Lys-63-specific_deubiquitinase_BRCC36_putative/Ge neDB:LmjF.26.2430

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lys-63-specific deubiquitinase BRCC36, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X069_LEIDO

TriTrypDb:

LdBPK_262450.1 , LdCL_260030200 , LDHU3_26.3170

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X069

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X069

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.489
CLV_C14_Caspase3-7	29	33	PF00656	0.462
CLV_NRD_NRD_1	136	138	PF00675	0.199
CLV_PCSK_KEX2_1	136	138	PF00082	0.199
CLV_PCSK_KEX2_1	63	65	PF00082	0.447
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.447
CLV_PCSK_SKI1_1	108	112	PF00082	0.199
DOC_USP7_MATH_1	125	129	PF00917	0.199
LIG_14-3-3_CanoR_1	102	110	PF00244	0.199
LIG_APCC_ABBA_1	10	15	PF00400	0.466
LIG_FHA_1	105	111	PF00498	0.199
LIG_FHA_2	14	20	PF00498	0.485
LIG_SH2_STAT5	141	144	PF00017	0.199
LIG_SH2_STAT5	69	72	PF00017	0.388
LIG_SH3_3	118	124	PF00018	0.199
MOD_CK1_1	40	46	PF00069	0.464
MOD_CK1_1	89	95	PF00069	0.199
MOD_CK2_1	3	9	PF00069	0.447
MOD_CK2_1	92	98	PF00069	0.199
MOD_GlcNHglycan	42	45	PF01048	0.462
MOD_GlcNHglycan	59	62	PF01048	0.439
MOD_GlcNHglycan	87	91	PF01048	0.199
MOD_GlcNHglycan	94	97	PF01048	0.199
MOD_GSK3_1	104	111	PF00069	0.199
MOD_GSK3_1	42	49	PF00069	0.460
MOD_GSK3_1	53	60	PF00069	0.447
MOD_NEK2_1	13	18	PF00069	0.482
MOD_NEK2_1	3	8	PF00069	0.447
MOD_NEK2_1	57	62	PF00069	0.444
MOD_NMyristoyl	1	7	PF02799	0.448
MOD_PIKK_1	131	137	PF00454	0.199
MOD_PIKK_1	26	32	PF00454	0.476
MOD_PKA_2	101	107	PF00069	0.199
MOD_PKA_2	40	46	PF00069	0.464
MOD_Plk_4	108	114	PF00069	0.199
MOD_SUMO_for_1	62	65	PF00179	0.446
TRG_ER_diArg_1	136	138	PF00400	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A5PJP6	BOVIN	39%	46%
B0KWU8	CALJA	39%	46%
B2RYM5	RAT	41%	50%
B5X8M4	SALSA	36%	56%
E2AXC7	CAMFO	38%	57%
P46736	HUMAN	39%	46%
P46737	MOUSE	39%	50%
Q4VA72	XENTR	38%	56%
Q5R9L6	PONAB	39%	59%
Q66GV6	XENLA	37%	56%
Q7M757	MOUSE	35%	50%