LeishMANIAdb
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Paraquat-inducible protein A, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Paraquat-inducible protein A, putative
Gene product:
Paraquat-inducible protein A, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X098_LEIDO
TriTrypDb:
LdBPK_262620.1 , LdCL_260032100 , LDHU3_26.3400
Length:
822

Annotations

LeishMANIAdb annotations

Distantly related to prokaryotic membrane integrity protein PqiA

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 9, no: 7
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

A0A3S7X098
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X098

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0008289 lipid binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 101 105 PF00656 0.407
CLV_NRD_NRD_1 178 180 PF00675 0.652
CLV_NRD_NRD_1 414 416 PF00675 0.389
CLV_NRD_NRD_1 592 594 PF00675 0.413
CLV_NRD_NRD_1 654 656 PF00675 0.514
CLV_NRD_NRD_1 811 813 PF00675 0.475
CLV_PCSK_KEX2_1 414 416 PF00082 0.445
CLV_PCSK_KEX2_1 592 594 PF00082 0.413
CLV_PCSK_KEX2_1 654 656 PF00082 0.500
CLV_PCSK_SKI1_1 349 353 PF00082 0.746
CLV_PCSK_SKI1_1 524 528 PF00082 0.397
CLV_PCSK_SKI1_1 690 694 PF00082 0.649
CLV_PCSK_SKI1_1 697 701 PF00082 0.578
CLV_PCSK_SKI1_1 737 741 PF00082 0.375
CLV_PCSK_SKI1_1 766 770 PF00082 0.689
CLV_PCSK_SKI1_1 773 777 PF00082 0.679
CLV_PCSK_SKI1_1 803 807 PF00082 0.485
DEG_APCC_DBOX_1 390 398 PF00400 0.422
DEG_APCC_DBOX_1 802 810 PF00400 0.746
DEG_APCC_DBOX_1 811 819 PF00400 0.552
DEG_SCF_FBW7_2 239 246 PF00400 0.376
DOC_CDC14_PxL_1 724 732 PF14671 0.492
DOC_CKS1_1 174 179 PF01111 0.575
DOC_CKS1_1 240 245 PF01111 0.382
DOC_CKS1_1 691 696 PF01111 0.494
DOC_CYCLIN_RxL_1 694 705 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 390 396 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 661 667 PF00134 0.549
DOC_CYCLIN_yCln2_LP_2 783 789 PF00134 0.360
DOC_MAPK_gen_1 204 212 PF00069 0.475
DOC_MAPK_MEF2A_6 386 394 PF00069 0.446
DOC_MAPK_MEF2A_6 654 663 PF00069 0.553
DOC_PP2B_LxvP_1 337 340 PF13499 0.437
DOC_PP2B_LxvP_1 390 393 PF13499 0.500
DOC_PP2B_LxvP_1 550 553 PF13499 0.529
DOC_PP2B_LxvP_1 661 664 PF13499 0.577
DOC_PP2B_LxvP_1 692 695 PF13499 0.399
DOC_PP2B_LxvP_1 725 728 PF13499 0.492
DOC_PP2B_PxIxI_1 392 398 PF00149 0.417
DOC_PP4_FxxP_1 656 659 PF00568 0.540
DOC_SPAK_OSR1_1 211 215 PF12202 0.387
DOC_USP7_MATH_1 197 201 PF00917 0.491
