Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WWE domain/WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZV3_LEIDO

TriTrypDb:

LdBPK_261380.1 , LdCL_260019400 , LDHU3_26.1690

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WZV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZV3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.722
CLV_NRD_NRD_1	36	38	PF00675	0.761
CLV_NRD_NRD_1	448	450	PF00675	0.372
CLV_PCSK_KEX2_1	155	157	PF00082	0.252
CLV_PCSK_KEX2_1	191	193	PF00082	0.245
CLV_PCSK_KEX2_1	35	37	PF00082	0.754
CLV_PCSK_KEX2_1	448	450	PF00082	0.372
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.254
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.251
CLV_PCSK_PC7_1	31	37	PF00082	0.542
CLV_PCSK_SKI1_1	188	192	PF00082	0.251
CLV_PCSK_SKI1_1	309	313	PF00082	0.413
CLV_PCSK_SKI1_1	517	521	PF00082	0.360
CLV_PCSK_SKI1_1	74	78	PF00082	0.643
DEG_SPOP_SBC_1	328	332	PF00917	0.575
DEG_SPOP_SBC_1	544	548	PF00917	0.300
DOC_ANK_TNKS_1	323	330	PF00023	0.408
DOC_ANK_TNKS_1	357	364	PF00023	0.485
DOC_MAPK_gen_1	154	162	PF00069	0.451
DOC_MAPK_gen_1	186	195	PF00069	0.446
DOC_MAPK_RevD_3	141	156	PF00069	0.480
DOC_PP4_FxxP_1	457	460	PF00568	0.438
DOC_USP7_MATH_1	131	135	PF00917	0.478
DOC_USP7_MATH_1	169	173	PF00917	0.481
DOC_USP7_MATH_1	391	395	PF00917	0.505
DOC_USP7_MATH_1	415	419	PF00917	0.576
DOC_USP7_MATH_1	44	48	PF00917	0.652
DOC_USP7_MATH_1	490	494	PF00917	0.547
DOC_USP7_MATH_1	506	510	PF00917	0.494
DOC_USP7_MATH_1	556	560	PF00917	0.555
DOC_USP7_MATH_2	78	84	PF00917	0.561
DOC_WW_Pin1_4	269	274	PF00397	0.450
DOC_WW_Pin1_4	277	282	PF00397	0.428
DOC_WW_Pin1_4	4	9	PF00397	0.655
DOC_WW_Pin1_4	510	515	PF00397	0.464
LIG_14-3-3_CanoR_1	146	152	PF00244	0.487
LIG_14-3-3_CanoR_1	156	161	PF00244	0.418
LIG_14-3-3_CanoR_1	24	34	PF00244	0.589
LIG_14-3-3_CanoR_1	35	41	PF00244	0.537
LIG_14-3-3_CanoR_1	411	415	PF00244	0.425
LIG_14-3-3_CanoR_1	448	454	PF00244	0.519
LIG_14-3-3_CanoR_1	491	500	PF00244	0.467
LIG_14-3-3_CanoR_1	517	527	PF00244	0.426
LIG_Actin_WH2_2	57	72	PF00022	0.600
LIG_AP2alpha_2	217	219	PF02296	0.412
LIG_APCC_ABBA_1	216	221	PF00400	0.511
LIG_BRCT_BRCA1_1	417	421	PF00533	0.454
LIG_deltaCOP1_diTrp_1	466	476	PF00928	0.554
LIG_eIF4E_1	379	385	PF01652	0.541
LIG_FHA_1	146	152	PF00498	0.458
LIG_FHA_1	157	163	PF00498	0.425
LIG_FHA_1	185	191	PF00498	0.585
LIG_FHA_1	201	207	PF00498	0.654
LIG_FHA_1	278	284	PF00498	0.581
LIG_FHA_1	316	322	PF00498	0.438
LIG_FHA_1	354	360	PF00498	0.472
LIG_FHA_1	373	379	PF00498	0.500
LIG_FHA_1	482	488	PF00498	0.523
LIG_FHA_1	492	498	PF00498	0.477
LIG_FHA_1	544	550	PF00498	0.472
LIG_FHA_1	66	72	PF00498	0.610
LIG_FHA_2	105	111	PF00498	0.677
LIG_FHA_2	195	201	PF00498	0.541
LIG_FHA_2	321	327	PF00498	0.523
LIG_FHA_2	433	439	PF00498	0.393
LIG_FHA_2	456	462	PF00498	0.568
LIG_LIR_Apic_2	197	201	PF02991	0.545
LIG_LIR_Apic_2	323	328	PF02991	0.546
LIG_LIR_Gen_1	525	531	PF02991	0.385
LIG_LIR_Nem_3	112	117	PF02991	0.452
LIG_LIR_Nem_3	126	130	PF02991	0.435
LIG_LIR_Nem_3	525	530	PF02991	0.424
LIG_LIR_Nem_3	574	578	PF02991	0.540
LIG_PCNA_yPIPBox_3	207	216	PF02747	0.454
LIG_PDZ_Class_1	576	581	PF00595	0.408
LIG_SH2_NCK_1	198	202	PF00017	0.529
LIG_SH2_NCK_1	325	329	PF00017	0.550
LIG_SH2_SRC	360	363	PF00017	0.390
LIG_SH2_STAP1	158	162	PF00017	0.491
