DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X087_LEIDO

TriTrypDb:

LdBPK_262550.1 , LdCL_260031400 , LDHU3_26.3280

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X087

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X087

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.637
CLV_C14_Caspase3-7	464	468	PF00656	0.671
CLV_NRD_NRD_1	105	107	PF00675	0.700
CLV_NRD_NRD_1	381	383	PF00675	0.685
CLV_NRD_NRD_1	40	42	PF00675	0.466
CLV_NRD_NRD_1	448	450	PF00675	0.659
CLV_NRD_NRD_1	81	83	PF00675	0.472
CLV_PCSK_FUR_1	275	279	PF00082	0.504
CLV_PCSK_KEX2_1	277	279	PF00082	0.497
CLV_PCSK_KEX2_1	352	354	PF00082	0.533
CLV_PCSK_KEX2_1	40	42	PF00082	0.466
CLV_PCSK_KEX2_1	448	450	PF00082	0.668
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.526
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.558
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.698
CLV_PCSK_SKI1_1	106	110	PF00082	0.712
CLV_PCSK_SKI1_1	352	356	PF00082	0.566
CLV_PCSK_SKI1_1	393	397	PF00082	0.731
CLV_PCSK_SKI1_1	401	405	PF00082	0.757
CLV_PCSK_SKI1_1	8	12	PF00082	0.536
DEG_MDM2_SWIB_1	227	235	PF02201	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.484
DEG_SCF_FBW7_2	366	372	PF00400	0.551
DEG_SPOP_SBC_1	112	116	PF00917	0.744
DEG_SPOP_SBC_1	411	415	PF00917	0.714
DOC_CKS1_1	29	34	PF01111	0.600
DOC_CKS1_1	366	371	PF01111	0.547
DOC_MAPK_FxFP_2	280	283	PF00069	0.409
DOC_MAPK_gen_1	233	241	PF00069	0.556
DOC_MAPK_gen_1	40	46	PF00069	0.460
DOC_PP4_FxxP_1	280	283	PF00568	0.409
DOC_PP4_FxxP_1	76	79	PF00568	0.582
DOC_USP7_MATH_1	120	124	PF00917	0.780
DOC_USP7_MATH_1	142	146	PF00917	0.572
DOC_USP7_MATH_1	184	188	PF00917	0.495
DOC_USP7_MATH_1	254	258	PF00917	0.482
DOC_USP7_MATH_1	39	43	PF00917	0.558
DOC_USP7_MATH_1	472	476	PF00917	0.731
DOC_USP7_UBL2_3	128	132	PF12436	0.667
DOC_USP7_UBL2_3	404	408	PF12436	0.794
DOC_WW_Pin1_4	188	193	PF00397	0.614
DOC_WW_Pin1_4	28	33	PF00397	0.518
DOC_WW_Pin1_4	365	370	PF00397	0.582
DOC_WW_Pin1_4	403	408	PF00397	0.731
DOC_WW_Pin1_4	412	417	PF00397	0.752
DOC_WW_Pin1_4	430	435	PF00397	0.567
LIG_14-3-3_CanoR_1	221	227	PF00244	0.498
LIG_14-3-3_CanoR_1	382	390	PF00244	0.664
LIG_14-3-3_CanoR_1	40	44	PF00244	0.609
LIG_14-3-3_CanoR_1	401	407	PF00244	0.469
LIG_14-3-3_CanoR_1	451	458	PF00244	0.735
LIG_Actin_WH2_2	42	58	PF00022	0.379
LIG_BRCT_BRCA1_1	256	260	PF00533	0.494
LIG_FHA_2	156	162	PF00498	0.648
LIG_FHA_2	180	186	PF00498	0.558
LIG_FHA_2	327	333	PF00498	0.597
LIG_FHA_2	99	105	PF00498	0.624
LIG_LIR_Apic_2	74	79	PF02991	0.587
LIG_LIR_Gen_1	171	180	PF02991	0.556
LIG_LIR_Gen_1	42	50	PF02991	0.577
LIG_LIR_Gen_1	63	73	PF02991	0.421
LIG_LIR_Nem_3	171	177	PF02991	0.558
LIG_LIR_Nem_3	265	270	PF02991	0.487
LIG_LIR_Nem_3	42	46	PF02991	0.582
LIG_LIR_Nem_3	478	484	PF02991	0.540
LIG_LIR_Nem_3	63	69	PF02991	0.421
LIG_LIR_Nem_3	71	76	PF02991	0.429
LIG_LYPXL_SIV_4	283	291	PF13949	0.405
LIG_PCNA_PIPBox_1	195	204	PF02747	0.483
LIG_PCNA_yPIPBox_3	190	202	PF02747	0.503
LIG_Pex14_2	227	231	PF04695	0.559
LIG_SH2_CRK	267	271	PF00017	0.498
LIG_SH2_CRK	43	47	PF00017	0.482
LIG_SH2_NCK_1	267	271	PF00017	0.563
LIG_SH2_SRC	484	487	PF00017	0.730
LIG_SH2_STAP1	224	228	PF00017	0.408
LIG_SH2_STAP1	262	266	PF00017	0.408
LIG_SH3_3	136	142	PF00018	0.645
LIG_SH3_3	204	210	PF00018	0.419
LIG_SH3_3	26	32	PF00018	0.487
LIG_SH3_3	280	286	PF00018	0.387
