DUF4460 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4460), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZZ9_LEIDO

TriTrypDb:

LdBPK_261890.1 , LdCL_260024400 , LDHU3_26.2450

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.512
CLV_C14_Caspase3-7	245	249	PF00656	0.555
CLV_C14_Caspase3-7	96	100	PF00656	0.587
CLV_NRD_NRD_1	177	179	PF00675	0.424
CLV_NRD_NRD_1	199	201	PF00675	0.542
CLV_NRD_NRD_1	208	210	PF00675	0.574
CLV_NRD_NRD_1	428	430	PF00675	0.497
CLV_NRD_NRD_1	507	509	PF00675	0.536
CLV_NRD_NRD_1	547	549	PF00675	0.569
CLV_NRD_NRD_1	579	581	PF00675	0.768
CLV_NRD_NRD_1	64	66	PF00675	0.524
CLV_NRD_NRD_1	699	701	PF00675	0.589
CLV_PCSK_FUR_1	206	210	PF00082	0.681
CLV_PCSK_KEX2_1	109	111	PF00082	0.689
CLV_PCSK_KEX2_1	177	179	PF00082	0.439
CLV_PCSK_KEX2_1	199	201	PF00082	0.536
CLV_PCSK_KEX2_1	206	208	PF00082	0.579
CLV_PCSK_KEX2_1	507	509	PF00082	0.572
CLV_PCSK_KEX2_1	547	549	PF00082	0.545
CLV_PCSK_KEX2_1	579	581	PF00082	0.768
CLV_PCSK_KEX2_1	64	66	PF00082	0.543
CLV_PCSK_KEX2_1	699	701	PF00082	0.595
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.731
CLV_PCSK_PC7_1	173	179	PF00082	0.416
CLV_PCSK_SKI1_1	173	177	PF00082	0.394
CLV_PCSK_SKI1_1	200	204	PF00082	0.647
CLV_PCSK_SKI1_1	221	225	PF00082	0.444
CLV_PCSK_SKI1_1	3	7	PF00082	0.328
CLV_PCSK_SKI1_1	375	379	PF00082	0.414
CLV_PCSK_SKI1_1	393	397	PF00082	0.441
CLV_PCSK_SKI1_1	43	47	PF00082	0.437
CLV_PCSK_SKI1_1	436	440	PF00082	0.445
CLV_PCSK_SKI1_1	476	480	PF00082	0.388
CLV_PCSK_SKI1_1	530	534	PF00082	0.589
CLV_PCSK_SKI1_1	537	541	PF00082	0.587
CLV_PCSK_SKI1_1	580	584	PF00082	0.648
CLV_PCSK_SKI1_1	684	688	PF00082	0.558
CLV_PCSK_SKI1_1	727	731	PF00082	0.691
DEG_APCC_DBOX_1	270	278	PF00400	0.441
DEG_APCC_DBOX_1	414	422	PF00400	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.417
DOC_CDC14_PxL_1	237	245	PF14671	0.510
DOC_CYCLIN_RxL_1	575	585	PF00134	0.648
DOC_CYCLIN_RxL_1	678	689	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.679
DOC_MAPK_MEF2A_6	397	406	PF00069	0.515
DOC_PP1_RVXF_1	469	475	PF00149	0.396
DOC_PP2B_LxvP_1	303	306	PF13499	0.385
DOC_PP2B_LxvP_1	50	53	PF13499	0.439
DOC_PP2B_LxvP_1	510	513	PF13499	0.478
DOC_PP4_FxxP_1	148	151	PF00568	0.460
DOC_USP7_MATH_1	102	106	PF00917	0.596
DOC_USP7_MATH_1	119	123	PF00917	0.731
DOC_USP7_MATH_1	156	160	PF00917	0.589
DOC_USP7_MATH_1	54	58	PF00917	0.507
DOC_USP7_MATH_1	79	83	PF00917	0.719
DOC_USP7_MATH_1	88	92	PF00917	0.743
DOC_USP7_UBL2_3	217	221	PF12436	0.664
DOC_USP7_UBL2_3	533	537	PF12436	0.596
DOC_WW_Pin1_4	130	135	PF00397	0.690
DOC_WW_Pin1_4	256	261	PF00397	0.428
DOC_WW_Pin1_4	495	500	PF00397	0.476
DOC_WW_Pin1_4	603	608	PF00397	0.613
LIG_14-3-3_CanoR_1	271	275	PF00244	0.553
LIG_14-3-3_CanoR_1	409	417	PF00244	0.448
LIG_14-3-3_CanoR_1	429	435	PF00244	0.263
LIG_14-3-3_CanoR_1	542	549	PF00244	0.564
LIG_14-3-3_CanoR_1	555	563	PF00244	0.525
