Aldo/keto reductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo/keto reductase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZZ0_LEIDO

TriTrypDb:

LdBPK_261190.1 , LdCL_260017500 , LDHU3_26.1480

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	1
GO:0004033	aldo-keto reductase (NADP) activity	5	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.508
CLV_NRD_NRD_1	253	255	PF00675	0.310
CLV_NRD_NRD_1	36	38	PF00675	0.477
CLV_NRD_NRD_1	407	409	PF00675	0.443
CLV_NRD_NRD_1	55	57	PF00675	0.446
CLV_PCSK_KEX2_1	406	408	PF00082	0.438
CLV_PCSK_KEX2_1	55	57	PF00082	0.492
CLV_PCSK_SKI1_1	192	196	PF00082	0.260
CLV_PCSK_SKI1_1	313	317	PF00082	0.329
CLV_PCSK_SKI1_1	530	534	PF00082	0.440
CLV_PCSK_SKI1_1	97	101	PF00082	0.457
DEG_APCC_DBOX_1	224	232	PF00400	0.529
DOC_CYCLIN_RxL_1	527	536	PF00134	0.479
DOC_MAPK_DCC_7	77	87	PF00069	0.468
DOC_MAPK_gen_1	113	122	PF00069	0.469
DOC_MAPK_gen_1	37	44	PF00069	0.474
DOC_MAPK_gen_1	406	413	PF00069	0.396
DOC_MAPK_gen_1	542	550	PF00069	0.433
DOC_MAPK_MEF2A_6	225	234	PF00069	0.475
DOC_MAPK_MEF2A_6	37	44	PF00069	0.462
DOC_PP2B_LxvP_1	382	385	PF13499	0.483
DOC_PP2B_LxvP_1	64	67	PF13499	0.490
DOC_PP4_FxxP_1	133	136	PF00568	0.448
DOC_PP4_FxxP_1	170	173	PF00568	0.362
DOC_PP4_MxPP_1	80	83	PF00568	0.468
DOC_USP7_MATH_1	14	18	PF00917	0.491
DOC_USP7_MATH_1	149	153	PF00917	0.562
DOC_USP7_MATH_1	186	190	PF00917	0.495
DOC_USP7_MATH_1	235	239	PF00917	0.529
DOC_USP7_MATH_1	340	344	PF00917	0.713
DOC_USP7_MATH_1	367	371	PF00917	0.634
DOC_USP7_MATH_1	375	379	PF00917	0.531
DOC_USP7_MATH_1	58	62	PF00917	0.496
DOC_USP7_UBL2_3	233	237	PF12436	0.475
DOC_WW_Pin1_4	115	120	PF00397	0.462
DOC_WW_Pin1_4	363	368	PF00397	0.643
DOC_WW_Pin1_4	380	385	PF00397	0.420
DOC_WW_Pin1_4	414	419	PF00397	0.378
DOC_WW_Pin1_4	454	459	PF00397	0.760
LIG_14-3-3_CanoR_1	109	115	PF00244	0.435
LIG_14-3-3_CanoR_1	150	155	PF00244	0.505
LIG_14-3-3_CanoR_1	18	24	PF00244	0.486
LIG_14-3-3_CanoR_1	49	55	PF00244	0.486
LIG_14-3-3_CanoR_1	530	540	PF00244	0.411
LIG_14-3-3_CanoR_1	59	67	PF00244	0.473
LIG_14-3-3_CanoR_1	69	78	PF00244	0.467
LIG_14-3-3_CanoR_1	97	107	PF00244	0.465
LIG_Actin_WH2_2	82	99	PF00022	0.466
LIG_BIR_III_4	278	282	PF00653	0.475
LIG_BRCT_BRCA1_1	117	121	PF00533	0.468
LIG_BRCT_BRCA1_1	166	170	PF00533	0.468
LIG_eIF4E_1	208	214	PF01652	0.472
LIG_eIF4E_1	260	266	PF01652	0.468
LIG_FHA_1	154	160	PF00498	0.526
LIG_FHA_1	177	183	PF00498	0.558
LIG_Integrin_RGD_1	183	185	PF01839	0.275
LIG_LIR_Apic_2	167	173	PF02991	0.450
LIG_LIR_Gen_1	227	236	PF02991	0.478
LIG_LIR_Gen_1	26	35	PF02991	0.469
LIG_LIR_Gen_1	500	509	PF02991	0.398
LIG_LIR_Nem_3	101	107	PF02991	0.471
LIG_LIR_Nem_3	227	232	PF02991	0.478
LIG_LIR_Nem_3	26	30	PF02991	0.474
LIG_LIR_Nem_3	500	505	PF02991	0.575
LIG_MYND_1	94	98	PF01753	0.435
LIG_PCNA_PIPBox_1	537	546	PF02747	0.460
LIG_Pex14_2	133	137	PF04695	0.450
LIG_SH2_CRK	304	308	PF00017	0.529
LIG_SH2_CRK	416	420	PF00017	0.385
LIG_SH2_CRK	479	483	PF00017	0.338
LIG_SH2_CRK	9	13	PF00017	0.504
LIG_SH2_GRB2like	88	91	PF00017	0.481
LIG_SH2_SRC	88	91	PF00017	0.481
LIG_SH2_STAP1	110	114	PF00017	0.468
LIG_SH2_STAP1	260	264	PF00017	0.451
LIG_SH2_STAP1	561	565	PF00017	0.398
LIG_SH2_STAT3	561	564	PF00017	0.446
