Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZZ6_LEIDO

TriTrypDb:

LdBPK_261310.1 , LdCL_260018700 , LDHU3_26.1610

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	462	464	PF00675	0.639
CLV_PCSK_KEX2_1	462	464	PF00082	0.639
CLV_PCSK_SKI1_1	264	268	PF00082	0.612
CLV_PCSK_SKI1_1	293	297	PF00082	0.600
CLV_PCSK_SKI1_1	34	38	PF00082	0.417
CLV_PCSK_SKI1_1	394	398	PF00082	0.584
DEG_APCC_DBOX_1	292	300	PF00400	0.602
DOC_CKS1_1	221	226	PF01111	0.597
DOC_CKS1_1	269	274	PF01111	0.725
DOC_CKS1_1	316	321	PF01111	0.600
DOC_CYCLIN_RxL_1	31	42	PF00134	0.393
DOC_MAPK_gen_1	290	300	PF00069	0.497
DOC_MAPK_gen_1	462	471	PF00069	0.729
DOC_MAPK_MEF2A_6	293	300	PF00069	0.502
DOC_MAPK_NFAT4_5	293	301	PF00069	0.509
DOC_PP4_FxxP_1	269	272	PF00568	0.754
DOC_USP7_MATH_1	139	143	PF00917	0.581
DOC_USP7_MATH_1	173	177	PF00917	0.605
DOC_USP7_MATH_1	186	190	PF00917	0.519
DOC_USP7_MATH_1	230	234	PF00917	0.603
DOC_USP7_MATH_1	374	378	PF00917	0.780
DOC_USP7_MATH_1	418	422	PF00917	0.717
DOC_USP7_MATH_1	482	486	PF00917	0.632
DOC_USP7_MATH_1	71	75	PF00917	0.403
DOC_WW_Pin1_4	135	140	PF00397	0.744
DOC_WW_Pin1_4	197	202	PF00397	0.728
DOC_WW_Pin1_4	22	27	PF00397	0.395
DOC_WW_Pin1_4	220	225	PF00397	0.576
DOC_WW_Pin1_4	268	273	PF00397	0.649
DOC_WW_Pin1_4	312	317	PF00397	0.806
DOC_WW_Pin1_4	411	416	PF00397	0.782
DOC_WW_Pin1_4	450	455	PF00397	0.714
LIG_14-3-3_CanoR_1	264	270	PF00244	0.637
LIG_14-3-3_CanoR_1	99	105	PF00244	0.625
LIG_Actin_WH2_2	147	162	PF00022	0.680
LIG_APCC_ABBAyCdc20_2	44	50	PF00400	0.413
LIG_BIR_III_2	152	156	PF00653	0.630
LIG_BRCT_BRCA1_1	125	129	PF00533	0.561
LIG_BRCT_BRCA1_1	451	455	PF00533	0.780
LIG_CSL_BTD_1	120	123	PF09270	0.667
LIG_FHA_1	269	275	PF00498	0.730
LIG_FHA_1	287	293	PF00498	0.629
LIG_FHA_1	316	322	PF00498	0.644
LIG_FHA_2	147	153	PF00498	0.669
LIG_FHA_2	198	204	PF00498	0.628
LIG_FHA_2	323	329	PF00498	0.704
LIG_FHA_2	345	351	PF00498	0.751
LIG_FHA_2	378	384	PF00498	0.751
LIG_LIR_Apic_2	238	244	PF02991	0.616
LIG_LIR_Apic_2	267	272	PF02991	0.738
LIG_LIR_Gen_1	126	134	PF02991	0.683
LIG_LIR_Gen_1	149	159	PF02991	0.621
LIG_LIR_Nem_3	126	132	PF02991	0.582
LIG_LIR_Nem_3	149	154	PF02991	0.634
LIG_LIR_Nem_3	452	458	PF02991	0.726
LIG_MLH1_MIPbox_1	125	129	PF16413	0.561
LIG_MYND_1	22	26	PF01753	0.394
LIG_NRBOX	204	210	PF00104	0.676
LIG_NRBOX	295	301	PF00104	0.611
LIG_Pex14_1	125	129	PF04695	0.583
LIG_Pex14_2	303	307	PF04695	0.656
LIG_SH2_CRK	301	305	PF00017	0.526
LIG_SH2_STAT5	265	268	PF00017	0.549
LIG_SH3_1	313	319	PF00018	0.736
LIG_SH3_3	151	157	PF00018	0.650
LIG_SH3_3	179	185	PF00018	0.641
LIG_SH3_3	221	227	PF00018	0.527
LIG_SH3_3	271	277	PF00018	0.773
LIG_SH3_3	313	319	PF00018	0.736
LIG_SH3_3	448	454	PF00018	0.681
LIG_SUMO_SIM_par_1	168	176	PF11976	0.704
LIG_SUMO_SIM_par_1	296	302	PF11976	0.518
LIG_SUMO_SIM_par_1	320	325	PF11976	0.546
LIG_SUMO_SIM_par_1	90	96	PF11976	0.424
LIG_SxIP_EBH_1	69	82	PF03271	0.406
LIG_TRAF2_1	325	328	PF00917	0.657
LIG_TYR_ITIM	299	304	PF00017	0.506
LIG_WRC_WIRS_1	266	271	PF05994	0.549
LIG_WRC_WIRS_1	300	305	PF05994	0.636
