Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X009_LEIDO

TriTrypDb:

LdBPK_261960.1 , LdCL_260025200 , LDHU3_26.2570

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7X009

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X009

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008569	minus-end-directed microtubule motor activity	3	1
GO:0045505	dynein intermediate chain binding	3	1
GO:0051959	dynein light intermediate chain binding	3	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.449
CLV_C14_Caspase3-7	368	372	PF00656	0.506
CLV_NRD_NRD_1	156	158	PF00675	0.465
CLV_NRD_NRD_1	170	172	PF00675	0.464
CLV_NRD_NRD_1	229	231	PF00675	0.384
CLV_NRD_NRD_1	251	253	PF00675	0.608
CLV_NRD_NRD_1	433	435	PF00675	0.579
CLV_NRD_NRD_1	478	480	PF00675	0.412
CLV_NRD_NRD_1	662	664	PF00675	0.531
CLV_NRD_NRD_1	781	783	PF00675	0.653
CLV_PCSK_FUR_1	229	233	PF00082	0.459
CLV_PCSK_KEX2_1	156	158	PF00082	0.466
CLV_PCSK_KEX2_1	229	231	PF00082	0.455
CLV_PCSK_KEX2_1	249	251	PF00082	0.630
CLV_PCSK_KEX2_1	366	368	PF00082	0.511
CLV_PCSK_KEX2_1	478	480	PF00082	0.412
CLV_PCSK_KEX2_1	505	507	PF00082	0.538
CLV_PCSK_KEX2_1	781	783	PF00082	0.735
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.421
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.693
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.549
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.611
CLV_PCSK_SKI1_1	106	110	PF00082	0.543
CLV_PCSK_SKI1_1	121	125	PF00082	0.463
CLV_PCSK_SKI1_1	315	319	PF00082	0.565
CLV_PCSK_SKI1_1	498	502	PF00082	0.549
CLV_PCSK_SKI1_1	635	639	PF00082	0.510
CLV_PCSK_SKI1_1	663	667	PF00082	0.518
CLV_Separin_Metazoa	410	414	PF03568	0.362
DEG_APCC_DBOX_1	155	163	PF00400	0.523
DEG_APCC_DBOX_1	314	322	PF00400	0.561
DOC_CDC14_PxL_1	666	674	PF14671	0.542
DOC_CYCLIN_yCln2_LP_2	547	553	PF00134	0.402
DOC_MAPK_gen_1	156	164	PF00069	0.580
DOC_MAPK_gen_1	229	236	PF00069	0.422
DOC_MAPK_gen_1	495	504	PF00069	0.520
DOC_MAPK_gen_1	663	669	PF00069	0.497
DOC_MAPK_MEF2A_6	319	328	PF00069	0.603
DOC_MAPK_MEF2A_6	495	504	PF00069	0.593
DOC_PP1_RVXF_1	212	219	PF00149	0.511
DOC_PP1_RVXF_1	597	603	PF00149	0.460
DOC_PP2B_LxvP_1	547	550	PF13499	0.363
DOC_PP4_FxxP_1	623	626	PF00568	0.443
DOC_USP7_MATH_1	114	118	PF00917	0.612
DOC_USP7_MATH_1	20	24	PF00917	0.686
DOC_USP7_MATH_1	267	271	PF00917	0.624
DOC_USP7_MATH_1	415	419	PF00917	0.467
DOC_USP7_MATH_1	772	776	PF00917	0.780
DOC_USP7_UBL2_3	599	603	PF12436	0.451
DOC_USP7_UBL2_3	93	97	PF12436	0.370
DOC_WW_Pin1_4	18	23	PF00397	0.629
DOC_WW_Pin1_4	220	225	PF00397	0.472
DOC_WW_Pin1_4	256	261	PF00397	0.624
DOC_WW_Pin1_4	43	48	PF00397	0.602
DOC_WW_Pin1_4	603	608	PF00397	0.476
LIG_14-3-3_CanoR_1	214	219	PF00244	0.431
LIG_14-3-3_CanoR_1	325	331	PF00244	0.583
LIG_14-3-3_CanoR_1	453	459	PF00244	0.537
LIG_14-3-3_CanoR_1	479	485	PF00244	0.526
LIG_Actin_WH2_2	145	162	PF00022	0.514
LIG_APCC_ABBA_1	189	194	PF00400	0.496
LIG_APCC_ABBA_1	593	598	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BIR_III_2	356	360	PF00653	0.634
LIG_BIR_III_4	397	401	PF00653	0.497
LIG_CtBP_PxDLS_1	224	228	PF00389	0.479
LIG_FHA_1	122	128	PF00498	0.530
LIG_FHA_1	144	150	PF00498	0.568
LIG_FHA_1	358	364	PF00498	0.486
LIG_FHA_1	499	505	PF00498	0.585
LIG_FHA_1	603	609	PF00498	0.433
LIG_FHA_1	62	68	PF00498	0.582
LIG_FHA_2	195	201	PF00498	0.487
LIG_FHA_2	405	411	PF00498	0.374
LIG_FHA_2	457	463	PF00498	0.444
LIG_FHA_2	645	651	PF00498	0.589
LIG_LIR_Apic_2	620	626	PF02991	0.430
LIG_LIR_Gen_1	166	175	PF02991	0.530
LIG_LIR_Gen_1	3	14	PF02991	0.682
LIG_LIR_Gen_1	329	338	PF02991	0.479
LIG_LIR_Gen_1	399	409	PF02991	0.482
LIG_LIR_Gen_1	508	518	PF02991	0.409
LIG_LIR_Gen_1	519	529	PF02991	0.433
LIG_LIR_Gen_1	674	684	PF02991	0.596
LIG_LIR_LC3C_4	261	266	PF02991	0.576
LIG_LIR_Nem_3	166	170	PF02991	0.429
LIG_LIR_Nem_3	197	202	PF02991	0.466
LIG_LIR_Nem_3	3	9	PF02991	0.609
LIG_LIR_Nem_3	329	333	PF02991	0.492
LIG_LIR_Nem_3	38	42	PF02991	0.377
LIG_LIR_Nem_3	399	404	PF02991	0.485
LIG_LIR_Nem_3	508	514	PF02991	0.411
LIG_LIR_Nem_3	519	525	PF02991	0.357
LIG_LIR_Nem_3	674	679	PF02991	0.575
LIG_NRBOX	468	474	PF00104	0.491
LIG_PTB_Apo_2	302	309	PF02174	0.548
LIG_PTB_Apo_2	584	591	PF02174	0.291
LIG_SH2_CRK	511	515	PF00017	0.502
LIG_SH2_GRB2like	641	644	PF00017	0.605
LIG_SH2_NCK_1	597	601	PF00017	0.408
LIG_SH2_NCK_1	676	680	PF00017	0.620
LIG_SH2_PTP2	401	404	PF00017	0.472
LIG_SH2_SRC	192	195	PF00017	0.471
LIG_SH2_SRC	676	679	PF00017	0.649
LIG_SH2_STAP1	192	196	PF00017	0.526
LIG_SH2_STAP1	676	680	PF00017	0.498
LIG_SH2_STAT5	401	404	PF00017	0.452
LIG_SH2_STAT5	511	514	PF00017	0.467
LIG_SH2_STAT5	553	556	PF00017	0.522
LIG_SH3_3	142	148	PF00018	0.302
LIG_SH3_3	257	263	PF00018	0.589
LIG_SH3_3	348	354	PF00018	0.723
LIG_SH3_3	678	684	PF00018	0.707
LIG_SH3_3	766	772	PF00018	0.720
