FtsJ-like methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X044_LEIDO

TriTrypDb:

LdBPK_262160.1 , LdCL_260027100 , LDHU3_26.2830

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X044

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X044

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	5
GO:0032259	methylation	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0008168	methyltransferase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016741	transferase activity, transferring one-carbon groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.570
CLV_NRD_NRD_1	121	123	PF00675	0.531
CLV_NRD_NRD_1	291	293	PF00675	0.355
CLV_NRD_NRD_1	427	429	PF00675	0.622
CLV_NRD_NRD_1	43	45	PF00675	0.550
CLV_NRD_NRD_1	524	526	PF00675	0.450
CLV_NRD_NRD_1	540	542	PF00675	0.729
CLV_NRD_NRD_1	543	545	PF00675	0.718
CLV_NRD_NRD_1	64	66	PF00675	0.571
CLV_PCSK_FUR_1	289	293	PF00082	0.330
CLV_PCSK_FUR_1	522	526	PF00082	0.457
CLV_PCSK_FUR_1	541	545	PF00082	0.732
CLV_PCSK_KEX2_1	121	123	PF00082	0.487
CLV_PCSK_KEX2_1	291	293	PF00082	0.357
CLV_PCSK_KEX2_1	43	45	PF00082	0.555
CLV_PCSK_KEX2_1	524	526	PF00082	0.458
CLV_PCSK_KEX2_1	540	542	PF00082	0.635
CLV_PCSK_KEX2_1	543	545	PF00082	0.628
CLV_PCSK_KEX2_1	552	554	PF00082	0.595
CLV_PCSK_KEX2_1	64	66	PF00082	0.571
CLV_PCSK_KEX2_1	92	94	PF00082	0.726
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.648
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.726
CLV_PCSK_PC7_1	117	123	PF00082	0.515
CLV_PCSK_SKI1_1	121	125	PF00082	0.420
CLV_PCSK_SKI1_1	354	358	PF00082	0.343
CLV_PCSK_SKI1_1	478	482	PF00082	0.579
DEG_SPOP_SBC_1	450	454	PF00917	0.553
DOC_MAPK_DCC_7	149	158	PF00069	0.408
DOC_MAPK_gen_1	482	489	PF00069	0.494
DOC_MAPK_RevD_3	77	93	PF00069	0.651
DOC_PP2B_LxvP_1	348	351	PF13499	0.544
DOC_PP2B_LxvP_1	5	8	PF13499	0.776
DOC_USP7_MATH_1	246	250	PF00917	0.480
DOC_USP7_MATH_1	323	327	PF00917	0.575
DOC_USP7_MATH_1	80	84	PF00917	0.745
DOC_WW_Pin1_4	149	154	PF00397	0.487
DOC_WW_Pin1_4	328	333	PF00397	0.568
DOC_WW_Pin1_4	392	397	PF00397	0.637
DOC_WW_Pin1_4	452	457	PF00397	0.555
DOC_WW_Pin1_4	465	470	PF00397	0.680
DOC_WW_Pin1_4	6	11	PF00397	0.739
DOC_WW_Pin1_4	78	83	PF00397	0.759
LIG_14-3-3_CanoR_1	30	35	PF00244	0.533
LIG_14-3-3_CanoR_1	463	469	PF00244	0.628
LIG_14-3-3_CanoR_1	51	61	PF00244	0.552
LIG_14-3-3_CanoR_1	543	551	PF00244	0.759
LIG_14-3-3_CanoR_1	71	79	PF00244	0.413
LIG_14-3-3_CanoR_1	84	91	PF00244	0.743
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BRCT_BRCA1_1	128	132	PF00533	0.476
LIG_BRCT_BRCA1_1	38	42	PF00533	0.476
LIG_deltaCOP1_diTrp_1	511	520	PF00928	0.412
LIG_EVH1_1	7	11	PF00568	0.656
LIG_FHA_1	100	106	PF00498	0.696
LIG_FHA_1	21	27	PF00498	0.615
LIG_FHA_1	252	258	PF00498	0.530
LIG_FHA_1	407	413	PF00498	0.436
LIG_FHA_1	443	449	PF00498	0.526
LIG_FHA_1	466	472	PF00498	0.629
LIG_FHA_1	546	552	PF00498	0.759
LIG_FHA_2	12	18	PF00498	0.697
LIG_LIR_Gen_1	207	215	PF02991	0.595
LIG_LIR_Gen_1	225	234	PF02991	0.391
LIG_LIR_Gen_1	377	385	PF02991	0.439
LIG_LIR_Nem_3	174	180	PF02991	0.556
LIG_LIR_Nem_3	207	211	PF02991	0.549
LIG_LIR_Nem_3	39	45	PF02991	0.419
LIG_LIR_Nem_3	501	506	PF02991	0.511
LIG_MLH1_MIPbox_1	128	132	PF16413	0.476
LIG_PALB2_WD40_1	341	349	PF16756	0.482
LIG_REV1ctd_RIR_1	129	135	PF16727	0.545
LIG_SH2_STAT5	170	173	PF00017	0.534
LIG_SH2_STAT5	25	28	PF00017	0.513
LIG_SH2_STAT5	34	37	PF00017	0.342
LIG_SH2_STAT5	359	362	PF00017	0.562
LIG_SH2_STAT5	418	421	PF00017	0.377
LIG_SH2_STAT5	470	473	PF00017	0.517
LIG_SH3_3	147	153	PF00018	0.593
LIG_SH3_3	212	218	PF00018	0.534
LIG_SH3_3	338	344	PF00018	0.498
LIG_SH3_3	386	392	PF00018	0.371
LIG_SH3_3	421	427	PF00018	0.575
LIG_SH3_3	5	11	PF00018	0.697
LIG_SH3_3	76	82	PF00018	0.756
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.528
LIG_WW_3	425	429	PF00397	0.643
MOD_CDC14_SPxK_1	81	84	PF00782	0.721
MOD_CDK_SPK_2	452	457	PF00069	0.555
MOD_CDK_SPxK_1	78	84	PF00069	0.762
MOD_CK1_1	140	146	PF00069	0.707
MOD_CK1_1	201	207	PF00069	0.512
MOD_CK1_1	235	241	PF00069	0.593
MOD_CK1_1	330	336	PF00069	0.548
MOD_CK1_1	452	458	PF00069	0.599
MOD_CK2_1	11	17	PF00069	0.748
MOD_CK2_1	82	88	PF00069	0.764
MOD_GlcNHglycan	1	4	PF01048	0.722
MOD_GlcNHglycan	128	131	PF01048	0.497
MOD_GlcNHglycan	20	23	PF01048	0.571
MOD_GlcNHglycan	203	206	PF01048	0.389
MOD_GlcNHglycan	224	227	PF01048	0.362
MOD_GlcNHglycan	249	252	PF01048	0.345
MOD_GlcNHglycan	260	263	PF01048	0.246
MOD_GlcNHglycan	268	271	PF01048	0.174
MOD_GlcNHglycan	301	304	PF01048	0.342
MOD_GlcNHglycan	314	317	PF01048	0.377
MOD_GlcNHglycan	397	400	PF01048	0.655
MOD_GlcNHglycan	533	536	PF01048	0.654
MOD_GlcNHglycan	55	58	PF01048	0.519
MOD_GlcNHglycan	72	75	PF01048	0.711
MOD_GlcNHglycan	84	87	PF01048	0.653
MOD_GSK3_1	137	144	PF00069	0.704
MOD_GSK3_1	20	27	PF00069	0.586
MOD_GSK3_1	213	220	PF00069	0.562
MOD_GSK3_1	247	254	PF00069	0.561
MOD_GSK3_1	260	267	PF00069	0.446
