Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZW7_LEIDO

TriTrypDb:

LdBPK_261560.1 , LdCL_260021300 , LDHU3_26.1970

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.500
CLV_C14_Caspase3-7	47	51	PF00656	0.515
CLV_C14_Caspase3-7	561	565	PF00656	0.560
CLV_C14_Caspase3-7	7	11	PF00656	0.695
CLV_NRD_NRD_1	238	240	PF00675	0.373
CLV_NRD_NRD_1	25	27	PF00675	0.564
CLV_NRD_NRD_1	488	490	PF00675	0.475
CLV_NRD_NRD_1	56	58	PF00675	0.463
CLV_NRD_NRD_1	93	95	PF00675	0.452
CLV_PCSK_FUR_1	23	27	PF00082	0.485
CLV_PCSK_FUR_1	91	95	PF00082	0.547
CLV_PCSK_KEX2_1	238	240	PF00082	0.371
CLV_PCSK_KEX2_1	25	27	PF00082	0.544
CLV_PCSK_KEX2_1	488	490	PF00082	0.475
CLV_PCSK_KEX2_1	91	93	PF00082	0.507
CLV_PCSK_PC7_1	87	93	PF00082	0.555
CLV_PCSK_SKI1_1	140	144	PF00082	0.486
CLV_PCSK_SKI1_1	184	188	PF00082	0.598
CLV_PCSK_SKI1_1	382	386	PF00082	0.340
CLV_PCSK_SKI1_1	446	450	PF00082	0.535
CLV_PCSK_SKI1_1	554	558	PF00082	0.433
DEG_APCC_DBOX_1	553	561	PF00400	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.650
DEG_SPOP_SBC_1	159	163	PF00917	0.616
DEG_SPOP_SBC_1	252	256	PF00917	0.572
DEG_SPOP_SBC_1	309	313	PF00917	0.353
DOC_AGCK_PIF_1	569	574	PF00069	0.407
DOC_CYCLIN_RxL_1	342	353	PF00134	0.399
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.429
DOC_MAPK_gen_1	57	65	PF00069	0.467
DOC_MAPK_MEF2A_6	257	266	PF00069	0.455
DOC_MAPK_MEF2A_6	57	65	PF00069	0.451
DOC_PP2B_LxvP_1	214	217	PF13499	0.512
DOC_PP4_FxxP_1	46	49	PF00568	0.521
DOC_USP7_MATH_1	260	264	PF00917	0.488
DOC_USP7_MATH_1	380	384	PF00917	0.375
DOC_USP7_MATH_1	523	527	PF00917	0.399
DOC_USP7_MATH_1	556	560	PF00917	0.437
DOC_WW_Pin1_4	449	454	PF00397	0.478
DOC_WW_Pin1_4	547	552	PF00397	0.499
DOC_WW_Pin1_4	572	577	PF00397	0.429
LIG_14-3-3_CanoR_1	169	174	PF00244	0.728
LIG_14-3-3_CanoR_1	190	196	PF00244	0.535
LIG_14-3-3_CanoR_1	319	325	PF00244	0.434
LIG_14-3-3_CanoR_1	398	403	PF00244	0.429
LIG_14-3-3_CanoR_1	45	49	PF00244	0.516
LIG_14-3-3_CanoR_1	541	551	PF00244	0.643
LIG_APCC_ABBA_1	136	141	PF00400	0.448
LIG_Clathr_ClatBox_1	531	535	PF01394	0.406
LIG_FHA_1	116	122	PF00498	0.521
LIG_FHA_1	266	272	PF00498	0.414
LIG_FHA_1	334	340	PF00498	0.425
LIG_FHA_1	431	437	PF00498	0.440
LIG_FHA_1	500	506	PF00498	0.512
LIG_FHA_1	527	533	PF00498	0.491
LIG_FHA_1	544	550	PF00498	0.389
LIG_FHA_2	130	136	PF00498	0.530
LIG_FHA_2	163	169	PF00498	0.524
LIG_FHA_2	265	271	PF00498	0.436
LIG_FHA_2	37	43	PF00498	0.611
LIG_FHA_2	401	407	PF00498	0.308
