Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZZ7_LEIDO

TriTrypDb:

LdBPK_261290.1 , LdCL_260018500 , LDHU3_26.1590

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7WZZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.344
CLV_NRD_NRD_1	14	16	PF00675	0.468
CLV_NRD_NRD_1	306	308	PF00675	0.439
CLV_NRD_NRD_1	321	323	PF00675	0.302
CLV_NRD_NRD_1	54	56	PF00675	0.474
CLV_NRD_NRD_1	99	101	PF00675	0.424
CLV_PCSK_KEX2_1	110	112	PF00082	0.383
CLV_PCSK_KEX2_1	306	308	PF00082	0.445
CLV_PCSK_KEX2_1	321	323	PF00082	0.302
CLV_PCSK_SKI1_1	10	14	PF00082	0.491
CLV_PCSK_SKI1_1	170	174	PF00082	0.394
CLV_PCSK_SKI1_1	191	195	PF00082	0.370
CLV_PCSK_SKI1_1	243	247	PF00082	0.277
DEG_APCC_DBOX_1	227	235	PF00400	0.352
DEG_Nend_Nbox_1	1	3	PF02207	0.727
DOC_CKS1_1	4	9	PF01111	0.572
DOC_CYCLIN_RxL_1	237	247	PF00134	0.340
DOC_CYCLIN_RxL_1	32	43	PF00134	0.631
DOC_CYCLIN_RxL_1	7	14	PF00134	0.722
DOC_MAPK_gen_1	304	313	PF00069	0.597
DOC_MAPK_MEF2A_6	146	155	PF00069	0.678
DOC_MAPK_MEF2A_6	306	315	PF00069	0.707
DOC_MAPK_MEF2A_6	327	335	PF00069	0.305
DOC_PP1_RVXF_1	196	203	PF00149	0.480
DOC_PP1_RVXF_1	241	247	PF00149	0.290
DOC_PP2B_LxvP_1	239	242	PF13499	0.369
DOC_PP2B_LxvP_1	67	70	PF13499	0.652
DOC_USP7_UBL2_3	97	101	PF12436	0.596
DOC_WW_Pin1_4	3	8	PF00397	0.700
LIG_14-3-3_CanoR_1	181	189	PF00244	0.600
LIG_14-3-3_CanoR_1	321	325	PF00244	0.461
LIG_Actin_WH2_2	216	234	PF00022	0.484
LIG_BIR_III_2	298	302	PF00653	0.634
LIG_eIF4E_1	251	257	PF01652	0.352
LIG_FHA_1	182	188	PF00498	0.646
LIG_FHA_1	3	9	PF00498	0.695
LIG_FHA_1	324	330	PF00498	0.418
LIG_FHA_2	315	321	PF00498	0.598
LIG_LIR_Gen_1	323	333	PF02991	0.354
LIG_LIR_Nem_3	194	200	PF02991	0.540
LIG_LIR_Nem_3	24	30	PF02991	0.595
LIG_LIR_Nem_3	272	278	PF02991	0.556
LIG_LIR_Nem_3	31	36	PF02991	0.588
LIG_LIR_Nem_3	323	328	PF02991	0.354
LIG_NRBOX	328	334	PF00104	0.317
LIG_PCNA_PIPBox_1	20	29	PF02747	0.614
LIG_SH2_CRK	197	201	PF00017	0.464
LIG_SH2_CRK	33	37	PF00017	0.697
LIG_SH2_STAP1	183	187	PF00017	0.694
LIG_SH2_STAT3	183	186	PF00017	0.650
LIG_SH2_STAT5	183	186	PF00017	0.677
LIG_SH2_STAT5	2	5	PF00017	0.670
LIG_SH2_STAT5	201	204	PF00017	0.166
LIG_SH2_STAT5	216	219	PF00017	0.385
LIG_SH3_3	150	156	PF00018	0.724
LIG_SH3_3	220	226	PF00018	0.454
LIG_SH3_3	260	266	PF00018	0.573
LIG_SUMO_SIM_par_1	331	337	PF11976	0.333
LIG_TYR_ITIM	195	200	PF00017	0.632
LIG_UBA3_1	172	176	PF00899	0.627
LIG_UBA3_1	8	16	PF00899	0.721
MOD_CDK_SPxxK_3	3	10	PF00069	0.704
MOD_CK1_1	141	147	PF00069	0.689
MOD_CK1_1	72	78	PF00069	0.691
MOD_CK1_1	80	86	PF00069	0.558
MOD_CK2_1	18	24	PF00069	0.685
MOD_CK2_1	314	320	PF00069	0.644
MOD_GlcNHglycan	140	143	PF01048	0.482
MOD_GlcNHglycan	146	149	PF01048	0.545
MOD_GlcNHglycan	246	249	PF01048	0.337
MOD_GlcNHglycan	283	286	PF01048	0.431
MOD_GlcNHglycan	71	74	PF01048	0.472
MOD_GlcNHglycan	81	85	PF01048	0.331
MOD_GSK3_1	187	194	PF00069	0.548
MOD_GSK3_1	72	79	PF00069	0.671
MOD_NEK2_1	182	187	PF00069	0.598
MOD_NEK2_1	244	249	PF00069	0.305
MOD_NEK2_1	256	261	PF00069	0.419
MOD_PIKK_1	175	181	PF00454	0.645
MOD_PIKK_1	182	188	PF00454	0.643
MOD_PKA_2	187	193	PF00069	0.557
MOD_PKA_2	320	326	PF00069	0.492
MOD_Plk_2-3	18	24	PF00069	0.695
MOD_Plk_4	18	24	PF00069	0.685
MOD_Plk_4	191	197	PF00069	0.539
MOD_Plk_4	207	213	PF00069	0.300
MOD_ProDKin_1	3	9	PF00069	0.700
TRG_AP2beta_CARGO_1	24	34	PF09066	0.599
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.418
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.702
TRG_ENDOCYTIC_2	197	200	PF00928	0.525
TRG_ENDOCYTIC_2	201	204	PF00928	0.288
TRG_ENDOCYTIC_2	216	219	PF00928	0.582
TRG_ENDOCYTIC_2	251	254	PF00928	0.352
TRG_ENDOCYTIC_2	33	36	PF00928	0.673
TRG_ER_diArg_1	110	112	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V8	Leptomonas seymouri	72%	96%
A0A0S4KIA3	Bodo saltans	33%	100%
A0A1X0NS63	Trypanosomatidae	47%	93%
A0A3R7M7G1	Trypanosoma rangeli	50%	100%
A4HEY6	Leishmania braziliensis	89%	100%
A4I260	Leishmania infantum	100%	100%
C9ZRU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AYB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q963	Leishmania major	96%	100%
V5B9S2	Trypanosoma cruzi	49%	99%