DOC_USP7_MATH_1 301 305 PF00917 0.370
DOC_USP7_MATH_1 55 59 PF00917 0.493
DOC_USP7_MATH_1 695 699 PF00917 0.466
DOC_USP7_MATH_1 779 783 PF00917 0.364
DOC_WW_Pin1_4 102 107 PF00397 0.556
DOC_WW_Pin1_4 173 178 PF00397 0.561
DOC_WW_Pin1_4 189 194 PF00397 0.412
DOC_WW_Pin1_4 239 244 PF00397 0.468
DOC_WW_Pin1_4 385 390 PF00397 0.430
DOC_WW_Pin1_4 615 620 PF00397 0.830
DOC_WW_Pin1_4 690 695 PF00397 0.494
LIG_14-3-3_CanoR_1 559 565 PF00244 0.348
LIG_14-3-3_CanoR_1 586 592 PF00244 0.584
LIG_14-3-3_CanoR_1 636 642 PF00244 0.679
LIG_14-3-3_CanoR_1 649 656 PF00244 0.785
LIG_14-3-3_CanoR_1 682 686 PF00244 0.357
LIG_14-3-3_CanoR_1 703 708 PF00244 0.417
LIG_14-3-3_CanoR_1 71 79 PF00244 0.469
LIG_APCC_ABBA_1 126 131 PF00400 0.384
LIG_BRCT_BRCA1_1 208 212 PF00533 0.464
LIG_BRCT_BRCA1_1 509 513 PF00533 0.340
LIG_deltaCOP1_diTrp_1 483 490 PF00928 0.332
LIG_eIF4E_1 503 509 PF01652 0.359
LIG_FHA_1 234 240 PF00498 0.404
LIG_FHA_1 291 297 PF00498 0.440
LIG_FHA_1 307 313 PF00498 0.409
LIG_FHA_1 430 436 PF00498 0.650
LIG_FHA_1 461 467 PF00498 0.388
LIG_FHA_1 538 544 PF00498 0.464
LIG_FHA_1 721 727 PF00498 0.372
LIG_FHA_2 38 44 PF00498 0.451
LIG_FHA_2 478 484 PF00498 0.422
LIG_LIR_Apic_2 309 314 PF02991 0.496
LIG_LIR_Gen_1 16 27 PF02991 0.451
LIG_LIR_Gen_1 289 298 PF02991 0.451
LIG_LIR_Gen_1 304 314 PF02991 0.344
LIG_LIR_Gen_1 438 448 PF02991 0.635
LIG_LIR_Gen_1 539 547 PF02991 0.366
LIG_LIR_Gen_1 56 64 PF02991 0.388
LIG_LIR_Gen_1 563 573 PF02991 0.486
LIG_LIR_Nem_3 16 22 PF02991 0.430
LIG_LIR_Nem_3 289 294 PF02991 0.475
LIG_LIR_Nem_3 304 310 PF02991 0.329
LIG_LIR_Nem_3 40 45 PF02991 0.474
LIG_LIR_Nem_3 431 436 PF02991 0.685
LIG_LIR_Nem_3 438 444 PF02991 0.582
LIG_LIR_Nem_3 500 506 PF02991 0.360
LIG_LIR_Nem_3 510 516 PF02991 0.519
LIG_LIR_Nem_3 56 62 PF02991 0.353
LIG_LIR_Nem_3 563 567 PF02991 0.486
LIG_LIR_Nem_3 650 656 PF02991 0.743
LIG_LIR_Nem_3 782 788 PF02991 0.467
LIG_LYPXL_L_2 502 511 PF13949 0.360
LIG_LYPXL_S_1 502 506 PF13949 0.360
LIG_LYPXL_yS_3 503 506 PF13949 0.368
LIG_NRBOX 329 335 PF00104 0.522
LIG_PCNA_yPIPBox_3 344 354 PF02747 0.477
LIG_Pex14_1 307 311 PF04695 0.500
LIG_Pex14_2 49 53 PF04695 0.366
LIG_Pex14_2 513 517 PF04695 0.675
LIG_Pex14_2 740 744 PF04695 0.411
LIG_PTB_Apo_2 167 174 PF02174 0.462
LIG_PTB_Phospho_1 167 173 PF10480 0.455
LIG_SH2_CRK 271 275 PF00017 0.512
LIG_SH2_CRK 569 573 PF00017 0.436
LIG_SH2_CRK 580 584 PF00017 0.394
