Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X099_LEIDO

TriTrypDb:

LdBPK_262680.1 , LdCL_260032800 , LDHU3_26.3490

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X099

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X099

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.578
CLV_NRD_NRD_1	27	29	PF00675	0.545
CLV_NRD_NRD_1	341	343	PF00675	0.671
CLV_NRD_NRD_1	367	369	PF00675	0.645
CLV_NRD_NRD_1	434	436	PF00675	0.546
CLV_NRD_NRD_1	547	549	PF00675	0.674
CLV_PCSK_KEX2_1	160	162	PF00082	0.638
CLV_PCSK_KEX2_1	27	29	PF00082	0.609
CLV_PCSK_KEX2_1	341	343	PF00082	0.671
CLV_PCSK_KEX2_1	367	369	PF00082	0.587
CLV_PCSK_KEX2_1	547	549	PF00082	0.674
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.638
CLV_PCSK_SKI1_1	212	216	PF00082	0.601
CLV_PCSK_SKI1_1	95	99	PF00082	0.602
DEG_APCC_DBOX_1	547	555	PF00400	0.621
DEG_APCC_DBOX_1	94	102	PF00400	0.542
DEG_SPOP_SBC_1	56	60	PF00917	0.674
DOC_CKS1_1	541	546	PF01111	0.571
DOC_MAPK_gen_1	476	485	PF00069	0.675
DOC_MAPK_MEF2A_6	476	485	PF00069	0.684
DOC_MAPK_MEF2A_6	68	75	PF00069	0.621
DOC_MAPK_MEF2A_6	77	84	PF00069	0.550
DOC_PP1_RVXF_1	566	572	PF00149	0.516
DOC_PP2B_LxvP_1	459	462	PF13499	0.682
DOC_PP4_FxxP_1	383	386	PF00568	0.430
DOC_PP4_FxxP_1	532	535	PF00568	0.403
DOC_USP7_MATH_1	124	128	PF00917	0.789
DOC_USP7_MATH_1	139	143	PF00917	0.820
DOC_USP7_MATH_1	234	238	PF00917	0.699
DOC_USP7_MATH_1	270	274	PF00917	0.711
DOC_USP7_MATH_1	275	279	PF00917	0.670
DOC_USP7_MATH_1	312	316	PF00917	0.629
DOC_USP7_MATH_1	370	374	PF00917	0.555
DOC_USP7_MATH_1	406	410	PF00917	0.567
DOC_USP7_MATH_1	466	470	PF00917	0.654
DOC_USP7_MATH_1	502	506	PF00917	0.607
DOC_USP7_MATH_1	56	60	PF00917	0.642
DOC_USP7_MATH_2	544	550	PF00917	0.579
DOC_USP7_UBL2_3	190	194	PF12436	0.511
DOC_WW_Pin1_4	239	244	PF00397	0.772
DOC_WW_Pin1_4	296	301	PF00397	0.583
DOC_WW_Pin1_4	306	311	PF00397	0.576
DOC_WW_Pin1_4	32	37	PF00397	0.498
DOC_WW_Pin1_4	448	453	PF00397	0.518
DOC_WW_Pin1_4	488	493	PF00397	0.681
DOC_WW_Pin1_4	540	545	PF00397	0.580
DOC_WW_Pin1_4	61	66	PF00397	0.542
LIG_14-3-3_CanoR_1	212	217	PF00244	0.576
LIG_14-3-3_CanoR_1	235	239	PF00244	0.666
LIG_14-3-3_CanoR_1	313	320	PF00244	0.764
LIG_14-3-3_CanoR_1	430	435	PF00244	0.648
LIG_14-3-3_CanoR_1	441	450	PF00244	0.649
LIG_Actin_WH2_2	90	108	PF00022	0.529
LIG_APCC_ABBA_1	460	465	PF00400	0.560
LIG_FHA_1	247	253	PF00498	0.826
LIG_FHA_1	317	323	PF00498	0.693
LIG_FHA_1	33	39	PF00498	0.548
LIG_FHA_1	380	386	PF00498	0.431
LIG_FHA_1	429	435	PF00498	0.643
LIG_FHA_1	465	471	PF00498	0.545
