Protein farnesyltransferase subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

farnesyltransferase beta subunit

Species:

Leishmania donovani

UniProt:

A0A3S7WZW4_LEIDO

TriTrypDb:

LdBPK_261450.1 , LdCL_260020100 , LDHU3_26.1790

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005965	protein farnesyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A0A3S7WZW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZW4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018343	protein farnesylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004660	protein farnesyltransferase activity	4	12
GO:0005488	binding	1	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008270	zinc ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.739
CLV_C14_Caspase3-7	465	469	PF00656	0.699
CLV_C14_Caspase3-7	644	648	PF00656	0.576
CLV_NRD_NRD_1	328	330	PF00675	0.568
CLV_NRD_NRD_1	395	397	PF00675	0.301
CLV_NRD_NRD_1	592	594	PF00675	0.278
CLV_PCSK_KEX2_1	278	280	PF00082	0.292
CLV_PCSK_KEX2_1	328	330	PF00082	0.568
CLV_PCSK_KEX2_1	395	397	PF00082	0.294
CLV_PCSK_KEX2_1	534	536	PF00082	0.635
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.287
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.596
CLV_PCSK_PC7_1	274	280	PF00082	0.344
CLV_PCSK_SKI1_1	279	283	PF00082	0.287
CLV_PCSK_SKI1_1	440	444	PF00082	0.608
CLV_PCSK_SKI1_1	577	581	PF00082	0.649
DEG_SPOP_SBC_1	46	50	PF00917	0.750
DEG_SPOP_SBC_1	51	55	PF00917	0.729
DEG_SPOP_SBC_1	687	691	PF00917	0.381
DOC_CYCLIN_RxL_1	274	283	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.500
DOC_MAPK_gen_1	228	236	PF00069	0.536
DOC_MAPK_gen_1	278	284	PF00069	0.487
DOC_MAPK_gen_1	474	484	PF00069	0.542
DOC_MAPK_gen_1	91	100	PF00069	0.504
DOC_MAPK_MEF2A_6	336	343	PF00069	0.549
DOC_PP2B_LxvP_1	684	687	PF13499	0.640
DOC_USP7_MATH_1	135	139	PF00917	0.409
DOC_USP7_MATH_1	174	178	PF00917	0.599
DOC_USP7_MATH_1	226	230	PF00917	0.695
DOC_USP7_MATH_1	363	367	PF00917	0.569
DOC_USP7_MATH_1	456	460	PF00917	0.791
DOC_USP7_MATH_1	46	50	PF00917	0.750
DOC_USP7_MATH_1	51	55	PF00917	0.729
DOC_USP7_MATH_1	62	66	PF00917	0.508
DOC_USP7_MATH_1	649	653	PF00917	0.619
DOC_USP7_MATH_1	687	691	PF00917	0.649
DOC_USP7_MATH_1	692	696	PF00917	0.566
DOC_USP7_MATH_1	70	74	PF00917	0.657
DOC_WW_Pin1_4	105	110	PF00397	0.621
DOC_WW_Pin1_4	141	146	PF00397	0.472
DOC_WW_Pin1_4	359	364	PF00397	0.536
DOC_WW_Pin1_4	699	704	PF00397	0.511
LIG_14-3-3_CanoR_1	15	22	PF00244	0.529
LIG_14-3-3_CanoR_1	279	285	PF00244	0.530
LIG_14-3-3_CanoR_1	302	306	PF00244	0.476
LIG_14-3-3_CanoR_1	535	545	PF00244	0.650
LIG_14-3-3_CanoR_1	640	650	PF00244	0.686
LIG_14-3-3_CanoR_1	699	703	PF00244	0.495
LIG_14-3-3_CanoR_1	711	719	PF00244	0.472
LIG_Actin_WH2_2	514	531	PF00022	0.649
LIG_BRCT_BRCA1_1	701	705	PF00533	0.480
LIG_Clathr_ClatBox_1	19	23	PF01394	0.558
LIG_Clathr_ClatBox_1	313	317	PF01394	0.428
LIG_CSL_BTD_1	214	217	PF09270	0.465
LIG_DCNL_PONY_1	1	4	PF03556	0.625
