Methyltransferase_domain_containing_protein_putat ive/Pfam:PF13489/Pfam:PF13649/Pfam:PF08242/Pfam:PF12847

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X035_LEIDO

TriTrypDb:

LdBPK_262000.1 , LdCL_260025600 , LDHU3_26.2630

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S7X035

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X035

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.538
CLV_NRD_NRD_1	23	25	PF00675	0.544
CLV_NRD_NRD_1	297	299	PF00675	0.516
CLV_NRD_NRD_1	347	349	PF00675	0.581
CLV_PCSK_KEX2_1	125	127	PF00082	0.512
CLV_PCSK_KEX2_1	191	193	PF00082	0.543
CLV_PCSK_KEX2_1	347	349	PF00082	0.594
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.532
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.543
CLV_PCSK_SKI1_1	176	180	PF00082	0.513
CLV_PCSK_SKI1_1	310	314	PF00082	0.536
CLV_Separin_Metazoa	195	199	PF03568	0.353
DEG_Nend_UBRbox_3	1	3	PF02207	0.783
DOC_MAPK_gen_1	125	133	PF00069	0.314
DOC_MAPK_gen_1	24	32	PF00069	0.553
DOC_PP2B_LxvP_1	194	197	PF13499	0.362
DOC_USP7_MATH_1	62	66	PF00917	0.548
DOC_WW_Pin1_4	87	92	PF00397	0.392
LIG_14-3-3_CanoR_1	261	267	PF00244	0.330
LIG_14-3-3_CanoR_1	7	15	PF00244	0.722
LIG_14-3-3_CanoR_1	99	104	PF00244	0.408
LIG_APCC_ABBA_1	213	218	PF00400	0.334
LIG_BRCT_BRCA1_1	144	148	PF00533	0.279
LIG_BRCT_BRCA1_1	157	161	PF00533	0.251
LIG_FHA_1	179	185	PF00498	0.336
LIG_FHA_1	224	230	PF00498	0.330
LIG_FHA_1	31	37	PF00498	0.403
LIG_FHA_1	95	101	PF00498	0.474
LIG_FHA_2	61	67	PF00498	0.505
LIG_LIR_Apic_2	104	110	PF02991	0.351
LIG_LIR_Apic_2	119	123	PF02991	0.280
LIG_LIR_Apic_2	179	183	PF02991	0.311
LIG_LIR_Gen_1	156	165	PF02991	0.311
LIG_LIR_Nem_3	156	160	PF02991	0.313
LIG_LIR_Nem_3	227	233	PF02991	0.286
LIG_LIR_Nem_3	242	247	PF02991	0.245
LIG_LYPXL_S_1	229	233	PF13949	0.586
LIG_LYPXL_yS_3	230	233	PF13949	0.362
LIG_PCNA_yPIPBox_3	255	267	PF02747	0.330
LIG_Pex14_2	157	161	PF04695	0.362
LIG_SH2_CRK	107	111	PF00017	0.448
LIG_SH2_CRK	180	184	PF00017	0.362
LIG_SH2_CRK	27	31	PF00017	0.447
LIG_SH2_PTP2	120	123	PF00017	0.233
LIG_SH2_STAP1	75	79	PF00017	0.408
LIG_SH2_STAP1	96	100	PF00017	0.428
LIG_SH2_STAT5	120	123	PF00017	0.326
LIG_SH2_STAT5	180	183	PF00017	0.334
LIG_SH2_STAT5	89	92	PF00017	0.369
LIG_SH2_STAT5	96	99	PF00017	0.387
LIG_SH3_3	166	172	PF00018	0.330
LIG_SH3_3	253	259	PF00018	0.282
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.333
LIG_SUMO_SIM_par_1	273	280	PF11976	0.278
MOD_CDK_SPxK_1	87	93	PF00069	0.349
MOD_CK1_1	220	226	PF00069	0.261
MOD_CK1_1	341	347	PF00069	0.309
MOD_CK1_1	69	75	PF00069	0.494
MOD_CK1_1	92	98	PF00069	0.423
MOD_CK2_1	137	143	PF00069	0.294
MOD_CK2_1	280	286	PF00069	0.296
MOD_CK2_1	60	66	PF00069	0.506
MOD_CK2_1	99	105	PF00069	0.406
MOD_Cter_Amidation	123	126	PF01082	0.558
MOD_Cter_Amidation	174	177	PF01082	0.586
MOD_Cter_Amidation	296	299	PF01082	0.516
MOD_GlcNHglycan	173	176	PF01048	0.546
MOD_GlcNHglycan	37	40	PF01048	0.385
MOD_GSK3_1	13	20	PF00069	0.716
MOD_GSK3_1	217	224	PF00069	0.358
MOD_GSK3_1	60	67	PF00069	0.546
MOD_N-GLC_1	320	325	PF02516	0.560
MOD_NEK2_1	142	147	PF00069	0.282
MOD_NEK2_1	262	267	PF00069	0.320
MOD_NEK2_1	338	343	PF00069	0.323
MOD_PIKK_1	94	100	PF00454	0.494
MOD_PK_1	99	105	PF00069	0.490
MOD_PKA_1	176	182	PF00069	0.346
MOD_PKA_2	6	12	PF00069	0.698
MOD_PKA_2	92	98	PF00069	0.348
MOD_PKB_1	99	107	PF00069	0.391
MOD_Plk_1	289	295	PF00069	0.358
MOD_Plk_2-3	280	286	PF00069	0.362
MOD_Plk_4	137	143	PF00069	0.295
MOD_Plk_4	262	268	PF00069	0.384
MOD_Plk_4	280	286	PF00069	0.233
MOD_Plk_4	341	347	PF00069	0.295
MOD_ProDKin_1	87	93	PF00069	0.396
MOD_SUMO_rev_2	217	223	PF00179	0.367
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.307
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.282
TRG_ENDOCYTIC_2	230	233	PF00928	0.287
TRG_ENDOCYTIC_2	27	30	PF00928	0.413
TRG_ENDOCYTIC_2	84	87	PF00928	0.368
TRG_ER_diArg_1	346	348	PF00400	0.338
TRG_NLS_MonoExtC_3	124	129	PF00514	0.302
TRG_NLS_MonoExtN_4	123	130	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D1	Leptomonas seymouri	71%	100%
A0A1X0P7E4	Trypanosomatidae	51%	96%
A0A422N3J7	Trypanosoma rangeli	55%	100%
A4HF44	Leishmania braziliensis	83%	100%
A4I2C8	Leishmania infantum	100%	100%
C9ZX82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	95%
E9AYI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8Z2	Leishmania major	95%	99%
V5AUM3	Trypanosoma cruzi	54%	85%