LIG_WW_3	310	314	PF00397	0.681
MOD_CDK_SPK_2	135	140	PF00069	0.556
MOD_CDK_SPK_2	220	225	PF00069	0.498
MOD_CK1_1	25	31	PF00069	0.390
MOD_CK1_1	275	281	PF00069	0.755
MOD_CK1_1	302	308	PF00069	0.563
MOD_CK1_1	315	321	PF00069	0.707
MOD_CK1_1	351	357	PF00069	0.810
MOD_CK1_1	377	383	PF00069	0.768
MOD_CK1_1	39	45	PF00069	0.382
MOD_CK1_1	407	413	PF00069	0.726
MOD_CK2_1	197	203	PF00069	0.638
MOD_CK2_1	322	328	PF00069	0.618
MOD_CK2_1	344	350	PF00069	0.676
MOD_CK2_1	377	383	PF00069	0.760
MOD_GlcNHglycan	100	103	PF01048	0.599
MOD_GlcNHglycan	117	120	PF01048	0.641
MOD_GlcNHglycan	125	128	PF01048	0.504
MOD_GlcNHglycan	175	178	PF01048	0.625
MOD_GlcNHglycan	212	215	PF01048	0.632
MOD_GlcNHglycan	247	250	PF01048	0.560
MOD_GlcNHglycan	344	347	PF01048	0.587
MOD_GlcNHglycan	361	364	PF01048	0.792
MOD_GlcNHglycan	408	412	PF01048	0.785
MOD_GlcNHglycan	41	44	PF01048	0.400
MOD_GlcNHglycan	420	423	PF01048	0.526
MOD_GlcNHglycan	446	449	PF01048	0.689
MOD_GlcNHglycan	484	487	PF01048	0.623
MOD_GlcNHglycan	496	499	PF01048	0.621
MOD_GSK3_1	135	142	PF00069	0.678
MOD_GSK3_1	195	202	PF00069	0.600
MOD_GSK3_1	204	211	PF00069	0.599
MOD_GSK3_1	216	223	PF00069	0.499
MOD_GSK3_1	264	271	PF00069	0.648
MOD_GSK3_1	272	279	PF00069	0.630
MOD_GSK3_1	299	306	PF00069	0.541
MOD_GSK3_1	342	349	PF00069	0.646
MOD_GSK3_1	374	381	PF00069	0.776
MOD_GSK3_1	407	414	PF00069	0.836
MOD_GSK3_1	6	13	PF00069	0.394
MOD_N-GLC_1	342	347	PF02516	0.645
MOD_N-GLC_1	359	364	PF02516	0.558
MOD_NEK2_1	109	114	PF00069	0.628
MOD_NEK2_1	158	163	PF00069	0.654
MOD_NEK2_1	208	213	PF00069	0.550
MOD_NEK2_1	216	221	PF00069	0.553
MOD_NEK2_1	285	290	PF00069	0.543
MOD_NEK2_1	299	304	PF00069	0.573
MOD_NEK2_1	342	347	PF00069	0.536
MOD_NEK2_1	36	41	PF00069	0.418
MOD_NEK2_1	7	12	PF00069	0.432
MOD_NEK2_1	81	86	PF00069	0.533
MOD_PK_1	225	231	PF00069	0.708
MOD_PKA_2	139	145	PF00069	0.606
MOD_PKA_2	418	424	PF00069	0.683
MOD_PKA_2	482	488	PF00069	0.665
MOD_PKA_2	98	104	PF00069	0.647
MOD_Plk_1	167	173	PF00069	0.566
MOD_Plk_1	195	201	PF00069	0.562
MOD_Plk_4	10	16	PF00069	0.389
MOD_Plk_4	167	173	PF00069	0.580
MOD_Plk_4	186	192	PF00069	0.517
MOD_Plk_4	204	210	PF00069	0.606
MOD_Plk_4	216	222	PF00069	0.524
MOD_Plk_4	299	305	PF00069	0.602
MOD_Plk_4	348	354	PF00069	0.726
MOD_Plk_4	71	77	PF00069	0.402
MOD_ProDKin_1	135	141	PF00069	0.746
MOD_ProDKin_1	197	203	PF00069	0.724
MOD_ProDKin_1	22	28	PF00069	0.392
MOD_ProDKin_1	220	226	PF00069	0.587
MOD_ProDKin_1	268	274	PF00069	0.652
MOD_ProDKin_1	312	318	PF00069	0.808
MOD_ProDKin_1	411	417	PF00069	0.783
MOD_ProDKin_1	450	456	PF00069	0.710
TRG_DiLeu_BaEn_4	466	472	PF01217	0.590
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.634
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.612
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.400
TRG_ENDOCYTIC_2	301	304	PF00928	0.517
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H2	Leptomonas seymouri	30%	100%
A4HEY8	Leishmania braziliensis	64%	100%
A4I262	Leishmania infantum	99%	100%
E9AYB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q961	Leishmania major	88%	100%