LIG_deltaCOP1_diTrp_1	572	580	PF00928	0.666
LIG_FHA_1	15	21	PF00498	0.485
LIG_FHA_1	188	194	PF00498	0.772
LIG_FHA_1	196	202	PF00498	0.763
LIG_FHA_1	309	315	PF00498	0.535
LIG_FHA_1	411	417	PF00498	0.483
LIG_FHA_1	6	12	PF00498	0.545
LIG_FHA_1	699	705	PF00498	0.443
LIG_FHA_2	239	245	PF00498	0.602
LIG_FHA_2	318	324	PF00498	0.519
LIG_FHA_2	362	368	PF00498	0.562
LIG_FHA_2	456	462	PF00498	0.790
LIG_FHA_2	615	621	PF00498	0.562
LIG_FHA_2	642	648	PF00498	0.650
LIG_FHA_2	651	657	PF00498	0.537
LIG_FHA_2	689	695	PF00498	0.461
LIG_FHA_2	78	84	PF00498	0.568
LIG_GBD_Chelix_1	149	157	PF00786	0.532
LIG_Integrin_isoDGR_2	410	412	PF01839	0.276
LIG_LIR_Apic_2	212	218	PF02991	0.586
LIG_LIR_Apic_2	86	90	PF02991	0.481
LIG_LIR_Gen_1	439	446	PF02991	0.552
LIG_LIR_Gen_1	539	550	PF02991	0.619
LIG_LIR_Nem_3	118	124	PF02991	0.421
LIG_LIR_Nem_3	190	194	PF02991	0.625
LIG_LIR_Nem_3	439	445	PF02991	0.539
LIG_LIR_Nem_3	539	545	PF02991	0.613
LIG_NRBOX	376	382	PF00104	0.517
LIG_PCNA_yPIPBox_3	374	384	PF02747	0.501
LIG_PCNA_yPIPBox_3	391	401	PF02747	0.501
LIG_PCNA_yPIPBox_3	592	601	PF02747	0.530
LIG_PDZ_Class_1	720	725	PF00595	0.488
LIG_RPA_C_Fungi	706	718	PF08784	0.502
LIG_SH2_GRB2like	589	592	PF00017	0.385
LIG_SH2_NCK_1	582	586	PF00017	0.609
LIG_SH2_SRC	263	266	PF00017	0.491
LIG_SH2_SRC	582	585	PF00017	0.618
LIG_SH2_SRC	663	666	PF00017	0.608
LIG_SH2_STAP1	421	425	PF00017	0.352
LIG_SH2_STAP1	438	442	PF00017	0.439
LIG_SH2_STAP1	542	546	PF00017	0.622
LIG_SH2_STAT3	589	592	PF00017	0.385
LIG_SH2_STAT5	305	308	PF00017	0.338
LIG_SH2_STAT5	372	375	PF00017	0.328
LIG_SH2_STAT5	438	441	PF00017	0.516
LIG_SH2_STAT5	589	592	PF00017	0.343
LIG_SH2_STAT5	598	601	PF00017	0.308
LIG_SH2_STAT5	654	657	PF00017	0.474
LIG_SH2_STAT5	663	666	PF00017	0.516
LIG_SH2_STAT5	87	90	PF00017	0.522
LIG_SH3_3	114	120	PF00018	0.524
LIG_SH3_3	181	187	PF00018	0.513
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.470
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.451
LIG_SUMO_SIM_par_1	17	23	PF11976	0.538
LIG_SUMO_SIM_par_1	339	345	PF11976	0.525
LIG_SUMO_SIM_par_1	480	485	PF11976	0.461
LIG_SUMO_SIM_par_1	7	12	PF11976	0.610
LIG_TRAF2_1	241	244	PF00917	0.530
LIG_TYR_ITIM	122	127	PF00017	0.390
LIG_UBA3_1	380	384	PF00899	0.413
MOD_CK1_1	155	161	PF00069	0.417
MOD_CK1_1	196	202	PF00069	0.748
MOD_CK1_1	204	210	PF00069	0.773
MOD_CK1_1	419	425	PF00069	0.344
MOD_CK1_1	469	475	PF00069	0.654
MOD_CK1_1	47	53	PF00069	0.757
MOD_CK1_1	56	62	PF00069	0.769
MOD_CK1_1	629	635	PF00069	0.328
MOD_CK1_1	669	675	PF00069	0.760
MOD_CK1_1	73	79	PF00069	0.752
MOD_CK2_1	131	137	PF00069	0.448
MOD_CK2_1	238	244	PF00069	0.518
MOD_CK2_1	361	367	PF00069	0.449
MOD_CK2_1	650	656	PF00069	0.534
MOD_CK2_1	670	676	PF00069	0.703
MOD_CK2_1	688	694	PF00069	0.522
MOD_CK2_1	77	83	PF00069	0.728
MOD_Cter_Amidation	326	329	PF01082	0.590
MOD_Cter_Amidation	532	535	PF01082	0.569
MOD_GlcNHglycan	133	136	PF01048	0.553
MOD_GlcNHglycan	146	149	PF01048	0.567
MOD_GlcNHglycan	176	179	PF01048	0.643