LIG_SH2_CRK 59 63 PF00017 0.386
LIG_SH2_CRK 79 83 PF00017 0.263
LIG_SH2_GRB2like 147 150 PF00017 0.394
LIG_SH2_NCK_1 59 63 PF00017 0.332
LIG_SH2_PTP2 505 508 PF00017 0.356
LIG_SH2_PTP2 731 734 PF00017 0.512
LIG_SH2_PTP2 808 811 PF00017 0.597
LIG_SH2_STAP1 4 8 PF00017 0.445
LIG_SH2_STAP1 473 477 PF00017 0.417
LIG_SH2_STAP1 569 573 PF00017 0.437
LIG_SH2_STAP1 580 584 PF00017 0.310
LIG_SH2_STAP1 777 781 PF00017 0.404
LIG_SH2_STAT5 147 150 PF00017 0.475
LIG_SH2_STAT5 155 158 PF00017 0.464
LIG_SH2_STAT5 175 178 PF00017 0.599
LIG_SH2_STAT5 259 262 PF00017 0.526
LIG_SH2_STAT5 311 314 PF00017 0.447
LIG_SH2_STAT5 505 508 PF00017 0.364
LIG_SH2_STAT5 565 568 PF00017 0.368
LIG_SH2_STAT5 683 686 PF00017 0.433
LIG_SH2_STAT5 731 734 PF00017 0.529
LIG_SH2_STAT5 777 780 PF00017 0.415
LIG_SH2_STAT5 788 791 PF00017 0.410
LIG_SH2_STAT5 800 803 PF00017 0.552
LIG_SH2_STAT5 808 811 PF00017 0.661
LIG_SH3_2 174 179 PF14604 0.559
LIG_SH3_3 100 106 PF00018 0.519
LIG_SH3_3 156 162 PF00018 0.432
LIG_SH3_3 171 177 PF00018 0.448
LIG_SH3_3 19 25 PF00018 0.447
LIG_SH3_3 237 243 PF00018 0.392
LIG_SH3_3 261 267 PF00018 0.517
LIG_SH3_3 85 91 PF00018 0.410
LIG_Sin3_3 448 455 PF02671 0.296
LIG_SUMO_SIM_anti_2 134 141 PF11976 0.376
LIG_SUMO_SIM_anti_2 711 718 PF11976 0.423
LIG_SUMO_SIM_anti_2 748 753 PF11976 0.417
LIG_SUMO_SIM_par_1 292 297 PF11976 0.478
LIG_SUMO_SIM_par_1 392 398 PF11976 0.496
LIG_SUMO_SIM_par_1 462 469 PF11976 0.446
LIG_SUMO_SIM_par_1 543 548 PF11976 0.481
LIG_TYR_ITIM 806 811 PF00017 0.594
LIG_UBA3_1 136 145 PF00899 0.412
LIG_UBA3_1 528 534 PF00899 0.536
LIG_WRC_WIRS_1 24 29 PF05994 0.542
LIG_WRC_WIRS_1 430 435 PF05994 0.605
LIG_WRC_WIRS_1 538 543 PF05994 0.403
LIG_WRC_WIRS_1 678 683 PF05994 0.394
MOD_CDC14_SPxK_1 388 391 PF00782 0.338
MOD_CDK_SPxK_1 173 179 PF00069 0.454
MOD_CDK_SPxK_1 385 391 PF00069 0.353
MOD_CDK_SPxxK_3 173 180 PF00069 0.604
MOD_CDK_SPxxK_3 189 196 PF00069 0.469
MOD_CDK_SPxxK_3 690 697 PF00069 0.506
MOD_CK1_1 114 120 PF00069 0.449
MOD_CK1_1 23 29 PF00069 0.452
MOD_CK1_1 360 366 PF00069 0.572
MOD_CK1_1 625 631 PF00069 0.717
MOD_CK2_1 23 29 PF00069 0.507
MOD_CK2_1 375 381 PF00069 0.506
MOD_CK2_1 545 551 PF00069 0.460
MOD_CK2_1 615 621 PF00069 0.856
MOD_GlcNHglycan 246 249 PF01048 0.686
MOD_GlcNHglycan 303 306 PF01048 0.697
MOD_GlcNHglycan 359 362 PF01048 0.780
MOD_GlcNHglycan 453 456 PF01048 0.458
MOD_GlcNHglycan 499 502 PF01048 0.371