LIG_SH2_STAP1	341	345	PF00017	0.481
LIG_SH2_STAT3	179	182	PF00017	0.445
LIG_SH2_STAT3	512	515	PF00017	0.407
LIG_SH2_STAT5	158	161	PF00017	0.518
LIG_SH2_STAT5	198	201	PF00017	0.635
LIG_SH2_STAT5	275	278	PF00017	0.454
LIG_SH2_STAT5	512	515	PF00017	0.479
LIG_SH3_1	424	430	PF00018	0.533
LIG_SH3_3	290	296	PF00018	0.448
LIG_SH3_3	424	430	PF00018	0.430
LIG_SH3_3	98	104	PF00018	0.655
LIG_Sin3_3	290	297	PF02671	0.407
LIG_TRFH_1	421	425	PF08558	0.429
MOD_CDK_SPxxK_3	4	11	PF00069	0.576
MOD_CDK_SPxxK_3	510	517	PF00069	0.467
MOD_CK1_1	16	22	PF00069	0.653
MOD_CK1_1	315	321	PF00069	0.522
MOD_CK1_1	332	338	PF00069	0.483
MOD_CK1_1	523	529	PF00069	0.483
MOD_CK1_1	566	572	PF00069	0.493
MOD_CK1_1	7	13	PF00069	0.616
MOD_CK2_1	104	110	PF00069	0.798
MOD_CK2_1	320	326	PF00069	0.508
MOD_CK2_1	432	438	PF00069	0.479
MOD_CK2_1	571	577	PF00069	0.585
MOD_GlcNHglycan	133	136	PF01048	0.318
MOD_GlcNHglycan	171	174	PF01048	0.277
MOD_GlcNHglycan	304	307	PF01048	0.450
MOD_GlcNHglycan	38	41	PF01048	0.670
MOD_GlcNHglycan	46	49	PF01048	0.819
MOD_GSK3_1	15	22	PF00069	0.709
MOD_GSK3_1	196	203	PF00069	0.572
MOD_GSK3_1	269	276	PF00069	0.430
MOD_GSK3_1	312	319	PF00069	0.491
MOD_GSK3_1	328	335	PF00069	0.488
MOD_GSK3_1	506	513	PF00069	0.452
MOD_GSK3_1	526	533	PF00069	0.411
MOD_GSK3_1	556	563	PF00069	0.566
MOD_N-GLC_1	339	344	PF02516	0.487
MOD_N-GLC_1	472	477	PF02516	0.408
MOD_N-GLC_1	534	539	PF02516	0.415
MOD_NEK2_1	145	150	PF00069	0.508
MOD_NEK2_1	15	20	PF00069	0.586
MOD_NEK2_1	263	268	PF00069	0.444
MOD_NEK2_1	301	306	PF00069	0.367
MOD_NEK2_1	481	486	PF00069	0.504
MOD_NEK2_1	499	504	PF00069	0.408
MOD_NEK2_1	530	535	PF00069	0.458
MOD_NEK2_2	506	511	PF00069	0.449
MOD_PIKK_1	80	86	PF00454	0.720
MOD_PK_1	449	455	PF00069	0.323
MOD_PKA_1	154	160	PF00069	0.554
MOD_PKA_1	36	42	PF00069	0.759
MOD_PKA_2	145	151	PF00069	0.536
MOD_PKA_2	36	42	PF00069	0.759
MOD_PKA_2	410	416	PF00069	0.447
MOD_PKA_2	490	496	PF00069	0.464
MOD_Plk_1	312	318	PF00069	0.492
MOD_Plk_1	460	466	PF00069	0.543
MOD_Plk_1	472	478	PF00069	0.502
MOD_Plk_1	534	540	PF00069	0.520
MOD_Plk_1	566	572	PF00069	0.476
MOD_Plk_4	109	115	PF00069	0.646
MOD_Plk_4	147	153	PF00069	0.506
MOD_Plk_4	317	323	PF00069	0.427
MOD_Plk_4	332	338	PF00069	0.436
MOD_Plk_4	523	529	PF00069	0.391
MOD_Plk_4	545	551	PF00069	0.448
MOD_Plk_4	556	562	PF00069	0.474
MOD_ProDKin_1	269	275	PF00069	0.447
MOD_ProDKin_1	277	283	PF00069	0.435
MOD_ProDKin_1	4	10	PF00069	0.655
MOD_ProDKin_1	510	516	PF00069	0.462
MOD_SUMO_rev_2	200	208	PF00179	0.691
MOD_SUMO_rev_2	438	442	PF00179	0.565
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.543
TRG_ER_diArg_1	34	37	PF00400	0.535
TRG_ER_diArg_1	447	449	PF00400	0.332
TRG_ER_diArg_1	550	553	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB1	Leptomonas seymouri	64%	100%
A0A0S4KLR3	Bodo saltans	27%	100%
A0A1X0NS60	Trypanosomatidae	33%	100%
A0A3S7WR72	Leishmania donovani	22%	100%
A0A422NIT0	Trypanosoma rangeli	36%	100%
A4H666	Leishmania braziliensis	22%	100%
A4HEZ5	Leishmania braziliensis	73%	100%
A4HUJ0	Leishmania infantum	22%	100%
A4I269	Leishmania infantum	100%	100%
C9ZRS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AYB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q954	Leishmania major	93%	100%
Q4QHD6	Leishmania major	22%	100%
V5BEB9	Trypanosoma cruzi	34%	100%