CAAX prenyl protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan M- Family M48

Species:

Leishmania donovani

UniProt:

A0A3S7X0A9_LEIDO

TriTrypDb:

LdBPK_270040.1 , LdCL_270005300 , LDHU3_27.0060

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X0A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0A9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	173	179	PF00089	0.287
CLV_NRD_NRD_1	245	247	PF00675	0.223
CLV_NRD_NRD_1	31	33	PF00675	0.297
CLV_NRD_NRD_1	362	364	PF00675	0.267
CLV_NRD_NRD_1	43	45	PF00675	0.263
CLV_PCSK_FUR_1	29	33	PF00082	0.350
CLV_PCSK_KEX2_1	245	247	PF00082	0.220
CLV_PCSK_KEX2_1	261	263	PF00082	0.180
CLV_PCSK_KEX2_1	31	33	PF00082	0.270
CLV_PCSK_KEX2_1	321	323	PF00082	0.504
CLV_PCSK_KEX2_1	362	364	PF00082	0.256
CLV_PCSK_KEX2_1	425	427	PF00082	0.421
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.223
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.504
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.395
CLV_PCSK_SKI1_1	153	157	PF00082	0.247
CLV_PCSK_SKI1_1	236	240	PF00082	0.297
CLV_PCSK_SKI1_1	262	266	PF00082	0.223
CLV_PCSK_SKI1_1	382	386	PF00082	0.232
CLV_PCSK_SKI1_1	45	49	PF00082	0.328
DEG_APCC_KENBOX_2	389	393	PF00400	0.465
DOC_CYCLIN_RxL_1	149	160	PF00134	0.456
DOC_CYCLIN_RxL_1	377	389	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.377
DOC_MAPK_DCC_7	158	167	PF00069	0.292
DOC_MAPK_gen_1	382	388	PF00069	0.455
DOC_MAPK_MEF2A_6	10	18	PF00069	0.265
DOC_MAPK_MEF2A_6	153	161	PF00069	0.423
DOC_MAPK_MEF2A_6	180	189	PF00069	0.290
DOC_MAPK_MEF2A_6	292	300	PF00069	0.560
DOC_MAPK_RevD_3	16	32	PF00069	0.265
DOC_PP1_RVXF_1	166	173	PF00149	0.265
DOC_PP1_RVXF_1	313	320	PF00149	0.287
DOC_PP2B_LxvP_1	121	124	PF13499	0.322
DOC_PP2B_LxvP_1	198	201	PF13499	0.309
DOC_PP2B_LxvP_1	83	86	PF13499	0.324
DOC_PP4_FxxP_1	345	348	PF00568	0.256
DOC_SPAK_OSR1_1	370	374	PF12202	0.504
DOC_USP7_MATH_1	12	16	PF00917	0.243
DOC_USP7_UBL2_3	149	153	PF12436	0.426
DOC_WW_Pin1_4	1	6	PF00397	0.411
DOC_WW_Pin1_4	209	214	PF00397	0.451
DOC_WW_Pin1_4	394	399	PF00397	0.407
LIG_14-3-3_CanoR_1	158	162	PF00244	0.351
LIG_14-3-3_CanoR_1	245	253	PF00244	0.467
LIG_14-3-3_CanoR_1	393	397	PF00244	0.522
LIG_14-3-3_CanoR_1	96	104	PF00244	0.302
LIG_Actin_WH2_2	144	160	PF00022	0.457
LIG_Actin_WH2_2	220	238	PF00022	0.465
LIG_APCC_ABBA_1	338	343	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.345
LIG_Clathr_ClatBox_1	316	320	PF01394	0.309
LIG_eIF4E_1	221	227	PF01652	0.424
LIG_FHA_1	143	149	PF00498	0.538
LIG_FHA_1	152	158	PF00498	0.485
LIG_FHA_2	141	147	PF00498	0.423
LIG_FHA_2	210	216	PF00498	0.576
LIG_FHA_2	266	272	PF00498	0.440
LIG_FHA_2	46	52	PF00498	0.477
LIG_GBD_Chelix_1	300	308	PF00786	0.265
LIG_LIR_Apic_2	343	348	PF02991	0.304
LIG_LIR_Gen_1	126	133	PF02991	0.443
LIG_LIR_Gen_1	23	33	PF02991	0.430
LIG_LIR_Gen_1	399	410	PF02991	0.429
LIG_LIR_Gen_1	63	71	PF02991	0.468
LIG_LIR_LC3C_4	190	195	PF02991	0.243
LIG_LIR_Nem_3	122	128	PF02991	0.257
LIG_LIR_Nem_3	179	184	PF02991	0.209
LIG_LIR_Nem_3	218	224	PF02991	0.428
LIG_LIR_Nem_3	23	28	PF02991	0.261
LIG_LIR_Nem_3	343	349	PF02991	0.284
LIG_LIR_Nem_3	350	355	PF02991	0.279
LIG_LIR_Nem_3	399	405	PF02991	0.496
LIG_LIR_Nem_3	63	68	PF02991	0.444
LIG_PCNA_yPIPBox_3	166	180	PF02747	0.309
LIG_Pex14_2	127	131	PF04695	0.370
LIG_Pex14_2	177	181	PF04695	0.209
LIG_Pex14_2	341	345	PF04695	0.284
LIG_SH2_CRK	266	270	PF00017	0.409
LIG_SH2_CRK	402	406	PF00017	0.456
LIG_SH2_GRB2like	128	131	PF00017	0.456
LIG_SH2_GRB2like	297	300	PF00017	0.265