MOD_GlcNHglycan 547 550 PF01048 0.381
MOD_GlcNHglycan 608 611 PF01048 0.642
MOD_GlcNHglycan 624 627 PF01048 0.448
MOD_GlcNHglycan 644 647 PF01048 0.640
MOD_GlcNHglycan 79 82 PF01048 0.621
MOD_GSK3_1 108 115 PF00069 0.496
MOD_GSK3_1 13 20 PF00069 0.349
MOD_GSK3_1 169 176 PF00069 0.568
MOD_GSK3_1 2 9 PF00069 0.487
MOD_GSK3_1 219 226 PF00069 0.384
MOD_GSK3_1 23 30 PF00069 0.426
MOD_GSK3_1 286 293 PF00069 0.423
MOD_GSK3_1 296 303 PF00069 0.308
MOD_GSK3_1 367 374 PF00069 0.595
MOD_GSK3_1 451 458 PF00069 0.376
MOD_GSK3_1 469 476 PF00069 0.275
MOD_GSK3_1 49 56 PF00069 0.369
MOD_GSK3_1 533 540 PF00069 0.520
MOD_GSK3_1 598 605 PF00069 0.814
MOD_GSK3_1 677 684 PF00069 0.469
MOD_GSK3_1 693 700 PF00069 0.371
MOD_GSK3_1 775 782 PF00069 0.480
MOD_N-GLC_1 111 116 PF02516 0.662
MOD_N-GLC_1 121 126 PF02516 0.590
MOD_N-GLC_1 169 174 PF02516 0.653
MOD_N-GLC_1 17 22 PF02516 0.657
MOD_N-GLC_1 27 32 PF02516 0.610
MOD_N-GLC_1 284 289 PF02516 0.650
MOD_N-GLC_1 367 372 PF02516 0.734
MOD_N-GLC_1 37 42 PF02516 0.506
MOD_N-GLC_1 72 77 PF02516 0.694
MOD_NEK2_1 108 113 PF00069 0.465
MOD_NEK2_1 12 17 PF00069 0.398
MOD_NEK2_1 169 174 PF00069 0.547
MOD_NEK2_1 213 218 PF00069 0.407
MOD_NEK2_1 27 32 PF00069 0.373
MOD_NEK2_1 284 289 PF00069 0.497
MOD_NEK2_1 357 362 PF00069 0.466
MOD_NEK2_1 37 42 PF00069 0.357
MOD_NEK2_1 375 380 PF00069 0.479
MOD_NEK2_1 442 447 PF00069 0.403
MOD_NEK2_1 451 456 PF00069 0.428
MOD_NEK2_1 475 480 PF00069 0.320
MOD_NEK2_1 49 54 PF00069 0.331
MOD_NEK2_1 497 502 PF00069 0.383
MOD_NEK2_1 512 517 PF00069 0.521
MOD_NEK2_1 537 542 PF00069 0.367
MOD_NEK2_1 568 573 PF00069 0.377
MOD_NEK2_1 681 686 PF00069 0.456
MOD_NEK2_1 740 745 PF00069 0.396
MOD_NEK2_1 77 82 PF00069 0.448
MOD_NEK2_2 429 434 PF00069 0.727
MOD_NEK2_2 587 592 PF00069 0.625
MOD_PIKK_1 2 8 PF00454 0.459
MOD_PIKK_1 213 219 PF00454 0.420
MOD_PIKK_1 284 290 PF00454 0.405
MOD_PK_1 163 169 PF00069 0.343
MOD_PK_1 206 212 PF00069 0.473
MOD_PK_1 507 513 PF00069 0.384
MOD_PKA_2 219 225 PF00069 0.477
MOD_PKA_2 519 525 PF00069 0.564
MOD_PKA_2 648 654 PF00069 0.802
MOD_PKA_2 681 687 PF00069 0.419
MOD_PKA_2 702 708 PF00069 0.324
MOD_PKB_1 204 212 PF00069 0.341
MOD_Plk_1 111 117 PF00069 0.459
MOD_Plk_1 121 127 PF00069 0.373
MOD_Plk_1 169 175 PF00069 0.444
MOD_Plk_1 20 26 PF00069 0.463
MOD_Plk_1 27 33 PF00069 0.433
MOD_Plk_1 296 302 PF00069 0.377
MOD_Plk_1 37 43 PF00069 0.366
MOD_Plk_1 380 386 PF00069 0.520
