Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X083_LEIDO

TriTrypDb:

LdBPK_262480.1 , LdCL_260030600 , LDHU3_26.3200

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X083

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X083

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.491
CLV_NRD_NRD_1	213	215	PF00675	0.673
CLV_NRD_NRD_1	287	289	PF00675	0.740
CLV_NRD_NRD_1	385	387	PF00675	0.628
CLV_NRD_NRD_1	46	48	PF00675	0.596
CLV_NRD_NRD_1	5	7	PF00675	0.534
CLV_NRD_NRD_1	89	91	PF00675	0.536
CLV_NRD_NRD_1	93	95	PF00675	0.532
CLV_PCSK_FUR_1	14	18	PF00082	0.483
CLV_PCSK_KEX2_1	16	18	PF00082	0.491
CLV_PCSK_KEX2_1	174	176	PF00082	0.656
CLV_PCSK_KEX2_1	213	215	PF00082	0.626
CLV_PCSK_KEX2_1	287	289	PF00082	0.736
CLV_PCSK_KEX2_1	45	47	PF00082	0.586
CLV_PCSK_KEX2_1	5	7	PF00082	0.534
CLV_PCSK_KEX2_1	89	91	PF00082	0.503
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.637
CLV_PCSK_SKI1_1	223	227	PF00082	0.635
CLV_PCSK_SKI1_1	330	334	PF00082	0.628
CLV_PCSK_SKI1_1	377	381	PF00082	0.524
CLV_PCSK_SKI1_1	6	10	PF00082	0.540
DEG_COP1_1	405	413	PF00400	0.390
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DEG_SPOP_SBC_1	22	26	PF00917	0.763
DOC_AGCK_PIF_1	138	143	PF00069	0.373
DOC_CKS1_1	322	327	PF01111	0.477
DOC_CYCLIN_RxL_1	326	336	PF00134	0.435
DOC_MAPK_FxFP_2	158	161	PF00069	0.478
DOC_MAPK_gen_1	103	111	PF00069	0.659
DOC_MAPK_gen_1	14	22	PF00069	0.733
DOC_MAPK_gen_1	174	180	PF00069	0.420
DOC_MAPK_gen_1	2	11	PF00069	0.708
DOC_MAPK_gen_1	257	265	PF00069	0.540
DOC_MAPK_MEF2A_6	115	124	PF00069	0.542
DOC_PP4_FxxP_1	158	161	PF00568	0.478
DOC_USP7_MATH_1	308	312	PF00917	0.490
DOC_USP7_MATH_1	55	59	PF00917	0.744
DOC_USP7_UBL2_3	170	174	PF12436	0.343
DOC_USP7_UBL2_3	326	330	PF12436	0.397
DOC_WW_Pin1_4	147	152	PF00397	0.498
DOC_WW_Pin1_4	321	326	PF00397	0.541
DOC_WW_Pin1_4	39	44	PF00397	0.741
LIG_14-3-3_CanoR_1	115	121	PF00244	0.653
LIG_14-3-3_CanoR_1	14	20	PF00244	0.704
LIG_14-3-3_CanoR_1	153	157	PF00244	0.471
LIG_14-3-3_CanoR_1	175	179	PF00244	0.459
LIG_14-3-3_CanoR_1	260	264	PF00244	0.551
LIG_14-3-3_CanoR_1	295	305	PF00244	0.532
LIG_14-3-3_CanoR_1	334	338	PF00244	0.400
LIG_14-3-3_CanoR_1	89	93	PF00244	0.721
LIG_Actin_WH2_2	372	388	PF00022	0.453
LIG_BRCT_BRCA1_1	154	158	PF00533	0.522
LIG_BRCT_BRCA1_1	23	27	PF00533	0.664
LIG_BRCT_BRCA1_1	261	265	PF00533	0.554
LIG_Clathr_ClatBox_1	234	238	PF01394	0.463
LIG_FHA_1	119	125	PF00498	0.399
LIG_FHA_1	140	146	PF00498	0.399
LIG_FHA_1	175	181	PF00498	0.477
LIG_FHA_1	229	235	PF00498	0.421
LIG_FHA_1	327	333	PF00498	0.486
LIG_FHA_1	405	411	PF00498	0.423
LIG_FHA_2	315	321	PF00498	0.554
LIG_FHA_2	403	409	PF00498	0.473
LIG_LIR_Apic_2	155	161	PF02991	0.499
LIG_LIR_Gen_1	139	149	PF02991	0.442
LIG_LIR_Gen_1	353	362	PF02991	0.453
LIG_LIR_Gen_1	418	428	PF02991	0.401
LIG_LIR_Nem_3	139	144	PF02991	0.439
LIG_LIR_Nem_3	155	160	PF02991	0.386
LIG_LIR_Nem_3	353	357	PF02991	0.434
LIG_LIR_Nem_3	418	424	PF02991	0.394
LIG_LYPXL_yS_3	98	101	PF13949	0.653
LIG_MLH1_MIPbox_1	154	158	PF16413	0.522
LIG_PCNA_yPIPBox_3	213	225	PF02747	0.429
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.364
LIG_PTB_Apo_2	151	158	PF02174	0.424
LIG_SH2_CRK	141	145	PF00017	0.448
LIG_SH2_SRC	371	374	PF00017	0.379
LIG_SH2_STAP1	141	145	PF00017	0.405
LIG_SH2_STAP1	314	318	PF00017	0.512
