Phosphatidate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CDP-DAG synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZX3_LEIDO

TriTrypDb:

LdBPK_261600.1 , LdCL_260021700 , LDHU3_26.2020

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A0A3S7WZX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZX3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016024	CDP-diacylglycerol biosynthetic process	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046341	CDP-diacylglycerol metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006655	phosphatidylglycerol biosynthetic process	6	1
GO:0046471	phosphatidylglycerol metabolic process	6	1
GO:0046488	phosphatidylinositol metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004605	phosphatidate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.677
CLV_C14_Caspase3-7	53	57	PF00656	0.531
CLV_MEL_PAP_1	85	91	PF00089	0.508
CLV_NRD_NRD_1	112	114	PF00675	0.205
CLV_NRD_NRD_1	178	180	PF00675	0.229
CLV_NRD_NRD_1	240	242	PF00675	0.257
CLV_NRD_NRD_1	417	419	PF00675	0.293
CLV_PCSK_KEX2_1	354	356	PF00082	0.205
CLV_PCSK_KEX2_1	417	419	PF00082	0.293
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.205
CLV_PCSK_SKI1_1	242	246	PF00082	0.322
CLV_PCSK_SKI1_1	330	334	PF00082	0.495
CLV_PCSK_SKI1_1	354	358	PF00082	0.234
CLV_PCSK_SKI1_1	408	412	PF00082	0.385
CLV_PCSK_SKI1_1	68	72	PF00082	0.242
CLV_PCSK_SKI1_1	8	12	PF00082	0.418
DEG_APCC_DBOX_1	240	248	PF00400	0.405
DEG_APCC_DBOX_1	7	15	PF00400	0.693
DEG_APCC_DBOX_1	87	95	PF00400	0.318
DOC_CYCLIN_RxL_1	237	248	PF00134	0.416
DOC_MAPK_DCC_7	113	123	PF00069	0.448
DOC_MAPK_gen_1	113	123	PF00069	0.431
DOC_MAPK_gen_1	241	247	PF00069	0.460
DOC_MAPK_gen_1	3	11	PF00069	0.694
DOC_MAPK_MEF2A_6	114	123	PF00069	0.448
DOC_MAPK_MEF2A_6	88	95	PF00069	0.386
DOC_MAPK_NFAT4_5	88	96	PF00069	0.386
DOC_MAPK_RevD_3	167	180	PF00069	0.250
DOC_PP1_RVXF_1	302	309	PF00149	0.165
DOC_PP2B_LxvP_1	341	344	PF13499	0.242
DOC_PP4_FxxP_1	10	13	PF00568	0.516
DOC_PP4_FxxP_1	218	221	PF00568	0.242
DOC_USP7_MATH_1	290	294	PF00917	0.208
DOC_USP7_MATH_1	50	54	PF00917	0.714
DOC_USP7_UBL2_3	354	358	PF12436	0.405
DOC_USP7_UBL2_3	59	63	PF12436	0.615
DOC_WW_Pin1_4	19	24	PF00397	0.676
DOC_WW_Pin1_4	245	250	PF00397	0.405
DOC_WW_Pin1_4	323	328	PF00397	0.308
DOC_WW_Pin1_4	43	48	PF00397	0.675
LIG_14-3-3_CanoR_1	417	422	PF00244	0.536
LIG_Actin_WH2_2	164	181	PF00022	0.242
LIG_APCC_ABBAyCdc20_2	391	397	PF00400	0.541
LIG_BRCT_BRCA1_1	119	123	PF00533	0.463
