Glutaredoxin/Glutathione S-transferase, N-terminal domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZV5_LEIDO

TriTrypDb:

LdBPK_261520.1 , LdCL_260020900 , LDHU3_26.1920

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A0A3S7WZV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZV5

Function

Biological processes
Term	Name	Level	Count
GO:0001516	prostaglandin biosynthetic process	8	4
GO:0006082	organic acid metabolic process	3	4
GO:0006629	lipid metabolic process	3	4
GO:0006631	fatty acid metabolic process	4	4
GO:0006633	fatty acid biosynthetic process	5	4
GO:0006636	unsaturated fatty acid biosynthetic process	6	4
GO:0006690	icosanoid metabolic process	6	4
GO:0006692	prostanoid metabolic process	6	4
GO:0006693	prostaglandin metabolic process	7	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0033559	unsaturated fatty acid metabolic process	5	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0046456	icosanoid biosynthetic process	6	4
GO:0046457	prostanoid biosynthetic process	7	4
GO:0071704	organic substance metabolic process	2	4
GO:0072330	monocarboxylic acid biosynthetic process	6	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0015035	protein-disulfide reductase activity	3	18
GO:0015036	disulfide oxidoreductase activity	4	18
GO:0016491	oxidoreductase activity	2	18
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	18
GO:0016740	transferase activity	2	14
GO:0097573	obsolete glutathione oxidoreductase activity	4	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	5
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0019153	protein-disulfide reductase (glutathione) activity	4	5
GO:0050220	prostaglandin-E synthase activity	4	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0036134	12-hydroxyheptadecatrienoic acid synthase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.350
CLV_C14_Caspase3-7	279	283	PF00656	0.685
CLV_NRD_NRD_1	153	155	PF00675	0.632
CLV_NRD_NRD_1	309	311	PF00675	0.405
CLV_NRD_NRD_1	335	337	PF00675	0.404
CLV_PCSK_KEX2_1	153	155	PF00082	0.613
CLV_PCSK_KEX2_1	309	311	PF00082	0.445
CLV_PCSK_KEX2_1	335	337	PF00082	0.396
CLV_PCSK_KEX2_1	56	58	PF00082	0.463
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.463
CLV_PCSK_SKI1_1	111	115	PF00082	0.518
CLV_PCSK_SKI1_1	309	313	PF00082	0.399
CLV_PCSK_SKI1_1	56	60	PF00082	0.581
CLV_PCSK_SKI1_1	6	10	PF00082	0.312
CLV_PCSK_SKI1_1	82	86	PF00082	0.637
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SPOP_SBC_1	7	11	PF00917	0.271
DOC_CDC14_PxL_1	155	163	PF14671	0.335
DOC_CKS1_1	243	248	PF01111	0.351
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.296
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.373
DOC_MAPK_DCC_7	131	140	PF00069	0.159
DOC_MAPK_MEF2A_6	131	140	PF00069	0.159
DOC_MAPK_MEF2A_6	154	163	PF00069	0.313
DOC_MAPK_RevD_3	140	154	PF00069	0.438
DOC_PP1_RVXF_1	109	115	PF00149	0.332
DOC_USP7_MATH_1	105	109	PF00917	0.409
DOC_USP7_MATH_1	178	182	PF00917	0.483
DOC_USP7_MATH_1	209	213	PF00917	0.433
DOC_USP7_MATH_1	35	39	PF00917	0.506
DOC_WW_Pin1_4	242	247	PF00397	0.337
DOC_WW_Pin1_4	344	349	PF00397	0.530
LIG_14-3-3_CanoR_1	101	110	PF00244	0.402
LIG_Actin_WH2_2	45	61	PF00022	0.436
LIG_deltaCOP1_diTrp_1	216	222	PF00928	0.363
LIG_FHA_1	35	41	PF00498	0.434
LIG_FHA_1	357	363	PF00498	0.544
LIG_FHA_1	390	396	PF00498	0.624
LIG_FHA_1	8	14	PF00498	0.357
LIG_FHA_1	83	89	PF00498	0.290
LIG_LIR_Apic_2	240	246	PF02991	0.330
LIG_LIR_Gen_1	134	145	PF02991	0.303
LIG_LIR_Gen_1	240	249	PF02991	0.361
LIG_LIR_Nem_3	134	140	PF02991	0.292
LIG_LIR_Nem_3	236	241	PF02991	0.321
LIG_LIR_Nem_3	247	252	PF02991	0.319
