J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Domain of unknown function (DUF3395), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZV8_LEIDO

TriTrypDb:

LdBPK_260910.1 , LdCL_260014700 , LDHU3_26.1160

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WZV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZV8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0007007	inner mitochondrial membrane organization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0042407	cristae formation	7	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.771
CLV_C14_Caspase3-7	22	26	PF00656	0.709
CLV_C14_Caspase3-7	85	89	PF00656	0.480
CLV_NRD_NRD_1	122	124	PF00675	0.563
CLV_NRD_NRD_1	453	455	PF00675	0.447
CLV_NRD_NRD_1	53	55	PF00675	0.378
CLV_NRD_NRD_1	683	685	PF00675	0.447
CLV_NRD_NRD_1	740	742	PF00675	0.419
CLV_NRD_NRD_1	817	819	PF00675	0.372
CLV_PCSK_KEX2_1	122	124	PF00082	0.537
CLV_PCSK_KEX2_1	53	55	PF00082	0.378
CLV_PCSK_KEX2_1	731	733	PF00082	0.421
CLV_PCSK_KEX2_1	739	741	PF00082	0.383
CLV_PCSK_KEX2_1	819	821	PF00082	0.334
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.441
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.410
CLV_PCSK_PC7_1	735	741	PF00082	0.266
CLV_PCSK_SKI1_1	112	116	PF00082	0.522
CLV_PCSK_SKI1_1	222	226	PF00082	0.628
CLV_PCSK_SKI1_1	356	360	PF00082	0.467
CLV_PCSK_SKI1_1	509	513	PF00082	0.550
CLV_PCSK_SKI1_1	53	57	PF00082	0.357
CLV_PCSK_SKI1_1	728	732	PF00082	0.468
CLV_PCSK_SKI1_1	8	12	PF00082	0.663
DEG_Nend_UBRbox_2	1	3	PF02207	0.738
DEG_SPOP_SBC_1	186	190	PF00917	0.836
DOC_CKS1_1	803	808	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	620	626	PF00134	0.589
DOC_MAPK_DCC_7	598	608	PF00069	0.562
DOC_MAPK_FxFP_2	162	165	PF00069	0.628
DOC_MAPK_gen_1	508	514	PF00069	0.629
DOC_MAPK_gen_1	53	59	PF00069	0.373
DOC_MAPK_gen_1	553	561	PF00069	0.527
DOC_MAPK_gen_1	596	605	PF00069	0.524
DOC_MAPK_gen_1	663	671	PF00069	0.447
DOC_MAPK_gen_1	681	691	PF00069	0.447
DOC_MAPK_gen_1	818	825	PF00069	0.348
DOC_MAPK_HePTP_8	593	605	PF00069	0.448
DOC_MAPK_MEF2A_6	596	605	PF00069	0.462
DOC_MAPK_MEF2A_6	762	770	PF00069	0.480
DOC_PP1_RVXF_1	810	817	PF00149	0.355
DOC_PP2B_LxvP_1	367	370	PF13499	0.547
DOC_PP2B_LxvP_1	620	623	PF13499	0.545
DOC_PP2B_LxvP_1	785	788	PF13499	0.335
DOC_PP4_FxxP_1	162	165	PF00568	0.663
DOC_PP4_FxxP_1	608	611	PF00568	0.529
DOC_PP4_FxxP_1	798	801	PF00568	0.335
DOC_USP7_MATH_1	165	169	PF00917	0.708
DOC_USP7_MATH_1	186	190	PF00917	0.824
DOC_USP7_MATH_1	209	213	PF00917	0.752
DOC_USP7_MATH_1	228	232	PF00917	0.723
DOC_USP7_MATH_1	251	255	PF00917	0.706
DOC_USP7_MATH_1	32	36	PF00917	0.584
DOC_USP7_MATH_1	538	542	PF00917	0.553
DOC_USP7_MATH_1	611	615	PF00917	0.578
DOC_USP7_MATH_1	670	674	PF00917	0.429
DOC_USP7_MATH_1	744	748	PF00917	0.476
