Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WZX2_LEIDO

TriTrypDb:

LdBPK_261580.1 , LdCL_260021500 , LDHU3_26.2000

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZX2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.564
CLV_C14_Caspase3-7	383	387	PF00656	0.527
CLV_C14_Caspase3-7	424	428	PF00656	0.433
CLV_C14_Caspase3-7	570	574	PF00656	0.651
CLV_NRD_NRD_1	310	312	PF00675	0.370
CLV_NRD_NRD_1	43	45	PF00675	0.607
CLV_NRD_NRD_1	477	479	PF00675	0.635
CLV_NRD_NRD_1	489	491	PF00675	0.653
CLV_NRD_NRD_1	515	517	PF00675	0.686
CLV_NRD_NRD_1	589	591	PF00675	0.480
CLV_NRD_NRD_1	75	77	PF00675	0.525
CLV_PCSK_FUR_1	486	490	PF00082	0.714
CLV_PCSK_FUR_1	510	514	PF00082	0.610
CLV_PCSK_FUR_1	587	591	PF00082	0.437
CLV_PCSK_KEX2_1	477	479	PF00082	0.636
CLV_PCSK_KEX2_1	488	490	PF00082	0.650
CLV_PCSK_KEX2_1	512	514	PF00082	0.769
CLV_PCSK_KEX2_1	515	517	PF00082	0.655
CLV_PCSK_KEX2_1	589	591	PF00082	0.454
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.760
CLV_PCSK_PC7_1	508	514	PF00082	0.620
CLV_PCSK_SKI1_1	120	124	PF00082	0.600
CLV_PCSK_SKI1_1	193	197	PF00082	0.445
CLV_PCSK_SKI1_1	280	284	PF00082	0.450
CLV_PCSK_SKI1_1	311	315	PF00082	0.465
CLV_PCSK_SKI1_1	459	463	PF00082	0.462
CLV_PCSK_SKI1_1	77	81	PF00082	0.478
CLV_Separin_Metazoa	190	194	PF03568	0.410
DEG_APCC_DBOX_1	119	127	PF00400	0.473
DEG_APCC_DBOX_1	279	287	PF00400	0.462
DEG_APCC_DBOX_1	289	297	PF00400	0.343
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DEG_SPOP_SBC_1	615	619	PF00917	0.472
DOC_CDC14_PxL_1	610	618	PF14671	0.438
DOC_CYCLIN_RxL_1	187	200	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.501
DOC_MAPK_gen_1	137	146	PF00069	0.414
DOC_MAPK_gen_1	442	450	PF00069	0.456
DOC_MAPK_MEF2A_6	280	288	PF00069	0.362
DOC_MAPK_MEF2A_6	322	330	PF00069	0.429
DOC_MAPK_RevD_3	63	77	PF00069	0.510
DOC_PP1_RVXF_1	191	198	PF00149	0.441
DOC_PP1_RVXF_1	74	81	PF00149	0.501
DOC_USP7_MATH_1	174	178	PF00917	0.479
DOC_USP7_MATH_1	214	218	PF00917	0.486
DOC_USP7_MATH_1	252	256	PF00917	0.344
DOC_USP7_MATH_1	267	271	PF00917	0.519
DOC_USP7_MATH_1	350	354	PF00917	0.378
DOC_USP7_MATH_1	377	381	PF00917	0.422
DOC_USP7_MATH_1	392	396	PF00917	0.495
DOC_USP7_MATH_1	52	56	PF00917	0.574
DOC_USP7_MATH_1	574	578	PF00917	0.703
DOC_USP7_MATH_1	643	647	PF00917	0.420
DOC_USP7_MATH_1	94	98	PF00917	0.597
