Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X061_LEIDO

TriTrypDb:

LdBPK_262300.1 , LdCL_260028700 , LDHU3_26.3010

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X061

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X061

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.671
CLV_NRD_NRD_1	114	116	PF00675	0.668
CLV_NRD_NRD_1	135	137	PF00675	0.577
CLV_NRD_NRD_1	17	19	PF00675	0.723
CLV_NRD_NRD_1	339	341	PF00675	0.516
CLV_NRD_NRD_1	390	392	PF00675	0.456
CLV_NRD_NRD_1	83	85	PF00675	0.610
CLV_PCSK_FUR_1	112	116	PF00082	0.625
CLV_PCSK_KEX2_1	113	115	PF00082	0.654
CLV_PCSK_KEX2_1	135	137	PF00082	0.558
CLV_PCSK_KEX2_1	17	19	PF00082	0.668
CLV_PCSK_KEX2_1	75	77	PF00082	0.675
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.678
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.675
CLV_PCSK_SKI1_1	290	294	PF00082	0.512
CLV_PCSK_SKI1_1	349	353	PF00082	0.457
CLV_PCSK_SKI1_1	396	400	PF00082	0.517
DEG_APCC_DBOX_1	357	365	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DEG_SPOP_SBC_1	154	158	PF00917	0.658
DOC_CDC14_PxL_1	332	340	PF14671	0.452
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.696
DOC_MAPK_gen_1	112	120	PF00069	0.643
DOC_MAPK_gen_1	17	25	PF00069	0.681
DOC_MAPK_gen_1	75	83	PF00069	0.662
DOC_MAPK_MEF2A_6	247	254	PF00069	0.607
DOC_MAPK_MEF2A_6	347	354	PF00069	0.263
DOC_MAPK_NFAT4_5	347	355	PF00069	0.267
DOC_PP1_RVXF_1	360	367	PF00149	0.446
DOC_PP4_FxxP_1	223	226	PF00568	0.425
DOC_WW_Pin1_4	102	107	PF00397	0.762
DOC_WW_Pin1_4	178	183	PF00397	0.586
DOC_WW_Pin1_4	238	243	PF00397	0.419
DOC_WW_Pin1_4	308	313	PF00397	0.530
LIG_14-3-3_CanoR_1	17	26	PF00244	0.768
LIG_14-3-3_CanoR_1	396	405	PF00244	0.666
LIG_Actin_WH2_2	144	162	PF00022	0.633
LIG_Actin_WH2_2	347	364	PF00022	0.487
LIG_deltaCOP1_diTrp_1	263	269	PF00928	0.421
LIG_deltaCOP1_diTrp_1	343	348	PF00928	0.463
LIG_deltaCOP1_diTrp_1	382	390	PF00928	0.395
LIG_eIF4E_1	345	351	PF01652	0.519
LIG_FHA_1	18	24	PF00498	0.679
LIG_FHA_1	301	307	PF00498	0.407
LIG_FHA_2	225	231	PF00498	0.429
LIG_FHA_2	289	295	PF00498	0.421
LIG_HCF-1_HBM_1	198	201	PF13415	0.331
LIG_LIR_Gen_1	198	206	PF02991	0.410
LIG_LIR_Gen_1	214	223	PF02991	0.369
LIG_LIR_Gen_1	227	233	PF02991	0.404
LIG_LIR_Gen_1	382	390	PF02991	0.386
LIG_LIR_Nem_3	131	137	PF02991	0.567
LIG_LIR_Nem_3	198	204	PF02991	0.409
LIG_LIR_Nem_3	214	218	PF02991	0.378
LIG_LIR_Nem_3	311	316	PF02991	0.549
LIG_LIR_Nem_3	325	329	PF02991	0.421
LIG_LIR_Nem_3	343	348	PF02991	0.428
LIG_LIR_Nem_3	382	386	PF02991	0.413
LIG_PDZ_Class_2	400	405	PF00595	0.676
LIG_Pex14_1	344	348	PF04695	0.466
LIG_PTB_Apo_2	360	367	PF02174	0.446
LIG_Rb_LxCxE_1	77	91	PF01857	0.662
LIG_REV1ctd_RIR_1	220	225	PF16727	0.414
LIG_SH2_CRK	185	189	PF00017	0.439
LIG_SH2_CRK	201	205	PF00017	0.386
LIG_SH2_CRK	326	330	PF00017	0.507
LIG_SH2_NCK_1	185	189	PF00017	0.463
LIG_SH2_PTP2	141	144	PF00017	0.627