DOC_USP7_MATH_1	756	760	PF00917	0.311
DOC_USP7_UBL2_3	681	685	PF12436	0.402
DOC_WW_Pin1_4	253	258	PF00397	0.820
DOC_WW_Pin1_4	41	46	PF00397	0.408
DOC_WW_Pin1_4	532	537	PF00397	0.538
DOC_WW_Pin1_4	567	572	PF00397	0.569
DOC_WW_Pin1_4	607	612	PF00397	0.517
DOC_WW_Pin1_4	707	712	PF00397	0.380
DOC_WW_Pin1_4	713	718	PF00397	0.450
DOC_WW_Pin1_4	802	807	PF00397	0.445
LIG_14-3-3_CanoR_1	361	365	PF00244	0.487
LIG_14-3-3_CanoR_1	371	377	PF00244	0.380
LIG_14-3-3_CanoR_1	383	391	PF00244	0.344
LIG_14-3-3_CanoR_1	454	462	PF00244	0.473
LIG_14-3-3_CanoR_1	477	481	PF00244	0.548
LIG_14-3-3_CanoR_1	527	533	PF00244	0.483
LIG_14-3-3_CanoR_1	598	604	PF00244	0.518
LIG_14-3-3_CanoR_1	644	652	PF00244	0.422
LIG_14-3-3_CanoR_1	757	762	PF00244	0.427
LIG_Actin_WH2_2	126	143	PF00022	0.490
LIG_APCC_ABBA_1	823	828	PF00400	0.447
LIG_BIR_III_2	764	768	PF00653	0.429
LIG_BIR_III_4	103	107	PF00653	0.513
LIG_BRCT_BRCA1_1	356	360	PF00533	0.536
LIG_BRCT_BRCA1_1	372	376	PF00533	0.586
LIG_BRCT_BRCA1_1	580	584	PF00533	0.639
LIG_EH1_1	626	634	PF00400	0.601
LIG_FHA_1	156	162	PF00498	0.608
LIG_FHA_1	386	392	PF00498	0.587
LIG_FHA_1	457	463	PF00498	0.491
LIG_FHA_1	482	488	PF00498	0.580
LIG_FHA_1	540	546	PF00498	0.505
LIG_FHA_1	560	566	PF00498	0.219
LIG_FHA_1	803	809	PF00498	0.491
LIG_FHA_2	28	34	PF00498	0.635
LIG_FHA_2	282	288	PF00498	0.654
LIG_FHA_2	391	397	PF00498	0.563
LIG_FHA_2	46	52	PF00498	0.422
LIG_HCF-1_HBM_1	472	475	PF13415	0.505
LIG_LIR_Apic_2	163	167	PF02991	0.684
LIG_LIR_Apic_2	546	551	PF02991	0.519
LIG_LIR_Gen_1	35	45	PF02991	0.357
LIG_LIR_Gen_1	362	372	PF02991	0.511
LIG_LIR_Gen_1	478	487	PF02991	0.505
LIG_LIR_Gen_1	492	502	PF02991	0.387
LIG_LIR_Gen_1	581	592	PF02991	0.530
LIG_LIR_Gen_1	699	709	PF02991	0.447
LIG_LIR_Gen_1	81	91	PF02991	0.323
LIG_LIR_Nem_3	35	41	PF02991	0.333
LIG_LIR_Nem_3	362	367	PF02991	0.564
LIG_LIR_Nem_3	478	483	PF02991	0.520
LIG_LIR_Nem_3	492	497	PF02991	0.424
LIG_LIR_Nem_3	581	587	PF02991	0.545
LIG_LIR_Nem_3	631	637	PF02991	0.580
LIG_LIR_Nem_3	699	705	PF02991	0.447
LIG_LIR_Nem_3	81	86	PF02991	0.334
LIG_LIR_Nem_3	88	93	PF02991	0.335
LIG_MAD2	265	273	PF02301	0.600
LIG_PCNA_yPIPBox_3	342	354	PF02747	0.624
LIG_PCNA_yPIPBox_3	661	675	PF02747	0.447
LIG_Pex14_2	360	364	PF04695	0.473
LIG_Pex14_2	476	480	PF04695	0.453
LIG_PTAP_UEV_1	241	246	PF05743	0.520
LIG_PTB_Apo_2	689	696	PF02174	0.335
LIG_PTB_Apo_2	77	84	PF02174	0.331
LIG_PTB_Phospho_1	689	695	PF10480	0.335
LIG_REV1ctd_RIR_1	574	584	PF16727	0.681
LIG_SH2_CRK	38	42	PF00017	0.355
LIG_SH2_PTP2	90	93	PF00017	0.434
LIG_SH2_SRC	549	552	PF00017	0.507
LIG_SH2_STAP1	405	409	PF00017	0.462
LIG_SH2_STAT3	646	649	PF00017	0.448
LIG_SH2_STAT5	129	132	PF00017	0.451
LIG_SH2_STAT5	475	478	PF00017	0.532
LIG_SH2_STAT5	501	504	PF00017	0.510
LIG_SH2_STAT5	549	552	PF00017	0.550
