Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X062_LEIDO

TriTrypDb:

LdBPK_262330.1 , LdCL_260029000 , LDHU3_26.3050

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X062

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X062

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.519
CLV_C14_Caspase3-7	263	267	PF00656	0.653
CLV_NRD_NRD_1	121	123	PF00675	0.445
CLV_NRD_NRD_1	129	131	PF00675	0.442
CLV_NRD_NRD_1	208	210	PF00675	0.620
CLV_NRD_NRD_1	221	223	PF00675	0.536
CLV_NRD_NRD_1	274	276	PF00675	0.595
CLV_NRD_NRD_1	37	39	PF00675	0.438
CLV_NRD_NRD_1	58	60	PF00675	0.537
CLV_NRD_NRD_1	78	80	PF00675	0.364
CLV_PCSK_FUR_1	38	42	PF00082	0.550
CLV_PCSK_KEX2_1	121	123	PF00082	0.433
CLV_PCSK_KEX2_1	129	131	PF00082	0.499
CLV_PCSK_KEX2_1	208	210	PF00082	0.607
CLV_PCSK_KEX2_1	40	42	PF00082	0.438
CLV_PCSK_KEX2_1	58	60	PF00082	0.316
CLV_PCSK_KEX2_1	78	80	PF00082	0.377
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.548
CLV_PCSK_SKI1_1	104	108	PF00082	0.467
CLV_PCSK_SKI1_1	129	133	PF00082	0.547
CLV_PCSK_SKI1_1	158	162	PF00082	0.588
CLV_PCSK_SKI1_1	208	212	PF00082	0.564
CLV_PCSK_SKI1_1	232	236	PF00082	0.577
CLV_PCSK_SKI1_1	239	243	PF00082	0.485
CLV_PCSK_SKI1_1	83	87	PF00082	0.454
CLV_Separin_Metazoa	75	79	PF03568	0.499
DEG_APCC_DBOX_1	242	250	PF00400	0.351
DOC_MAPK_DCC_7	193	202	PF00069	0.525
DOC_MAPK_gen_1	193	202	PF00069	0.525
DOC_MAPK_gen_1	222	229	PF00069	0.651
DOC_MAPK_MEF2A_6	193	202	PF00069	0.525
DOC_USP7_MATH_1	153	157	PF00917	0.702
DOC_USP7_MATH_1	169	173	PF00917	0.601
DOC_USP7_MATH_1	19	23	PF00917	0.508
DOC_USP7_MATH_1	198	202	PF00917	0.651
DOC_USP7_MATH_1	241	245	PF00917	0.426
DOC_USP7_UBL2_3	136	140	PF12436	0.606
DOC_USP7_UBL2_3	189	193	PF12436	0.523
DOC_WW_Pin1_4	161	166	PF00397	0.736
DOC_WW_Pin1_4	17	22	PF00397	0.428
DOC_WW_Pin1_4	57	62	PF00397	0.607
DOC_WW_Pin1_4	94	99	PF00397	0.564
LIG_14-3-3_CanoR_1	151	160	PF00244	0.607
LIG_14-3-3_CanoR_1	209	218	PF00244	0.645
LIG_14-3-3_CanoR_1	222	231	PF00244	0.649
LIG_14-3-3_CanoR_1	99	106	PF00244	0.502
LIG_FHA_1	105	111	PF00498	0.543
LIG_FHA_2	132	138	PF00498	0.539
LIG_FHA_2	233	239	PF00498	0.647
LIG_LIR_Apic_2	192	198	PF02991	0.526
LIG_LIR_Apic_2	216	221	PF02991	0.568
LIG_LIR_Nem_3	213	218	PF02991	0.624
LIG_PCNA_yPIPBox_3	25	39	PF02747	0.526
LIG_SH2_CRK	149	153	PF00017	0.680
LIG_SH2_CRK	18	22	PF00017	0.428
LIG_SH2_GRB2like	67	70	PF00017	0.442
LIG_SH2_NCK_1	18	22	PF00017	0.466
LIG_SH2_SRC	114	117	PF00017	0.481
LIG_SH2_SRC	147	150	PF00017	0.554
LIG_SH2_SRC	218	221	PF00017	0.604
