk_4 7 13 PF00069 0.589
MOD_Plk_4 97 103 PF00069 0.361
MOD_ProDKin_1 110 116 PF00069 0.389
MOD_ProDKin_1 159 165 PF00069 0.505
MOD_ProDKin_1 255 261 PF00069 0.314
MOD_ProDKin_1 281 287 PF00069 0.665
MOD_SUMO_rev_2 66 75 PF00179 0.310
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.389
TRG_ENDOCYTIC_2 131 134 PF00928 0.334
TRG_ENDOCYTIC_2 257 260 PF00928 0.400
TRG_ER_diArg_1 211 214 PF00400 0.467
TRG_ER_diArg_1 243 245 PF00400 0.327
TRG_NLS_Bipartite_1 194 216 PF00514 0.483
TRG_NLS_MonoCore_2 210 215 PF00514 0.495
TRG_NLS_MonoExtN_4 208 215 PF00514 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD93 Leptomonas seymouri 51% 100%
A0A1X0NLP1 Trypanosomatidae 28% 100%
A0A3R7RDJ4 Trypanosoma rangeli 26% 100%
A4HFC6 Leishmania braziliensis 72% 99%
A4I2K3 Leishmania infantum 100% 100%
C9ZKU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9ACY4 Leishmania major 90% 100%
E9AYQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BKS2 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS