Primase zinc finger/Mcm10 replication factor, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Primase zinc finger/Mcm10 replication factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X073_LEIDO

TriTrypDb:

LdBPK_262410.1 , LdCL_260029800 , LDHU3_26.3130

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0031298	replication fork protection complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X073

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X073

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006270	DNA replication initiation	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003690	double-stranded DNA binding	5	8
GO:0003697	single-stranded DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003688	DNA replication origin binding	7	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.697
CLV_C14_Caspase3-7	51	55	PF00656	0.566
CLV_C14_Caspase3-7	589	593	PF00656	0.816
CLV_C14_Caspase3-7	668	672	PF00656	0.598
CLV_C14_Caspase3-7	789	793	PF00656	0.585
CLV_NRD_NRD_1	161	163	PF00675	0.579
CLV_NRD_NRD_1	230	232	PF00675	0.574
CLV_NRD_NRD_1	245	247	PF00675	0.313
CLV_NRD_NRD_1	313	315	PF00675	0.587
CLV_NRD_NRD_1	377	379	PF00675	0.466
CLV_NRD_NRD_1	561	563	PF00675	0.627
CLV_NRD_NRD_1	565	567	PF00675	0.664
CLV_NRD_NRD_1	689	691	PF00675	0.679
CLV_PCSK_KEX2_1	160	162	PF00082	0.583
CLV_PCSK_KEX2_1	230	232	PF00082	0.588
CLV_PCSK_KEX2_1	313	315	PF00082	0.603
CLV_PCSK_KEX2_1	561	563	PF00082	0.596
CLV_PCSK_KEX2_1	565	567	PF00082	0.612
CLV_PCSK_KEX2_1	624	626	PF00082	0.685
CLV_PCSK_KEX2_1	689	691	PF00082	0.746
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.690
CLV_PCSK_PC7_1	226	232	PF00082	0.554
CLV_PCSK_PC7_1	561	567	PF00082	0.507
CLV_PCSK_SKI1_1	127	131	PF00082	0.623
CLV_PCSK_SKI1_1	201	205	PF00082	0.474
CLV_PCSK_SKI1_1	296	300	PF00082	0.508
CLV_PCSK_SKI1_1	391	395	PF00082	0.676
CLV_PCSK_SKI1_1	481	485	PF00082	0.618
CLV_PCSK_SKI1_1	541	545	PF00082	0.499
CLV_PCSK_SKI1_1	749	753	PF00082	0.735
CLV_PCSK_SKI1_1	816	820	PF00082	0.382
CLV_PCSK_SKI1_1	869	873	PF00082	0.420
DEG_SCF_FBW7_1	695	701	PF00400	0.621
DEG_SPOP_SBC_1	631	635	PF00917	0.621
DEG_SPOP_SBC_1	81	85	PF00917	0.624
DOC_ANK_TNKS_1	669	676	PF00023	0.558
DOC_CKS1_1	695	700	PF01111	0.687
DOC_CYCLIN_RxL_1	333	343	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	913	919	PF00134	0.553
DOC_MAPK_gen_1	125	134	PF00069	0.628
DOC_MAPK_gen_1	199	207	PF00069	0.414
DOC_MAPK_gen_1	258	267	PF00069	0.427
DOC_MAPK_gen_1	624	630	PF00069	0.657
DOC_MAPK_MEF2A_6	908	917	PF00069	0.382
DOC_PP1_RVXF_1	334	341	PF00149	0.415