MOD_GSK3_1	323	330	PF00069	0.555
MOD_GSK3_1	355	362	PF00069	0.586
MOD_GSK3_1	461	468	PF00069	0.655
MOD_GSK3_1	66	73	PF00069	0.633
MOD_GSK3_1	78	85	PF00069	0.649
MOD_LATS_1	119	125	PF00433	0.511
MOD_N-GLC_1	138	143	PF02516	0.641
MOD_N-GLC_1	222	227	PF02516	0.341
MOD_NEK2_1	198	203	PF00069	0.519
MOD_NEK2_1	24	29	PF00069	0.560
MOD_NEK2_1	260	265	PF00069	0.531
MOD_NEK2_1	312	317	PF00069	0.593
MOD_NEK2_1	327	332	PF00069	0.490
MOD_NEK2_1	36	41	PF00069	0.381
MOD_NEK2_1	419	424	PF00069	0.441
MOD_NEK2_1	451	456	PF00069	0.546
MOD_NEK2_1	461	466	PF00069	0.635
MOD_PIKK_1	121	127	PF00454	0.528
MOD_PIKK_1	213	219	PF00454	0.562
MOD_PIKK_1	92	98	PF00454	0.726
MOD_PKA_1	121	127	PF00069	0.528
MOD_PKA_1	92	98	PF00069	0.715
MOD_PKA_2	121	127	PF00069	0.531
MOD_PKA_2	246	252	PF00069	0.433
MOD_PKA_2	462	468	PF00069	0.658
MOD_PKA_2	53	59	PF00069	0.537
MOD_PKA_2	70	76	PF00069	0.518
MOD_PKA_2	92	98	PF00069	0.649
MOD_Plk_1	107	113	PF00069	0.504
MOD_Plk_1	296	302	PF00069	0.502
MOD_Plk_1	323	329	PF00069	0.433
MOD_Plk_1	36	42	PF00069	0.482
MOD_Plk_4	107	113	PF00069	0.555
MOD_Plk_4	20	26	PF00069	0.655
MOD_Plk_4	204	210	PF00069	0.534
MOD_Plk_4	260	266	PF00069	0.580
MOD_Plk_4	296	302	PF00069	0.429
MOD_Plk_4	355	361	PF00069	0.593
MOD_Plk_4	36	42	PF00069	0.413
MOD_Plk_4	374	380	PF00069	0.393
MOD_ProDKin_1	149	155	PF00069	0.473
MOD_ProDKin_1	328	334	PF00069	0.568
MOD_ProDKin_1	392	398	PF00069	0.634
MOD_ProDKin_1	452	458	PF00069	0.553
MOD_ProDKin_1	465	471	PF00069	0.676
MOD_ProDKin_1	6	12	PF00069	0.738
MOD_ProDKin_1	78	84	PF00069	0.762
MOD_SUMO_rev_2	141	151	PF00179	0.615
TRG_DiLeu_BaEn_1	296	301	PF01217	0.377
TRG_DiLeu_LyEn_5	192	197	PF01217	0.530
TRG_ENDOCYTIC_2	228	231	PF00928	0.488
TRG_ENDOCYTIC_2	506	509	PF00928	0.512
TRG_ER_diArg_1	121	123	PF00400	0.531
TRG_ER_diArg_1	289	292	PF00400	0.560
TRG_ER_diArg_1	401	404	PF00400	0.621
TRG_ER_diArg_1	42	44	PF00400	0.565
TRG_ER_diArg_1	521	524	PF00400	0.453
TRG_ER_diArg_1	539	541	PF00400	0.591
TRG_NLS_Bipartite_1	540	556	PF00514	0.679
TRG_NLS_MonoExtC_3	551	557	PF00514	0.722
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL5	Leptomonas seymouri	47%	97%
A0A1X0P8D1	Trypanosomatidae	31%	100%
A0A422N0J7	Trypanosoma rangeli	34%	100%
A4HF59	Leishmania braziliensis	75%	100%
A4I2E3	Leishmania infantum	99%	100%
C9ZX64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8X7	Leishmania major	91%	100%
V5BJ25	Trypanosoma cruzi	32%	100%