LIG_SH2_NCK_1	407	411	PF00017	0.423
LIG_SH2_PTP2	297	300	PF00017	0.265
LIG_SH2_STAP1	108	112	PF00017	0.327
LIG_SH2_STAP1	266	270	PF00017	0.409
LIG_SH2_STAT3	163	166	PF00017	0.309
LIG_SH2_STAT5	184	187	PF00017	0.255
LIG_SH2_STAT5	25	28	PF00017	0.290
LIG_SH2_STAT5	253	256	PF00017	0.418
LIG_SH2_STAT5	297	300	PF00017	0.265
LIG_SH2_STAT5	359	362	PF00017	0.432
LIG_SH2_STAT5	407	410	PF00017	0.465
LIG_SH2_STAT5	42	45	PF00017	0.409
LIG_SH2_STAT5	91	94	PF00017	0.388
LIG_SH3_3	200	206	PF00018	0.265
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.265
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.309
LIG_SUMO_SIM_anti_2	275	285	PF11976	0.370
LIG_SUMO_SIM_par_1	384	389	PF11976	0.424
LIG_TRAF2_1	48	51	PF00917	0.477
LIG_TYR_ITIM	264	269	PF00017	0.409
LIG_TYR_ITSM	217	224	PF00017	0.370
LIG_UBA3_1	161	168	PF00899	0.265
LIG_UBA3_1	385	390	PF00899	0.444
LIG_WRC_WIRS_1	349	354	PF05994	0.265
MOD_CK1_1	244	250	PF00069	0.438
MOD_CK1_1	63	69	PF00069	0.485
MOD_CK1_1	98	104	PF00069	0.368
MOD_CK2_1	123	129	PF00069	0.329
MOD_CK2_1	140	146	PF00069	0.344
MOD_CK2_1	265	271	PF00069	0.440
MOD_CK2_1	45	51	PF00069	0.450
MOD_GlcNHglycan	402	405	PF01048	0.256
MOD_GSK3_1	225	232	PF00069	0.541
MOD_GSK3_1	98	105	PF00069	0.264
MOD_N-GLC_1	33	38	PF02516	0.224
MOD_NEK2_1	157	162	PF00069	0.314
MOD_NEK2_1	187	192	PF00069	0.248
MOD_NEK2_1	265	270	PF00069	0.416
MOD_NEK2_1	308	313	PF00069	0.288
MOD_NEK2_1	371	376	PF00069	0.444
MOD_NEK2_1	405	410	PF00069	0.436
MOD_NEK2_1	74	79	PF00069	0.409
MOD_NEK2_2	216	221	PF00069	0.492
MOD_PKA_2	157	163	PF00069	0.322
MOD_PKA_2	244	250	PF00069	0.452
MOD_PKA_2	392	398	PF00069	0.490
MOD_PKA_2	95	101	PF00069	0.273
MOD_Plk_1	216	222	PF00069	0.463
MOD_Plk_1	229	235	PF00069	0.520
MOD_Plk_1	276	282	PF00069	0.551
MOD_Plk_1	60	66	PF00069	0.463
MOD_Plk_4	151	157	PF00069	0.479
MOD_Plk_4	187	193	PF00069	0.293
MOD_Plk_4	199	205	PF00069	0.193
MOD_Plk_4	216	222	PF00069	0.423
MOD_Plk_4	265	271	PF00069	0.409
MOD_Plk_4	276	282	PF00069	0.409
MOD_Plk_4	348	354	PF00069	0.306
MOD_Plk_4	38	44	PF00069	0.508
MOD_ProDKin_1	1	7	PF00069	0.404
MOD_ProDKin_1	209	215	PF00069	0.454
MOD_ProDKin_1	394	400	PF00069	0.407
TRG_ENDOCYTIC_2	128	131	PF00928	0.442
TRG_ENDOCYTIC_2	184	187	PF00928	0.259
TRG_ENDOCYTIC_2	221	224	PF00928	0.483
TRG_ENDOCYTIC_2	25	28	PF00928	0.423
TRG_ENDOCYTIC_2	266	269	PF00928	0.418
TRG_ENDOCYTIC_2	297	300	PF00928	0.265
TRG_ENDOCYTIC_2	324	327	PF00928	0.223
TRG_ENDOCYTIC_2	346	349	PF00928	0.309
TRG_ENDOCYTIC_2	402	405	PF00928	0.465
TRG_ENDOCYTIC_2	90	93	PF00928	0.321
TRG_ER_diArg_1	28	31	PF00400	0.484
TRG_ER_diLys_1	424	427	PF00400	0.526
TRG_NES_CRM1_1	122	135	PF08389	0.188
TRG_NES_CRM1_1	230	242	PF08389	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC87	Leptomonas seymouri	60%	100%
A0A0S4J5R2	Bodo saltans	47%	100%
A0A1X0P508	Trypanosomatidae	47%	100%
A4HFC3	Leishmania braziliensis	76%	100%
A4I2K0	Leishmania infantum	100%	100%
C9ZYC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ACY1	Leishmania major	96%	100%
E9AYQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O75844	Homo sapiens	34%	90%
P40769	Bacillus subtilis (strain 168)	27%	100%
P47154	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
Q10071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	90%
Q3Y6B8	Taenia solium	32%	90%
Q54FH7	Dictyostelium discoideum	35%	100%
Q6EPN8	Oryza sativa subsp. japonica	39%	100%
Q80W54	Mus musculus	33%	90%
Q8RX88	Arabidopsis thaliana	40%	100%
Q9XVE5	Caenorhabditis elegans	33%	97%
V5DQF4	Trypanosoma cruzi	47%	100%