LIG_FHA_2	45	51	PF00498	0.465
LIG_LIR_Apic_2	171	176	PF02991	0.593
LIG_LIR_Apic_2	43	49	PF02991	0.539
LIG_LIR_Gen_1	179	189	PF02991	0.514
LIG_LIR_Gen_1	207	217	PF02991	0.518
LIG_LIR_Gen_1	67	75	PF02991	0.465
LIG_LIR_Nem_3	133	139	PF02991	0.389
LIG_LIR_Nem_3	207	212	PF02991	0.565
LIG_LIR_Nem_3	383	388	PF02991	0.401
LIG_LIR_Nem_3	567	572	PF02991	0.378
LIG_LIR_Nem_3	573	577	PF02991	0.395
LIG_LIR_Nem_3	60	65	PF02991	0.404
LIG_LIR_Nem_3	67	72	PF02991	0.401
LIG_PDZ_Class_2	581	586	PF00595	0.444
LIG_Pex14_1	244	248	PF04695	0.506
LIG_Pex14_1	324	328	PF04695	0.520
LIG_Pex14_2	187	191	PF04695	0.584
LIG_Pex14_2	385	389	PF04695	0.415
LIG_REV1ctd_RIR_1	134	143	PF16727	0.465
LIG_SH2_CRK	471	475	PF00017	0.393
LIG_SH2_GRB2like	248	251	PF00017	0.441
LIG_SH2_PTP2	317	320	PF00017	0.330
LIG_SH2_PTP2	62	65	PF00017	0.503
LIG_SH2_PTP2	69	72	PF00017	0.411
LIG_SH2_SRC	226	229	PF00017	0.435
LIG_SH2_SRC	248	251	PF00017	0.640
LIG_SH2_SRC	69	72	PF00017	0.477
LIG_SH2_STAP1	226	230	PF00017	0.460
LIG_SH2_STAP1	248	252	PF00017	0.512
LIG_SH2_STAP1	578	582	PF00017	0.424
LIG_SH2_STAT3	464	467	PF00017	0.398
LIG_SH2_STAT3	577	580	PF00017	0.422
LIG_SH2_STAT5	245	248	PF00017	0.455
LIG_SH2_STAT5	281	284	PF00017	0.384
LIG_SH2_STAT5	317	320	PF00017	0.380
LIG_SH2_STAT5	322	325	PF00017	0.429
LIG_SH2_STAT5	572	575	PF00017	0.401
LIG_SH2_STAT5	578	581	PF00017	0.422
LIG_SH2_STAT5	62	65	PF00017	0.444
LIG_SH2_STAT5	69	72	PF00017	0.412
LIG_SH3_3	151	157	PF00018	0.642
LIG_SH3_3	361	367	PF00018	0.621
LIG_SH3_3	416	422	PF00018	0.521
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.436
LIG_SUMO_SIM_par_1	267	273	PF11976	0.411
LIG_SUMO_SIM_par_1	306	313	PF11976	0.394
LIG_SUMO_SIM_par_1	520	526	PF11976	0.392
LIG_TRAF2_1	165	168	PF00917	0.522
LIG_TYR_ITIM	469	474	PF00017	0.427
LIG_WRC_WIRS_1	399	404	PF05994	0.406
LIG_WRC_WIRS_1	571	576	PF05994	0.411
MOD_CDK_SPK_2	449	454	PF00069	0.478
MOD_CDK_SPxxK_3	547	554	PF00069	0.486
MOD_CK1_1	129	135	PF00069	0.611
MOD_CK1_1	251	257	PF00069	0.681
MOD_CK1_1	350	356	PF00069	0.430
MOD_CK1_1	36	42	PF00069	0.602
MOD_CK1_1	4	10	PF00069	0.566
MOD_CK1_1	458	464	PF00069	0.481
MOD_CK1_1	525	531	PF00069	0.423
MOD_CK1_1	550	556	PF00069	0.439
MOD_CK2_1	162	168	PF00069	0.523
MOD_CK2_1	36	42	PF00069	0.566
MOD_GlcNHglycan	249	253	PF01048	0.535
MOD_GlcNHglycan	35	38	PF01048	0.523
MOD_GlcNHglycan	369	372	PF01048	0.571
MOD_GlcNHglycan	509	512	PF01048	0.433
MOD_GSK3_1	1	8	PF00069	0.635
MOD_GSK3_1	122	129	PF00069	0.640