DOC_PP2B_LxvP_1	132	135	PF13499	0.649
DOC_PP2B_LxvP_1	405	408	PF13499	0.622
DOC_PP2B_LxvP_1	913	916	PF13499	0.542
DOC_PP4_FxxP_1	102	105	PF00568	0.603
DOC_USP7_MATH_1	119	123	PF00917	0.677
DOC_USP7_MATH_1	136	140	PF00917	0.587
DOC_USP7_MATH_1	149	153	PF00917	0.774
DOC_USP7_MATH_1	218	222	PF00917	0.356
DOC_USP7_MATH_1	250	254	PF00917	0.541
DOC_USP7_MATH_1	256	260	PF00917	0.592
DOC_USP7_MATH_1	380	384	PF00917	0.512
DOC_USP7_MATH_1	400	404	PF00917	0.709
DOC_USP7_MATH_1	446	450	PF00917	0.680
DOC_USP7_MATH_1	524	528	PF00917	0.655
DOC_USP7_MATH_1	601	605	PF00917	0.706
DOC_USP7_MATH_1	632	636	PF00917	0.619
DOC_USP7_MATH_1	657	661	PF00917	0.630
DOC_USP7_MATH_1	698	702	PF00917	0.694
DOC_USP7_MATH_1	726	730	PF00917	0.727
DOC_USP7_MATH_1	733	737	PF00917	0.611
DOC_USP7_MATH_1	763	767	PF00917	0.712
DOC_USP7_MATH_1	81	85	PF00917	0.657
DOC_USP7_UBL2_3	864	868	PF12436	0.442
DOC_WW_Pin1_4	10	15	PF00397	0.567
DOC_WW_Pin1_4	101	106	PF00397	0.553
DOC_WW_Pin1_4	127	132	PF00397	0.696
DOC_WW_Pin1_4	147	152	PF00397	0.690
DOC_WW_Pin1_4	271	276	PF00397	0.415
DOC_WW_Pin1_4	45	50	PF00397	0.658
DOC_WW_Pin1_4	613	618	PF00397	0.698
DOC_WW_Pin1_4	642	647	PF00397	0.720
DOC_WW_Pin1_4	649	654	PF00397	0.620
DOC_WW_Pin1_4	68	73	PF00397	0.630
DOC_WW_Pin1_4	694	699	PF00397	0.695
DOC_WW_Pin1_4	708	713	PF00397	0.790
DOC_WW_Pin1_4	758	763	PF00397	0.705
DOC_WW_Pin1_4	86	91	PF00397	0.667
LIG_14-3-3_CanoR_1	180	185	PF00244	0.666
LIG_14-3-3_CanoR_1	201	206	PF00244	0.454
LIG_14-3-3_CanoR_1	230	236	PF00244	0.586
LIG_14-3-3_CanoR_1	246	250	PF00244	0.333
LIG_14-3-3_CanoR_1	313	318	PF00244	0.473
LIG_14-3-3_CanoR_1	357	362	PF00244	0.366
LIG_14-3-3_CanoR_1	398	405	PF00244	0.707
LIG_14-3-3_CanoR_1	452	460	PF00244	0.705
LIG_14-3-3_CanoR_1	464	472	PF00244	0.609
LIG_14-3-3_CanoR_1	473	478	PF00244	0.688
LIG_14-3-3_CanoR_1	523	529	PF00244	0.655
LIG_14-3-3_CanoR_1	568	578	PF00244	0.713
LIG_14-3-3_CanoR_1	67	75	PF00244	0.590
LIG_14-3-3_CanoR_1	689	695	PF00244	0.641
LIG_14-3-3_CanoR_1	718	722	PF00244	0.674
LIG_14-3-3_CanoR_1	82	92	PF00244	0.559
LIG_14-3-3_CanoR_1	899	907	PF00244	0.464
LIG_Actin_WH2_2	674	691	PF00022	0.596
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BRCT_BRCA1_1	651	655	PF00533	0.584
LIG_BRCT_BRCA1_1	692	696	PF00533	0.651
LIG_EVH1_1	132	136	PF00568	0.595
LIG_FHA_1	11	17	PF00498	0.592
LIG_FHA_1	190	196	PF00498	0.556
LIG_FHA_1	202	208	PF00498	0.403
LIG_FHA_1	297	303	PF00498	0.484
LIG_FHA_1	320	326	PF00498	0.495
LIG_FHA_1	39	45	PF00498	0.682
LIG_FHA_1	415	421	PF00498	0.731
LIG_FHA_1	59	65	PF00498	0.738