LIG_FHA_1	493	499	PF00498	0.580
LIG_FHA_1	529	535	PF00498	0.404
LIG_FHA_2	121	127	PF00498	0.799
LIG_FHA_2	166	172	PF00498	0.657
LIG_FHA_2	201	207	PF00498	0.494
LIG_FHA_2	541	547	PF00498	0.528
LIG_FHA_2	6	12	PF00498	0.622
LIG_FXI_DFP_1	218	222	PF00024	0.551
LIG_GBD_Chelix_1	38	46	PF00786	0.581
LIG_Integrin_isoDGR_2	210	212	PF01839	0.613
LIG_IRF3_LxIS_1	74	81	PF10401	0.544
LIG_LIR_Apic_2	382	386	PF02991	0.430
LIG_LIR_Apic_2	531	535	PF02991	0.403
LIG_LIR_Apic_2	539	544	PF02991	0.501
LIG_LIR_Gen_1	215	226	PF02991	0.498
LIG_LIR_Gen_1	409	419	PF02991	0.492
LIG_LIR_Nem_3	171	177	PF02991	0.486
LIG_LIR_Nem_3	20	26	PF02991	0.599
LIG_LIR_Nem_3	215	221	PF02991	0.504
LIG_LIR_Nem_3	409	414	PF02991	0.464
LIG_LIR_Nem_3	468	474	PF02991	0.548
LIG_LIR_Nem_3	505	511	PF02991	0.610
LIG_LYPXL_yS_3	508	511	PF13949	0.473
LIG_LYPXL_yS_3	579	582	PF13949	0.585
LIG_PCNA_yPIPBox_3	194	208	PF02747	0.575
LIG_PROFILIN_1	149	155	PF00235	0.613
LIG_SH2_NCK_1	541	545	PF00017	0.608
LIG_SH2_SRC	463	466	PF00017	0.614
LIG_SH2_STAT5	100	103	PF00017	0.585
LIG_SH2_STAT5	224	227	PF00017	0.462
LIG_SH2_STAT5	471	474	PF00017	0.597
LIG_SH2_STAT5	484	487	PF00017	0.564
LIG_SH2_STAT5	499	502	PF00017	0.448
LIG_SH3_3	144	150	PF00018	0.813
LIG_SH3_3	194	200	PF00018	0.472
LIG_SH3_3	238	244	PF00018	0.774
LIG_SH3_3	319	325	PF00018	0.668
LIG_SH3_3	559	565	PF00018	0.557
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.531
LIG_TRAF2_1	203	206	PF00917	0.536
LIG_TRAF2_1	462	465	PF00917	0.648
LIG_TRAF2_1	543	546	PF00917	0.520
LIG_TRAF2_2	562	567	PF00917	0.508
LIG_UBA3_1	480	486	PF00899	0.621
LIG_WRC_WIRS_1	356	361	PF05994	0.639
LIG_WW_2	152	155	PF00397	0.503
MOD_CDK_SPxxK_3	306	313	PF00069	0.733
MOD_CDK_SPxxK_3	540	547	PF00069	0.577
MOD_CDK_SPxxK_3	61	68	PF00069	0.626
MOD_CK1_1	127	133	PF00069	0.753
MOD_CK1_1	159	165	PF00069	0.566
MOD_CK1_1	242	248	PF00069	0.772
MOD_CK1_1	278	284	PF00069	0.690
MOD_CK1_1	34	40	PF00069	0.677
MOD_CK1_1	417	423	PF00069	0.481
MOD_CK1_1	453	459	PF00069	0.665
MOD_CK1_1	523	529	PF00069	0.529
MOD_CK1_1	533	539	PF00069	0.481
MOD_CK1_1	59	65	PF00069	0.583
MOD_CK2_1	120	126	PF00069	0.725
MOD_CK2_1	139	145	PF00069	0.575
MOD_CK2_1	200	206	PF00069	0.552
MOD_CK2_1	5	11	PF00069	0.648
MOD_CK2_1	533	539	PF00069	0.465
MOD_CK2_1	540	546	PF00069	0.477
MOD_CK2_1	61	67	PF00069	0.525
MOD_GlcNHglycan	130	133	PF01048	0.704
MOD_GlcNHglycan	372	375	PF01048	0.649
MOD_GlcNHglycan	424	427	PF01048	0.732
MOD_GlcNHglycan	500	503	PF01048	0.592
MOD_GlcNHglycan	504	507	PF01048	0.559
MOD_GlcNHglycan	522	525	PF01048	0.507