LIG_BRCT_BRCA1_1	266	270	PF00533	0.336
LIG_BRCT_BRCA1_1	98	102	PF00533	0.270
LIG_BRCT_BRCA1_2	119	125	PF00533	0.508
LIG_Clathr_ClatBox_1	94	98	PF01394	0.318
LIG_deltaCOP1_diTrp_1	229	235	PF00928	0.242
LIG_eIF4E_1	133	139	PF01652	0.246
LIG_FHA_1	286	292	PF00498	0.275
LIG_FHA_1	319	325	PF00498	0.309
LIG_FHA_2	34	40	PF00498	0.643
LIG_GBD_Chelix_1	421	429	PF00786	0.391
LIG_LIR_Gen_1	148	156	PF02991	0.307
LIG_LIR_Gen_1	191	199	PF02991	0.257
LIG_LIR_Gen_1	229	239	PF02991	0.361
LIG_LIR_Gen_1	337	345	PF02991	0.366
LIG_LIR_Gen_1	386	395	PF02991	0.409
LIG_LIR_Gen_1	69	79	PF02991	0.277
LIG_LIR_Nem_3	148	152	PF02991	0.229
LIG_LIR_Nem_3	153	159	PF02991	0.229
LIG_LIR_Nem_3	229	234	PF02991	0.361
LIG_LIR_Nem_3	267	273	PF02991	0.314
LIG_LIR_Nem_3	337	341	PF02991	0.366
LIG_LIR_Nem_3	361	365	PF02991	0.405
LIG_LIR_Nem_3	386	390	PF02991	0.405
LIG_LIR_Nem_3	69	74	PF02991	0.290
LIG_LIR_Nem_3	99	105	PF02991	0.276
LIG_PCNA_yPIPBox_3	227	241	PF02747	0.386
LIG_PCNA_yPIPBox_3	412	426	PF02747	0.602
LIG_PDZ_Class_2	426	431	PF00595	0.618
LIG_Pex14_1	231	235	PF04695	0.242
LIG_Pex14_1	266	270	PF04695	0.244
LIG_Pex14_2	135	139	PF04695	0.246
LIG_Pex14_2	235	239	PF04695	0.405
LIG_Pex14_2	256	260	PF04695	0.242
LIG_Pex14_2	262	266	PF04695	0.242
LIG_Pex14_2	273	277	PF04695	0.242
LIG_Pex14_2	345	349	PF04695	0.242
LIG_PTB_Apo_2	295	302	PF02174	0.308
LIG_SH2_CRK	156	160	PF00017	0.260
LIG_SH2_CRK	185	189	PF00017	0.430
LIG_SH2_CRK	387	391	PF00017	0.442
LIG_SH2_PTP2	133	136	PF00017	0.294
LIG_SH2_PTP2	77	80	PF00017	0.277
LIG_SH2_STAT3	183	186	PF00017	0.405
LIG_SH2_STAT5	127	130	PF00017	0.351
LIG_SH2_STAT5	133	136	PF00017	0.364
LIG_SH2_STAT5	233	236	PF00017	0.368
LIG_SH2_STAT5	281	284	PF00017	0.230
LIG_SH2_STAT5	387	390	PF00017	0.430
LIG_SH2_STAT5	393	396	PF00017	0.489
LIG_SH2_STAT5	77	80	PF00017	0.257
LIG_SH3_3	10	16	PF00018	0.614
LIG_SH3_3	303	309	PF00018	0.223
LIG_SUMO_SIM_par_1	243	248	PF11976	0.408
LIG_TRFH_1	156	160	PF08558	0.260
LIG_TYR_ITIM	131	136	PF00017	0.378
LIG_TYR_ITIM	60	65	PF00017	0.554
LIG_UBA3_1	244	251	PF00899	0.411
LIG_WRC_WIRS_1	265	270	PF05994	0.386
LIG_WRC_WIRS_1	320	325	PF05994	0.308
LIG_WRC_WIRS_1	335	340	PF05994	0.336
MOD_CDC14_SPxK_1	248	251	PF00782	0.405
MOD_CDK_SPK_2	245	250	PF00069	0.405
MOD_CDK_SPxK_1	245	251	PF00069	0.405
MOD_CDK_SPxxK_3	323	330	PF00069	0.308
MOD_CK1_1	46	52	PF00069	0.684
MOD_CK2_1	290	296	PF00069	0.225
MOD_CMANNOS	266	269	PF00535	0.257
MOD_Cter_Amidation	239	242	PF01082	0.260
MOD_Cter_Amidation	56	59	PF01082	0.371