LIG_FHA_1	603	609	PF00498	0.595
LIG_FHA_1	664	670	PF00498	0.708
LIG_FHA_1	850	856	PF00498	0.463
LIG_FHA_1	878	884	PF00498	0.362
LIG_FHA_1	93	99	PF00498	0.642
LIG_FHA_2	33	39	PF00498	0.561
LIG_FHA_2	49	55	PF00498	0.564
LIG_FHA_2	570	576	PF00498	0.697
LIG_FHA_2	636	642	PF00498	0.727
LIG_FHA_2	666	672	PF00498	0.568
LIG_FHA_2	851	857	PF00498	0.572
LIG_Integrin_RGD_1	908	910	PF01839	0.437
LIG_LIR_Apic_2	100	105	PF02991	0.611
LIG_LIR_Gen_1	216	225	PF02991	0.439
LIG_LIR_Gen_1	259	270	PF02991	0.452
LIG_LIR_Gen_1	288	298	PF02991	0.381
LIG_LIR_Gen_1	3	14	PF02991	0.591
LIG_LIR_Nem_3	111	115	PF02991	0.610
LIG_LIR_Nem_3	216	222	PF02991	0.431
LIG_LIR_Nem_3	259	265	PF02991	0.475
LIG_LIR_Nem_3	288	293	PF02991	0.375
LIG_LIR_Nem_3	3	9	PF02991	0.590
LIG_LIR_Nem_3	475	480	PF02991	0.681
LIG_LIR_Nem_3	502	508	PF02991	0.640
LIG_LIR_Nem_3	652	658	PF02991	0.537
LIG_LIR_Nem_3	693	699	PF02991	0.665
LIG_MYND_1	14	18	PF01753	0.518
LIG_NBox_RRM_1	741	751	PF00076	0.514
LIG_NRBOX	280	286	PF00104	0.423
LIG_REV1ctd_RIR_1	475	485	PF16727	0.618
LIG_SH2_CRK	262	266	PF00017	0.369
LIG_SH2_CRK	294	298	PF00017	0.353
LIG_SH2_CRK	505	509	PF00017	0.588
LIG_SH2_CRK	847	851	PF00017	0.441
LIG_SH2_STAP1	294	298	PF00017	0.374
LIG_SH2_STAT5	839	842	PF00017	0.426
LIG_SH2_STAT5	870	873	PF00017	0.409
LIG_SH3_1	892	898	PF00018	0.413
LIG_SH3_2	695	700	PF14604	0.637
LIG_SH3_3	118	124	PF00018	0.673
LIG_SH3_3	12	18	PF00018	0.581
LIG_SH3_3	130	136	PF00018	0.560
LIG_SH3_3	692	698	PF00018	0.668
LIG_SH3_3	892	898	PF00018	0.450
LIG_SH3_3	916	922	PF00018	0.592
LIG_SH3_4	864	871	PF00018	0.430
LIG_SUMO_SIM_anti_2	278	285	PF11976	0.492
LIG_SUMO_SIM_anti_2	782	789	PF11976	0.587
LIG_SUMO_SIM_par_1	20	28	PF11976	0.685
LIG_SUMO_SIM_par_1	203	208	PF11976	0.465
LIG_SUMO_SIM_par_1	301	306	PF11976	0.390
LIG_SUMO_SIM_par_1	60	66	PF11976	0.549
LIG_SUMO_SIM_par_1	915	920	PF11976	0.491
LIG_WRC_WIRS_1	219	224	PF05994	0.380
LIG_WRC_WIRS_1	636	641	PF05994	0.615
LIG_WRC_WIRS_1	878	883	PF05994	0.425
MOD_CDK_SPxK_1	694	700	PF00069	0.636
MOD_CDK_SPxxK_3	45	52	PF00069	0.659
MOD_CDK_SPxxK_3	708	715	PF00069	0.605
MOD_CK1_1	104	110	PF00069	0.502
MOD_CK1_1	152	158	PF00069	0.821
MOD_CK1_1	229	235	PF00069	0.576
MOD_CK1_1	30	36	PF00069	0.756
MOD_CK1_1	383	389	PF00069	0.674
MOD_CK1_1	401	407	PF00069	0.725
MOD_CK1_1	414	420	PF00069	0.594
MOD_CK1_1	43	49	PF00069	0.591
MOD_CK1_1	454	460	PF00069	0.698
MOD_CK1_1	499	505	PF00069	0.634
MOD_CK1_1	527	533	PF00069	0.697
MOD_CK1_1	602	608	PF00069	0.734
MOD_CK1_1	63	69	PF00069	0.668
MOD_CK1_1	635	641	PF00069	0.606
