NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 74, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZS4_LEIDO

TriTrypDb:

LdBPK_261230.1 , LdCL_260017900 , LDHU3_26.1530

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1

Previous1Next

Expansion

Sequence features

A0A3S7WZS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZS4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1

Previous1 2 3Next

Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.383
CLV_C14_Caspase3-7	317	321	PF00656	0.397
CLV_C14_Caspase3-7	636	640	PF00656	0.666
CLV_NRD_NRD_1	105	107	PF00675	0.339
CLV_NRD_NRD_1	27	29	PF00675	0.437
CLV_NRD_NRD_1	510	512	PF00675	0.626
CLV_NRD_NRD_1	524	526	PF00675	0.529
CLV_NRD_NRD_1	539	541	PF00675	0.365
CLV_NRD_NRD_1	546	548	PF00675	0.448
CLV_NRD_NRD_1	621	623	PF00675	0.613

Previous1 2 3 4 5…21Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D9	Leptomonas seymouri	79%	100%
A0A0S4JNM6	Bodo saltans	53%	100%
A0A1X0NSW1	Trypanosomatidae	63%	100%
A0A3R7KNJ7	Trypanosoma rangeli	71%	100%
A4HEY0	Leishmania braziliensis	88%	100%
A4I254	Leishmania infantum	99%	100%
C9ZRU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AYA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
G0S902	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
O74879	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%

Previous1 2Next