Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X011_LEIDO

TriTrypDb:

LdBPK_261990.1 , LdCL_260025500 , LDHU3_26.2620

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X011

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X011

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.707
CLV_C14_Caspase3-7	20	24	PF00656	0.604
CLV_NRD_NRD_1	12	14	PF00675	0.747
CLV_NRD_NRD_1	142	144	PF00675	0.694
CLV_NRD_NRD_1	168	170	PF00675	0.640
CLV_NRD_NRD_1	212	214	PF00675	0.661
CLV_PCSK_KEX2_1	142	144	PF00082	0.734
CLV_PCSK_KEX2_1	168	170	PF00082	0.640
CLV_PCSK_KEX2_1	212	214	PF00082	0.661
CLV_PCSK_KEX2_1	67	69	PF00082	0.606
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.606
CLV_PCSK_PC7_1	138	144	PF00082	0.724
CLV_PCSK_SKI1_1	146	150	PF00082	0.698
DOC_CKS1_1	96	101	PF01111	0.655
DOC_MAPK_gen_1	210	220	PF00069	0.744
DOC_MAPK_MEF2A_6	213	222	PF00069	0.737
DOC_PP1_RVXF_1	89	96	PF00149	0.791
DOC_SPAK_OSR1_1	94	98	PF12202	0.643
DOC_USP7_MATH_1	17	21	PF00917	0.728
DOC_WW_Pin1_4	167	172	PF00397	0.767
DOC_WW_Pin1_4	95	100	PF00397	0.668
LIG_14-3-3_CanoR_1	212	220	PF00244	0.686
LIG_BRCT_BRCA1_1	215	219	PF00533	0.670
LIG_BRCT_BRCA1_1	51	55	PF00533	0.635
LIG_FHA_1	213	219	PF00498	0.654
LIG_FHA_1	48	54	PF00498	0.714
LIG_FHA_2	98	104	PF00498	0.646
LIG_LIR_Apic_2	59	63	PF02991	0.691
LIG_LIR_Gen_1	125	135	PF02991	0.741
LIG_LIR_Gen_1	216	226	PF02991	0.676
LIG_LIR_Nem_3	125	131	PF02991	0.629
LIG_LIR_Nem_3	216	222	PF02991	0.683
LIG_OCRL_FandH_1	105	117	PF00620	0.658
LIG_PDZ_Class_2	221	226	PF00595	0.652
LIG_PTB_Apo_2	89	96	PF02174	0.674
LIG_REV1ctd_RIR_1	175	184	PF16727	0.704
LIG_SH2_STAP1	203	207	PF00017	0.689
LIG_SH2_STAT3	203	206	PF00017	0.766
LIG_SH3_2	144	149	PF14604	0.718
LIG_SH3_3	141	147	PF00018	0.758
MOD_CK1_1	126	132	PF00069	0.521
MOD_CK1_1	4	10	PF00069	0.714
MOD_GlcNHglycan	215	218	PF01048	0.695
MOD_GlcNHglycan	23	26	PF01048	0.647
MOD_GSK3_1	122	129	PF00069	0.662
MOD_GSK3_1	163	170	PF00069	0.729
MOD_GSK3_1	17	24	PF00069	0.548
MOD_GSK3_1	9	16	PF00069	0.754
MOD_N-GLC_1	173	178	PF02516	0.712
MOD_NEK2_1	122	127	PF00069	0.713
MOD_NEK2_1	163	168	PF00069	0.714
MOD_NEK2_1	211	216	PF00069	0.618
MOD_NEK2_1	218	223	PF00069	0.618
MOD_NEK2_1	46	51	PF00069	0.666
MOD_NEK2_2	104	109	PF00069	0.735
MOD_PIKK_1	62	68	PF00454	0.667
MOD_PKA_1	13	19	PF00069	0.698
MOD_PKA_1	212	218	PF00069	0.655
MOD_PKA_2	17	23	PF00069	0.659
MOD_PKA_2	211	217	PF00069	0.654
MOD_Plk_1	173	179	PF00069	0.708
MOD_Plk_4	173	179	PF00069	0.762
MOD_ProDKin_1	167	173	PF00069	0.767
MOD_ProDKin_1	95	101	PF00069	0.665
MOD_SUMO_rev_2	204	211	PF00179	0.729
TRG_ER_diArg_1	141	143	PF00400	0.742
TRG_ER_diArg_1	211	213	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.758
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW3	Leptomonas seymouri	62%	100%
A0A1X0P7C9	Trypanosomatidae	42%	100%
A4HF43	Leishmania braziliensis	74%	100%
A4I2C7	Leishmania infantum	100%	100%
E9AYH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8Z3	Leishmania major	96%	100%
V5BJ41	Trypanosoma cruzi	40%	100%