LIG_SH2_STAP1	215	219	PF00017	0.634
LIG_SH2_STAT3	187	190	PF00017	0.514
LIG_SH2_STAT5	187	190	PF00017	0.616
LIG_SH2_STAT5	224	227	PF00017	0.550
LIG_SH2_STAT5	67	70	PF00017	0.440
LIG_SH3_3	252	258	PF00018	0.578
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.537
LIG_TRAF2_1	261	264	PF00917	0.564
LIG_TRAF2_1	46	49	PF00917	0.458
LIG_TYR_ITIM	31	36	PF00017	0.547
MOD_CDK_SPK_2	161	166	PF00069	0.780
MOD_CDK_SPK_2	94	99	PF00069	0.556
MOD_CK1_1	164	170	PF00069	0.773
MOD_CK2_1	232	238	PF00069	0.537
MOD_CK2_1	241	247	PF00069	0.517
MOD_CK2_1	99	105	PF00069	0.502
MOD_GlcNHglycan	155	158	PF01048	0.713
MOD_GlcNHglycan	166	169	PF01048	0.677
MOD_GlcNHglycan	171	174	PF01048	0.602
MOD_GlcNHglycan	55	58	PF01048	0.596
MOD_GSK3_1	100	107	PF00069	0.522
MOD_GSK3_1	160	167	PF00069	0.749
MOD_GSK3_1	19	26	PF00069	0.403
MOD_GSK3_1	237	244	PF00069	0.619
MOD_GSK3_1	53	60	PF00069	0.572
MOD_N-GLC_1	24	29	PF02516	0.514
MOD_N-GLC_2	186	188	PF02516	0.470
MOD_N-GLC_2	69	71	PF02516	0.423
MOD_NEK2_1	210	215	PF00069	0.618
MOD_NEK2_1	23	28	PF00069	0.452
MOD_NEK2_1	271	276	PF00069	0.637
MOD_PIKK_1	210	216	PF00454	0.627
MOD_PK_1	196	202	PF00069	0.534
MOD_PKA_1	142	148	PF00069	0.656
MOD_PKA_1	222	228	PF00069	0.607
MOD_PKA_2	250	256	PF00069	0.683
MOD_PKA_2	271	277	PF00069	0.609
MOD_PKB_1	230	238	PF00069	0.654
MOD_Plk_1	225	231	PF00069	0.663
MOD_Plk_1	237	243	PF00069	0.573
MOD_Plk_1	24	30	PF00069	0.520
MOD_Plk_4	142	148	PF00069	0.660
MOD_Plk_4	19	25	PF00069	0.404
MOD_ProDKin_1	161	167	PF00069	0.739
MOD_ProDKin_1	17	23	PF00069	0.421
MOD_ProDKin_1	57	63	PF00069	0.603
MOD_ProDKin_1	94	100	PF00069	0.561
MOD_SUMO_for_1	141	144	PF00179	0.640
TRG_DiLeu_BaEn_3	95	101	PF01217	0.498
TRG_DiLeu_BaEn_4	263	269	PF01217	0.417
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.657
TRG_ENDOCYTIC_2	149	152	PF00928	0.684
TRG_ENDOCYTIC_2	224	227	PF00928	0.621
TRG_ENDOCYTIC_2	33	36	PF00928	0.537
TRG_ER_diArg_1	120	122	PF00400	0.448
TRG_ER_diArg_1	128	130	PF00400	0.422
TRG_ER_diArg_1	208	210	PF00400	0.614
TRG_ER_diArg_1	229	232	PF00400	0.681
TRG_ER_diArg_1	242	245	PF00400	0.459
TRG_ER_diArg_1	77	79	PF00400	0.450
TRG_NLS_MonoExtN_4	272	279	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P3	Leptomonas seymouri	65%	100%
A0A0S4J034	Bodo saltans	27%	100%
A0A1X0P7J6	Trypanosomatidae	35%	100%
A0A3R7NVA4	Trypanosoma rangeli	32%	100%
A4HF76	Leishmania braziliensis	85%	100%
A4I2F9	Leishmania infantum	100%	100%
C9ZX38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8W0	Leishmania major	95%	100%
V5D9J1	Trypanosoma cruzi	34%	100%