TLC_domain_containing_protein_putative/Pfam:PF037 98

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLC domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X033_LEIDO

TriTrypDb:

LdCL_260024800 , LDHU3_26.2510

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X033

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X033

Function

Biological processes
Term	Name	Level	Count
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	271	273	PF00082	0.405
CLV_PCSK_KEX2_1	303	305	PF00082	0.541
CLV_PCSK_KEX2_1	47	49	PF00082	0.379
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.442
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.565
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.394
CLV_PCSK_SKI1_1	47	51	PF00082	0.427
DOC_CKS1_1	10	15	PF01111	0.427
DOC_MAPK_MEF2A_6	241	250	PF00069	0.320
DOC_USP7_MATH_1	225	229	PF00917	0.273
DOC_USP7_MATH_1	294	298	PF00917	0.712
DOC_USP7_UBL2_3	298	302	PF12436	0.714
DOC_WW_Pin1_4	236	241	PF00397	0.290
DOC_WW_Pin1_4	9	14	PF00397	0.376
LIG_14-3-3_CanoR_1	103	112	PF00244	0.443
LIG_14-3-3_CanoR_1	179	185	PF00244	0.560
LIG_APCC_ABBA_1	141	146	PF00400	0.556
LIG_BRCT_BRCA1_1	106	110	PF00533	0.443
LIG_BRCT_BRCA1_1	158	162	PF00533	0.515
LIG_CaM_NSCaTE_8	218	225	PF13499	0.306
LIG_FHA_1	237	243	PF00498	0.334
LIG_FHA_1	34	40	PF00498	0.494
LIG_FHA_2	191	197	PF00498	0.531
LIG_LIR_Apic_2	8	13	PF02991	0.321
LIG_LIR_Gen_1	113	123	PF02991	0.428
LIG_LIR_Gen_1	137	144	PF02991	0.524
LIG_LIR_Gen_1	180	188	PF02991	0.548
LIG_LIR_Gen_1	217	225	PF02991	0.201
LIG_LIR_Gen_1	91	101	PF02991	0.352
LIG_LIR_Nem_3	113	118	PF02991	0.384
LIG_LIR_Nem_3	137	141	PF02991	0.495
LIG_LIR_Nem_3	145	151	PF02991	0.446
LIG_LIR_Nem_3	180	185	PF02991	0.548
LIG_LIR_Nem_3	196	202	PF02991	0.492
LIG_LIR_Nem_3	217	223	PF02991	0.254
LIG_LIR_Nem_3	91	96	PF02991	0.292
LIG_MLH1_MIPbox_1	106	110	PF16413	0.443
LIG_Pex14_2	118	122	PF04695	0.359
LIG_Pex14_2	266	270	PF04695	0.568
LIG_SH2_CRK	138	142	PF00017	0.531
LIG_SH2_CRK	203	207	PF00017	0.462
LIG_SH2_CRK	220	224	PF00017	0.214
LIG_SH2_CRK	93	97	PF00017	0.373
LIG_SH2_GRB2like	119	122	PF00017	0.573
LIG_SH2_NCK_1	93	97	PF00017	0.331
LIG_SH2_STAP1	138	142	PF00017	0.470
LIG_SH2_STAP1	7	11	PF00017	0.350
LIG_SH2_STAT5	109	112	PF00017	0.313
LIG_SH2_STAT5	138	141	PF00017	0.449
LIG_SH2_STAT5	152	155	PF00017	0.470
LIG_SH2_STAT5	197	200	PF00017	0.443
LIG_SH2_STAT5	213	216	PF00017	0.428
LIG_SH2_STAT5	238	241	PF00017	0.290
LIG_SH2_STAT5	263	266	PF00017	0.308
LIG_SH2_STAT5	33	36	PF00017	0.437
LIG_SUMO_SIM_par_1	251	256	PF11976	0.304
LIG_WRC_WIRS_1	131	136	PF05994	0.495
MOD_CDK_SPK_2	236	241	PF00069	0.290
MOD_CDK_SPxxK_3	9	16	PF00069	0.417
MOD_CK1_1	102	108	PF00069	0.303
MOD_CK2_1	180	186	PF00069	0.543
MOD_CK2_1	190	196	PF00069	0.522
MOD_Cter_Amidation	300	303	PF01082	0.485
MOD_GlcNHglycan	106	109	PF01048	0.443
MOD_GlcNHglycan	172	175	PF01048	0.359
MOD_GlcNHglycan	223	226	PF01048	0.486
MOD_GlcNHglycan	288	291	PF01048	0.486
MOD_GlcNHglycan	4	7	PF01048	0.636
MOD_GlcNHglycan	72	75	PF01048	0.388
MOD_GSK3_1	130	137	PF00069	0.492
MOD_GSK3_1	180	187	PF00069	0.517
MOD_GSK3_1	2	9	PF00069	0.421
MOD_GSK3_1	221	228	PF00069	0.359
MOD_N-GLC_2	66	68	PF02516	0.466
MOD_NEK2_1	134	139	PF00069	0.531
MOD_NEK2_1	156	161	PF00069	0.454
MOD_NEK2_1	163	168	PF00069	0.479
MOD_NEK2_1	209	214	PF00069	0.305
MOD_NEK2_1	253	258	PF00069	0.431
MOD_NEK2_1	27	32	PF00069	0.344
MOD_NEK2_1	70	75	PF00069	0.341
MOD_NEK2_1	92	97	PF00069	0.378
MOD_PIKK_1	177	183	PF00454	0.573
MOD_PK_1	60	66	PF00069	0.481
MOD_PKA_1	47	53	PF00069	0.614
MOD_PKA_2	47	53	PF00069	0.614
MOD_PKA_2	99	105	PF00069	0.333
MOD_Plk_4	130	136	PF00069	0.476
MOD_Plk_4	163	169	PF00069	0.552
MOD_Plk_4	209	215	PF00069	0.298
MOD_Plk_4	253	259	PF00069	0.428
MOD_Plk_4	6	12	PF00069	0.381
MOD_ProDKin_1	236	242	PF00069	0.290
MOD_ProDKin_1	9	15	PF00069	0.379
MOD_SUMO_rev_2	282	287	PF00179	0.739
TRG_ENDOCYTIC_2	138	141	PF00928	0.545
TRG_ENDOCYTIC_2	203	206	PF00928	0.421
TRG_ENDOCYTIC_2	220	223	PF00928	0.212
TRG_ENDOCYTIC_2	263	266	PF00928	0.322
TRG_ENDOCYTIC_2	93	96	PF00928	0.270
TRG_ENDOCYTIC_2	98	101	PF00928	0.310
TRG_ER_diLys_1	302	305	PF00400	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH5	Leptomonas seymouri	65%	100%
A0A0S4IR24	Bodo saltans	33%	98%
A0A1X0P7L3	Trypanosomatidae	39%	100%
A0A422NQS0	Trypanosoma rangeli	40%	100%
A4HF37	Leishmania braziliensis	77%	100%
C9ZX92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AYH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4Q900	Leishmania major	94%	100%
V5DB81	Trypanosoma cruzi	38%	100%