Nicalin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nicalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZU9_LEIDO

TriTrypDb:

LdBPK_261020.1 , LdCL_260015800 , LDHU3_26.1300

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A0A3S7WZU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZU9

Function

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Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	11
GO:0010646	regulation of cell communication	4	11
GO:0023051	regulation of signaling	3	11
GO:0048583	regulation of response to stimulus	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.399
CLV_NRD_NRD_1	168	170	PF00675	0.618
CLV_NRD_NRD_1	240	242	PF00675	0.515
CLV_NRD_NRD_1	389	391	PF00675	0.606
CLV_PCSK_KEX2_1	168	170	PF00082	0.618
CLV_PCSK_KEX2_1	240	242	PF00082	0.515
CLV_PCSK_KEX2_1	320	322	PF00082	0.648
CLV_PCSK_KEX2_1	389	391	PF00082	0.617
CLV_PCSK_KEX2_1	403	405	PF00082	0.496
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.648

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P650	Leptomonas seymouri	61%	100%
A0A1X0NSR2	Trypanosomatidae	33%	86%
A0A3R7MV36	Trypanosoma rangeli	34%	91%
A4HEW0	Leishmania braziliensis	79%	100%
A4I233	Leishmania infantum	100%	100%
C9ZRX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
E9AY83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q990	Leishmania major	95%	100%
V5BPU6	Trypanosoma cruzi	34%	91%

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