MOD_GlcNHglycan	315	318	PF01048	0.519
MOD_GlcNHglycan	350	353	PF01048	0.242
MOD_GlcNHglycan	52	55	PF01048	0.510
MOD_GSK3_1	245	252	PF00069	0.419
MOD_GSK3_1	260	267	PF00069	0.242
MOD_GSK3_1	319	326	PF00069	0.272
MOD_GSK3_1	39	46	PF00069	0.721
MOD_N-GLC_1	66	71	PF02516	0.257
MOD_NEK2_1	145	150	PF00069	0.263
MOD_NEK2_1	174	179	PF00069	0.242
MOD_NEK2_1	190	195	PF00069	0.242
MOD_NEK2_1	260	265	PF00069	0.257
MOD_NEK2_1	319	324	PF00069	0.317
MOD_NEK2_1	348	353	PF00069	0.242
MOD_NEK2_1	395	400	PF00069	0.582
MOD_NEK2_1	425	430	PF00069	0.530
MOD_PKA_1	417	423	PF00069	0.442
MOD_PKA_2	417	423	PF00069	0.522
MOD_Plk_1	25	31	PF00069	0.675
MOD_Plk_1	66	72	PF00069	0.257
MOD_Plk_1	97	103	PF00069	0.289
MOD_Plk_4	117	123	PF00069	0.386
MOD_Plk_4	134	140	PF00069	0.402
MOD_Plk_4	319	325	PF00069	0.308
MOD_Plk_4	337	343	PF00069	0.242
MOD_Plk_4	417	423	PF00069	0.600
MOD_Plk_4	97	103	PF00069	0.282
MOD_ProDKin_1	19	25	PF00069	0.679
MOD_ProDKin_1	245	251	PF00069	0.405
MOD_ProDKin_1	323	329	PF00069	0.308
MOD_ProDKin_1	43	49	PF00069	0.675
MOD_SUMO_rev_2	53	60	PF00179	0.622
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.643
TRG_ENDOCYTIC_2	127	130	PF00928	0.351
TRG_ENDOCYTIC_2	133	136	PF00928	0.359
TRG_ENDOCYTIC_2	156	159	PF00928	0.216
TRG_ENDOCYTIC_2	185	188	PF00928	0.416
TRG_ENDOCYTIC_2	387	390	PF00928	0.430
TRG_ENDOCYTIC_2	62	65	PF00928	0.506
TRG_ENDOCYTIC_2	77	80	PF00928	0.211

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P387	Leptomonas seymouri	83%	100%
A0A0S4JNH9	Bodo saltans	48%	100%
A0A1X0NS18	Trypanosomatidae	61%	100%
A0A422N205	Trypanosoma rangeli	56%	100%
A0JNC1	Bos taurus	34%	97%
A4HF17	Leishmania braziliensis	88%	100%
A4I295	Leishmania infantum	100%	100%
C9ZRP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AYE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O04928	Arabidopsis thaliana	36%	100%
O04940	Solanum tuberosum	37%	100%
O35052	Rattus norvegicus	35%	93%
O49639	Arabidopsis thaliana	38%	100%
O95674	Homo sapiens	34%	97%
P38221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	94%
P53439	Caenorhabditis elegans	32%	93%
P56079	Drosophila melanogaster	34%	96%
P98191	Mus musculus	35%	93%
Q1PE48	Arabidopsis thaliana	36%	92%
Q4Q932	Leishmania major	97%	100%
Q55D90	Dictyostelium discoideum	38%	90%
Q91XU8	Rattus norvegicus	34%	97%
Q92903	Homo sapiens	35%	93%
Q99L43	Mus musculus	34%	97%
Q9P381	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	98%
V5D1I7	Trypanosoma cruzi	57%	100%