CAAX prenyl protease 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAAX prenyl protease 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0B2_LEIDO

TriTrypDb:

LdBPK_262720.1 , LdCL_260033300 , LDHU3_26.3580

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0B2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	88	90	PF00675	0.484
CLV_PCSK_KEX2_1	88	90	PF00082	0.496
CLV_PCSK_SKI1_1	196	200	PF00082	0.437
CLV_PCSK_SKI1_1	79	83	PF00082	0.506
DEG_APCC_DBOX_1	78	86	PF00400	0.296
DEG_Nend_UBRbox_4	1	3	PF02207	0.664
DOC_CKS1_1	54	59	PF01111	0.362
DOC_PP1_RVXF_1	77	84	PF00149	0.384
DOC_PP4_FxxP_1	41	44	PF00568	0.447
DOC_PP4_FxxP_1	54	57	PF00568	0.454
DOC_WW_Pin1_4	53	58	PF00397	0.453
LIG_14-3-3_CanoR_1	196	204	PF00244	0.626
LIG_14-3-3_CanoR_1	22	27	PF00244	0.653
LIG_14-3-3_CanoR_1	32	41	PF00244	0.497
LIG_14-3-3_CanoR_1	88	97	PF00244	0.275
LIG_BRCT_BRCA1_1	194	198	PF00533	0.596
LIG_FHA_1	35	41	PF00498	0.347
LIG_FHA_1	58	64	PF00498	0.313
LIG_FHA_2	197	203	PF00498	0.648
LIG_LIR_Apic_2	53	57	PF02991	0.458
LIG_LIR_Gen_1	189	198	PF02991	0.571
LIG_LIR_Gen_1	6	17	PF02991	0.692
LIG_LIR_Nem_3	153	159	PF02991	0.407
LIG_LIR_Nem_3	189	193	PF02991	0.579
LIG_LIR_Nem_3	6	12	PF02991	0.686
LIG_LIR_Nem_3	75	81	PF02991	0.304
LIG_NRBOX	154	160	PF00104	0.447
LIG_NRBOX	81	87	PF00104	0.313
LIG_Pex14_2	152	156	PF04695	0.418
LIG_Pex14_2	96	100	PF04695	0.494
LIG_SH2_CRK	78	82	PF00017	0.384
LIG_SH2_SRC	164	167	PF00017	0.362
LIG_SH2_STAT5	210	213	PF00017	0.354
LIG_SH2_STAT5	67	70	PF00017	0.324
LIG_SH2_STAT5	9	12	PF00017	0.667
LIG_SH3_3	65	71	PF00018	0.357
LIG_TYR_ITIM	76	81	PF00017	0.384
LIG_WRC_WIRS_1	51	56	PF05994	0.437
LIG_WW_3	15	19	PF00397	0.711
MOD_CK1_1	33	39	PF00069	0.434
MOD_CK2_1	196	202	PF00069	0.657
MOD_GlcNHglycan	140	143	PF01048	0.384
MOD_GlcNHglycan	159	162	PF01048	0.426
MOD_GlcNHglycan	205	208	PF01048	0.386
MOD_GlcNHglycan	5	8	PF01048	0.465
MOD_GlcNHglycan	90	93	PF01048	0.444
MOD_GlcNHglycan	97	100	PF01048	0.432
MOD_GSK3_1	188	195	PF00069	0.607
MOD_GSK3_1	30	37	PF00069	0.518
MOD_GSK3_1	53	60	PF00069	0.358
MOD_NEK2_1	100	105	PF00069	0.389
MOD_NEK2_1	150	155	PF00069	0.440
MOD_PKA_1	88	94	PF00069	0.321
MOD_PKA_2	21	27	PF00069	0.680
MOD_PKA_2	31	37	PF00069	0.558
MOD_PKA_2	87	93	PF00069	0.334
MOD_PKB_1	194	202	PF00069	0.577
MOD_Plk_1	168	174	PF00069	0.337
MOD_Plk_1	188	194	PF00069	0.611
MOD_Plk_1	57	63	PF00069	0.339
MOD_Plk_4	22	28	PF00069	0.666
MOD_Plk_4	34	40	PF00069	0.245
MOD_Plk_4	5	11	PF00069	0.617
MOD_Plk_4	57	63	PF00069	0.325
MOD_ProDKin_1	53	59	PF00069	0.447
MOD_SUMO_rev_2	116	126	PF00179	0.597
TRG_DiLeu_BaEn_1	58	63	PF01217	0.275
TRG_ENDOCYTIC_2	164	167	PF00928	0.316
TRG_ENDOCYTIC_2	78	81	PF00928	0.372
TRG_ENDOCYTIC_2	9	12	PF00928	0.715
TRG_ER_diArg_1	193	196	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS3	Leptomonas seymouri	48%	79%
A0A0S4JSY4	Bodo saltans	34%	72%
A0A1X0NYX6	Trypanosomatidae	37%	74%
A4HFB3	Leishmania braziliensis	75%	100%
A4I2J5	Leishmania infantum	99%	100%
C9ZK27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	74%
E9AYQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8S2	Leishmania major	92%	100%
V5BHT4	Trypanosoma cruzi	33%	93%