Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S33, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZW5_LEIDO

TriTrypDb:

LdBPK_261630.1 , LdCL_260022000 , LDHU3_26.2050

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WZW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.531
CLV_C14_Caspase3-7	39	43	PF00656	0.497
CLV_NRD_NRD_1	118	120	PF00675	0.436
CLV_NRD_NRD_1	183	185	PF00675	0.432
CLV_NRD_NRD_1	64	66	PF00675	0.423
CLV_NRD_NRD_1	71	73	PF00675	0.431
CLV_PCSK_KEX2_1	118	120	PF00082	0.442
CLV_PCSK_KEX2_1	57	59	PF00082	0.501
CLV_PCSK_KEX2_1	64	66	PF00082	0.430
CLV_PCSK_KEX2_1	71	73	PF00082	0.457
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.561
CLV_PCSK_SKI1_1	168	172	PF00082	0.479
CLV_PCSK_SKI1_1	205	209	PF00082	0.597
CLV_PCSK_SKI1_1	220	224	PF00082	0.545
CLV_PCSK_SKI1_1	309	313	PF00082	0.428
CLV_Separin_Metazoa	165	169	PF03568	0.437
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DOC_CKS1_1	126	131	PF01111	0.439
DOC_PP1_RVXF_1	107	113	PF00149	0.366
DOC_PP4_FxxP_1	126	129	PF00568	0.385
DOC_USP7_MATH_1	159	163	PF00917	0.481
DOC_USP7_MATH_1	166	170	PF00917	0.470
DOC_USP7_UBL2_3	208	212	PF12436	0.659
DOC_WW_Pin1_4	102	107	PF00397	0.489
DOC_WW_Pin1_4	125	130	PF00397	0.432
DOC_WW_Pin1_4	261	266	PF00397	0.445
LIG_14-3-3_CanoR_1	168	174	PF00244	0.474
LIG_14-3-3_CanoR_1	194	198	PF00244	0.517
LIG_Actin_WH2_2	103	120	PF00022	0.478
LIG_Actin_WH2_2	180	196	PF00022	0.503
LIG_BIR_III_2	206	210	PF00653	0.504
LIG_BRCT_BRCA1_1	107	111	PF00533	0.433
LIG_BRCT_BRCA1_1	145	149	PF00533	0.514
LIG_Clathr_ClatBox_1	314	318	PF01394	0.555
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.432
LIG_EH1_1	293	301	PF00400	0.452
LIG_FHA_1	126	132	PF00498	0.439
LIG_FHA_1	155	161	PF00498	0.534
LIG_FHA_1	295	301	PF00498	0.472
LIG_FHA_1	310	316	PF00498	0.444
LIG_FHA_1	58	64	PF00498	0.483
LIG_FHA_1	86	92	PF00498	0.550
LIG_FHA_2	17	23	PF00498	0.429
LIG_FHA_2	170	176	PF00498	0.536
LIG_FHA_2	224	230	PF00498	0.566
LIG_FHA_2	37	43	PF00498	0.199
LIG_LIR_Apic_2	98	103	PF02991	0.477
LIG_LIR_Gen_1	105	114	PF02991	0.476
LIG_LIR_Nem_3	105	110	PF02991	0.389
LIG_LIR_Nem_3	213	218	PF02991	0.626
LIG_LIR_Nem_3	250	255	PF02991	0.402
LIG_LIR_Nem_3	80	86	PF02991	0.523
LIG_LIR_Nem_3	87	93	PF02991	0.503
LIG_NRBOX	112	118	PF00104	0.362
LIG_PCNA_yPIPBox_3	302	315	PF02747	0.514
LIG_Pex14_1	252	256	PF04695	0.351
LIG_Pex14_2	107	111	PF04695	0.376
LIG_Pex14_2	86	90	PF04695	0.595
LIG_SH2_CRK	100	104	PF00017	0.535
LIG_SH2_CRK	285	289	PF00017	0.362
LIG_SH2_STAP1	156	160	PF00017	0.443
LIG_SH2_STAP1	232	236	PF00017	0.481
LIG_SH2_STAT3	255	258	PF00017	0.417
LIG_SH2_STAT5	132	135	PF00017	0.390
LIG_SH2_STAT5	156	159	PF00017	0.412