DOC_WW_Pin1_4	265	270	PF00397	0.530
DOC_WW_Pin1_4	34	39	PF00397	0.570
DOC_WW_Pin1_4	449	454	PF00397	0.430
DOC_WW_Pin1_4	533	538	PF00397	0.603
LIG_14-3-3_CanoR_1	109	115	PF00244	0.630
LIG_14-3-3_CanoR_1	120	130	PF00244	0.428
LIG_14-3-3_CanoR_1	137	147	PF00244	0.357
LIG_14-3-3_CanoR_1	379	385	PF00244	0.457
LIG_14-3-3_CanoR_1	393	399	PF00244	0.312
LIG_14-3-3_CanoR_1	410	418	PF00244	0.348
LIG_14-3-3_CanoR_1	44	53	PF00244	0.513
LIG_Actin_WH2_2	295	313	PF00022	0.385
LIG_BRCT_BRCA1_1	230	234	PF00533	0.620
LIG_Clathr_ClatBox_1	550	554	PF01394	0.542
LIG_EH1_1	182	190	PF00400	0.442
LIG_EH1_1	235	243	PF00400	0.376
LIG_eIF4E_1	236	242	PF01652	0.367
LIG_FHA_1	152	158	PF00498	0.449
LIG_FHA_1	220	226	PF00498	0.679
LIG_FHA_1	30	36	PF00498	0.583
LIG_FHA_1	346	352	PF00498	0.352
LIG_FHA_1	536	542	PF00498	0.599
LIG_FHA_1	597	603	PF00498	0.528
LIG_FHA_1	617	623	PF00498	0.429
LIG_FHA_2	110	116	PF00498	0.659
LIG_FHA_2	197	203	PF00498	0.416
LIG_FHA_2	381	387	PF00498	0.597
LIG_FHA_2	392	398	PF00498	0.338
LIG_LIR_Gen_1	199	208	PF02991	0.513
LIG_LIR_Gen_1	249	259	PF02991	0.299
LIG_LIR_Gen_1	303	314	PF02991	0.586
LIG_LIR_Gen_1	421	426	PF02991	0.447
LIG_LIR_Gen_1	452	462	PF02991	0.502
LIG_LIR_LC3C_4	649	652	PF02991	0.403
LIG_LIR_Nem_3	160	165	PF02991	0.415
LIG_LIR_Nem_3	196	201	PF02991	0.466
LIG_LIR_Nem_3	303	309	PF02991	0.507
LIG_LIR_Nem_3	421	425	PF02991	0.453
LIG_LIR_Nem_3	452	458	PF02991	0.490
LIG_LIR_Nem_3	630	634	PF02991	0.384
LIG_NRBOX	295	301	PF00104	0.433
LIG_NRBOX	64	70	PF00104	0.510
LIG_SH2_CRK	162	166	PF00017	0.459
LIG_SH2_CRK	306	310	PF00017	0.468
LIG_SH2_CRK	455	459	PF00017	0.503
LIG_SH2_CRK	528	532	PF00017	0.580
LIG_SH2_SRC	257	260	PF00017	0.313
LIG_SH2_STAP1	248	252	PF00017	0.306
LIG_SH2_STAP1	306	310	PF00017	0.468
LIG_SH2_STAT5	257	260	PF00017	0.492
LIG_SH2_STAT5	265	268	PF00017	0.485
LIG_SH2_STAT5	601	604	PF00017	0.396
LIG_SH2_STAT5	621	624	PF00017	0.234
LIG_SH2_STAT5	631	634	PF00017	0.386
LIG_SH3_3	32	38	PF00018	0.527
LIG_SH3_3	320	326	PF00018	0.354
LIG_SH3_3	466	472	PF00018	0.684
LIG_Sin3_3	648	655	PF02671	0.462
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.490
LIG_SUMO_SIM_anti_2	152	160	PF11976	0.451
LIG_SUMO_SIM_par_1	127	133	PF11976	0.543
LIG_SUMO_SIM_par_1	292	298	PF11976	0.435
LIG_SUMO_SIM_par_1	347	354	PF11976	0.274
