Ring finger domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZT2_LEIDO

TriTrypDb:

LdBPK_261150.1 , LdCL_260017100 , LDHU3_26.1430

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.647
CLV_NRD_NRD_1	116	118	PF00675	0.581
CLV_NRD_NRD_1	229	231	PF00675	0.574
CLV_NRD_NRD_1	401	403	PF00675	0.463
CLV_NRD_NRD_1	428	430	PF00675	0.463
CLV_NRD_NRD_1	456	458	PF00675	0.466
CLV_NRD_NRD_1	463	465	PF00675	0.510
CLV_NRD_NRD_1	504	506	PF00675	0.840
CLV_PCSK_FUR_1	399	403	PF00082	0.463
CLV_PCSK_KEX2_1	116	118	PF00082	0.581
CLV_PCSK_KEX2_1	231	233	PF00082	0.586
CLV_PCSK_KEX2_1	399	401	PF00082	0.456
CLV_PCSK_KEX2_1	428	430	PF00082	0.450
CLV_PCSK_KEX2_1	456	458	PF00082	0.458
CLV_PCSK_KEX2_1	504	506	PF00082	0.840
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.586
CLV_PCSK_SKI1_1	296	300	PF00082	0.581
CLV_PCSK_SKI1_1	393	397	PF00082	0.486
CLV_PCSK_SKI1_1	402	406	PF00082	0.429
CLV_PCSK_SKI1_1	510	514	PF00082	0.581
DEG_APCC_DBOX_1	401	409	PF00400	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DEG_SPOP_SBC_1	141	145	PF00917	0.685
DEG_SPOP_SBC_1	281	285	PF00917	0.608
DEG_SPOP_SBC_1	437	441	PF00917	0.472
DOC_ANK_TNKS_1	271	278	PF00023	0.625
DOC_MAPK_gen_1	399	408	PF00069	0.477
DOC_MAPK_gen_1	423	432	PF00069	0.520
DOC_MAPK_MEF2A_6	195	202	PF00069	0.514
DOC_MAPK_MEF2A_6	399	408	PF00069	0.456
DOC_PP2B_LxvP_1	23	26	PF13499	0.586
DOC_PP2B_LxvP_1	292	295	PF13499	0.625
DOC_PP2B_LxvP_1	406	409	PF13499	0.541
DOC_PP2B_LxvP_1	498	501	PF13499	0.650
DOC_USP7_MATH_1	110	114	PF00917	0.726
DOC_USP7_MATH_1	141	145	PF00917	0.713
DOC_USP7_MATH_1	206	210	PF00917	0.555
DOC_USP7_MATH_1	222	226	PF00917	0.437
DOC_USP7_MATH_1	276	280	PF00917	0.604
DOC_USP7_MATH_1	281	285	PF00917	0.569
DOC_USP7_MATH_1	318	322	PF00917	0.785
DOC_USP7_MATH_1	331	335	PF00917	0.521
DOC_USP7_MATH_1	43	47	PF00917	0.654
DOC_USP7_MATH_1	437	441	PF00917	0.557
DOC_USP7_MATH_1	483	487	PF00917	0.741
DOC_USP7_UBL2_3	461	465	PF12436	0.451
DOC_WW_Pin1_4	108	113	PF00397	0.605
DOC_WW_Pin1_4	262	267	PF00397	0.635
DOC_WW_Pin1_4	29	34	PF00397	0.610
DOC_WW_Pin1_4	510	515	PF00397	0.581
DOC_WW_Pin1_4	55	60	PF00397	0.782
DOC_WW_Pin1_4	99	104	PF00397	0.686
LIG_14-3-3_CanoR_1	117	123	PF00244	0.576
LIG_14-3-3_CanoR_1	199	203	PF00244	0.657
LIG_14-3-3_CanoR_1	282	292	PF00244	0.578
LIG_14-3-3_CanoR_1	358	364	PF00244	0.427
LIG_14-3-3_CanoR_1	393	398	PF00244	0.512
LIG_14-3-3_CanoR_1	435	445	PF00244	0.504