MOD_CK1_1	645	651	PF00069	0.781
MOD_CK1_1	660	666	PF00069	0.635
MOD_CK1_1	753	759	PF00069	0.754
MOD_CK1_1	782	788	PF00069	0.702
MOD_CK1_1	85	91	PF00069	0.753
MOD_CK2_1	152	158	PF00069	0.770
MOD_CK2_1	32	38	PF00069	0.563
MOD_CK2_1	569	575	PF00069	0.703
MOD_CK2_1	635	641	PF00069	0.730
MOD_CK2_1	758	764	PF00069	0.757
MOD_CK2_1	850	856	PF00069	0.463
MOD_GlcNHglycan	136	139	PF01048	0.609
MOD_GlcNHglycan	151	154	PF01048	0.732
MOD_GlcNHglycan	182	185	PF01048	0.633
MOD_GlcNHglycan	187	190	PF01048	0.494
MOD_GlcNHglycan	28	32	PF01048	0.804
MOD_GlcNHglycan	287	290	PF01048	0.416
MOD_GlcNHglycan	315	318	PF01048	0.590
MOD_GlcNHglycan	382	385	PF01048	0.675
MOD_GlcNHglycan	400	403	PF01048	0.732
MOD_GlcNHglycan	422	425	PF01048	0.632
MOD_GlcNHglycan	449	452	PF01048	0.786
MOD_GlcNHglycan	456	459	PF01048	0.666
MOD_GlcNHglycan	498	501	PF01048	0.599
MOD_GlcNHglycan	529	532	PF01048	0.650
MOD_GlcNHglycan	588	591	PF01048	0.795
MOD_GlcNHglycan	662	665	PF01048	0.692
MOD_GlcNHglycan	68	71	PF01048	0.623
MOD_GlcNHglycan	692	695	PF01048	0.779
MOD_GlcNHglycan	724	727	PF01048	0.665
MOD_GlcNHglycan	728	731	PF01048	0.626
MOD_GlcNHglycan	733	736	PF01048	0.511
MOD_GlcNHglycan	767	770	PF01048	0.698
MOD_GlcNHglycan	781	784	PF01048	0.688
MOD_GlcNHglycan	795	798	PF01048	0.668
MOD_GlcNHglycan	85	88	PF01048	0.632
MOD_GSK3_1	104	111	PF00069	0.584
MOD_GSK3_1	119	126	PF00069	0.517
MOD_GSK3_1	136	143	PF00069	0.685
MOD_GSK3_1	147	154	PF00069	0.756
MOD_GSK3_1	176	183	PF00069	0.675
MOD_GSK3_1	185	192	PF00069	0.528
MOD_GSK3_1	250	257	PF00069	0.713
MOD_GSK3_1	292	299	PF00069	0.405
MOD_GSK3_1	357	364	PF00069	0.293
MOD_GSK3_1	38	45	PF00069	0.763
MOD_GSK3_1	407	414	PF00069	0.677
MOD_GSK3_1	447	454	PF00069	0.740
MOD_GSK3_1	566	573	PF00069	0.595
MOD_GSK3_1	58	65	PF00069	0.597
MOD_GSK3_1	602	609	PF00069	0.689
MOD_GSK3_1	611	618	PF00069	0.834
MOD_GSK3_1	631	638	PF00069	0.584
MOD_GSK3_1	641	648	PF00069	0.731
MOD_GSK3_1	649	656	PF00069	0.659
MOD_GSK3_1	690	697	PF00069	0.635
MOD_GSK3_1	717	724	PF00069	0.668
MOD_GSK3_1	749	756	PF00069	0.665
MOD_GSK3_1	763	770	PF00069	0.569
MOD_GSK3_1	782	789	PF00069	0.548
MOD_GSK3_1	81	88	PF00069	0.635
MOD_LATS_1	800	806	PF00433	0.545
MOD_N-GLC_1	391	396	PF02516	0.619
MOD_N-GLC_1	753	758	PF02516	0.632
MOD_NEK2_1	285	290	PF00069	0.365
MOD_NEK2_1	292	297	PF00069	0.352
MOD_NEK2_1	361	366	PF00069	0.333
MOD_NEK2_1	411	416	PF00069	0.661
MOD_NEK2_1	420	425	PF00069	0.559
MOD_NEK2_1	44	49	PF00069	0.707
MOD_NEK2_1	465	470	PF00069	0.624
MOD_NEK2_1	472	477	PF00069	0.634
MOD_NEK2_1	534	539	PF00069	0.534