MOD_GSK3_1	158	165	PF00069	0.618
MOD_GSK3_1	248	255	PF00069	0.530
MOD_GSK3_1	260	267	PF00069	0.359
MOD_GSK3_1	32	39	PF00069	0.676
MOD_GSK3_1	367	374	PF00069	0.656
MOD_GSK3_1	398	405	PF00069	0.416
MOD_GSK3_1	40	47	PF00069	0.587
MOD_GSK3_1	455	462	PF00069	0.453
MOD_GSK3_1	496	503	PF00069	0.460
MOD_GSK3_1	507	514	PF00069	0.474
MOD_GSK3_1	522	529	PF00069	0.305
MOD_GSK3_1	543	550	PF00069	0.499
MOD_GSK3_1	572	579	PF00069	0.375
MOD_N-GLC_1	371	376	PF02516	0.480
MOD_N-GLC_1	430	435	PF02516	0.371
MOD_N-GLC_1	449	454	PF02516	0.413
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	158	163	PF00069	0.651
MOD_NEK2_1	177	182	PF00069	0.556
MOD_NEK2_1	308	313	PF00069	0.396
MOD_NEK2_1	320	325	PF00069	0.326
MOD_NEK2_1	347	352	PF00069	0.425
MOD_NEK2_1	44	49	PF00069	0.474
MOD_NEK2_1	500	505	PF00069	0.494
MOD_NEK2_1	522	527	PF00069	0.397
MOD_NEK2_1	542	547	PF00069	0.317
MOD_NEK2_2	333	338	PF00069	0.426
MOD_NEK2_2	380	385	PF00069	0.398
MOD_PIKK_1	543	549	PF00454	0.497
MOD_PIKK_1	576	582	PF00454	0.414
MOD_PK_1	338	344	PF00069	0.468
MOD_PK_1	57	63	PF00069	0.383
MOD_PKA_1	57	63	PF00069	0.383
MOD_PKA_2	104	110	PF00069	0.443
MOD_PKA_2	126	132	PF00069	0.413
MOD_PKA_2	168	174	PF00069	0.611
MOD_PKA_2	191	197	PF00069	0.545
MOD_PKA_2	32	38	PF00069	0.717
MOD_PKA_2	44	50	PF00069	0.486
MOD_PKB_1	396	404	PF00069	0.453
MOD_Plk_1	226	232	PF00069	0.372
MOD_Plk_1	371	377	PF00069	0.504
MOD_Plk_1	405	411	PF00069	0.428
MOD_Plk_1	458	464	PF00069	0.407
MOD_Plk_2-3	50	56	PF00069	0.511
MOD_Plk_4	338	344	PF00069	0.555
MOD_Plk_4	459	465	PF00069	0.386
MOD_Plk_4	496	502	PF00069	0.463
MOD_Plk_4	57	63	PF00069	0.467
MOD_ProDKin_1	449	455	PF00069	0.468
MOD_ProDKin_1	547	553	PF00069	0.488
MOD_ProDKin_1	572	578	PF00069	0.430
MOD_SUMO_for_1	337	340	PF00179	0.466
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.527
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.541
TRG_ENDOCYTIC_2	317	320	PF00928	0.330
TRG_ENDOCYTIC_2	471	474	PF00928	0.407
TRG_ENDOCYTIC_2	62	65	PF00928	0.443
TRG_ENDOCYTIC_2	69	72	PF00928	0.357
TRG_ER_diArg_1	396	399	PF00400	0.462
TRG_ER_diArg_1	487	489	PF00400	0.478
TRG_ER_diArg_1	90	93	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II93	Leptomonas seymouri	44%	100%
A4HF13	Leishmania braziliensis	80%	100%
A4I292	Leishmania infantum	99%	100%
C9ZRP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AYD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q936	Leishmania major	93%	100%