WW_domain/Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_ similar)_putative/Pfam:PF00397/Pfam:PF00642

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0B7_LEIDO

TriTrypDb:

LdBPK_270130.1 , LdCL_270006200 , LDHU3_27.0170

Length:

151

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Phosphorylation

Promastigote: 141

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X0B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0B7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.644
CLV_PCSK_KEX2_1	10	12	PF00082	0.644
CLV_PCSK_SKI1_1	126	130	PF00082	0.243
DOC_MAPK_gen_1	104	113	PF00069	0.488
DOC_PP4_MxPP_1	1	4	PF00568	0.458
DOC_PP4_MxPP_1	47	50	PF00568	0.408
DOC_USP7_UBL2_3	106	110	PF12436	0.442
DOC_WW_Pin1_4	14	19	PF00397	0.675
LIG_14-3-3_CanoR_1	137	143	PF00244	0.615
LIG_APCC_ABBA_1	111	116	PF00400	0.261
LIG_APCC_ABBAyCdc20_2	110	116	PF00400	0.261
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_FHA_2	77	83	PF00498	0.515
LIG_Integrin_isoDGR_2	87	89	PF01839	0.615
LIG_LIR_Apic_2	71	77	PF02991	0.289
LIG_LIR_Nem_3	79	84	PF02991	0.493
LIG_MYND_1	46	50	PF01753	0.287
LIG_Pex14_1	52	56	PF04695	0.304
LIG_SH2_GRB2like	84	87	PF00017	0.520
LIG_SH2_SRC	64	67	PF00017	0.347
LIG_SH2_STAT3	41	44	PF00017	0.515
LIG_SH2_STAT5	41	44	PF00017	0.505
LIG_SH2_STAT5	56	59	PF00017	0.421
LIG_SH2_STAT5	64	67	PF00017	0.304
LIG_SH3_3	12	18	PF00018	0.429
LIG_SH3_3	43	49	PF00018	0.479
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.452
LIG_SUMO_SIM_par_1	23	30	PF11976	0.452
MOD_CDK_SPxxK_3	17	24	PF00069	0.566
MOD_CK1_1	17	23	PF00069	0.606
MOD_CK2_1	76	82	PF00069	0.509
MOD_DYRK1A_RPxSP_1	14	18	PF00069	0.427
MOD_GSK3_1	102	109	PF00069	0.568
MOD_GSK3_1	27	34	PF00069	0.507
MOD_GSK3_1	68	75	PF00069	0.314
MOD_N-GLC_1	30	35	PF02516	0.498
MOD_NEK2_1	29	34	PF00069	0.663
MOD_PIKK_1	138	144	PF00454	0.558
MOD_Plk_1	30	36	PF00069	0.660
MOD_ProDKin_1	14	20	PF00069	0.671
MOD_SUMO_rev_2	55	62	PF00179	0.375
TRG_ER_diArg_1	9	11	PF00400	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E5	Leptomonas seymouri	85%	100%
A0A0S4IT37	Bodo saltans	48%	100%
A0A1X0NLL7	Trypanosomatidae	58%	100%
A0A3R7NZE2	Trypanosoma rangeli	54%	100%
A0A3S7X5L3	Leishmania donovani	46%	100%
A4HFD2	Leishmania braziliensis	96%	100%
A4HKG1	Leishmania braziliensis	46%	100%
A4I363	Leishmania infantum	100%	100%
A4I7Y9	Leishmania infantum	47%	100%
C9ZKV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ACZ0	Leishmania major	96%	100%
E9AYR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B2V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q5A6	Leishmania major	48%	100%