LIG_14-3-3_CanoR_1	456	463	PF00244	0.520
LIG_AP2alpha_2	92	94	PF02296	0.552
LIG_EVH1_1	498	502	PF00568	0.592
LIG_FHA_1	312	318	PF00498	0.551
LIG_FHA_1	36	42	PF00498	0.651
LIG_FHA_1	392	398	PF00498	0.628
LIG_FHA_1	440	446	PF00498	0.460
LIG_FHA_2	360	366	PF00498	0.428
LIG_LIR_Gen_1	349	357	PF02991	0.522
LIG_LIR_Nem_3	349	355	PF02991	0.524
LIG_Pex14_2	77	81	PF04695	0.561
LIG_SH2_GRB2like	172	175	PF00017	0.392
LIG_SH2_SRC	172	175	PF00017	0.477
LIG_SH2_SRC	218	221	PF00017	0.561
LIG_SH2_STAP1	352	356	PF00017	0.437
LIG_SH2_STAT5	163	166	PF00017	0.580
LIG_SH2_STAT5	21	24	PF00017	0.464
LIG_SH2_STAT5	218	221	PF00017	0.561
LIG_SH2_STAT5	462	465	PF00017	0.395
LIG_SH3_1	24	30	PF00018	0.594
LIG_SH3_2	499	504	PF14604	0.586
LIG_SH3_3	120	126	PF00018	0.560
LIG_SH3_3	150	156	PF00018	0.416
LIG_SH3_3	173	179	PF00018	0.416
LIG_SH3_3	24	30	PF00018	0.606
LIG_SH3_3	260	266	PF00018	0.592
LIG_SH3_3	272	278	PF00018	0.577
LIG_SH3_3	496	502	PF00018	0.631
LIG_SH3_3	56	62	PF00018	0.624
LIG_SH3_3	90	96	PF00018	0.553
LIG_SH3_3	97	103	PF00018	0.604
LIG_SUMO_SIM_anti_2	334	342	PF11976	0.583
LIG_SUMO_SIM_anti_2	97	102	PF11976	0.629
LIG_TRFH_1	21	25	PF08558	0.560
LIG_UBA3_1	405	412	PF00899	0.558
MOD_CDK_SPK_2	102	107	PF00069	0.564
MOD_CDK_SPK_2	55	60	PF00069	0.640
MOD_CK1_1	102	108	PF00069	0.615
MOD_CK1_1	137	143	PF00069	0.646
MOD_CK1_1	210	216	PF00069	0.612
MOD_CK1_1	225	231	PF00069	0.478
MOD_CK1_1	265	271	PF00069	0.662
MOD_CK1_1	32	38	PF00069	0.607
MOD_CK1_1	386	392	PF00069	0.507
MOD_CK1_1	439	445	PF00069	0.504
MOD_CK1_1	46	52	PF00069	0.674
MOD_CK1_1	55	61	PF00069	0.745
MOD_CK1_1	68	74	PF00069	0.555
MOD_CK1_1	88	94	PF00069	0.442
MOD_CK2_1	102	108	PF00069	0.800
MOD_CK2_1	141	147	PF00069	0.676
MOD_CK2_1	285	291	PF00069	0.689
MOD_CK2_1	359	365	PF00069	0.418
MOD_CK2_1	386	392	PF00069	0.464
MOD_CK2_1	408	414	PF00069	0.606
MOD_CK2_1	464	470	PF00069	0.651
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.609
MOD_GlcNHglycan	112	115	PF01048	0.615
MOD_GlcNHglycan	127	130	PF01048	0.689
MOD_GlcNHglycan	134	137	PF01048	0.677
MOD_GlcNHglycan	186	189	PF01048	0.498
MOD_GlcNHglycan	209	212	PF01048	0.570
MOD_GlcNHglycan	224	227	PF01048	0.498
MOD_GlcNHglycan	267	270	PF01048	0.619
MOD_GlcNHglycan	287	290	PF01048	0.642
MOD_GlcNHglycan	291	295	PF01048	0.646
MOD_GlcNHglycan	324	327	PF01048	0.690
MOD_GlcNHglycan	38	41	PF01048	0.592
MOD_GlcNHglycan	419	422	PF01048	0.568
MOD_GlcNHglycan	45	48	PF01048	0.651
MOD_GlcNHglycan	470	473	PF01048	0.581
MOD_GlcNHglycan	485	488	PF01048	0.539
MOD_GlcNHglycan	489	492	PF01048	0.532
MOD_GlcNHglycan	52	55	PF01048	0.816
MOD_GlcNHglycan	65	68	PF01048	0.584
MOD_GlcNHglycan	70	73	PF01048	0.576
MOD_GSK3_1	137	144	PF00069	0.768
MOD_GSK3_1	206	213	PF00069	0.548
MOD_GSK3_1	25	32	PF00069	0.598
MOD_GSK3_1	276	283	PF00069	0.588
MOD_GSK3_1	318	325	PF00069	0.594
MOD_GSK3_1	41	48	PF00069	0.621
MOD_GSK3_1	433	440	PF00069	0.622
MOD_GSK3_1	464	471	PF00069	0.519
MOD_GSK3_1	479	486	PF00069	0.543
MOD_N-GLC_1	132	137	PF02516	0.700
MOD_N-GLC_1	331	336	PF02516	0.532
MOD_N-GLC_1	68	73	PF02516	0.588
MOD_N-GLC_2	20	22	PF02516	0.444
MOD_N-GLC_2	307	309	PF02516	0.511
MOD_NEK2_1	134	139	PF00069	0.737
MOD_NEK2_1	198	203	PF00069	0.591
MOD_NEK2_1	303	308	PF00069	0.519
MOD_NEK2_1	322	327	PF00069	0.574
MOD_NEK2_1	356	361	PF00069	0.432
MOD_NEK2_1	36	41	PF00069	0.628
MOD_NEK2_1	377	382	PF00069	0.438
MOD_NEK2_1	391	396	PF00069	0.438
MOD_NEK2_1	438	443	PF00069	0.487
MOD_NEK2_1	63	68	PF00069	0.714
MOD_NEK2_1	77	82	PF00069	0.504
MOD_PIKK_1	283	289	PF00454	0.642
MOD_PIKK_1	311	317	PF00454	0.614
MOD_PIKK_1	346	352	PF00454	0.497
MOD_PIKK_1	377	383	PF00454	0.439
MOD_PIKK_1	440	446	PF00454	0.458
MOD_PKA_1	456	462	PF00069	0.506
MOD_PKA_1	464	470	PF00069	0.474
MOD_PKA_2	198	204	PF00069	0.541
MOD_PKA_2	281	287	PF00069	0.588
MOD_PKA_2	357	363	PF00069	0.431
MOD_PKA_2	456	462	PF00069	0.521
MOD_PKA_2	94	100	PF00069	0.669
MOD_Plk_1	336	342	PF00069	0.593
MOD_Plk_1	391	397	PF00069	0.568
MOD_Plk_2-3	142	148	PF00069	0.607
MOD_Plk_2-3	237	243	PF00069	0.556
MOD_Plk_4	198	204	PF00069	0.626
MOD_ProDKin_1	108	114	PF00069	0.605
MOD_ProDKin_1	262	268	PF00069	0.633
MOD_ProDKin_1	29	35	PF00069	0.614
MOD_ProDKin_1	510	516	PF00069	0.580
MOD_ProDKin_1	55	61	PF00069	0.781
MOD_ProDKin_1	99	105	PF00069	0.686
TRG_ENDOCYTIC_2	352	355	PF00928	0.445
TRG_ER_diArg_1	116	118	PF00400	0.579
TRG_ER_diArg_1	229	232	PF00400	0.639
TRG_ER_diArg_1	399	402	PF00400	0.462
TRG_ER_diArg_1	427	429	PF00400	0.446
TRG_ER_diArg_1	455	457	PF00400	0.459
TRG_NES_CRM1_1	422	433	PF08389	0.521
TRG_NLS_MonoExtC_3	229	234	PF00514	0.590
TRG_NLS_MonoExtN_4	230	235	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J9	Leptomonas seymouri	47%	97%
A4HEX2	Leishmania braziliensis	68%	98%
A4I246	Leishmania infantum	100%	100%
E9AY96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q977	Leishmania major	89%	100%