LIG_SH2_STAP1	354	358	PF00017	0.359
LIG_SH2_STAP1	371	375	PF00017	0.467
LIG_SH2_STAP1	389	393	PF00017	0.300
LIG_SH2_STAP1	435	439	PF00017	0.417
LIG_SH2_STAT5	123	126	PF00017	0.448
LIG_SH2_STAT5	137	140	PF00017	0.369
LIG_SH2_STAT5	141	144	PF00017	0.264
LIG_SH2_STAT5	227	230	PF00017	0.357
LIG_SH2_STAT5	437	440	PF00017	0.446
LIG_SH3_2	325	330	PF14604	0.515
LIG_SH3_3	319	325	PF00018	0.569
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.461
LIG_SUMO_SIM_par_1	18	26	PF11976	0.713
LIG_SUMO_SIM_par_1	231	238	PF11976	0.389
LIG_TRAF2_1	83	86	PF00917	0.766
LIG_TYR_ITSM	137	144	PF00017	0.510
LIG_WW_3	42	46	PF00397	0.571
MOD_CDC14_SPxK_1	150	153	PF00782	0.652
MOD_CDK_SPK_2	321	326	PF00069	0.522
MOD_CDK_SPxK_1	147	153	PF00069	0.638
MOD_CDK_SPxK_1	39	45	PF00069	0.572
MOD_CDK_SPxxK_3	39	46	PF00069	0.672
MOD_CK1_1	21	27	PF00069	0.641
MOD_CK1_1	233	239	PF00069	0.549
MOD_CK1_1	259	265	PF00069	0.635
MOD_CK1_1	281	287	PF00069	0.731
MOD_CK1_1	309	315	PF00069	0.693
MOD_CK1_1	38	44	PF00069	0.626
MOD_CK2_1	314	320	PF00069	0.675
MOD_CK2_1	402	408	PF00069	0.607
MOD_CMANNOS	289	292	PF00535	0.682
MOD_GlcNHglycan	112	115	PF01048	0.607
MOD_GlcNHglycan	306	309	PF01048	0.617
MOD_GlcNHglycan	311	314	PF01048	0.589
MOD_GlcNHglycan	38	41	PF01048	0.661
MOD_GlcNHglycan	382	385	PF01048	0.624
MOD_GlcNHglycan	399	402	PF01048	0.389
MOD_GlcNHglycan	50	53	PF01048	0.787
MOD_GSK3_1	139	146	PF00069	0.439
MOD_GSK3_1	18	25	PF00069	0.719
MOD_GSK3_1	277	284	PF00069	0.692
MOD_GSK3_1	304	311	PF00069	0.674
MOD_GSK3_1	35	42	PF00069	0.566
MOD_N-GLC_1	147	152	PF02516	0.632
MOD_NEK2_1	104	109	PF00069	0.673
MOD_NEK2_1	125	130	PF00069	0.367
MOD_NEK2_1	304	309	PF00069	0.647
MOD_NEK2_1	332	337	PF00069	0.471
MOD_NEK2_1	339	344	PF00069	0.539
MOD_NEK2_1	375	380	PF00069	0.521
MOD_NEK2_2	152	157	PF00069	0.553
MOD_NEK2_2	88	93	PF00069	0.672
MOD_PIKK_1	282	288	PF00454	0.757
MOD_PKA_1	174	180	PF00069	0.637
MOD_PKA_2	104	110	PF00069	0.605
MOD_PKA_2	15	21	PF00069	0.694
MOD_PKA_2	152	158	PF00069	0.618
MOD_PKA_2	174	180	PF00069	0.573
MOD_PKA_2	259	265	PF00069	0.731
MOD_PKA_2	278	284	PF00069	0.442
MOD_PKA_2	333	339	PF00069	0.533
MOD_PKA_2	88	94	PF00069	0.763
MOD_Plk_2-3	402	408	PF00069	0.509
MOD_Plk_4	118	124	PF00069	0.333
MOD_Plk_4	139	145	PF00069	0.468
MOD_Plk_4	152	158	PF00069	0.567
MOD_Plk_4	216	222	PF00069	0.498
MOD_Plk_4	230	236	PF00069	0.425
MOD_ProDKin_1	147	153	PF00069	0.638
MOD_ProDKin_1	321	327	PF00069	0.682
MOD_ProDKin_1	39	45	PF00069	0.695
MOD_SUMO_rev_2	163	172	PF00179	0.541
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.548
TRG_ENDOCYTIC_2	141	144	PF00928	0.568
TRG_ENDOCYTIC_2	246	249	PF00928	0.559
TRG_ENDOCYTIC_2	354	357	PF00928	0.581
TRG_ENDOCYTIC_2	371	374	PF00928	0.529
TRG_ENDOCYTIC_2	98	101	PF00928	0.578
TRG_ER_diArg_1	14	17	PF00400	0.617
TRG_ER_diArg_1	213	215	PF00400	0.597
TRG_ER_diArg_1	287	289	PF00400	0.691
TRG_ER_diArg_1	337	340	PF00400	0.463
TRG_ER_diArg_1	44	47	PF00400	0.655
TRG_ER_diArg_1	88	90	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	50%	100%
A0A1X0P8N3	Trypanosomatidae	25%	100%
A4HF91	Leishmania braziliensis	68%	100%
A4I2H3	Leishmania infantum	99%	100%
C9ZX21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AYM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q8U5	Leishmania major	84%	100%