LIG_LIR_Nem_3	315	321	PF02991	0.630
LIG_LIR_Nem_3	48	52	PF02991	0.373
LIG_PDZ_Class_2	392	397	PF00595	0.639
LIG_PTB_Apo_2	228	235	PF02174	0.395
LIG_PTB_Apo_2	248	255	PF02174	0.236
LIG_PTB_Phospho_1	248	254	PF10480	0.263
LIG_SH2_CRK	115	119	PF00017	0.280
LIG_SH2_CRK	241	245	PF00017	0.333
LIG_SH2_CRK	78	82	PF00017	0.330
LIG_SH2_GRB2like	249	252	PF00017	0.360
LIG_SH2_GRB2like	78	81	PF00017	0.326
LIG_SH2_PTP2	243	246	PF00017	0.342
LIG_SH2_STAP1	202	206	PF00017	0.413
LIG_SH2_STAT3	268	271	PF00017	0.597
LIG_SH2_STAT5	103	106	PF00017	0.456
LIG_SH2_STAT5	122	125	PF00017	0.259
LIG_SH2_STAT5	162	165	PF00017	0.387
LIG_SH2_STAT5	185	188	PF00017	0.356
LIG_SH2_STAT5	24	27	PF00017	0.447
LIG_SH2_STAT5	241	244	PF00017	0.333
LIG_SH2_STAT5	78	81	PF00017	0.326
LIG_TRAF2_1	320	323	PF00917	0.603
LIG_TRAF2_1	383	386	PF00917	0.481
LIG_TRFH_1	155	159	PF08558	0.328
LIG_TYR_ITIM	113	118	PF00017	0.320
LIG_TYR_ITIM	130	135	PF00017	0.261
LIG_WRC_WIRS_1	329	334	PF05994	0.544
MOD_CK1_1	11	17	PF00069	0.473
MOD_CK1_1	194	200	PF00069	0.347
MOD_CK1_1	263	269	PF00069	0.423
MOD_CK1_1	295	301	PF00069	0.664
MOD_CK1_1	305	311	PF00069	0.624
MOD_CK1_1	38	44	PF00069	0.498
MOD_CK1_1	89	95	PF00069	0.519
MOD_CK2_1	42	48	PF00069	0.339
MOD_GlcNHglycan	10	13	PF01048	0.392
MOD_GlcNHglycan	145	148	PF01048	0.552
MOD_GlcNHglycan	170	173	PF01048	0.698
MOD_GlcNHglycan	188	191	PF01048	0.540
MOD_GlcNHglycan	196	199	PF01048	0.523
MOD_GlcNHglycan	211	214	PF01048	0.495
MOD_GlcNHglycan	258	261	PF01048	0.369
MOD_GlcNHglycan	43	47	PF01048	0.557
MOD_GSK3_1	101	108	PF00069	0.426
MOD_GSK3_1	223	230	PF00069	0.308
MOD_GSK3_1	256	263	PF00069	0.401
MOD_GSK3_1	283	290	PF00069	0.680
MOD_GSK3_1	34	41	PF00069	0.507
MOD_GSK3_1	7	14	PF00069	0.436
MOD_GSK3_1	82	89	PF00069	0.457
MOD_N-GLC_1	230	235	PF02516	0.512
MOD_NEK2_1	227	232	PF00069	0.315
MOD_NEK2_1	312	317	PF00069	0.600
MOD_PIKK_1	191	197	PF00454	0.329
MOD_PIKK_1	83	89	PF00454	0.445
MOD_PKA_2	76	82	PF00069	0.403
MOD_Plk_1	230	236	PF00069	0.315
MOD_Plk_4	239	245	PF00069	0.359
MOD_Plk_4	260	266	PF00069	0.414
MOD_Plk_4	328	334	PF00069	0.557
MOD_Plk_4	391	397	PF00069	0.564
MOD_ProDKin_1	242	248	PF00069	0.339
MOD_ProDKin_1	344	350	PF00069	0.525
MOD_SUMO_for_1	124	127	PF00179	0.296
MOD_SUMO_for_1	276	279	PF00179	0.625
MOD_SUMO_rev_2	106	113	PF00179	0.405
TRG_DiLeu_BaEn_2	327	333	PF01217	0.534
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.312
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.519
TRG_ENDOCYTIC_2	115	118	PF00928	0.281
TRG_ENDOCYTIC_2	132	135	PF00928	0.273
TRG_ENDOCYTIC_2	241	244	PF00928	0.323
TRG_ENDOCYTIC_2	249	252	PF00928	0.323
TRG_ENDOCYTIC_2	78	81	PF00928	0.434
TRG_ER_diArg_1	153	155	PF00400	0.432
TRG_ER_diArg_1	335	337	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS46	Leptomonas seymouri	25%	100%
A0A0N1ILY8	Leptomonas seymouri	59%	100%
A0A0S4IXT4	Bodo saltans	23%	100%
A0A0S4JV60	Bodo saltans	31%	100%
A0A1X0NND6	Trypanosomatidae	28%	100%
A0A1X0NTT0	Trypanosomatidae	41%	100%
A0A3S7WT83	Leishmania donovani	25%	81%
A0A422MZ79	Trypanosoma rangeli	42%	100%
A0A422N3R5	Trypanosoma rangeli	25%	100%
A4H7W8	Leishmania braziliensis	27%	100%
A4HF09	Leishmania braziliensis	84%	100%
A4HW95	Leishmania infantum	25%	81%
A4I288	Leishmania infantum	99%	100%
C9ZRQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZSR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9APZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AYD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q940	Leishmania major	92%	100%
Q4QFI5	Leishmania major	25%	81%
V5AYZ4	Trypanosoma cruzi	42%	100%
V5DC17	Trypanosoma cruzi	26%	100%