Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZY2_LEIDO

TriTrypDb:

LdBPK_261660.1 , LdCL_260022200 , LDHU3_26.2070

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.445
CLV_NRD_NRD_1	16	18	PF00675	0.499
CLV_NRD_NRD_1	193	195	PF00675	0.570
CLV_NRD_NRD_1	30	32	PF00675	0.342
CLV_NRD_NRD_1	42	44	PF00675	0.369
CLV_NRD_NRD_1	51	53	PF00675	0.368
CLV_NRD_NRD_1	64	66	PF00675	0.428
CLV_NRD_NRD_1	68	70	PF00675	0.605
CLV_PCSK_KEX2_1	16	18	PF00082	0.499
CLV_PCSK_KEX2_1	193	195	PF00082	0.574
CLV_PCSK_KEX2_1	30	32	PF00082	0.342
CLV_PCSK_KEX2_1	42	44	PF00082	0.369
CLV_PCSK_KEX2_1	64	66	PF00082	0.594
CLV_PCSK_KEX2_1	68	70	PF00082	0.486
CLV_PCSK_PC7_1	64	70	PF00082	0.517
CLV_PCSK_SKI1_1	24	28	PF00082	0.451
DOC_MAPK_gen_1	33	41	PF00069	0.405
DOC_MAPK_gen_1	42	50	PF00069	0.396
DOC_MAPK_MEF2A_6	96	104	PF00069	0.376
DOC_USP7_MATH_1	148	152	PF00917	0.622
DOC_WW_Pin1_4	150	155	PF00397	0.600
LIG_14-3-3_CanoR_1	68	75	PF00244	0.453
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_FHA_1	118	124	PF00498	0.462
LIG_FHA_1	160	166	PF00498	0.645
LIG_FHA_1	87	93	PF00498	0.381
LIG_FHA_1	97	103	PF00498	0.331
LIG_LIR_Nem_3	136	141	PF02991	0.600
LIG_LIR_Nem_3	177	183	PF02991	0.528
LIG_NRP_CendR_1	193	196	PF00754	0.549
LIG_Pex14_1	134	138	PF04695	0.380
LIG_REV1ctd_RIR_1	38	47	PF16727	0.328
LIG_RPA_C_Fungi	40	52	PF08784	0.364
LIG_SH2_NCK_1	55	59	PF00017	0.487
LIG_SH2_STAP1	138	142	PF00017	0.381
LIG_SH2_STAT5	141	144	PF00017	0.471
LIG_SH3_3	151	157	PF00018	0.598
MOD_CK1_1	176	182	PF00069	0.508
MOD_GlcNHglycan	159	162	PF01048	0.625
MOD_GlcNHglycan	3	6	PF01048	0.450
MOD_GlcNHglycan	70	73	PF01048	0.595
MOD_GlcNHglycan	75	78	PF01048	0.452
MOD_GSK3_1	130	137	PF00069	0.586
MOD_GSK3_1	148	155	PF00069	0.497
MOD_GSK3_1	172	179	PF00069	0.721
MOD_GSK3_1	20	27	PF00069	0.424
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	25	30	PF00069	0.559
MOD_NEK2_1	41	46	PF00069	0.383
MOD_PKA_1	68	74	PF00069	0.460
MOD_PKA_2	41	47	PF00069	0.418
MOD_PKA_2	68	74	PF00069	0.547
MOD_Plk_4	117	123	PF00069	0.466
MOD_ProDKin_1	150	156	PF00069	0.602
TRG_ENDOCYTIC_2	180	183	PF00928	0.512
TRG_ER_diArg_1	193	196	PF00400	0.592
TRG_ER_diArg_1	30	33	PF00400	0.399
TRG_ER_diArg_1	41	43	PF00400	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I008	Leptomonas seymouri	37%	100%
A4HF22	Leishmania braziliensis	80%	100%
A4I2A1	Leishmania infantum	99%	100%
C9ZRP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AYE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q927	Leishmania major	90%	100%