Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZU2_LEIDO

TriTrypDb:

LdBPK_261300.1 , LdCL_260018600 , LDHU3_26.1600

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WZU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.411
CLV_NRD_NRD_1	209	211	PF00675	0.455
CLV_PCSK_FUR_1	207	211	PF00082	0.411
CLV_PCSK_KEX2_1	193	195	PF00082	0.413
CLV_PCSK_KEX2_1	204	206	PF00082	0.417
CLV_PCSK_KEX2_1	209	211	PF00082	0.450
CLV_PCSK_KEX2_1	268	270	PF00082	0.549
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.385
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.581
CLV_PCSK_PC7_1	189	195	PF00082	0.413
CLV_PCSK_PC7_1	205	211	PF00082	0.389
CLV_PCSK_SKI1_1	121	125	PF00082	0.606
CLV_PCSK_SKI1_1	201	205	PF00082	0.413
CLV_PCSK_SKI1_1	37	41	PF00082	0.633
DEG_APCC_DBOX_1	120	128	PF00400	0.639
DEG_APCC_DBOX_1	209	217	PF00400	0.373
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DOC_MAPK_JIP1_4	121	127	PF00069	0.636
DOC_PP4_FxxP_1	87	90	PF00568	0.596
DOC_USP7_MATH_1	138	142	PF00917	0.697
DOC_USP7_MATH_1	149	153	PF00917	0.588
DOC_USP7_MATH_1	184	188	PF00917	0.417
DOC_USP7_MATH_1	255	259	PF00917	0.481
DOC_USP7_MATH_1	47	51	PF00917	0.621
DOC_USP7_MATH_1	82	86	PF00917	0.687
DOC_USP7_MATH_1	90	94	PF00917	0.554
DOC_USP7_UBL2_3	171	175	PF12436	0.515
DOC_USP7_UBL2_3	264	268	PF12436	0.637
DOC_WW_Pin1_4	22	27	PF00397	0.639
DOC_WW_Pin1_4	40	45	PF00397	0.690
LIG_14-3-3_CanoR_1	111	120	PF00244	0.559
LIG_14-3-3_CanoR_1	9	18	PF00244	0.679
LIG_Actin_WH2_2	218	236	PF00022	0.394
LIG_Clathr_ClatBox_1	124	128	PF01394	0.631
LIG_FHA_1	34	40	PF00498	0.753
LIG_FHA_1	41	47	PF00498	0.599
LIG_FHA_2	112	118	PF00498	0.598
LIG_FHA_2	26	32	PF00498	0.650
LIG_FHA_2	84	90	PF00498	0.622
LIG_LIR_Apic_2	85	90	PF02991	0.616
LIG_LIR_Gen_1	62	72	PF02991	0.542
LIG_LIR_Nem_3	155	160	PF02991	0.595
LIG_LIR_Nem_3	62	67	PF02991	0.558
LIG_PDZ_Class_2	273	278	PF00595	0.471
LIG_Pex14_1	168	172	PF04695	0.393
LIG_PTB_Apo_2	215	222	PF02174	0.394
LIG_SH2_CRK	173	177	PF00017	0.388
LIG_SH2_STAT5	27	30	PF00017	0.563
LIG_SH3_3	66	72	PF00018	0.577
LIG_SUMO_SIM_par_1	122	130	PF11976	0.645
LIG_UBA3_1	229	237	PF00899	0.410
LIG_WRC_WIRS_1	105	110	PF05994	0.559
MOD_CDK_SPK_2	40	45	PF00069	0.631
MOD_CDK_SPxxK_3	22	29	PF00069	0.651
MOD_CK1_1	141	147	PF00069	0.714
MOD_CK1_1	152	158	PF00069	0.432
MOD_CK1_1	235	241	PF00069	0.457
MOD_CK1_1	50	56	PF00069	0.635
MOD_Cter_Amidation	266	269	PF01082	0.559
MOD_GlcNHglycan	11	14	PF01048	0.595
MOD_GlcNHglycan	143	146	PF01048	0.630
MOD_GlcNHglycan	151	154	PF01048	0.584
MOD_GlcNHglycan	253	256	PF01048	0.412
MOD_GlcNHglycan	258	261	PF01048	0.498
MOD_GlcNHglycan	3	6	PF01048	0.635
MOD_GlcNHglycan	31	36	PF01048	0.658
MOD_GlcNHglycan	92	95	PF01048	0.727
MOD_GSK3_1	18	25	PF00069	0.602
MOD_GSK3_1	247	254	PF00069	0.454
MOD_GSK3_1	256	263	PF00069	0.507
MOD_GSK3_1	267	274	PF00069	0.480
MOD_GSK3_1	90	97	PF00069	0.723
MOD_N-GLC_1	138	143	PF02516	0.682
MOD_N-GLC_1	40	45	PF02516	0.596
MOD_N-GLC_1	50	55	PF02516	0.509
MOD_N-GLC_1	82	87	PF02516	0.636
MOD_N-GLC_2	101	103	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	127	132	PF00069	0.633
MOD_NEK2_1	233	238	PF00069	0.436
MOD_NEK2_1	246	251	PF00069	0.461
MOD_PIKK_1	127	133	PF00454	0.640
MOD_PIKK_1	247	253	PF00454	0.523
MOD_PKA_2	256	262	PF00069	0.517
MOD_PKA_2	59	65	PF00069	0.500
MOD_PKB_1	109	117	PF00069	0.565
MOD_PKB_1	269	277	PF00069	0.480
MOD_Plk_1	116	122	PF00069	0.577
MOD_Plk_1	138	144	PF00069	0.634
MOD_Plk_1	50	56	PF00069	0.613
MOD_Plk_4	72	78	PF00069	0.557
MOD_Plk_4	83	89	PF00069	0.539
MOD_ProDKin_1	22	28	PF00069	0.641
MOD_ProDKin_1	40	46	PF00069	0.689
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.628
TRG_ENDOCYTIC_2	157	160	PF00928	0.564
TRG_ENDOCYTIC_2	173	176	PF00928	0.301
TRG_ER_diArg_1	108	111	PF00400	0.542
TRG_ER_diArg_1	193	195	PF00400	0.413
TRG_ER_diArg_1	208	210	PF00400	0.447
TRG_ER_diArg_1	269	272	PF00400	0.500
TRG_ER_diLys_1	273	278	PF00400	0.471
TRG_NLS_Bipartite_1	193	208	PF00514	0.394
TRG_NLS_MonoExtC_3	267	272	PF00514	0.623
TRG_NLS_MonoExtN_4	201	208	PF00514	0.401
TRG_NLS_MonoExtN_4	266	272	PF00514	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC03	Leptomonas seymouri	66%	100%
A0A1X0NS69	Trypanosomatidae	62%	100%
A0A3R7ND13	Trypanosoma rangeli	62%	100%
A4HEY7	Leishmania braziliensis	77%	100%
A4I261	Leishmania infantum	100%	100%
C9ZRT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AYB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q962	Leishmania major	92%	100%
V5BIT0	Trypanosoma cruzi	63%	91%