LIG_SH2_STAT5	255	258	PF00017	0.499
LIG_SH2_STAT5	34	37	PF00017	0.363
LIG_SH3_1	100	106	PF00018	0.544
LIG_SH3_1	313	319	PF00018	0.575
LIG_SH3_3	100	106	PF00018	0.422
LIG_SH3_3	262	268	PF00018	0.546
LIG_SH3_3	313	319	PF00018	0.586
LIG_SH3_3	88	94	PF00018	0.552
LIG_SH3_4	208	215	PF00018	0.636
LIG_SH3_5	96	100	PF00018	0.607
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.499
LIG_SUMO_SIM_par_1	295	301	PF11976	0.405
LIG_TRAF2_1	226	229	PF00917	0.587
LIG_ULM_U2AF65_1	71	76	PF00076	0.567
LIG_WRC_WIRS_1	83	88	PF05994	0.646
MOD_CDK_SPxxK_3	102	109	PF00069	0.505
MOD_CK1_1	105	111	PF00069	0.440
MOD_CK1_1	169	175	PF00069	0.604
MOD_CK1_1	73	79	PF00069	0.582
MOD_CK1_1	85	91	PF00069	0.634
MOD_CK2_1	159	165	PF00069	0.437
MOD_CK2_1	223	229	PF00069	0.534
MOD_CK2_1	238	244	PF00069	0.288
MOD_GlcNHglycan	157	160	PF01048	0.480
MOD_GlcNHglycan	161	164	PF01048	0.502
MOD_GlcNHglycan	22	26	PF01048	0.416
MOD_GlcNHglycan	240	243	PF01048	0.400
MOD_GlcNHglycan	285	288	PF01048	0.408
MOD_GlcNHglycan	322	325	PF01048	0.658
MOD_GSK3_1	127	134	PF00069	0.510
MOD_GSK3_1	155	162	PF00069	0.485
MOD_GSK3_1	192	199	PF00069	0.504
MOD_GSK3_1	223	230	PF00069	0.582
MOD_GSK3_1	234	241	PF00069	0.470
MOD_GSK3_1	73	80	PF00069	0.509
MOD_NEK2_1	117	122	PF00069	0.351
MOD_NEK2_1	21	26	PF00069	0.552
MOD_NEK2_1	52	57	PF00069	0.523
MOD_NEK2_1	70	75	PF00069	0.555
MOD_NEK2_2	143	148	PF00069	0.489
MOD_PIKK_1	85	91	PF00454	0.583
MOD_PKA_1	57	63	PF00069	0.479
MOD_PKA_2	117	123	PF00069	0.331
MOD_PKA_2	193	199	PF00069	0.517
MOD_PKA_2	57	63	PF00069	0.479
MOD_PKA_2	70	76	PF00069	0.505
MOD_Plk_1	1	7	PF00069	0.507
MOD_Plk_1	294	300	PF00069	0.471
MOD_Plk_1	77	83	PF00069	0.620
MOD_Plk_4	127	133	PF00069	0.510
MOD_Plk_4	210	216	PF00069	0.642
MOD_Plk_4	294	300	PF00069	0.424
MOD_Plk_4	78	84	PF00069	0.622
MOD_ProDKin_1	102	108	PF00069	0.485
MOD_ProDKin_1	125	131	PF00069	0.432
MOD_ProDKin_1	261	267	PF00069	0.440
MOD_SUMO_for_1	319	322	PF00179	0.526
MOD_SUMO_rev_2	200	209	PF00179	0.589
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.358
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.476
TRG_ENDOCYTIC_2	285	288	PF00928	0.387
TRG_ER_diArg_1	117	119	PF00400	0.437
TRG_ER_diArg_1	63	65	PF00400	0.403
TRG_ER_diArg_1	70	72	PF00400	0.407
TRG_NES_CRM1_1	283	295	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG5	Leptomonas seymouri	78%	99%
A0A0S4JUF0	Bodo saltans	36%	99%
A0A1X0NS29	Trypanosomatidae	44%	100%
A0A3R7KFL2	Trypanosoma rangeli	44%	100%
A4HF20	Leishmania braziliensis	89%	100%
A4I299	Leishmania infantum	100%	100%
E9AYE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q929	Leishmania major	97%	100%
V5AKX8	Trypanosoma cruzi	47%	99%