LIG_14-3-3_CanoR_1	603	607	PF00244	0.643
LIG_14-3-3_CanoR_1	627	635	PF00244	0.643
LIG_APCC_ABBA_1	11	16	PF00400	0.328
LIG_BRCT_BRCA1_1	56	60	PF00533	0.501
LIG_BRCT_BRCA1_1	697	701	PF00533	0.620
LIG_deltaCOP1_diTrp_1	116	124	PF00928	0.769
LIG_deltaCOP1_diTrp_1	489	495	PF00928	0.455
LIG_FHA_1	139	145	PF00498	0.518
LIG_FHA_1	298	304	PF00498	0.397
LIG_FHA_1	385	391	PF00498	0.407
LIG_FHA_1	409	415	PF00498	0.530
LIG_FHA_1	492	498	PF00498	0.375
LIG_FHA_1	556	562	PF00498	0.487
LIG_FHA_1	659	665	PF00498	0.596
LIG_FHA_1	668	674	PF00498	0.527
LIG_FHA_2	220	226	PF00498	0.574
LIG_FHA_2	240	246	PF00498	0.244
LIG_FHA_2	335	341	PF00498	0.457
LIG_FHA_2	346	352	PF00498	0.411
LIG_FHA_2	408	414	PF00498	0.425
LIG_FHA_2	612	618	PF00498	0.768
LIG_FHA_2	637	643	PF00498	0.655
LIG_LIR_Apic_2	146	151	PF02991	0.442
LIG_LIR_Apic_2	648	654	PF02991	0.575
LIG_LIR_Gen_1	280	289	PF02991	0.446
LIG_LIR_Gen_1	308	317	PF02991	0.488
LIG_LIR_Gen_1	489	497	PF02991	0.440
LIG_LIR_Gen_1	702	710	PF02991	0.592
LIG_LIR_Nem_3	308	312	PF02991	0.449
LIG_LIR_Nem_3	489	493	PF02991	0.436
LIG_LIR_Nem_3	57	63	PF02991	0.507
LIG_MYND_3	240	244	PF01753	0.579
LIG_NRBOX	171	177	PF00104	0.389
LIG_NRBOX	34	40	PF00104	0.328
LIG_Pex14_1	41	45	PF04695	0.328
LIG_Pex14_1	647	651	PF04695	0.533
LIG_REV1ctd_RIR_1	7	14	PF16727	0.328
LIG_SH2_SRC	651	654	PF00017	0.599
LIG_SH2_STAP1	468	472	PF00017	0.403
LIG_SH2_STAT3	655	658	PF00017	0.581
LIG_SH2_STAT5	524	527	PF00017	0.418
LIG_SH2_STAT5	655	658	PF00017	0.584
LIG_SH3_3	583	589	PF00018	0.700
LIG_SH3_3	622	628	PF00018	0.628
LIG_SUMO_SIM_par_1	138	147	PF11976	0.593
LIG_SUMO_SIM_par_1	283	291	PF11976	0.394
LIG_SUMO_SIM_par_1	400	405	PF11976	0.451
LIG_SUMO_SIM_par_1	621	626	PF11976	0.664
LIG_TRAF2_1	242	245	PF00917	0.490
LIG_TRAF2_1	410	413	PF00917	0.491
LIG_TRAF2_1	550	553	PF00917	0.582
LIG_TRFH_1	495	499	PF08558	0.394
MOD_CDK_SPxxK_3	130	137	PF00069	0.570
MOD_CK1_1	239	245	PF00069	0.531
MOD_CK1_1	407	413	PF00069	0.508
MOD_CK2_1	143	149	PF00069	0.450
MOD_CK2_1	181	187	PF00069	0.469
MOD_CK2_1	239	245	PF00069	0.446
MOD_CK2_1	270	276	PF00069	0.524
MOD_CK2_1	334	340	PF00069	0.447
MOD_CK2_1	345	351	PF00069	0.442
MOD_CK2_1	357	363	PF00069	0.448
MOD_CK2_1	407	413	PF00069	0.436
MOD_CK2_1	528	534	PF00069	0.575
MOD_CK2_1	547	553	PF00069	0.585
MOD_CK2_1	611	617	PF00069	0.767
MOD_CK2_1	634	640	PF00069	0.588
MOD_CK2_1	88	94	PF00069	0.817
MOD_Cter_Amidation	694	697	PF01082	0.555
MOD_GlcNHglycan	120	124	PF01048	0.773
MOD_GlcNHglycan	125	129	PF01048	0.771
MOD_GlcNHglycan	217	220	PF01048	0.710
MOD_GlcNHglycan	263	266	PF01048	0.398
MOD_GlcNHglycan	530	533	PF01048	0.518
MOD_GlcNHglycan	543	546	PF01048	0.377
MOD_GlcNHglycan	81	84	PF01048	0.694
MOD_GlcNHglycan	90	93	PF01048	0.719
MOD_GSK3_1	181	188	PF00069	0.473
MOD_GSK3_1	215	222	PF00069	0.607
MOD_GSK3_1	225	232	PF00069	0.374
MOD_GSK3_1	235	242	PF00069	0.276