MOD_NEK2_1	786	791	PF00069	0.564
MOD_NEK2_2	665	670	PF00069	0.584
MOD_PIKK_1	361	367	PF00454	0.370
MOD_PIKK_1	465	471	PF00454	0.644
MOD_PIKK_1	733	739	PF00454	0.621
MOD_PKA_1	160	166	PF00069	0.578
MOD_PKA_1	313	319	PF00069	0.593
MOD_PKA_2	160	166	PF00069	0.692
MOD_PKA_2	229	235	PF00069	0.664
MOD_PKA_2	245	251	PF00069	0.328
MOD_PKA_2	257	263	PF00069	0.462
MOD_PKA_2	313	319	PF00069	0.727
MOD_PKA_2	451	457	PF00069	0.758
MOD_PKA_2	472	478	PF00069	0.770
MOD_PKA_2	602	608	PF00069	0.640
MOD_PKA_2	611	617	PF00069	0.581
MOD_PKA_2	66	72	PF00069	0.646
MOD_PKA_2	717	723	PF00069	0.673
MOD_PKA_2	81	87	PF00069	0.566
MOD_PKB_1	199	207	PF00069	0.458
MOD_PKB_1	566	574	PF00069	0.551
MOD_Plk_1	279	285	PF00069	0.537
MOD_Plk_4	140	146	PF00069	0.683
MOD_Plk_4	263	269	PF00069	0.426
MOD_Plk_4	279	285	PF00069	0.553
MOD_Plk_4	298	304	PF00069	0.239
MOD_Plk_4	357	363	PF00069	0.246
MOD_Plk_4	473	479	PF00069	0.639
MOD_Plk_4	717	723	PF00069	0.735
MOD_Plk_4	782	788	PF00069	0.511
MOD_Plk_4	877	883	PF00069	0.430
MOD_Plk_4	901	907	PF00069	0.406
MOD_ProDKin_1	10	16	PF00069	0.571
MOD_ProDKin_1	101	107	PF00069	0.553
MOD_ProDKin_1	127	133	PF00069	0.646
MOD_ProDKin_1	147	153	PF00069	0.692
MOD_ProDKin_1	271	277	PF00069	0.424
MOD_ProDKin_1	45	51	PF00069	0.657
MOD_ProDKin_1	613	619	PF00069	0.699
MOD_ProDKin_1	642	648	PF00069	0.720
MOD_ProDKin_1	649	655	PF00069	0.622
MOD_ProDKin_1	68	74	PF00069	0.630
MOD_ProDKin_1	694	700	PF00069	0.695
MOD_ProDKin_1	708	714	PF00069	0.790
MOD_ProDKin_1	758	764	PF00069	0.709
MOD_ProDKin_1	86	92	PF00069	0.663
MOD_SUMO_for_1	871	874	PF00179	0.420
MOD_SUMO_rev_2	555	560	PF00179	0.496
MOD_SUMO_rev_2	856	866	PF00179	0.475
TRG_AP2beta_CARGO_1	216	226	PF09066	0.462
TRG_DiLeu_BaEn_1	280	285	PF01217	0.402
TRG_DiLeu_BaEn_1	555	560	PF01217	0.481
TRG_DiLeu_BaEn_4	555	561	PF01217	0.544
TRG_ENDOCYTIC_2	262	265	PF00928	0.370
TRG_ENDOCYTIC_2	294	297	PF00928	0.372
TRG_ENDOCYTIC_2	505	508	PF00928	0.606
TRG_ENDOCYTIC_2	878	881	PF00928	0.433
TRG_ER_diArg_1	124	127	PF00400	0.614
TRG_ER_diArg_1	160	162	PF00400	0.583
TRG_ER_diArg_1	197	200	PF00400	0.452
TRG_ER_diArg_1	560	562	PF00400	0.618
TRG_ER_diArg_1	564	566	PF00400	0.656
TRG_ER_diArg_1	625	628	PF00400	0.714
TRG_ER_diArg_1	688	690	PF00400	0.692
TRG_NLS_MonoExtC_3	623	629	PF00514	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I857	Leptomonas seymouri	54%	100%
A0A1X0P7F7	Trypanosomatidae	29%	100%
A4HF84	Leishmania braziliensis	72%	100%
A4I2G7	Leishmania infantum	100%	100%
E9AYM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8V2	Leishmania major	88%	100%