LIG_SH3_3	422	428	PF00018	0.781
LIG_SH3_3	46	52	PF00018	0.240
LIG_TRAF2_1	296	299	PF00917	0.560
MOD_CDK_SPK_2	403	408	PF00069	0.724
MOD_CK1_1	114	120	PF00069	0.688
MOD_CK1_1	164	170	PF00069	0.716
MOD_CK1_1	381	387	PF00069	0.618
MOD_CK1_1	456	462	PF00069	0.680
MOD_CK1_1	474	480	PF00069	0.722
MOD_CK1_1	97	103	PF00069	0.530
MOD_CK2_1	149	155	PF00069	0.726
MOD_CK2_1	179	185	PF00069	0.567
MOD_CK2_1	211	217	PF00069	0.546
MOD_CK2_1	307	313	PF00069	0.618
MOD_CK2_1	326	332	PF00069	0.347
MOD_CK2_1	456	462	PF00069	0.683
MOD_CK2_1	463	469	PF00069	0.670
MOD_CK2_1	68	74	PF00069	0.379
MOD_CK2_1	90	96	PF00069	0.610
MOD_Cter_Amidation	104	107	PF01082	0.694
MOD_Cter_Amidation	231	234	PF01082	0.420
MOD_Cter_Amidation	439	442	PF01082	0.779
MOD_GlcNHglycan	120	123	PF01048	0.763
MOD_GlcNHglycan	144	147	PF01048	0.720
MOD_GlcNHglycan	256	259	PF01048	0.472
MOD_GlcNHglycan	375	378	PF01048	0.560
MOD_GlcNHglycan	421	424	PF01048	0.807
MOD_GlcNHglycan	443	446	PF01048	0.790
MOD_GlcNHglycan	70	73	PF01048	0.392
MOD_GSK3_1	111	118	PF00069	0.764
MOD_GSK3_1	149	156	PF00069	0.744
MOD_GSK3_1	184	191	PF00069	0.535
MOD_GSK3_1	262	269	PF00069	0.435
MOD_GSK3_1	378	385	PF00069	0.638
MOD_GSK3_1	399	406	PF00069	0.724
MOD_GSK3_1	412	419	PF00069	0.750
MOD_GSK3_1	430	437	PF00069	0.554
MOD_GSK3_1	461	468	PF00069	0.666
MOD_GSK3_1	471	478	PF00069	0.695
MOD_GSK3_1	90	97	PF00069	0.610
MOD_LATS_1	351	357	PF00433	0.626
MOD_N-GLC_1	188	193	PF02516	0.665
MOD_NEK2_1	266	271	PF00069	0.468
MOD_NEK2_1	337	342	PF00069	0.514
MOD_NEK2_1	373	378	PF00069	0.682
MOD_NEK2_2	222	227	PF00069	0.519
MOD_NEK2_2	262	267	PF00069	0.423
MOD_PIKK_1	120	126	PF00454	0.757
MOD_PIKK_1	285	291	PF00454	0.468
MOD_PKA_1	382	388	PF00069	0.680
MOD_PKA_1	441	447	PF00069	0.742
MOD_PKA_2	118	124	PF00069	0.739
MOD_PKA_2	378	384	PF00069	0.719
MOD_PKA_2	39	45	PF00069	0.596
MOD_PKA_2	97	103	PF00069	0.596
MOD_PKB_1	449	457	PF00069	0.709
MOD_Plk_1	164	170	PF00069	0.643
MOD_Plk_1	262	268	PF00069	0.428
MOD_Plk_1	461	467	PF00069	0.726
MOD_Plk_1	475	481	PF00069	0.782
MOD_Plk_2-3	149	155	PF00069	0.688
MOD_Plk_2-3	463	469	PF00069	0.643
MOD_Plk_4	222	228	PF00069	0.398
MOD_Plk_4	262	268	PF00069	0.408
MOD_Plk_4	6	12	PF00069	0.454
MOD_ProDKin_1	188	194	PF00069	0.611
MOD_ProDKin_1	28	34	PF00069	0.513
MOD_ProDKin_1	365	371	PF00069	0.588
MOD_ProDKin_1	403	409	PF00069	0.728
MOD_ProDKin_1	412	418	PF00069	0.751
MOD_ProDKin_1	430	436	PF00069	0.567
MOD_SUMO_rev_2	164	173	PF00179	0.623
MOD_SUMO_rev_2	74	81	PF00179	0.532
TRG_DiLeu_BaEn_1	332	337	PF01217	0.486
TRG_DiLeu_BaEn_4	344	350	PF01217	0.576
TRG_ENDOCYTIC_2	224	227	PF00928	0.385
TRG_ENDOCYTIC_2	267	270	PF00928	0.485
TRG_ENDOCYTIC_2	284	287	PF00928	0.270
TRG_ENDOCYTIC_2	43	46	PF00928	0.455
TRG_NLS_Bipartite_1	127	144	PF00514	0.674
TRG_NLS_MonoCore_2	139	144	PF00514	0.748
TRG_NLS_MonoCore_2	447	452	PF00514	0.710
TRG_NLS_MonoExtC_3	448	453	PF00514	0.723
TRG_NLS_MonoExtN_4	137	144	PF00514	0.753
TRG_NLS_MonoExtN_4	446	453	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P789	Trypanosomatidae	43%	100%
A0A3R7KYR3	Trypanosoma rangeli	41%	100%
A4HF97	Leishmania braziliensis	70%	96%
A4I2I9	Leishmania infantum	100%	100%
C9ZX14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AYN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8T9	Leishmania major	91%	100%