MOD_GSK3_1	266	273	PF00069	0.489
MOD_GSK3_1	297	304	PF00069	0.441
MOD_GSK3_1	404	411	PF00069	0.460
MOD_GSK3_1	491	498	PF00069	0.457
MOD_GSK3_1	54	61	PF00069	0.474
MOD_GSK3_1	627	634	PF00069	0.644
MOD_GSK3_1	667	674	PF00069	0.531
MOD_GSK3_1	75	82	PF00069	0.677
MOD_GSK3_1	83	90	PF00069	0.678
MOD_N-GLC_1	384	389	PF02516	0.432
MOD_N-GLC_2	464	466	PF02516	0.512
MOD_NEK2_1	124	129	PF00069	0.801
MOD_NEK2_1	143	148	PF00069	0.268
MOD_NEK2_1	233	238	PF00069	0.481
MOD_NEK2_1	254	259	PF00069	0.479
MOD_NEK2_1	261	266	PF00069	0.439
MOD_NEK2_1	270	275	PF00069	0.396
MOD_NEK2_1	438	443	PF00069	0.395
MOD_NEK2_1	541	546	PF00069	0.483
MOD_NEK2_1	667	672	PF00069	0.519
MOD_NEK2_1	690	695	PF00069	0.633
MOD_NEK2_2	102	107	PF00069	0.705
MOD_NEK2_2	266	271	PF00069	0.419
MOD_PIKK_1	136	142	PF00454	0.709
MOD_PK_1	430	436	PF00069	0.478
MOD_PKA_1	547	553	PF00069	0.598
MOD_PKA_2	136	142	PF00069	0.534
MOD_PKA_2	270	276	PF00069	0.548
MOD_PKA_2	408	414	PF00069	0.440
MOD_PKA_2	541	547	PF00069	0.567
MOD_PKA_2	602	608	PF00069	0.624
MOD_PKA_2	671	677	PF00069	0.633
MOD_PKA_2	83	89	PF00069	0.774
MOD_Plk_1	164	170	PF00069	0.517
MOD_Plk_1	307	313	PF00069	0.522
MOD_Plk_1	384	390	PF00069	0.407
MOD_Plk_1	404	410	PF00069	0.219
MOD_Plk_1	439	445	PF00069	0.397
MOD_Plk_1	464	470	PF00069	0.438
MOD_Plk_1	491	497	PF00069	0.383
MOD_Plk_2-3	187	193	PF00069	0.491
MOD_Plk_2-3	621	627	PF00069	0.644
MOD_Plk_4	102	108	PF00069	0.754
MOD_Plk_4	138	144	PF00069	0.528
MOD_Plk_4	219	225	PF00069	0.479
MOD_Plk_4	439	445	PF00069	0.397
MOD_ProDKin_1	130	136	PF00069	0.687
MOD_ProDKin_1	256	262	PF00069	0.422
MOD_ProDKin_1	495	501	PF00069	0.482
MOD_ProDKin_1	603	609	PF00069	0.616
MOD_SUMO_for_1	645	648	PF00179	0.558
TRG_DiLeu_BaEn_1	338	343	PF01217	0.500
TRG_DiLeu_BaEn_1	492	497	PF01217	0.497
TRG_DiLeu_BaEn_1	536	541	PF01217	0.581
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.498
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.497
TRG_ENDOCYTIC_2	63	66	PF00928	0.556
TRG_ENDOCYTIC_2	703	706	PF00928	0.606
TRG_ER_diArg_1	176	178	PF00400	0.435
TRG_ER_diArg_1	205	208	PF00400	0.598
TRG_ER_diArg_1	546	548	PF00400	0.565
TRG_ER_diArg_1	63	65	PF00400	0.547
TRG_ER_diArg_1	699	701	PF00400	0.595
TRG_NES_CRM1_1	180	194	PF08389	0.536
TRG_NES_CRM1_1	340	354	PF08389	0.385
TRG_NES_CRM1_1	416	428	PF08389	0.518
TRG_NLS_Bipartite_1	684	700	PF00514	0.577
TRG_NLS_MonoExtC_3	695	700	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB5	Leptomonas seymouri	78%	100%
A0A0S4IT81	Bodo saltans	50%	100%
A0A1X0P7G1	Trypanosomatidae	58%	100%
A0A3R7MTD0	Trypanosoma rangeli	58%	100%
A4HF33	Leishmania braziliensis	87%	99%
A4I272	Leishmania infantum	99%	100%
C9ZX97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AYG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q904	Leishmania major	97%	100%
V5DB85	Trypanosoma cruzi	58%	100%