LIG_SUMO_SIM_par_1	445	452	PF11976	0.422
LIG_SxIP_EBH_1	589	603	PF03271	0.415
LIG_TRAF2_1	200	203	PF00917	0.490
LIG_TYR_ITIM	632	637	PF00017	0.482
MOD_CK1_1	110	116	PF00069	0.529
MOD_CK1_1	121	127	PF00069	0.429
MOD_CK1_1	133	139	PF00069	0.597
MOD_CK1_1	219	225	PF00069	0.534
MOD_CK1_1	228	234	PF00069	0.447
MOD_CK1_1	268	274	PF00069	0.601
MOD_CK1_1	353	359	PF00069	0.396
MOD_CK1_1	380	386	PF00069	0.493
MOD_CK1_1	409	415	PF00069	0.395
MOD_CK1_1	451	457	PF00069	0.535
MOD_CK1_1	557	563	PF00069	0.636
MOD_CK1_1	641	647	PF00069	0.452
MOD_CK2_1	109	115	PF00069	0.627
MOD_CK2_1	150	156	PF00069	0.462
MOD_CK2_1	196	202	PF00069	0.478
MOD_CK2_1	28	34	PF00069	0.613
MOD_CK2_1	391	397	PF00069	0.422
MOD_CK2_1	557	563	PF00069	0.682
MOD_GlcNHglycan	109	112	PF01048	0.572
MOD_GlcNHglycan	132	135	PF01048	0.587
MOD_GlcNHglycan	176	179	PF01048	0.464
MOD_GlcNHglycan	227	230	PF01048	0.516
MOD_GlcNHglycan	378	382	PF01048	0.357
MOD_GlcNHglycan	394	397	PF01048	0.545
MOD_GlcNHglycan	411	414	PF01048	0.347
MOD_GlcNHglycan	427	430	PF01048	0.494
MOD_GlcNHglycan	46	49	PF01048	0.516
MOD_GlcNHglycan	611	614	PF01048	0.408
MOD_GlcNHglycan	640	643	PF01048	0.447
MOD_GlcNHglycan	98	101	PF01048	0.529
MOD_GSK3_1	109	116	PF00069	0.551
MOD_GSK3_1	157	164	PF00069	0.451
MOD_GSK3_1	193	200	PF00069	0.386
MOD_GSK3_1	219	226	PF00069	0.682
MOD_GSK3_1	267	274	PF00069	0.674
MOD_GSK3_1	30	37	PF00069	0.579
MOD_GSK3_1	353	360	PF00069	0.361
MOD_GSK3_1	380	387	PF00069	0.394
MOD_GSK3_1	4	11	PF00069	0.491
MOD_GSK3_1	421	428	PF00069	0.565
MOD_GSK3_1	436	443	PF00069	0.438
MOD_GSK3_1	498	505	PF00069	0.777
MOD_GSK3_1	532	539	PF00069	0.594
MOD_GSK3_1	554	561	PF00069	0.678
MOD_GSK3_1	592	599	PF00069	0.636
MOD_GSK3_1	601	608	PF00069	0.392
MOD_GSK3_1	96	103	PF00069	0.701
MOD_LATS_1	105	111	PF00433	0.531
MOD_N-GLC_1	368	373	PF02516	0.511
MOD_N-GLC_1	498	503	PF02516	0.606
MOD_NEK2_1	101	106	PF00069	0.679
MOD_NEK2_1	28	33	PF00069	0.551
MOD_NEK2_1	284	289	PF00069	0.543
MOD_NEK2_1	295	300	PF00069	0.287
MOD_NEK2_1	345	350	PF00069	0.516
MOD_NEK2_1	384	389	PF00069	0.525
MOD_NEK2_1	4	9	PF00069	0.558
MOD_NEK2_1	448	453	PF00069	0.436
MOD_NEK2_1	46	51	PF00069	0.348
MOD_NEK2_1	605	610	PF00069	0.403
MOD_NEK2_1	616	621	PF00069	0.442
MOD_NEK2_2	252	257	PF00069	0.310
MOD_NEK2_2	340	345	PF00069	0.458
MOD_PIKK_1	121	127	PF00454	0.458