LIG_SH2_PTP2	286	289	PF00017	0.403
LIG_SH2_SRC	141	144	PF00017	0.621
LIG_SH2_SRC	334	337	PF00017	0.531
LIG_SH2_STAP1	185	189	PF00017	0.518
LIG_SH2_STAP1	229	233	PF00017	0.551
LIG_SH2_STAT5	141	144	PF00017	0.619
LIG_SH2_STAT5	286	289	PF00017	0.403
LIG_SH2_STAT5	334	337	PF00017	0.492
LIG_SH2_STAT5	389	392	PF00017	0.428
LIG_SH3_3	115	121	PF00018	0.606
LIG_SH3_3	148	154	PF00018	0.629
LIG_SH3_3	194	200	PF00018	0.444
LIG_SH3_3	28	34	PF00018	0.757
LIG_SH3_3	309	315	PF00018	0.512
LIG_SH3_3	330	336	PF00018	0.388
LIG_SH3_3	354	360	PF00018	0.561
LIG_SUMO_SIM_par_1	201	207	PF11976	0.398
LIG_TYR_ITIM	183	188	PF00017	0.500
MOD_CDC14_SPxK_1	311	314	PF00782	0.616
MOD_CDK_SPxK_1	308	314	PF00069	0.533
MOD_CK1_1	172	178	PF00069	0.589
MOD_CK1_1	19	25	PF00069	0.764
MOD_CK2_1	172	178	PF00069	0.568
MOD_CK2_1	224	230	PF00069	0.473
MOD_CK2_1	288	294	PF00069	0.413
MOD_CK2_1	51	57	PF00069	0.725
MOD_DYRK1A_RPxSP_1	308	312	PF00069	0.531
MOD_GlcNHglycan	170	174	PF01048	0.526
MOD_GlcNHglycan	27	30	PF01048	0.768
MOD_GlcNHglycan	308	311	PF01048	0.523
MOD_GlcNHglycan	35	38	PF01048	0.636
MOD_GlcNHglycan	400	403	PF01048	0.601
MOD_GSK3_1	47	54	PF00069	0.756
MOD_GSK3_1	8	15	PF00069	0.665
MOD_GSK3_1	98	105	PF00069	0.722
MOD_N-GLC_1	129	134	PF02516	0.606
MOD_N-GLC_1	61	66	PF02516	0.671
MOD_NEK2_1	155	160	PF00069	0.645
MOD_NEK2_1	300	305	PF00069	0.417
MOD_NEK2_1	306	311	PF00069	0.488
MOD_NEK2_1	8	13	PF00069	0.678
MOD_NEK2_1	96	101	PF00069	0.696
MOD_PIKK_1	88	94	PF00454	0.579
MOD_PIKK_1	96	102	PF00454	0.640
MOD_PK_1	61	67	PF00069	0.745
MOD_PKA_1	17	23	PF00069	0.755
MOD_PKA_2	16	22	PF00069	0.712
MOD_PKA_2	224	230	PF00069	0.473
MOD_Plk_1	129	135	PF00069	0.588
MOD_Plk_1	169	175	PF00069	0.523
MOD_Plk_1	56	62	PF00069	0.656
MOD_Plk_4	183	189	PF00069	0.448
MOD_Plk_4	328	334	PF00069	0.384
MOD_ProDKin_1	102	108	PF00069	0.760
MOD_ProDKin_1	178	184	PF00069	0.580
MOD_ProDKin_1	238	244	PF00069	0.422
MOD_ProDKin_1	308	314	PF00069	0.533
MOD_SUMO_rev_2	158	166	PF00179	0.617
MOD_SUMO_rev_2	186	195	PF00179	0.536
TRG_ENDOCYTIC_2	185	188	PF00928	0.435
TRG_ENDOCYTIC_2	201	204	PF00928	0.403
TRG_ENDOCYTIC_2	229	232	PF00928	0.551
TRG_ENDOCYTIC_2	286	289	PF00928	0.403
TRG_ENDOCYTIC_2	326	329	PF00928	0.541
TRG_ENDOCYTIC_2	345	348	PF00928	0.425
TRG_ENDOCYTIC_2	375	378	PF00928	0.411
TRG_ER_diArg_1	111	114	PF00400	0.631
TRG_ER_diArg_1	134	136	PF00400	0.564
TRG_ER_diArg_1	356	359	PF00400	0.476
TRG_NLS_MonoCore_2	111	116	PF00514	0.670
TRG_NLS_MonoExtN_4	112	117	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P2	Leptomonas seymouri	85%	100%
A0A0S4JRL5	Bodo saltans	61%	100%
A0A1X0P7G6	Trypanosomatidae	66%	100%
A4HF73	Leishmania braziliensis	86%	100%
A4I2F6	Leishmania infantum	100%	100%
C9ZX41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AYK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8W3	Leishmania major	96%	100%
V5BI14	Trypanosoma cruzi	64%	100%