LIG_SH2_STAT5	646	649	PF00017	0.480
LIG_SH2_STAT5	804	807	PF00017	0.408
LIG_SH2_STAT5	90	93	PF00017	0.378
LIG_SH3_3	239	245	PF00018	0.811
LIG_SH3_3	294	300	PF00018	0.552
LIG_SH3_3	516	522	PF00018	0.657
LIG_SH3_3	568	574	PF00018	0.610
LIG_SH3_3	694	700	PF00018	0.334
LIG_SH3_3	705	711	PF00018	0.322
LIG_SH3_3	800	806	PF00018	0.434
LIG_SH3_3	829	835	PF00018	0.335
LIG_SH3_CIN85_PxpxPR_1	334	339	PF14604	0.707
LIG_Sin3_3	561	568	PF02671	0.573
LIG_SUMO_SIM_anti_2	672	678	PF11976	0.447
LIG_SUMO_SIM_par_1	129	134	PF11976	0.542
LIG_SUMO_SIM_par_1	766	771	PF11976	0.361
LIG_TRAF2_1	300	303	PF00917	0.685
LIG_TRAF2_1	680	683	PF00917	0.447
LIG_UBA3_1	605	612	PF00899	0.614
LIG_WRPW_2	634	637	PF00400	0.536
LIG_WW_1	522	525	PF00397	0.613
MOD_CDK_SPK_2	41	46	PF00069	0.480
MOD_CDK_SPK_2	607	612	PF00069	0.531
MOD_CK1_1	147	153	PF00069	0.499
MOD_CK1_1	155	161	PF00069	0.504
MOD_CK1_1	173	179	PF00069	0.715
MOD_CK1_1	227	233	PF00069	0.700
MOD_CK1_1	321	327	PF00069	0.665
MOD_CK1_1	390	396	PF00069	0.572
MOD_CK1_1	760	766	PF00069	0.442
MOD_CK1_1	783	789	PF00069	0.408
MOD_CK2_1	175	181	PF00069	0.731
MOD_CK2_1	194	200	PF00069	0.825
MOD_CK2_1	210	216	PF00069	0.658
MOD_CK2_1	281	287	PF00069	0.611
MOD_CK2_1	390	396	PF00069	0.545
MOD_CK2_1	466	472	PF00069	0.480
MOD_Cter_Amidation	506	509	PF01082	0.567
MOD_GlcNHglycan	146	149	PF01048	0.569
MOD_GlcNHglycan	177	180	PF01048	0.806
MOD_GlcNHglycan	20	24	PF01048	0.752
MOD_GlcNHglycan	226	229	PF01048	0.746
MOD_GlcNHglycan	242	245	PF01048	0.753
MOD_GlcNHglycan	253	256	PF01048	0.816
MOD_GlcNHglycan	274	277	PF01048	0.721
MOD_GlcNHglycan	319	323	PF01048	0.665
MOD_GlcNHglycan	325	328	PF01048	0.717
MOD_GlcNHglycan	33	37	PF01048	0.488
MOD_GlcNHglycan	441	444	PF01048	0.617
MOD_GlcNHglycan	456	459	PF01048	0.442
MOD_GlcNHglycan	580	583	PF01048	0.664
MOD_GlcNHglycan	620	623	PF01048	0.561
MOD_GlcNHglycan	717	720	PF01048	0.445
MOD_GlcNHglycan	782	785	PF01048	0.447
MOD_GSK3_1	146	153	PF00069	0.554
MOD_GSK3_1	170	177	PF00069	0.770
MOD_GSK3_1	19	26	PF00069	0.802
MOD_GSK3_1	218	225	PF00069	0.770
MOD_GSK3_1	236	243	PF00069	0.710
MOD_GSK3_1	28	35	PF00069	0.650
MOD_GSK3_1	321	328	PF00069	0.634
MOD_GSK3_1	356	363	PF00069	0.531
MOD_GSK3_1	375	382	PF00069	0.508
MOD_GSK3_1	385	392	PF00069	0.508
MOD_GSK3_1	401	408	PF00069	0.369
MOD_GSK3_1	41	48	PF00069	0.301
MOD_GSK3_1	450	457	PF00069	0.470
MOD_GSK3_1	528	535	PF00069	0.457
MOD_GSK3_1	607	614	PF00069	0.555
MOD_GSK3_1	618	625	PF00069	0.540
MOD_GSK3_1	67	74	PF00069	0.457
MOD_GSK3_1	740	747	PF00069	0.482
MOD_GSK3_1	756	763	PF00069	0.150
MOD_GSK3_1	766	773	PF00069	0.397
MOD_N-GLC_1	259	264	PF02516	0.787
MOD_N-GLC_1	532	537	PF02516	0.531
MOD_N-GLC_1	713	718	PF02516	0.402
MOD_NEK2_1	139	144	PF00069	0.524
MOD_NEK2_1	146	151	PF00069	0.493
MOD_NEK2_1	224	229	PF00069	0.830