MOD_GlcNHglycan	548	551	PF01048	0.593
MOD_GlcNHglycan	557	560	PF01048	0.557
MOD_GSK3_1	120	127	PF00069	0.669
MOD_GSK3_1	239	246	PF00069	0.715
MOD_GSK3_1	270	277	PF00069	0.693
MOD_GSK3_1	292	299	PF00069	0.617
MOD_GSK3_1	312	319	PF00069	0.627
MOD_GSK3_1	34	41	PF00069	0.606
MOD_GSK3_1	446	453	PF00069	0.590
MOD_GSK3_1	488	495	PF00069	0.624
MOD_GSK3_1	498	505	PF00069	0.391
MOD_GSK3_1	51	58	PF00069	0.645
MOD_GSK3_1	530	537	PF00069	0.520
MOD_GSK3_1	7	14	PF00069	0.613
MOD_N-GLC_1	200	205	PF02516	0.582
MOD_N-GLC_1	31	36	PF02516	0.598
MOD_N-GLC_1	406	411	PF02516	0.557
MOD_N-GLC_2	118	120	PF02516	0.748
MOD_NEK2_1	165	170	PF00069	0.621
MOD_NEK2_1	379	384	PF00069	0.430
MOD_NEK2_1	414	419	PF00069	0.529
MOD_NEK2_1	498	503	PF00069	0.593
MOD_NEK2_1	55	60	PF00069	0.587
MOD_NEK2_1	78	83	PF00069	0.501
MOD_NEK2_2	466	471	PF00069	0.585
MOD_PIKK_1	108	114	PF00454	0.694
MOD_PIKK_1	234	240	PF00454	0.739
MOD_PK_1	430	436	PF00069	0.536
MOD_PKA_2	234	240	PF00069	0.651
MOD_PKA_2	292	298	PF00069	0.687
MOD_PKA_2	312	318	PF00069	0.664
MOD_PKA_2	340	346	PF00069	0.770
MOD_PKA_2	546	552	PF00069	0.607
MOD_Plk_1	293	299	PF00069	0.692
MOD_Plk_1	354	360	PF00069	0.638
MOD_Plk_1	50	56	PF00069	0.518
MOD_Plk_1	69	75	PF00069	0.576
MOD_Plk_2-3	355	361	PF00069	0.646
MOD_Plk_2-3	507	513	PF00069	0.568
MOD_Plk_4	278	284	PF00069	0.746
MOD_Plk_4	293	299	PF00069	0.580
MOD_Plk_4	318	324	PF00069	0.728
MOD_Plk_4	38	44	PF00069	0.498
MOD_Plk_4	466	472	PF00069	0.538
MOD_Plk_4	69	75	PF00069	0.531
MOD_ProDKin_1	239	245	PF00069	0.774
MOD_ProDKin_1	296	302	PF00069	0.582
MOD_ProDKin_1	306	312	PF00069	0.576
MOD_ProDKin_1	32	38	PF00069	0.488
MOD_ProDKin_1	448	454	PF00069	0.521
MOD_ProDKin_1	488	494	PF00069	0.676
MOD_ProDKin_1	540	546	PF00069	0.574
MOD_ProDKin_1	61	67	PF00069	0.536
MOD_SUMO_rev_2	512	520	PF00179	0.559
MOD_SUMO_rev_2	9	15	PF00179	0.657
TRG_DiLeu_BaEn_1	410	415	PF01217	0.466
TRG_DiLeu_BaEn_1	70	75	PF01217	0.529
TRG_DiLeu_LyEn_5	410	415	PF01217	0.466
TRG_ENDOCYTIC_2	218	221	PF00928	0.447
TRG_ENDOCYTIC_2	508	511	PF00928	0.589
TRG_ENDOCYTIC_2	579	582	PF00928	0.585
TRG_ER_diArg_1	26	28	PF00400	0.546
TRG_ER_diArg_1	341	344	PF00400	0.671
TRG_ER_diArg_1	366	368	PF00400	0.617
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I848	Leptomonas seymouri	56%	100%
A0A1X0P7D0	Trypanosomatidae	32%	100%
A0A3R7MCE3	Trypanosoma rangeli	35%	100%
A4HFA9	Leishmania braziliensis	79%	100%
A4I2J1	Leishmania infantum	100%	100%
C9ZWZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8S6	Leishmania major	94%	100%
V5B7P2	Trypanosoma cruzi	35%	100%