Axonemal dynein light chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZS2_LEIDO

TriTrypDb:

LdBPK_261100.1 , LdCL_260016600 , LDHU3_26.1380

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.639
CLV_C14_Caspase3-7	246	250	PF00656	0.648
CLV_C14_Caspase3-7	82	86	PF00656	0.546
CLV_MEL_PAP_1	89	95	PF00089	0.636
CLV_NRD_NRD_1	290	292	PF00675	0.317
CLV_NRD_NRD_1	31	33	PF00675	0.579
CLV_NRD_NRD_1	311	313	PF00675	0.315
CLV_NRD_NRD_1	359	361	PF00675	0.255
CLV_NRD_NRD_1	380	382	PF00675	0.342
CLV_NRD_NRD_1	405	407	PF00675	0.312
CLV_NRD_NRD_1	431	433	PF00675	0.406
CLV_PCSK_KEX2_1	290	292	PF00082	0.317
CLV_PCSK_KEX2_1	311	313	PF00082	0.315
CLV_PCSK_KEX2_1	359	361	PF00082	0.255
CLV_PCSK_KEX2_1	404	406	PF00082	0.314
CLV_PCSK_KEX2_1	422	424	PF00082	0.463
CLV_PCSK_KEX2_1	443	445	PF00082	0.385
CLV_PCSK_KEX2_1	454	456	PF00082	0.396
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.312
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.381
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.396
CLV_PCSK_SKI1_1	341	345	PF00082	0.312
CLV_PCSK_SKI1_1	350	354	PF00082	0.312
DEG_SCF_FBW7_1	259	264	PF00400	0.647
DEG_SPOP_SBC_1	104	108	PF00917	0.572
DOC_CYCLIN_RxL_1	347	356	PF00134	0.388
DOC_PP4_FxxP_1	148	151	PF00568	0.544
DOC_PP4_FxxP_1	41	44	PF00568	0.707
DOC_USP7_MATH_1	104	108	PF00917	0.676
DOC_USP7_MATH_1	113	117	PF00917	0.732
DOC_USP7_MATH_1	139	143	PF00917	0.603
DOC_USP7_MATH_1	196	200	PF00917	0.589
DOC_USP7_MATH_1	210	214	PF00917	0.501
DOC_USP7_MATH_1	265	269	PF00917	0.660
DOC_USP7_MATH_1	278	282	PF00917	0.478
DOC_USP7_MATH_1	314	318	PF00917	0.326
DOC_WW_Pin1_4	115	120	PF00397	0.816
DOC_WW_Pin1_4	147	152	PF00397	0.577
DOC_WW_Pin1_4	257	262	PF00397	0.698
DOC_WW_Pin1_4	282	287	PF00397	0.323
LIG_14-3-3_CanoR_1	115	119	PF00244	0.595
LIG_14-3-3_CanoR_1	161	165	PF00244	0.572
LIG_14-3-3_CanoR_1	171	179	PF00244	0.558
LIG_14-3-3_CanoR_1	280	286	PF00244	0.632
LIG_14-3-3_CanoR_1	341	346	PF00244	0.312
LIG_14-3-3_CanoR_1	381	388	PF00244	0.337
LIG_Actin_RPEL_3	352	371	PF02755	0.388
LIG_APCC_ABBAyCdc20_2	328	334	PF00400	0.312
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BIR_III_1	1	5	PF00653	0.556
LIG_BIR_III_3	1	5	PF00653	0.556
LIG_Clathr_ClatBox_1	230	234	PF01394	0.587
LIG_FHA_1	104	110	PF00498	0.673
LIG_FHA_1	120	126	PF00498	0.540
LIG_FHA_1	18	24	PF00498	0.539
LIG_FHA_1	202	208	PF00498	0.643
LIG_FHA_1	258	264	PF00498	0.713
LIG_FHA_1	265	271	PF00498	0.649
LIG_FHA_1	365	371	PF00498	0.312
LIG_FHA_2	382	388	PF00498	0.312
LIG_FHA_2	395	401	PF00498	0.312
LIG_FHA_2	80	86	PF00498	0.546
LIG_LIR_Apic_2	39	44	PF02991	0.712
LIG_LIR_Gen_1	366	375	PF02991	0.330
LIG_LIR_Gen_1	8	18	PF02991	0.516
LIG_LIR_Nem_3	15	21	PF02991	0.522
LIG_LIR_Nem_3	366	371	PF02991	0.330
LIG_LIR_Nem_3	8	13	PF02991	0.517
LIG_PCNA_yPIPBox_3	328	340	PF02747	0.388
LIG_Pex14_1	413	417	PF04695	0.312
LIG_Rb_LxCxE_1	344	356	PF01857	0.331
LIG_RPA_C_Fungi	185	197	PF08784	0.493
LIG_SH2_CRK	18	22	PF00017	0.586
LIG_SH2_CRK	368	372	PF00017	0.312
LIG_SH2_CRK	417	421	PF00017	0.312
LIG_SH2_STAP1	368	372	PF00017	0.312
LIG_SH2_STAP1	441	445	PF00017	0.312
LIG_SH2_STAP1	47	51	PF00017	0.503
LIG_SH2_STAT5	185	188	PF00017	0.690
LIG_SH2_STAT5	391	394	PF00017	0.315
LIG_SH2_STAT5	65	68	PF00017	0.565
LIG_SH3_2	110	115	PF14604	0.681
LIG_SH3_3	106	112	PF00018	0.656
LIG_SH3_3	256	262	PF00018	0.599
LIG_SH3_3	320	326	PF00018	0.340
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.316
LIG_TYR_ITIM	16	21	PF00017	0.513
LIG_TYR_ITIM	304	309	PF00017	0.312
MOD_CK1_1	117	123	PF00069	0.590
MOD_CK1_1	152	158	PF00069	0.590
MOD_CK1_1	199	205	PF00069	0.753
MOD_CK1_1	264	270	PF00069	0.765
MOD_CK1_1	272	278	PF00069	0.500
MOD_CK1_1	281	287	PF00069	0.242
MOD_CK1_1	94	100	PF00069	0.631
MOD_CK2_1	147	153	PF00069	0.719
MOD_CK2_1	159	165	PF00069	0.702
MOD_CK2_1	394	400	PF00069	0.418
MOD_CK2_1	5	11	PF00069	0.689
MOD_DYRK1A_RPxSP_1	115	119	PF00069	0.696
MOD_GlcNHglycan	101	104	PF01048	0.617
MOD_GlcNHglycan	122	125	PF01048	0.659
MOD_GlcNHglycan	128	131	PF01048	0.656
MOD_GlcNHglycan	136	139	PF01048	0.663
MOD_GlcNHglycan	201	204	PF01048	0.628
MOD_GlcNHglycan	244	248	PF01048	0.646
MOD_GlcNHglycan	263	266	PF01048	0.671
MOD_GlcNHglycan	272	275	PF01048	0.525
MOD_GlcNHglycan	280	283	PF01048	0.450
MOD_GlcNHglycan	316	319	PF01048	0.312
MOD_GlcNHglycan	373	376	PF01048	0.346
MOD_GlcNHglycan	74	77	PF01048	0.556
MOD_GlcNHglycan	94	97	PF01048	0.685
MOD_GSK3_1	113	120	PF00069	0.661
MOD_GSK3_1	134	141	PF00069	0.604
MOD_GSK3_1	155	162	PF00069	0.710
MOD_GSK3_1	197	204	PF00069	0.660
MOD_GSK3_1	239	246	PF00069	0.689
MOD_GSK3_1	257	264	PF00069	0.762
MOD_GSK3_1	265	272	PF00069	0.679
MOD_GSK3_1	278	285	PF00069	0.523
MOD_GSK3_1	394	401	PF00069	0.340
MOD_GSK3_1	91	98	PF00069	0.613
MOD_GSK3_1	99	106	PF00069	0.570
MOD_N-GLC_1	171	176	PF02516	0.594
MOD_NEK2_1	17	22	PF00069	0.534
MOD_NEK2_1	263	268	PF00069	0.690
MOD_NEK2_1	371	376	PF00069	0.448
MOD_PIKK_1	139	145	PF00454	0.659
MOD_PIKK_1	178	184	PF00454	0.566
MOD_PKA_1	381	387	PF00069	0.327
MOD_PKA_2	114	120	PF00069	0.529
MOD_PKA_2	160	166	PF00069	0.589
MOD_PKA_2	211	217	PF00069	0.679
MOD_PKA_2	380	386	PF00069	0.328
MOD_PKA_2	91	97	PF00069	0.600
MOD_PKA_2	99	105	PF00069	0.689
MOD_Plk_1	152	158	PF00069	0.602
MOD_Plk_1	57	63	PF00069	0.470
MOD_Plk_2-3	5	11	PF00069	0.601
MOD_Plk_4	12	18	PF00069	0.510
MOD_Plk_4	341	347	PF00069	0.418
MOD_ProDKin_1	115	121	PF00069	0.820
MOD_ProDKin_1	147	153	PF00069	0.576
MOD_ProDKin_1	257	263	PF00069	0.699
MOD_ProDKin_1	282	288	PF00069	0.323
MOD_SUMO_rev_2	245	255	PF00179	0.648
MOD_SUMO_rev_2	426	434	PF00179	0.312
MOD_SUMO_rev_2	451	456	PF00179	0.388
TRG_DiLeu_BaEn_1	349	354	PF01217	0.312
TRG_ENDOCYTIC_2	10	13	PF00928	0.540
TRG_ENDOCYTIC_2	18	21	PF00928	0.564
TRG_ENDOCYTIC_2	306	309	PF00928	0.312
TRG_ENDOCYTIC_2	368	371	PF00928	0.312
TRG_ENDOCYTIC_2	417	420	PF00928	0.312
TRG_ER_diArg_1	289	291	PF00400	0.312
TRG_ER_diArg_1	359	362	PF00400	0.255
TRG_ER_diArg_1	403	406	PF00400	0.314
TRG_ER_diLys_1	462	466	PF00400	0.627
TRG_NES_CRM1_1	11	27	PF08389	0.573
TRG_NES_CRM1_1	334	349	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.224
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P322	Leptomonas seymouri	46%	94%
A4HEW7	Leishmania braziliensis	75%	100%
A4I241	Leishmania infantum	100%	100%
E9AY91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q982	Leishmania major	92%	100%