LIG_SH3_3	777	783	PF00018	0.568
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.465
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.430
LIG_SUMO_SIM_anti_2	407	414	PF11976	0.351
LIG_SUMO_SIM_par_1	186	195	PF11976	0.354
LIG_SUMO_SIM_par_1	552	558	PF11976	0.514
LIG_SUMO_SIM_par_1	57	64	PF11976	0.445
LIG_TRAF2_1	459	462	PF00917	0.542
LIG_UBA3_1	335	339	PF00899	0.528
LIG_UBA3_1	342	350	PF00899	0.618
MOD_CDC14_SPxK_1	46	49	PF00782	0.609
MOD_CDK_SPxK_1	43	49	PF00069	0.585
MOD_CK1_1	2	8	PF00069	0.752
MOD_CK1_1	270	276	PF00069	0.516
MOD_CK1_1	294	300	PF00069	0.488
MOD_CK1_1	794	800	PF00069	0.706
MOD_CK2_1	114	120	PF00069	0.558
MOD_CK2_1	194	200	PF00069	0.490
MOD_CK2_1	2	8	PF00069	0.682
MOD_CK2_1	289	295	PF00069	0.516
MOD_CK2_1	326	332	PF00069	0.523
MOD_CK2_1	404	410	PF00069	0.419
MOD_CK2_1	456	462	PF00069	0.503
MOD_CK2_1	524	530	PF00069	0.574
MOD_CK2_1	644	650	PF00069	0.577
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.581
MOD_GlcNHglycan	116	119	PF01048	0.604
MOD_GlcNHglycan	176	179	PF01048	0.533
MOD_GlcNHglycan	23	26	PF01048	0.698
MOD_GlcNHglycan	252	255	PF01048	0.718
MOD_GlcNHglycan	417	420	PF01048	0.457
MOD_GlcNHglycan	518	521	PF01048	0.411
MOD_GlcNHglycan	572	575	PF01048	0.539
MOD_GlcNHglycan	590	593	PF01048	0.452
MOD_GlcNHglycan	629	632	PF01048	0.632
MOD_GlcNHglycan	696	699	PF01048	0.687
MOD_GlcNHglycan	716	722	PF01048	0.697
MOD_GlcNHglycan	742	745	PF01048	0.703
MOD_GlcNHglycan	774	777	PF01048	0.792
MOD_GSK3_1	14	21	PF00069	0.599
MOD_GSK3_1	170	177	PF00069	0.567
MOD_GSK3_1	214	221	PF00069	0.459
MOD_GSK3_1	250	257	PF00069	0.667
MOD_GSK3_1	267	274	PF00069	0.561
MOD_GSK3_1	566	573	PF00069	0.479
MOD_GSK3_1	598	605	PF00069	0.398
MOD_GSK3_1	700	707	PF00069	0.674
MOD_GSK3_1	717	724	PF00069	0.728
MOD_GSK3_1	740	747	PF00069	0.710
MOD_GSK3_1	750	757	PF00069	0.614
MOD_GSK3_1	785	792	PF00069	0.670
MOD_GSK3_1	793	800	PF00069	0.588
MOD_N-GLC_1	271	276	PF02516	0.543
MOD_N-GLC_1	608	613	PF02516	0.493
MOD_N-GLC_1	75	80	PF02516	0.633
MOD_N-GLC_1	754	759	PF02516	0.756
MOD_N-GLC_2	305	307	PF02516	0.557
MOD_N-GLC_2	587	589	PF02516	0.312
MOD_NEK2_1	170	175	PF00069	0.581
MOD_NEK2_1	225	230	PF00069	0.479
MOD_NEK2_1	279	284	PF00069	0.393
MOD_NEK2_1	509	514	PF00069	0.450
MOD_NEK2_1	602	607	PF00069	0.485
MOD_NEK2_1	608	613	PF00069	0.458
MOD_NEK2_1	705	710	PF00069	0.739
MOD_NEK2_1	730	735	PF00069	0.645
MOD_NEK2_1	740	745	PF00069	0.785
MOD_NEK2_2	359	364	PF00069	0.566
MOD_PIKK_1	121	127	PF00454	0.563
MOD_PIKK_1	404	410	PF00454	0.519
MOD_PIKK_1	608	614	PF00454	0.468
MOD_PIKK_1	721	727	PF00454	0.640
MOD_PIKK_1	78	84	PF00454	0.714
MOD_PKA_1	250	256	PF00069	0.648
MOD_PKA_2	170	176	PF00069	0.515
MOD_PKA_2	250	256	PF00069	0.624
MOD_PKA_2	516	522	PF00069	0.533
MOD_PKB_1	256	264	PF00069	0.680
MOD_Plk_1	131	137	PF00069	0.514
MOD_Plk_1	165	171	PF00069	0.491
MOD_Plk_1	192	198	PF00069	0.540
MOD_Plk_1	2	8	PF00069	0.580
MOD_Plk_1	279	285	PF00069	0.359
MOD_Plk_1	498	504	PF00069	0.573
MOD_Plk_1	541	547	PF00069	0.422
MOD_Plk_1	566	572	PF00069	0.473
MOD_Plk_1	75	81	PF00069	0.668
MOD_Plk_1	797	803	PF00069	0.769
MOD_Plk_2-3	650	656	PF00069	0.610
MOD_Plk_4	359	365	PF00069	0.543
MOD_Plk_4	521	527	PF00069	0.471
MOD_Plk_4	542	548	PF00069	0.427
MOD_Plk_4	549	555	PF00069	0.524
MOD_Plk_4	560	566	PF00069	0.398
MOD_Plk_4	700	706	PF00069	0.613
MOD_ProDKin_1	18	24	PF00069	0.630
MOD_ProDKin_1	220	226	PF00069	0.472
MOD_ProDKin_1	256	262	PF00069	0.620
MOD_ProDKin_1	43	49	PF00069	0.609
MOD_ProDKin_1	603	609	PF00069	0.475
MOD_SUMO_rev_2	332	341	PF00179	0.419
MOD_SUMO_rev_2	46	54	PF00179	0.558
MOD_SUMO_rev_2	649	658	PF00179	0.508
TRG_DiLeu_BaEn_1	313	318	PF01217	0.446
TRG_DiLeu_BaEn_1	427	432	PF01217	0.507
TRG_DiLeu_BaEn_4	461	467	PF01217	0.428
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.482
TRG_ENDOCYTIC_2	401	404	PF00928	0.472
TRG_ENDOCYTIC_2	511	514	PF00928	0.416
TRG_ENDOCYTIC_2	532	535	PF00928	0.507
TRG_ENDOCYTIC_2	597	600	PF00928	0.353
TRG_ENDOCYTIC_2	676	679	PF00928	0.616
TRG_ER_diArg_1	229	232	PF00400	0.464
TRG_ER_diArg_1	250	252	PF00400	0.666
TRG_ER_diArg_1	445	448	PF00400	0.476
TRG_ER_diArg_1	780	782	PF00400	0.713
TRG_NES_CRM1_1	179	194	PF08389	0.377
TRG_NLS_Bipartite_1	230	252	PF00514	0.542
TRG_NLS_MonoCore_2	247	252	PF00514	0.692
TRG_NLS_MonoExtC_3	247	252	PF00514	0.705
TRG_NLS_MonoExtN_4	229	234	PF00514	0.395
TRG_NLS_MonoExtN_4	246	253	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD7	Leptomonas seymouri	71%	97%
A0A1X0P8A9	Trypanosomatidae	37%	96%
A0A422N0G0	Trypanosoma rangeli	34%	100%
A0A422NQU4	Trypanosoma rangeli	22%	98%
A4HF40	Leishmania braziliensis	69%	100%
A4I2C4	Leishmania infantum	100%	100%
C9ZX89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZX90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8Z6	Leishmania major	87%	100%