MOD_NEK2_1	325	330	PF00069	0.777
MOD_NEK2_1	360	365	PF00069	0.435
MOD_NEK2_1	372	377	PF00069	0.263
MOD_NEK2_1	384	389	PF00069	0.357
MOD_NEK2_1	439	444	PF00069	0.529
MOD_NEK2_1	448	453	PF00069	0.329
MOD_NEK2_1	466	471	PF00069	0.267
MOD_NEK2_1	476	481	PF00069	0.250
MOD_NEK2_1	500	505	PF00069	0.450
MOD_NEK2_1	528	533	PF00069	0.466
MOD_NEK2_1	559	564	PF00069	0.464
MOD_NEK2_1	57	62	PF00069	0.351
MOD_NEK2_1	618	623	PF00069	0.526
MOD_NEK2_2	405	410	PF00069	0.518
MOD_NEK2_2	428	433	PF00069	0.538
MOD_PIKK_1	147	153	PF00454	0.613
MOD_PIKK_1	45	51	PF00454	0.374
MOD_PIKK_1	551	557	PF00454	0.592
MOD_PIKK_1	57	63	PF00454	0.374
MOD_PIKK_1	67	73	PF00454	0.378
MOD_PIKK_1	720	726	PF00454	0.447
MOD_PKA_1	454	460	PF00069	0.488
MOD_PKA_1	740	746	PF00069	0.340
MOD_PKA_2	193	199	PF00069	0.705
MOD_PKA_2	360	366	PF00069	0.524
MOD_PKA_2	370	376	PF00069	0.533
MOD_PKA_2	476	482	PF00069	0.481
MOD_PKA_2	599	605	PF00069	0.545
MOD_PKA_2	740	746	PF00069	0.476
MOD_PKA_2	756	762	PF00069	0.250
MOD_PKA_2	780	786	PF00069	0.337
MOD_Plk_1	3	9	PF00069	0.578
MOD_Plk_1	405	411	PF00069	0.563
MOD_Plk_1	448	454	PF00069	0.433
MOD_Plk_1	770	776	PF00069	0.319
MOD_Plk_2-3	401	407	PF00069	0.624
MOD_Plk_4	434	440	PF00069	0.552
MOD_Plk_4	490	496	PF00069	0.506
MOD_Plk_4	588	594	PF00069	0.453
MOD_Plk_4	622	628	PF00069	0.586
MOD_Plk_4	670	676	PF00069	0.383
MOD_Plk_4	791	797	PF00069	0.447
MOD_ProDKin_1	253	259	PF00069	0.819
MOD_ProDKin_1	41	47	PF00069	0.408
MOD_ProDKin_1	532	538	PF00069	0.542
MOD_ProDKin_1	567	573	PF00069	0.570
MOD_ProDKin_1	607	613	PF00069	0.516
MOD_ProDKin_1	707	713	PF00069	0.380
MOD_ProDKin_1	802	808	PF00069	0.445
MOD_SUMO_for_1	680	683	PF00179	0.402
MOD_SUMO_rev_2	195	203	PF00179	0.806
MOD_SUMO_rev_2	515	522	PF00179	0.621
TRG_DiLeu_BaEn_1	672	677	PF01217	0.447
TRG_ENDOCYTIC_2	38	41	PF00928	0.338
TRG_ENDOCYTIC_2	494	497	PF00928	0.472
TRG_ENDOCYTIC_2	525	528	PF00928	0.555
TRG_ENDOCYTIC_2	695	698	PF00928	0.335
TRG_ENDOCYTIC_2	90	93	PF00928	0.335
TRG_ER_diArg_1	121	123	PF00400	0.573
TRG_ER_diArg_1	308	311	PF00400	0.648
TRG_ER_diArg_1	52	54	PF00400	0.378
TRG_ER_diArg_1	598	601	PF00400	0.609
TRG_ER_diArg_1	663	666	PF00400	0.432
TRG_ER_diArg_1	738	741	PF00400	0.441
TRG_ER_diArg_1	817	820	PF00400	0.360
TRG_NES_CRM1_1	461	472	PF08389	0.573
TRG_NLS_MonoCore_2	817	822	PF00514	0.447
TRG_NLS_MonoExtN_4	818	823	PF00514	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P653	Leptomonas seymouri	62%	92%
A0A1X0NU14	Trypanosomatidae	32%	100%
A0A422MXE6	Trypanosoma rangeli	35%	100%
A4HEU9	Leishmania braziliensis	79%	99%
A4I223	Leishmania infantum	100%	100%
C9ZRY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AY72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9A0	Leishmania major	93%	100%
V5B9C2	Trypanosoma cruzi	35%	100%