LIG_SH2_STAT5	110	113	PF00017	0.467
LIG_SH2_STAT5	304	307	PF00017	0.529
LIG_SH2_STAT5	404	407	PF00017	0.383
LIG_SH2_STAT5	439	442	PF00017	0.412
LIG_SH2_STAT5	479	482	PF00017	0.336
LIG_SH2_STAT5	501	504	PF00017	0.476
LIG_SH2_STAT5	88	91	PF00017	0.493
LIG_SH3_3	446	452	PF00018	0.661
LIG_SH3_3	64	70	PF00018	0.498
LIG_SH3_3	76	82	PF00018	0.459
LIG_SH3_3	92	98	PF00018	0.409
LIG_TYR_ITIM	302	307	PF00017	0.529
LIG_UBA3_1	249	255	PF00899	0.460
LIG_UBA3_1	292	301	PF00899	0.529
MOD_CDK_SPxxK_3	414	421	PF00069	0.386
MOD_CK1_1	17	23	PF00069	0.487
MOD_CK1_1	238	244	PF00069	0.451
MOD_CK1_1	359	365	PF00069	0.719
MOD_CK1_1	366	372	PF00069	0.618
MOD_CK1_1	376	382	PF00069	0.430
MOD_CK1_1	441	447	PF00069	0.649
MOD_CK1_1	522	528	PF00069	0.680
MOD_CK1_1	72	78	PF00069	0.516
MOD_CK2_1	326	332	PF00069	0.614
MOD_CK2_1	365	371	PF00069	0.659
MOD_GlcNHglycan	100	103	PF01048	0.462
MOD_GlcNHglycan	188	191	PF01048	0.295
MOD_GlcNHglycan	220	223	PF01048	0.275
MOD_GlcNHglycan	278	282	PF01048	0.352
MOD_GlcNHglycan	362	365	PF01048	0.672
MOD_GlcNHglycan	375	378	PF01048	0.501
MOD_GlcNHglycan	524	527	PF01048	0.620
MOD_GlcNHglycan	60	63	PF01048	0.504
MOD_GlcNHglycan	74	77	PF01048	0.492
MOD_GSK3_1	10	17	PF00069	0.495
MOD_GSK3_1	149	156	PF00069	0.584
MOD_GSK3_1	19	26	PF00069	0.458
MOD_GSK3_1	356	363	PF00069	0.697
MOD_GSK3_1	376	383	PF00069	0.397
MOD_GSK3_1	40	47	PF00069	0.474
MOD_GSK3_1	478	485	PF00069	0.400
MOD_GSK3_1	521	528	PF00069	0.673
MOD_GSK3_1	65	72	PF00069	0.502
MOD_LATS_1	436	442	PF00433	0.430
MOD_N-GLC_1	359	364	PF02516	0.550
MOD_N-GLC_1	441	446	PF02516	0.572
MOD_NEK2_1	120	125	PF00069	0.476
MOD_NEK2_1	138	143	PF00069	0.481
MOD_NEK2_1	154	159	PF00069	0.578
MOD_NEK2_1	201	206	PF00069	0.475
MOD_NEK2_1	482	487	PF00069	0.391
MOD_NEK2_1	71	76	PF00069	0.527
MOD_NEK2_2	340	345	PF00069	0.570
MOD_PIKK_1	519	525	PF00454	0.656
MOD_PIKK_1	560	566	PF00454	0.517
MOD_PIKK_1	69	75	PF00454	0.521
MOD_PKA_1	150	156	PF00069	0.504
MOD_PKA_2	10	16	PF00069	0.496
MOD_PKA_2	108	114	PF00069	0.468
MOD_PKA_2	149	155	PF00069	0.503
MOD_PKA_2	17	23	PF00069	0.470
MOD_PKA_2	58	64	PF00069	0.501
MOD_PKB_1	148	156	PF00069	0.504
MOD_Plk_4	19	25	PF00069	0.482
MOD_Plk_4	478	484	PF00069	0.341
MOD_ProDKin_1	115	121	PF00069	0.464
MOD_ProDKin_1	363	369	PF00069	0.641
MOD_ProDKin_1	380	386	PF00069	0.410
MOD_ProDKin_1	414	420	PF00069	0.378
MOD_ProDKin_1	454	460	PF00069	0.754
MOD_SUMO_for_1	344	347	PF00179	0.554
TRG_DiLeu_BaEn_1	467	472	PF01217	0.367
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.475
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.419
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.418
TRG_ENDOCYTIC_2	199	202	PF00928	0.475
TRG_ENDOCYTIC_2	27	30	PF00928	0.432
TRG_ENDOCYTIC_2	304	307	PF00928	0.529
TRG_ENDOCYTIC_2	416	419	PF00928	0.387
TRG_ENDOCYTIC_2	479	482	PF00928	0.321
TRG_ENDOCYTIC_2	9	12	PF00928	0.506
TRG_ER_diArg_1	406	408	PF00400	0.402
TRG_ER_diArg_1	54	56	PF00400	0.493
TRG_NES_CRM1_1	247	262	PF08389	0.495
TRG_NLS_MonoExtC_3	253	259	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	58%	100%
A4HEX6	Leishmania braziliensis	77%	100%
A4I250	Leishmania infantum	99%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q973	Leishmania major	92%	100%