MOD_PIKK_1	216	222	PF00454	0.574
MOD_PIKK_1	516	522	PF00454	0.586
MOD_PIKK_1	543	549	PF00454	0.639
MOD_PIKK_1	57	63	PF00454	0.538
MOD_PIKK_1	596	602	PF00454	0.394
MOD_PK_1	477	483	PF00069	0.639
MOD_PKA_1	44	50	PF00069	0.523
MOD_PKA_1	477	483	PF00069	0.606
MOD_PKA_2	392	398	PF00069	0.483
MOD_PKA_2	409	415	PF00069	0.340
MOD_PKA_2	477	483	PF00069	0.618
MOD_PKB_1	107	115	PF00069	0.532
MOD_PKB_1	506	514	PF00069	0.698
MOD_Plk_1	118	124	PF00069	0.600
MOD_Plk_1	151	157	PF00069	0.378
MOD_Plk_1	193	199	PF00069	0.364
MOD_Plk_1	340	346	PF00069	0.414
MOD_Plk_1	367	373	PF00069	0.535
MOD_Plk_1	377	383	PF00069	0.579
MOD_Plk_1	543	549	PF00069	0.628
MOD_Plk_1	583	589	PF00069	0.475
MOD_Plk_2-3	558	564	PF00069	0.720
MOD_Plk_4	193	199	PF00069	0.385
MOD_Plk_4	252	258	PF00069	0.436
MOD_Plk_4	284	290	PF00069	0.401
MOD_Plk_4	295	301	PF00069	0.268
MOD_Plk_4	340	346	PF00069	0.429
MOD_Plk_4	368	374	PF00069	0.364
MOD_Plk_4	4	10	PF00069	0.589
MOD_Plk_4	421	427	PF00069	0.578
MOD_Plk_4	605	611	PF00069	0.407
MOD_ProDKin_1	265	271	PF00069	0.543
MOD_ProDKin_1	34	40	PF00069	0.570
MOD_ProDKin_1	449	455	PF00069	0.426
MOD_ProDKin_1	533	539	PF00069	0.603
MOD_SUMO_for_1	656	659	PF00179	0.426
TRG_DiLeu_BaEn_1	279	284	PF01217	0.434
TRG_DiLeu_BaEn_2	117	123	PF01217	0.486
TRG_DiLeu_BaEn_2	340	346	PF01217	0.414
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.413
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.468
TRG_ENDOCYTIC_2	162	165	PF00928	0.384
TRG_ENDOCYTIC_2	201	204	PF00928	0.584
TRG_ENDOCYTIC_2	248	251	PF00928	0.436
TRG_ENDOCYTIC_2	306	309	PF00928	0.481
TRG_ENDOCYTIC_2	455	458	PF00928	0.494
TRG_ENDOCYTIC_2	528	531	PF00928	0.584
TRG_ENDOCYTIC_2	634	637	PF00928	0.490
TRG_ER_diArg_1	444	447	PF00400	0.454
TRG_ER_diArg_1	485	488	PF00400	0.700
TRG_ER_diArg_1	489	492	PF00400	0.661
TRG_ER_diArg_1	513	516	PF00400	0.674
TRG_ER_diArg_1	588	590	PF00400	0.434
TRG_NES_CRM1_1	181	194	PF08389	0.394
TRG_NLS_MonoCore_2	511	516	PF00514	0.620
TRG_NLS_MonoExtC_3	511	516	PF00514	0.620
TRG_NLS_MonoExtN_4	510	516	PF00514	0.799

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I134	Leptomonas seymouri	40%	100%
A4HF15	Leishmania braziliensis	75%	100%
A4I293	Leishmania infantum	100%	100%
E9AYD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q934	Leishmania major	92%	100%