MOD_GlcNHglycan	206	209	PF01048	0.763
MOD_GlcNHglycan	211	214	PF01048	0.709
MOD_GlcNHglycan	468	471	PF01048	0.644
MOD_GlcNHglycan	49	52	PF01048	0.785
MOD_GlcNHglycan	497	500	PF01048	0.605
MOD_GlcNHglycan	529	532	PF01048	0.615
MOD_GlcNHglycan	628	631	PF01048	0.328
MOD_GlcNHglycan	668	671	PF01048	0.720
MOD_GlcNHglycan	672	675	PF01048	0.700
MOD_GlcNHglycan	713	716	PF01048	0.474
MOD_GlcNHglycan	73	76	PF01048	0.759
MOD_GSK3_1	111	118	PF00069	0.590
MOD_GSK3_1	131	138	PF00069	0.224
MOD_GSK3_1	155	162	PF00069	0.462
MOD_GSK3_1	189	196	PF00069	0.731
MOD_GSK3_1	197	204	PF00069	0.717
MOD_GSK3_1	357	364	PF00069	0.415
MOD_GSK3_1	436	443	PF00069	0.503
MOD_GSK3_1	46	53	PF00069	0.748
MOD_GSK3_1	505	512	PF00069	0.579
MOD_GSK3_1	666	673	PF00069	0.747
MOD_GSK3_1	688	695	PF00069	0.456
MOD_GSK3_1	707	714	PF00069	0.474
MOD_GSK3_1	73	80	PF00069	0.734
MOD_N-GLC_1	103	108	PF02516	0.509
MOD_N-GLC_1	687	692	PF02516	0.571
MOD_N-GLC_1	70	75	PF02516	0.703
MOD_NEK2_1	152	157	PF00069	0.467
MOD_NEK2_1	193	198	PF00069	0.761
MOD_NEK2_1	25	30	PF00069	0.503
MOD_NEK2_1	416	421	PF00069	0.328
MOD_NEK2_1	545	550	PF00069	0.666
MOD_NEK2_1	659	664	PF00069	0.581
MOD_NEK2_1	697	702	PF00069	0.488
MOD_NEK2_2	111	116	PF00069	0.509
MOD_NEK2_2	280	285	PF00069	0.363
MOD_NEK2_2	621	626	PF00069	0.385
MOD_OFUCOSY	156	163	PF10250	0.540
MOD_PIKK_1	370	376	PF00454	0.344
MOD_PIKK_1	545	551	PF00454	0.522
MOD_PK_1	717	723	PF00069	0.491
MOD_PKA_2	14	20	PF00069	0.533
MOD_PKA_2	204	210	PF00069	0.726
MOD_PKA_2	227	233	PF00069	0.449
MOD_PKA_2	25	31	PF00069	0.551
MOD_PKA_2	301	307	PF00069	0.328
MOD_PKA_2	666	672	PF00069	0.690
MOD_PKA_2	698	704	PF00069	0.431
MOD_Plk_1	103	109	PF00069	0.513
MOD_Plk_2-3	318	324	PF00069	0.570
MOD_Plk_2-3	7	13	PF00069	0.564
MOD_Plk_4	111	117	PF00069	0.526
MOD_Plk_4	211	217	PF00069	0.639
MOD_Plk_4	258	264	PF00069	0.448
MOD_Plk_4	309	315	PF00069	0.342
MOD_Plk_4	650	656	PF00069	0.502
MOD_Plk_4	692	698	PF00069	0.617
MOD_ProDKin_1	105	111	PF00069	0.622
MOD_ProDKin_1	141	147	PF00069	0.474
MOD_ProDKin_1	359	365	PF00069	0.413
MOD_ProDKin_1	699	705	PF00069	0.507
MOD_SUMO_rev_2	485	495	PF00179	0.532
MOD_SUMO_rev_2	530	536	PF00179	0.650
TRG_DiLeu_BaEn_1	607	612	PF01217	0.359
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.609
TRG_ENDOCYTIC_2	124	127	PF00928	0.363
TRG_ENDOCYTIC_2	542	545	PF00928	0.625
TRG_ENDOCYTIC_2	582	585	PF00928	0.618
TRG_ER_diArg_1	394	396	PF00400	0.363
TRG_ER_diArg_1	476	479	PF00400	0.532
TRG_ER_diArg_1	574	577	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	593	597	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA19	Leptomonas seymouri	57%	100%
A0A0S4KLG2	Bodo saltans	39%	100%
A0A1X0NSS5	Trypanosomatidae	37%	100%
A0A422NJ04	Trypanosoma rangeli	39%	100%
A4HF02	Leishmania braziliensis	81%	100%
A4I281	Leishmania infantum	99%	100%
C9ZRR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q8WR00	Leishmania major	93%	100%
V5DA92	Trypanosoma cruzi	39%	100%