MOD_Plk_1 72 78 PF00069 0.499
MOD_Plk_2-3 551 557 PF00069 0.332
MOD_Plk_4 121 127 PF00069 0.475
MOD_Plk_4 132 138 PF00069 0.456
MOD_Plk_4 143 149 PF00069 0.428
MOD_Plk_4 163 169 PF00069 0.296
MOD_Plk_4 27 33 PF00069 0.441
MOD_Plk_4 286 292 PF00069 0.533
MOD_Plk_4 306 312 PF00069 0.495
MOD_Plk_4 349 355 PF00069 0.438
MOD_Plk_4 380 386 PF00069 0.495
MOD_Plk_4 442 448 PF00069 0.402
MOD_Plk_4 460 466 PF00069 0.356
MOD_Plk_4 49 55 PF00069 0.416
MOD_Plk_4 507 513 PF00069 0.389
MOD_Plk_4 533 539 PF00069 0.617
MOD_Plk_4 568 574 PF00069 0.340
MOD_Plk_4 579 585 PF00069 0.306
MOD_Plk_4 697 703 PF00069 0.411
MOD_Plk_4 7 13 PF00069 0.343
MOD_Plk_4 779 785 PF00069 0.371
MOD_ProDKin_1 102 108 PF00069 0.554
MOD_ProDKin_1 173 179 PF00069 0.560
MOD_ProDKin_1 189 195 PF00069 0.409
MOD_ProDKin_1 239 245 PF00069 0.474
MOD_ProDKin_1 385 391 PF00069 0.433
MOD_ProDKin_1 615 621 PF00069 0.831
MOD_ProDKin_1 690 696 PF00069 0.493
TRG_DiLeu_BaEn_1 276 281 PF01217 0.526
TRG_DiLeu_BaEn_1 341 346 PF01217 0.475
TRG_DiLeu_BaEn_1 438 443 PF01217 0.536
TRG_DiLeu_BaLyEn_6 190 195 PF01217 0.522
TRG_DiLeu_BaLyEn_6 390 395 PF01217 0.408
TRG_DiLeu_BaLyEn_6 687 692 PF01217 0.426
TRG_ENDOCYTIC_2 503 506 PF00928 0.353
TRG_ENDOCYTIC_2 565 568 PF00928 0.352
TRG_ENDOCYTIC_2 569 572 PF00928 0.352
TRG_ENDOCYTIC_2 580 583 PF00928 0.352
TRG_ENDOCYTIC_2 59 62 PF00928 0.474
TRG_ENDOCYTIC_2 731 734 PF00928 0.397
TRG_ENDOCYTIC_2 79 82 PF00928 0.267
TRG_ENDOCYTIC_2 808 811 PF00928 0.720
TRG_ER_diArg_1 204 207 PF00400 0.375
TRG_ER_diArg_1 413 415 PF00400 0.607
TRG_ER_diArg_1 591 593 PF00400 0.587
TRG_ER_diArg_1 653 655 PF00400 0.741
TRG_ER_diArg_1 68 71 PF00400 0.481
TRG_NES_CRM1_1 29 43 PF08389 0.385
TRG_NES_CRM1_1 760 771 PF08389 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J9 Leptomonas seymouri 42% 99%
A0A0S4JN79 Bodo saltans 28% 100%
A0A1X0NF04 Trypanosomatidae 30% 100%
A0A1X0NFV0 Trypanosomatidae 26% 100%
A0A1X0NHK5 Trypanosomatidae 26% 100%
A0A1X0NP47 Trypanosomatidae 26% 100%
A0A422MXK2 Trypanosoma rangeli 28% 100%
A0A422NF17 Trypanosoma rangeli 27% 100%
A4HFA3 Leishmania braziliensis 64% 100%
A4I2I0 Leishmania infantum 100% 100%
C9ZX02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZX07 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AYP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q8T2 Leishmania major 91% 100%
V5BC53 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS