NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 74, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZS4_LEIDO

TriTrypDb:

LdBPK_261230.1 , LdCL_260017900 , LDHU3_26.1530

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WZS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZS4

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.383
CLV_C14_Caspase3-7	317	321	PF00656	0.397
CLV_C14_Caspase3-7	636	640	PF00656	0.666
CLV_NRD_NRD_1	105	107	PF00675	0.339
CLV_NRD_NRD_1	27	29	PF00675	0.437
CLV_NRD_NRD_1	510	512	PF00675	0.626
CLV_NRD_NRD_1	524	526	PF00675	0.529
CLV_NRD_NRD_1	539	541	PF00675	0.365
CLV_NRD_NRD_1	546	548	PF00675	0.448
CLV_NRD_NRD_1	621	623	PF00675	0.613
CLV_NRD_NRD_1	678	680	PF00675	0.491
CLV_PCSK_FUR_1	618	622	PF00082	0.679
CLV_PCSK_KEX2_1	27	29	PF00082	0.450
CLV_PCSK_KEX2_1	31	33	PF00082	0.438
CLV_PCSK_KEX2_1	458	460	PF00082	0.485
CLV_PCSK_KEX2_1	524	526	PF00082	0.536
CLV_PCSK_KEX2_1	539	541	PF00082	0.365
CLV_PCSK_KEX2_1	546	548	PF00082	0.448
CLV_PCSK_KEX2_1	620	622	PF00082	0.627
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.467
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.478
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.702
CLV_PCSK_PC7_1	27	33	PF00082	0.490
CLV_PCSK_SKI1_1	107	111	PF00082	0.303
CLV_PCSK_SKI1_1	115	119	PF00082	0.323
CLV_PCSK_SKI1_1	265	269	PF00082	0.470
CLV_PCSK_SKI1_1	303	307	PF00082	0.333
CLV_PCSK_SKI1_1	539	543	PF00082	0.496
CLV_PCSK_SKI1_1	54	58	PF00082	0.290
CLV_PCSK_SKI1_1	576	580	PF00082	0.491
CLV_PCSK_SKI1_1	642	646	PF00082	0.675
CLV_PCSK_SKI1_1	653	657	PF00082	0.524
DEG_APCC_DBOX_1	575	583	PF00400	0.486
DEG_APCC_DBOX_1	606	614	PF00400	0.633
DEG_APCC_KENBOX_2	470	474	PF00400	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.367
DOC_CYCLIN_RxL_1	262	271	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.365
DOC_MAPK_gen_1	679	689	PF00069	0.504
DOC_USP7_MATH_1	16	20	PF00917	0.424
DOC_USP7_MATH_1	205	209	PF00917	0.338
DOC_USP7_MATH_1	340	344	PF00917	0.534
DOC_USP7_MATH_1	491	495	PF00917	0.650
DOC_USP7_MATH_1	516	520	PF00917	0.609
DOC_USP7_MATH_1	541	545	PF00917	0.474
DOC_USP7_MATH_1	629	633	PF00917	0.657
DOC_USP7_UBL2_3	306	310	PF12436	0.331
DOC_WW_Pin1_4	150	155	PF00397	0.467
DOC_WW_Pin1_4	99	104	PF00397	0.327
LIG_14-3-3_CanoR_1	235	245	PF00244	0.485
LIG_14-3-3_CanoR_1	371	376	PF00244	0.382
LIG_14-3-3_CanoR_1	540	550	PF00244	0.575
LIG_BRCT_BRCA1_1	83	87	PF00533	0.387
LIG_FHA_1	120	126	PF00498	0.484
LIG_FHA_1	246	252	PF00498	0.392
LIG_FHA_1	300	306	PF00498	0.381
LIG_FHA_1	378	384	PF00498	0.392
LIG_FHA_1	386	392	PF00498	0.493
LIG_FHA_1	9	15	PF00498	0.333
LIG_FHA_2	315	321	PF00498	0.331
LIG_FHA_2	388	394	PF00498	0.462
LIG_FHA_2	533	539	PF00498	0.557
LIG_FHA_2	654	660	PF00498	0.568
LIG_FHA_2	686	692	PF00498	0.569
LIG_LIR_Gen_1	137	148	PF02991	0.436
LIG_LIR_Gen_1	314	323	PF02991	0.340
LIG_LIR_Gen_1	374	383	PF02991	0.391
LIG_LIR_Gen_1	389	398	PF02991	0.520
LIG_LIR_Gen_1	528	536	PF02991	0.418
LIG_LIR_Gen_1	553	561	PF02991	0.570
LIG_LIR_Nem_3	102	108	PF02991	0.325
LIG_LIR_Nem_3	137	143	PF02991	0.358
LIG_LIR_Nem_3	314	319	PF02991	0.332
LIG_LIR_Nem_3	326	331	PF02991	0.305
LIG_LIR_Nem_3	374	378	PF02991	0.380
LIG_LIR_Nem_3	389	395	PF02991	0.489
LIG_LIR_Nem_3	442	447	PF02991	0.488
LIG_LIR_Nem_3	528	532	PF02991	0.415
LIG_LIR_Nem_3	553	558	PF02991	0.515
LIG_Pex14_2	505	509	PF04695	0.474
LIG_PTB_Apo_2	426	433	PF02174	0.370
LIG_PTB_Apo_2	523	530	PF02174	0.509
LIG_PTB_Phospho_1	426	432	PF10480	0.364
LIG_PTB_Phospho_1	523	529	PF10480	0.565
LIG_REV1ctd_RIR_1	281	291	PF16727	0.384
LIG_RPA_C_Fungi	204	216	PF08784	0.364
LIG_RPA_C_Fungi	535	547	PF08784	0.478
LIG_SH2_CRK	529	533	PF00017	0.431
LIG_SH2_STAP1	259	263	PF00017	0.333
LIG_SH2_STAP1	529	533	PF00017	0.431
LIG_SH2_STAP1	550	554	PF00017	0.466
LIG_SH2_STAT5	282	285	PF00017	0.312
LIG_SH2_STAT5	447	450	PF00017	0.439
LIG_SH3_3	126	132	PF00018	0.354
LIG_SH3_3	435	441	PF00018	0.380
LIG_SUMO_SIM_anti_2	374	382	PF11976	0.381
LIG_SUMO_SIM_par_1	265	271	PF11976	0.354
LIG_TRAF2_1	238	241	PF00917	0.463
LIG_TRAF2_1	35	38	PF00917	0.607
MOD_CDK_SPxxK_3	99	106	PF00069	0.333
MOD_CK1_1	169	175	PF00069	0.555
MOD_CK1_1	222	228	PF00069	0.525
MOD_CK1_1	288	294	PF00069	0.406
MOD_CK1_1	299	305	PF00069	0.350
MOD_CK1_1	314	320	PF00069	0.362
MOD_CK1_1	343	349	PF00069	0.424
MOD_CK1_1	640	646	PF00069	0.582
MOD_CK1_1	661	667	PF00069	0.502
MOD_CK2_1	16	22	PF00069	0.452
MOD_CK2_1	371	377	PF00069	0.346
MOD_CK2_1	396	402	PF00069	0.402
MOD_CK2_1	532	538	PF00069	0.501
MOD_CK2_1	653	659	PF00069	0.572
MOD_CK2_1	679	685	PF00069	0.546
MOD_Cter_Amidation	509	512	PF01082	0.368
MOD_GlcNHglycan	122	125	PF01048	0.396
MOD_GlcNHglycan	148	151	PF01048	0.292
MOD_GlcNHglycan	173	176	PF01048	0.483
MOD_GlcNHglycan	190	193	PF01048	0.356
MOD_GlcNHglycan	221	224	PF01048	0.405
MOD_GlcNHglycan	225	228	PF01048	0.357
MOD_GlcNHglycan	240	244	PF01048	0.279
MOD_GlcNHglycan	252	255	PF01048	0.382
MOD_GlcNHglycan	298	301	PF01048	0.299
MOD_GlcNHglycan	33	36	PF01048	0.674
MOD_GlcNHglycan	344	348	PF01048	0.348
MOD_GlcNHglycan	493	496	PF01048	0.581
MOD_GlcNHglycan	543	546	PF01048	0.512
MOD_GlcNHglycan	589	592	PF01048	0.714
MOD_GlcNHglycan	615	618	PF01048	0.621
MOD_GlcNHglycan	631	634	PF01048	0.579
MOD_GlcNHglycan	639	642	PF01048	0.645
MOD_GlcNHglycan	659	663	PF01048	0.386
MOD_GlcNHglycan	697	700	PF01048	0.672
MOD_GlcNHglycan	96	99	PF01048	0.436
MOD_GSK3_1	1	8	PF00069	0.401
MOD_GSK3_1	115	122	PF00069	0.350
MOD_GSK3_1	12	19	PF00069	0.322
MOD_GSK3_1	146	153	PF00069	0.293
MOD_GSK3_1	166	173	PF00069	0.243
MOD_GSK3_1	219	226	PF00069	0.424
MOD_GSK3_1	288	295	PF00069	0.418
MOD_GSK3_1	311	318	PF00069	0.362
MOD_GSK3_1	326	333	PF00069	0.309
MOD_GSK3_1	491	498	PF00069	0.598
MOD_GSK3_1	629	636	PF00069	0.695
MOD_GSK3_1	658	665	PF00069	0.609
MOD_GSK3_1	81	88	PF00069	0.330
MOD_N-GLC_1	12	17	PF02516	0.340
MOD_N-GLC_1	314	319	PF02516	0.332
MOD_N-GLC_1	60	65	PF02516	0.294
MOD_NEK2_1	1	6	PF00069	0.378
MOD_NEK2_1	134	139	PF00069	0.371
MOD_NEK2_1	166	171	PF00069	0.534
MOD_NEK2_1	245	250	PF00069	0.315
MOD_NEK2_1	330	335	PF00069	0.445
MOD_NEK2_1	658	663	PF00069	0.633
MOD_NEK2_1	695	700	PF00069	0.503
MOD_NEK2_1	85	90	PF00069	0.325
MOD_PIKK_1	330	336	PF00454	0.361
MOD_PKA_1	31	37	PF00069	0.536
MOD_PKA_1	679	685	PF00069	0.594
MOD_PKA_2	31	37	PF00069	0.536
MOD_PKA_2	454	460	PF00069	0.450
MOD_PKA_2	462	468	PF00069	0.501
MOD_PKA_2	491	497	PF00069	0.602
MOD_PKA_2	637	643	PF00069	0.755
MOD_Plk_1	292	298	PF00069	0.350
MOD_Plk_1	314	320	PF00069	0.338
MOD_Plk_1	326	332	PF00069	0.305
MOD_Plk_1	386	392	PF00069	0.441
MOD_Plk_1	393	399	PF00069	0.369
MOD_Plk_1	81	87	PF00069	0.441
MOD_Plk_2-3	377	383	PF00069	0.370
MOD_Plk_2-3	387	393	PF00069	0.443
MOD_Plk_2-3	566	572	PF00069	0.540
MOD_Plk_2-3	685	691	PF00069	0.530
MOD_Plk_4	278	284	PF00069	0.301
MOD_Plk_4	292	298	PF00069	0.481
MOD_Plk_4	371	377	PF00069	0.368
MOD_Plk_4	387	393	PF00069	0.443
MOD_Plk_4	653	659	PF00069	0.582
MOD_ProDKin_1	150	156	PF00069	0.463
MOD_ProDKin_1	99	105	PF00069	0.327
MOD_SUMO_rev_2	381	388	PF00179	0.402
TRG_DiLeu_BaEn_1	241	246	PF01217	0.499
TRG_DiLeu_BaEn_1	528	533	PF01217	0.415
TRG_DiLeu_BaEn_2	161	167	PF01217	0.376
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.365
TRG_ENDOCYTIC_2	105	108	PF00928	0.457
TRG_ENDOCYTIC_2	140	143	PF00928	0.459
TRG_ENDOCYTIC_2	392	395	PF00928	0.469
TRG_ENDOCYTIC_2	432	435	PF00928	0.385
TRG_ENDOCYTIC_2	529	532	PF00928	0.430
TRG_ER_diArg_1	128	131	PF00400	0.331
TRG_NES_CRM1_1	92	104	PF08389	0.308
TRG_NLS_MonoExtC_3	27	32	PF00514	0.442
TRG_NLS_MonoExtC_3	619	624	PF00514	0.712
TRG_NLS_MonoExtC_3	678	683	PF00514	0.515
TRG_NLS_MonoExtN_4	27	32	PF00514	0.442
TRG_NLS_MonoExtN_4	618	624	PF00514	0.714
TRG_NLS_MonoExtN_4	679	684	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D9	Leptomonas seymouri	79%	100%
A0A0S4JNM6	Bodo saltans	53%	100%
A0A1X0NSW1	Trypanosomatidae	63%	100%
A0A3R7KNJ7	Trypanosoma rangeli	71%	100%
A4HEY0	Leishmania braziliensis	88%	100%
A4I254	Leishmania infantum	99%	100%
C9ZRU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AYA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
G0S902	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
O74879	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4Q969	Leishmania major	95%	99%
Q5RJG1	Mus musculus	35%	100%
Q66H99	Rattus norvegicus	35%	100%
Q6NVM6	Xenopus tropicalis	35%	100%
Q7T0Q5	Xenopus laevis	33%	100%
Q802W4	Danio rerio	35%	97%
Q9BSC4	Homo sapiens	34%	100%